Faculty profile

Arkady Khoutorsky

ResearcherAnesthesiaMcGill University

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a McGill University directory, so their courses may be missing. Find their university profile.

Arkady Khoutorsky

Researcher

Anesthesia

Health Sciences

McGill University

Montreal, Quebec, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
34 publications in the last five years, latest in 2026.
Senior (last) author on 15 recent papers, a sign of leading a research group.
Principal investigator on 7 research grants (5 CIHR, 2 NSERC), most recently in 2023.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

Publications

Citations

h-index

Collaborators

Grants

Publications by year

Counts cover the works listed on the university profile; citation counts come from Dimensions.

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Signals and details

Research

Extracellular Matrix Perineuronal Nets Galns Mouse Models Neuropathic Pain Projection Neurons Chronic Pain Electrophysiology

Latest papers

SNCA triplication disrupts proteostasis and extracellular architecture prior to neurodegeneration in human midbrain organoids.
NPJ Parkinson's disease · 2026
4E-BP2-dependent translational control in GABAergic interneurons is required for long-term memory.
Molecular neurobiology · 2026
Translational control in the spinal cord regulates gene expression and pain hypersensitivity in the chronic phase of neuropathic pain.
eLife · 2026 · senior author

All 74 publications

Latest funding

Perineuronal nets around spinal projection neurons in neuropathic pain
CIHR · 2023 · Nominated PI
$1,132,200
Perineuronal nets around spinal projection neurons in neuropathic pain
CIHR · 2023 · Nominated PI
$100,000
The role of the gut microbiota in mediating pain hypersensitivity and other symptoms of fibromyalgia
CIHR · 2023 · Nominated PI
$1,361,700

All 9 grants and awards

74 publications.

SNCA triplication disrupts proteostasis and extracellular architecture prior to neurodegeneration in human midbrain organoids.

Statoulla E, Zafeiri M, Chalkiadaki K, Voudouri G, Gkika KS, Papazoglou C, Durcan TM, Khoutorsky A, Jafarnejad SM, Maguire S, Dityatev A, Gkogkas CG

NPJ Parkinson's disease2026

DOI: 10.1038/s41531-026-01292-0 PMID: 41698927

4E-BP2-dependent translational control in GABAergic interneurons is required for long-term memory.

Huang Z, Mahmood N, Psycharis K, Lister K, Hooshmandi M, Nageshwar Inturi N, Tavares-Ferreira D, Wiebe S, Khoutorsky A, Sonenberg N

Molecular neurobiology2026

DOI: 10.1007/s12035-026-05684-4 PMID: 41615594

Translational control in the spinal cord regulates gene expression and pain hypersensitivity in the chronic phase of neuropathic pain.

Lister KC, Wong C, Uttam S, Parisien M, Stecum P, Brown N, Cai W, Ho-Tieng D, Hooshmandi M, Gu N, Amiri M, Beaudry F, Jafarnejad SM, Tavares-Ferreira D, Inturi NN, Mazhar K, Zhao HT, Fitzsimmons B, Gkogkas CG, Sonenberg N, Price TJ, Diatchenko L, Atlasi Y, Mogil JS, Khoutorsky A

eLife2026Senior author

DOI: 10.7554/elife.100451 PMID: 41960785

The 4EHP/GIGYF2 translation repressor complex is co-opted by the vaccinia virus K3L protein as a potential mechanism of immunoevasion.

Ladak RJ, Pelin A, Zhuang H, Abboud C, Mahmood N, Blanchet J, Wu C, Hoang HD, McGirr T, Moshari A, Moustafa-Kamal M, Snell PH, Düsterhöft S, Berghuis AM, Trempe JF, Tremblay ML, Teodoro JG, Khoutorsky A, Alain T, Krogan NJ, Choi JH, Jafarnejad SM, Sonenberg N

Proceedings of the National Academy of Sciences of the United States of America2026

DOI: 10.1073/pnas.2618090123 PMID: 42709808

The ISR downstream effector ATF4 promotes mGluR-dependent long-term depression and associated behavior.

Mahmood N, Dang CL, Wu PY, Huang Z, Choi JH, Psycharis K, Portugese R, Khoutorsky A, Costa-Mattioli M, McKinney RA, Sonenberg N

Proceedings of the National Academy of Sciences of the United States of America2026

DOI: 10.1073/pnas.2532796123 PMID: 41706892

Glial cells in neuropathic pain.

Berta T, Khoutorsky A, Xu J, Ji RR

Physiological reviews2026

DOI: 10.1152/physrev.00034.2025 PMID: 42113554

Revisiting the role of Substance P and CGRPα.

Cai W, Khoutorsky A

eLife2025Senior author

DOI: 10.7554/elife.106766 PMID: 40235300

Postnatal downregulation of Fmr1 in microglia promotes microglial reactivity and causes behavioural alterations in female mice.

Hooshmandi M, Ho-Tieng D, Lister KC, Cai W, Wong C, Brown N, Fan J, Hovhannisyan V, Uttam S, Prager-Khoutorsky M, Sonenberg N, Gkogkas CG, Khoutorsky A

Molecular autism2025Senior author

DOI: 10.1186/s13229-025-00648-2 PMID: 40055803

Cardioprotective effects of l-glutamine in an ischemic rat heart model.

Kawakami A, Sato H, Nakadate Y, Roque P, Khoutorsky A, Matsukawa T, Schricker T

Microvascular research2025

DOI: 10.1016/j.mvr.2024.104764 PMID: 39571748

Targeting spinal mechanistic target of rapamycin complex 2 alleviates inflammatory and neuropathic pain.

