Steve Bourgault, Université du Québec à Montréal

Research

Bactériologie/Virologie (Maladies Infectieuses) 5201 Cytokines Immunologie 5204 Infections Expérimentales Modèle Murin P97c Comme Adjuvant Sciences De La Vie 1201 Sciences Médicales Et De La Santé 1211

Latest papers

Comparative study of synthetic nanofilaments assembled from amphiphilic peptides and β-peptides as antigen delivery nanostructures.
Nanomedicine : nanotechnology, biology, and medicine · 2026 · senior author
Total Chemical Synthesis and Evaluation of the Antimicrobial Properties of Porcine β-Defensin 5 Against Gram-Positive and Gram-Negative Bacteria.
Probiotics and antimicrobial proteins · 2026
Molecular Mechanisms of Islet Amyloid Polypeptide Aggregation: Towards Chemical Strategies to Prevent Amyloid Formation and to Design Non-Aggregating Peptide Therapeutics.
International journal of molecular sciences · 2026 · senior author

All 49 publications

Latest funding

Replace an obsolete Zetasizer for nanoparticle, colloid and protein size & charge measurements
NSERC · 2023 · Co-investigator
$145,000
Functional Repulpable, Recyclable and Compostable Protein-Based Barrier Paper
NSERC · 2023 · Co-investigator
$74,782
Chemistry of Biological Nanoassemblies
NSERC · 2021 · Principal investigator
$275,000

All 17 grants and awards

49 publications.

01

Comparative study of synthetic nanofilaments assembled from amphiphilic peptides and β-peptides as antigen delivery nanostructures.

Tshibwabwa LM, Nguyen PT, Bourgault S

Nanomedicine : nanotechnology, biology, and medicine2026Senior author

DOI: 10.1016/j.nano.2026.102949 PMID: 42035816

02

Total Chemical Synthesis and Evaluation of the Antimicrobial Properties of Porcine β-Defensin 5 Against Gram-Positive and Gram-Negative Bacteria.

Finatto AN, Nguyen V, Nguyen PT, Bourgault S, de Oliveira Costa M

Probiotics and antimicrobial proteins2026

DOI: 10.1007/s12602-025-10870-2 PMID: 41779113

03

Molecular Mechanisms of Islet Amyloid Polypeptide Aggregation: Towards Chemical Strategies to Prevent Amyloid Formation and to Design Non-Aggregating Peptide Therapeutics.

Bousch C, Bérubé F, Babych M, Ongeri S, Bourgault S

International journal of molecular sciences2026Senior author

DOI: 10.3390/ijms27062598 PMID: 41898461

04

Protein Amyloid and Synthetic Polymer Self-Assemblies: Similar Challenges for Their Preparation Associated with Shared Properties.

Lonetti B, Bourgault S, Chamieh J, Cottet H, Couderc F, Mingotaud C, Vicendo P, Mingotaud AF, Collin F

Biomacromolecules2026

DOI: 10.1021/acs.biomac.5c01931 PMID: 41552839

05

Probing the Effect of α-Helical Stapling Strategies on the Inhibition of Peptide Aggregation and Amyloid Cytotoxicity.

Babych M, Nguyen PT, Bérubé F, Bourgault S

ACS chemical biology2026Senior author

DOI: 10.1021/acschembio.5c00685 PMID: 41486923

06

Effect of Copper-Catalyzed Oxidation on the Aggregation of the Islet Amyloid Polypeptide.

Amilca O, Nguyen PT, Perquis L, Collin F, Bourgault S

Antioxidants (Basel, Switzerland)2025Senior author

DOI: 10.3390/antiox14111269 PMID: 41300426

07

Polyphenolic Gallotannins 1,3,6-Tri-O-galloyl-β-d-glucose and Corilagin Attenuate IAPP Amyloid Formation and Cytotoxicity by Primarily Targeting Secondary Nucleation.

Khalifa J, Sulaimon R, Côté-Cyr M, Nguyen PT, Peslherbe G, Bourgault S, Gaudreault R

Biochemistry2025

DOI: 10.1021/acs.biochem.5c00139 PMID: 40768411

08

Design and applications of self-assembled polypeptide matrices in wound healing.

Côté-Cyr M, Bourgault S

Frontiers in bioengineering and biotechnology2025Senior author

DOI: 10.3389/fbioe.2025.1646622 PMID: 40861854

09

Probing the relationships between self-assembly and the antimicrobial activity of amyloidogenic peptides: The islet amyloid polypeptide as a case study.

