Walter Reisner, McGill University

Research

Raman Spectroscopy Sing Extracellular Vesicles Nanofluidics Meduloblastoma Glioblastoma Molecular Fingerprint Temozolomide Therapy Detection Of New Variants

Latest papers

DNA Nanostructures Characterized via Dual Nanopore Resensing.
ACS nano · 2025 · senior author
Single-molecule capture, release, and dynamical manipulation via reversible electrokinetic confinement (RECON).
Science advances · 2025 · senior author
Quantifying the growth mechanism of solid-state nanopores under high-voltage conditioning.
Nanoscale · 2025 · senior author

All 28 publications

Latest funding

Early characterization and long-term monitoring of Medulloblastoma via spectral fingerprinting of single extracellular vesicles
CIHR · 2025 · Principal investigator
$933,300
Molecular profiling of single extracellular vesicles reveals therapeutic effects of temozolomide in GBM patients
CIHR · 2024 · Principal investigator
$677,026
Building a Nanofluidic DNA Nanostructure Factory
NSERC · 2024 · Principal investigator
$25,000

All 18 grants and awards

28 publications.

01

DNA Nanostructures Characterized via Dual Nanopore Resensing.

Dong W, Liu Z, Liu R, Fygenson DK, Reisner W

ACS nano2025Senior author

DOI: 10.1021/acsnano.5c09529 PMID: 41042049

02

Single-molecule capture, release, and dynamical manipulation via reversible electrokinetic confinement (RECON).

Pessôa MAS, Jakuc P, Martins E Queiroz C, Duggan N, Liu R, Kautz S, Ameur S, Liu Z, Dong W, Ravikumar P, Shiekh S, Cao H, Austin M, Mahshid S, Fygenson D, Reisner W

Science advances2025Senior author

DOI: 10.1126/sciadv.adv8863 PMID: 40961196

03

Quantifying the growth mechanism of solid-state nanopores under high-voltage conditioning.

St-Denis T, Huang R, Capaldi X, Pereira M, Duchastel-Vassaramva I, Liu Z, Grütter P, Reisner W

Nanoscale2025Senior author

DOI: 10.1039/d4nr03071k PMID: 39775683

04

Tunable nanofluidic device for digital nucleic acid analysis.

Hosseini II, Hamidi SV, Capaldi X, Liu Z, Silva Pessoa MA, Mahshid S, Reisner W

Nanoscale2024Senior author

DOI: 10.1039/d3nr05553a PMID: 38682564

05

Dynamics and quantitative contribution of the aminoglycoside 6'-N-acetyltransferase type Ib to amikacin resistance.

d'Udekem d'Acoz O, Hue F, Ye T, Wang L, Leroux M, Rajngewerc L, Tran T, Phan K, Ramirez MS, Reisner W, Tolmasky ME, Reyes-Lamothe R

mSphere2024

DOI: 10.1128/msphere.00789-23 PMID: 38353533

06

Dynamics and quantitative contribution of the aminoglycoside 6'-N-acetyltransferase type Ib [AAC(6')-Ib] to amikacin resistance.

d'Acoz OD, Hue F, Ye T, Wang L, Leroux M, Rajngewerc L, Tran T, Phan K, Ramirez MS, Reisner W, Tolmasky ME, Reyes-Lamothe R

bioRxiv : the preprint server for biology2023

DOI: 10.1101/2023.09.05.556435 PMID: 38168340

07

Characterizing interaction of multiple nanocavity confined plasmids in presence of large DNA model nucleoid.

Liu Z, Christensen SM, Capaldi X, Hosseini SI, Zeng L, Zhang Y, Reyes-Lamothe R, Reisner W

Soft matter2023Senior author

DOI: 10.1039/d3sm00491k PMID: 37599597

08

Confinement anisotropy drives polar organization of two DNA molecules interacting in a nanoscale cavity.

Liu Z, Capaldi X, Zeng L, Zhang Y, Reyes-Lamothe R, Reisner W

Nature communications2022Senior author

DOI: 10.1038/s41467-022-31398-x PMID: 35902565

09

Discriminating protein tags on a dsDNA construct using a Dual Nanopore Device.

Seth S, Rand A, Reisner W, Dunbar WB, Sladek R, Bhattacharya A

Scientific reports2022

DOI: 10.1038/s41598-022-14609-9 PMID: 35787637

10

Nanofluidics for Simultaneous Size and Charge Profiling of Extracellular Vesicles.

