Faculty profile

Stefano Stifani

ResearcherNeurology and NeurosurgeryMcGill University

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a McGill University directory, so their courses may be missing. Find their university profile.

Stefano Stifani

Researcher

Neurology and Neurosurgery

Health Sciences

McGill University

Montreal, Quebec, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
12 publications in the last five years, latest in 2026.
Senior (last) author on 7 recent papers, a sign of leading a research group.
Principal investigator on 4 research grants (4 CIHR), most recently in 2018.
Supervised 1 trainee who won CIHR awards, most recently in 2012.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

Publications

Citations

h-index

Collaborators

Grants

Publications by year

Counts cover the works listed on the university profile; citation counts come from Dimensions.

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Signals and details

Research

Motor Neuron Disease Amyotrophic Lateral Sclerosis Motor Neuron Development Neurodegenerative Disease Hindbrain Motor Neuron Circuit Muscle Control Regeneration

Latest papers

The microtubule-binding protein EML3 is required for mammalian embryonic growth and cerebral cortical development, and Eml3 null mice are a model of cobblestone brain malformation.
eLife · 2026
Runx1 transcription factor modulates opioid analgesia and withdrawal in humans and rodents.
Neuron · 2026
Adrenergic Control of P2Y6 Receptor-Dependent Phagocytosis in Rodent and Human Microglia.
Glia · 2025

All 48 publications

Latest funding

INTEGRative multi-OMICs approaches on iPSC-derived 2D and 3D models to elucidate the role of immune and energy metabolism related genes/pathways in Amyotrophic Lateral Sclerosis
CIHR · 2018 · Nominated PI
$150,000
Regulation of motor neuron identity and circuit development
CIHR · 2012 · Nominated PI
$746,830
Regulation of the tumourigenic ability of glioblastoma stem-like cells
CIHR · 2012 · Supervisor
$105,000

All 5 grants and awards

48 publications.

The microtubule-binding protein EML3 is required for mammalian embryonic growth and cerebral cortical development, and Eml3 null mice are a model of cobblestone brain malformation.

Carrier I, Diez E, Piscopo VE, Bechstedt S, van Bokhoven H, Srour M, Berghuis AM, Stifani S, Yamanaka Y, McInnes R

eLife2026

DOI: 10.7554/elife.107102 PMID: 42423433

Runx1 transcription factor modulates opioid analgesia and withdrawal in humans and rodents.

Leduc-Pessah H, McAllister BB, Sinha S, Stokes-Heck S, Nishizawa D, Fan CY, St-Pierre MK, Bradaia A, Defaye M, Burma NE, Damblon J, Muñoz-Pino E, Visser F, Dorion MF, Healy LM, Tang YM, Canet-Pons J, van den Hoogen NJ, Zhang Z, Antunes FTT, Piscopo VEC, Medina M, Fukuda KI, Ichinohe T, Nagashima M, Hayashida M, Johnson E, Agrawal A, Degenhardt L, Martin NG, Zamponi GW, Nelson EC, Altier C, Tremblay ME, Bousman C, Stifani S, De Koninck Y, Ikeda K, Biernaskie J, Trang T

Neuron2026

DOI: 10.1016/j.neuron.2025.11.018 PMID: 41619726

Adrenergic Control of P2Y6 Receptor-Dependent Phagocytosis in Rodent and Human Microglia.

Deluc T, Ase A, Dorion MF, Maussion G, Tang Y, Lo RTM, Shlaifer I, Piscopo VE, Durcan TM, Stifani S, Séguéla P

Glia2025

DOI: 10.1002/glia.70054 PMID: 40665609

Derivation and Culture of Enriched Phrenic-Like Motor Neurons From Human iPSCs.

Thiry L, Sirois J, Durcan TM, Stifani S

Bio-protocol2025Senior author

DOI: 10.21769/bioprotoc.5363 PMID: 40655414

Dysregulated Expression of Inflammasome and Extracellular Matrix Genes in C9orf72-ALS/FTD Microglia.

Thiry L, Pulimood NS, Tang YM, Stifani S

ASN neuro2025Senior author

DOI: 10.1080/17590914.2025.2542998 PMID: 40776416

Early nuclear phenotypes and reactive transformation in human iPSC-derived astrocytes from ALS patients with SOD1 mutations.