Wong C, Rodriguez-Hernandez LD, Lister KC, Gu N, Cai W, Hooshmandi M, Fan J, Brown N, Nguyen V, Ribeiro-da-Silva A, Bonin RP, Khoutorsky A

Brain : a journal of neurology2025Senior author

DOI: 10.1093/brain/awae275 PMID: 39167538

Perineuronal nets around spinal projection neurons in neuropathic pain

Nominated PICIHR2023Project Grant

Principal investigators: Khoutorsky, Arkady

Keywords: Extracellular Matrix; Galns; Mouse Models; Neuropathic Pain; Perineuronal Nets; Projection Neurons

$1,132,200

Perineuronal nets around spinal projection neurons in neuropathic pain

Nominated PICIHR2023Project Grant

Principal investigators: Khoutorsky, Arkady

Keywords: Extracellular Matrix; Galns; Mouse Models; Neuropathic Pain; Perineuronal Nets; Projection Neurons

$100,000

The role of the gut microbiota in mediating pain hypersensitivity and other symptoms of fibromyalgia

Nominated PICIHR2023Project Grant

Principal investigators: Khoutorsky, Arkady

Keywords: Chronic Pain; Electrophysiology; Fibromyalgia; Microbiota; Microglia; Mouse Behaviour; Neuroimunology; Spinal Cord

$1,361,700

Neuron-specific deamidation of translational repressor 4E-BP2 in postnatal brain

Principal investigatorNSERC2020Discovery Launch Supplement

Principal investigators: Khoutorsky, Arkady

$12,500

Neuron-specific deamidation of translational repressor 4E-BP2 in postnatal brain

Principal investigatorNSERC2020Discovery Grants Program - Individual

Principal investigators: Khoutorsky, Arkady

$205,000

Anesthesia-induced memory impairment is mediated by a specific loss of inhibitory neurons

Co-investigatorCIHR2020Project Grant

Principal investigators: Schricker, Thomas Peter S

Keywords: Anesthesia; Apoptosis; Behavioral Tests; Insulin; Memory Impairment; Mitochondria; Neuronal Cuircuits; Synaptic Plasticity

$956,250

Perineuronal nets-mediated regulation of spinal nociceptive circuits

Nominated PICIHR2018Project Grant

Principal investigators: Khoutorsky, Arkady

Keywords: Extracellular Matrix; Inhibitory Neurons; Intracellular Signaling; Matrix Metalloproteinases (Mmps); Pain; Perineuronal Nets; Spinal Nociceptive Circuits

$856,800

Dysregulation of eIF2a-dependent translational control in Fragile X syndrome and autism spectrum disorders

Nominated PICIHR2018Project Grant

Principal investigators: Khoutorsky, Arkady

Keywords: Autism; Eif2alpha Phosphorylation; Fragile X Syndrome; Gene Expression; Integrated Stress Response (Isr) Pathway; Mrna Translation; Synaptic Plasticity

$891,225

The role of mTOR pathway in age-associated memory decline.

Co-investigatorCIHR2010Catalyst Grant: Pilot Projects in Aging - Biological & Clinical Aspects of Aging

Principal investigators: Sonenberg, Nahum

Keywords: Age-Associated Memory Decline; Aging; Caloric Restriction; Metformin; Mtor Pathway; Rapamycin

$50,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

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Arkady Khoutorsky

Research

Latest papers

Latest funding

SNCA triplication disrupts proteostasis and extracellular architecture prior to neurodegeneration in human midbrain organoids.

4E-BP2-dependent translational control in GABAergic interneurons is required for long-term memory.

Translational control in the spinal cord regulates gene expression and pain hypersensitivity in the chronic phase of neuropathic pain.

The 4EHP/GIGYF2 translation repressor complex is co-opted by the vaccinia virus K3L protein as a potential mechanism of immunoevasion.

The ISR downstream effector ATF4 promotes mGluR-dependent long-term depression and associated behavior.

Glial cells in neuropathic pain.

Revisiting the role of Substance P and CGRP&#x3b1;.

Postnatal downregulation of Fmr1 in microglia promotes microglial reactivity and causes behavioural alterations in female mice.

Cardioprotective effects of l-glutamine in an ischemic rat heart model.

Targeting spinal mechanistic target of rapamycin complex 2 alleviates inflammatory and neuropathic pain.

Perineuronal nets around spinal projection neurons in neuropathic pain

Perineuronal nets around spinal projection neurons in neuropathic pain

The role of the gut microbiota in mediating pain hypersensitivity and other symptoms of fibromyalgia

Neuron-specific deamidation of translational repressor 4E-BP2 in postnatal brain

Neuron-specific deamidation of translational repressor 4E-BP2 in postnatal brain

Anesthesia-induced memory impairment is mediated by a specific loss of inhibitory neurons

Perineuronal nets-mediated regulation of spinal nociceptive circuits

Dysregulation of eIF2a-dependent translational control in Fragile X syndrome and autism spectrum disorders

The role of mTOR pathway in age-associated memory decline.

Frequent collaborators

Nahum Sonenberg

Masha Prager-Khoutorsky

Alfredo Ribeiro-Da-Silva

Luda Diatchenko

Jean-Claude Lacaille

Karim Nader

Yves De Koninck

Yves De Koninck

Guillaume Bourque

Ji Zhang

Tommy Alain

Yojiro Yamanaka

Argel Aguilar Valles

Feng Wang

Linda Wykes

Thomas Schricker

Massimo Avoli

Xiang-Jiao Yang

Emerson Krock

Aparna Suvrathan

Marie-Eve Paquet

Ivan Topisirovic

Jean Ouellet

Philippe Séguéla

Artur Kania

Shimon Amir

Katrina Choe

Shimon Amir

Ciriaco Piccirillo

Revisiting the role of Substance P and CGRPα.