Hosseini II, Liu Z, Capaldi X, AbdelFatah T, Montermini L, Rak J, Reisner W, Mahshid S

Nano letters2021

DOI: 10.1021/acs.nanolett.0c02558 PMID: 34061534

Early characterization and long-term monitoring of Medulloblastoma via spectral fingerprinting of single extracellular vesicles

Principal investigatorCIHR2025Project Grant

Principal investigators: Mahshid, Sara; Garzia, Livia; Rak, Janusz; Reisner, Walter W

Keywords: Meduloblastoma; Raman Spectroscopy; Sing Extracellular Vesicles

$933,300

Molecular profiling of single extracellular vesicles reveals therapeutic effects of temozolomide in GBM patients

Principal investigatorCIHR2024Project Grant

Principal investigators: Mahshid, Sara; Rak, Janusz; Reisner, Walter W; Zadeh, Gelareh

Keywords: Glioblastoma; Molecular Fingerprint; Raman Spectroscopy; Sing Extracellular Vesicles; Temozolomide Therapy

$677,026

Building a Nanofluidic DNA Nanostructure Factory

Principal investigatorNSERC2024Alliance Grants

Principal investigators: Reisner, Walter WW

Keywords: dna nanotechnology; dna nanotube; molecular self-assembly; nanoconfinement; nanofluidics

$25,000

Harnessing nanofluidics to achieve a patient specific view of depressive disorder via targeted RNA analysis in single extracellular vesicles

Co-investigatorSSHRC2023New Frontiers in Research Fund - Exploration

Principal investigators: Mahshid, Sara

Keywords: extracellular vesicles ; single cell analysis; depressive disorder ; nanoplatform ; mental health; RNA detection ; nanofluidics; nanoelectronics

$250,000

Using a Dual Nanopore Device to Characterize DNA Nanotubes and Nunchucks

Principal investigatorNSERC2022Alliance Grants

Principal investigators: Reisner, Walter WW

$25,000

Development of a miniaturized imaging system for antimicrobial resistance profiling at the point of need

Co-investigatorNSERC2021Alliance Grants

Principal investigators: Mahshid, Sara

$396,000

An Automated Molecular Point of Care Testing Device for Rapid Detection of SARS-CoV-2 and New Variants

Principal investigatorCIHR2021Op Gr: Emerging COVID-19 Research Gap & Priorities - Testing models/surveillance

Principal investigators: Mahshid, Sara; Costiniuk, Cecilia T; Liang, Chen; Reisner, Walter W

Keywords: Detection Of New Variants; Molecular Detection Of Sars-Cov-2; Point Of Care Diagnostics; Rna-Based Covid-19 Test

$320,000

Upgrade and Renewal of Setup for Combined Optical, Mechanical and Electrical Probing of Single Molecules

Principal investigatorNSERC2019Research Tools and Instruments

Principal investigators: Reisner, Walter

$146,041

Nanofluidic systems with integrated nanopores for macromolecular sensing, manipulation and confinement

Principal investigatorNSERC2018Discovery Grants Program - Individual

Principal investigators: Reisner, Walter

$525,000

Fabrication of solid-state nanopores via tip-controlled local breakdown

Principal investigatorNSERC2018Idea to Innovation

Principal investigators: Reisner, Walter

$184,106

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Physics
Biology
Biomedical Engineering
Pediatrics
Other

Co-authors at McGill University, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

David Juncker

Biomedical Engineering

1 shared papers, latest 2018

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mentionMention their CIHR grant from 2025

Subject: Prospective PhD student: Raman Spectroscopy Dear Professor Reisner, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "DNA Nanostructures Characterized via Dual Nanopore Resensing." (2025), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your CIHR-funded project "Early characterization and long-term monitoring of Medulloblastoma via spectral fingerprinting of single extracellular vesicles" (2025), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]

Walter Reisner

Research

Latest papers

Latest funding

DNA Nanostructures Characterized via Dual Nanopore Resensing.

Single-molecule capture, release, and dynamical manipulation via reversible electrokinetic confinement (RECON).

Quantifying the growth mechanism of solid-state nanopores under high-voltage conditioning.

Tunable nanofluidic device for digital nucleic acid analysis.

Dynamics and quantitative contribution of the aminoglycoside 6'-N-acetyltransferase type Ib to amikacin resistance.

Dynamics and quantitative contribution of the aminoglycoside 6'-N-acetyltransferase type Ib [AAC(6')-Ib] to amikacin resistance.

Characterizing interaction of multiple nanocavity confined plasmids in presence of large DNA model nucleoid.

Confinement anisotropy drives polar organization of two DNA molecules interacting in a nanoscale cavity.

Discriminating protein tags on a dsDNA construct using a Dual Nanopore Device.

Nanofluidics for Simultaneous Size and Charge Profiling of Extracellular Vesicles.

Early characterization and long-term monitoring of Medulloblastoma via spectral fingerprinting of single extracellular vesicles

Molecular profiling of single extracellular vesicles reveals therapeutic effects of temozolomide in GBM patients

Building a Nanofluidic DNA Nanostructure Factory

Harnessing nanofluidics to achieve a patient specific view of depressive disorder via targeted RNA analysis in single extracellular vesicles

Using a Dual Nanopore Device to Characterize DNA Nanotubes and Nunchucks

Development of a miniaturized imaging system for antimicrobial resistance profiling at the point of need

An Automated Molecular Point of Care Testing Device for Rapid Detection of SARS-CoV-2 and New Variants

Upgrade and Renewal of Setup for Combined Optical, Mechanical and Electrical Probing of Single Molecules

Nanofluidic systems with integrated nanopores for macromolecular sensing, manipulation and confinement

Fabrication of solid-state nanopores via tip-controlled local breakdown

Frequent collaborators

Sara Mahshid

Rodrigo Reyes Lamothe

Robert Sladek

Janusz Rak

Michael Hilke

David Juncker