Soubannier V, Chaineau M, Gursu L, Lépine S, Kalaydjian D, Sirois J, Haghi G, Rouleau G, Durcan TM, Stifani S

Glia2024Senior author

DOI: 10.1002/glia.24598 PMID: 39092466

Autism-associated CHD8 controls reactive gliosis and neuroinflammation via remodeling chromatin in astrocytes.

Megagiannis P, Mei Y, Yan RE, Yuan L, Wilde JJ, Eckersberg H, Suresh R, Tan X, Chen H, Farmer WT, Cha K, Le PU, Catoire H, Rochefort D, Kwan T, Yee BA, Dion P, Krishnaswamy A, Cloutier JF, Stifani S, Petrecca K, Yeo GW, Murai KK, Feng G, Rouleau GA, Ideker T, Sanjana NE, Zhou Y

Cell reports2024

DOI: 10.1016/j.celrep.2024.114637 PMID: 39154337

Generation of human iPSC-derived phrenic-like motor neurons to model respiratory motor neuron degeneration in ALS.

Thiry L, Sirois J, Durcan TM, Stifani S

Communications biology2024Senior author

DOI: 10.1038/s42003-024-05925-z PMID: 38418587

Spinal cord extracts of amyotrophic lateral sclerosis spread TDP-43 pathology in cerebral organoids.

Tamaki Y, Ross JP, Alipour P, Castonguay CÉ, Li B, Catoire H, Rochefort D, Urushitani M, Takahashi R, Sonnen JA, Stifani S, Dion PA, Rouleau GA

PLoS genetics2023

DOI: 10.1371/journal.pgen.1010606 PMID: 36745687

Rapid Generation of Ventral Spinal Cord-like Astrocytes from Human iPSCs for Modeling Non-Cell Autonomous Mechanisms of Lower Motor Neuron Disease.

Soubannier V, Chaineau M, Gursu L, Haghi G, Franco Flores AK, Rouleau G, Durcan TM, Stifani S

Cells2022Senior author

DOI: 10.3390/cells11030399 PMID: 35159209

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Stefano Stifani

Research

Latest papers

Latest funding

The microtubule-binding protein EML3 is required for mammalian embryonic growth and cerebral cortical development, and Eml3 null mice are a model of cobblestone brain malformation.

Runx1 transcription factor modulates opioid analgesia and withdrawal in humans and rodents.

Adrenergic Control of P2Y6 Receptor-Dependent Phagocytosis in Rodent and Human Microglia.

Derivation and Culture of Enriched Phrenic-Like Motor Neurons From Human iPSCs.

Dysregulated Expression of Inflammasome and Extracellular Matrix Genes in C9orf72-ALS/FTD Microglia.

Early nuclear phenotypes and reactive transformation in human iPSC-derived astrocytes from ALS patients with SOD1 mutations.

Autism-associated CHD8 controls reactive gliosis and neuroinflammation via remodeling chromatin in astrocytes.

Generation of human iPSC-derived phrenic-like motor neurons to model respiratory motor neuron degeneration in ALS.

Spinal cord extracts of amyotrophic lateral sclerosis spread TDP-43 pathology in cerebral organoids.

Rapid Generation of Ventral Spinal Cord-like Astrocytes from Human iPSCs for Modeling Non-Cell Autonomous Mechanisms of Lower Motor Neuron Disease.

INTEGRative multi-OMICs approaches on iPSC-derived 2D and 3D models to elucidate the role of immune and energy metabolism related genes/pathways in Amyotrophic Lateral Sclerosis

Regulation of motor neuron identity and circuit development

Regulation of the tumourigenic ability of glioblastoma stem-like cells

Regeneration of motor neurons controlling movement and respiration from embryonic stem cells

Transcriptional regulation of proliferation and self-renewal in glial progenitors and glioblastoma stem-like cells

Frequent collaborators

Guy Rouleau

Artur Kania

Jean-Francois Cloutier

Sylvain Williams

Samuel David

Yves De Koninck

Tuan Trang

Kevin Petrecca

Arjun Krishnaswamy

Samuel Weiss

Susanne Bechstedt

Kevin Petrecca

Thomas Durcan

YANG ZHOU

Myriam Srour

Marie-Ève Tremblay

Yojiro Yamanaka

Chad Bousman

Hong Chen

Robert Sladek

Christophe Altier