Nguyen V, Côté-Cyr M, Finatto AN, Babych M, Nguyen PT, Sebastiao M, Bourgault S

Biochimica et biophysica acta. General subjects2025Senior author

DOI: 10.1016/j.bbagen.2025.130812 PMID: 40268062

10

Nanoparticles as Delivery Systems for Antigenic Saccharides: From Conjugation Chemistry to Vaccine Design.

Archambault MJ, Tshibwabwa LM, Côté-Cyr M, Moffet S, Shiao TC, Bourgault S

Vaccines2024Senior author

DOI: 10.3390/vaccines12111290 PMID: 39591192

Replace an obsolete Zetasizer for nanoparticle, colloid and protein size & charge measurements

Co-investigatorNSERC2023Research Tools and Instruments

Principal investigators: Siaj, Mohamed

$145,000

Functional Repulpable, Recyclable and Compostable Protein-Based Barrier Paper

Co-investigatorNSERC2023Alliance Grants

Principal investigators: Gaudreault, Roger R

Keywords: Curli-specific gene A; Fibrillated cellulose fiber; Filters; Fluorocarbon-free; Food Packaging; Functional barrier paper; Protein fibrils; Recyclable; Sustainable; Water repellent

$74,782

Chemistry of Biological Nanoassemblies

Principal investigatorNSERC2021Canada Research Chairs

Principal investigators: Bourgault, Steve

$275,000

COVID-19 Variant Supplement - SARS-CoV-2 immunization strategies to enhance protective immunity with reduced risk of antibody-dependent enhancement (ADE)

Co-investigatorCIHR2021Operating Grant: SARS-CoV-2 variants supplement stream 1

Principal investigators: Archambault, Denis

Keywords: Antibody-Dependent Enhancement; Immune Response; Nanovaccine; Pre-Clinical Study; Sars-Cov2; Vaccine Safety

$50,000

Prevention of SARS-CoV2 (COVID-19) related CoV Spike protein neuroinvasion and -induced respiratory distress by polyphenols_x000d_ _x000d_ _x000d_ _x000d_ _x000d_

Co-investigatorNSERC2020Alliance Grants

Principal investigators: Mousseau, Normand

$50,000

Inhibition of TMPRSS2 and 3CL Proteases by natural polyphenols to prevent SARS-CoV-2 infectivity and replication_x000d_ _x000d_

Co-investigatorNSERC2020Alliance Grants

Principal investigators: RAMASSAMY, Charles

$50,000

SARS-CoV-2 immunization strategies to enhance protective immunity with reduced risk of antibody-dependent enhancement (ADE)

Co-investigatorCIHR2020Operating Grant: COVID-19 Rapid Research Funding Opportunity - Vaccines

Principal investigators: Archambault, Denis

Keywords: Antibody-Dependent Enhancement; Immune Response; Nanovaccine; Pre-Clinical Study; Sars-Cov2; Vaccine Safety

$622,782

Manipulating amyloid self-assembly: toward the design of functionalized proteinaceous nanostructures

Principal investigatorNSERC2018Discovery Grants Program - Individual

Principal investigators: Bourgault, Steve

$252,000

Development of biophysical assays for fragment-based lead discovery strategies

Principal investigatorNSERC2017Engage Grants Program

Principal investigators: Bourgault, Steve

$25,000

Chemistry Of Biological Nano-Assemblies

Principal investigatorNSERC2016Canada Research Chairs

Principal investigators: Bourgault, Steve

$150,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Sciences biologiques
Ophthalmology
Engineering Physics
Other

Co-authors at Université du Québec à Montréal, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

Denis Archambault

Sciences biologiques

9 shared papers, latest 2023

Benoit Barbeau

Sciences biologiques

2 shared papers, latest 2020

Przemyslaw Sapieha

Ophthalmology

1 shared papers, latest 2021

Przemyslaw Sapieha

Engineering Physics

1 shared papers, latest 2021

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mentionMention their NSERC grant from 2021

Subject: Prospective PhD student: Bactériologie/Virologie (Maladies Infectieuses) 5201 Dear Professor Bourgault, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Comparative study of synthetic nanofilaments assembled from amphiphilic peptides and β-peptides as antigen delivery nanostructures." (2026), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your NSERC-funded project "Chemistry of Biological Nanoassemblies" (2021), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]

Steve Bourgault

Research

Latest papers

Latest funding

Comparative study of synthetic nanofilaments assembled from amphiphilic peptides and β-peptides as antigen delivery nanostructures.

Total Chemical Synthesis and Evaluation of the Antimicrobial Properties of Porcine β-Defensin 5 Against Gram-Positive and Gram-Negative Bacteria.

Molecular Mechanisms of Islet Amyloid Polypeptide Aggregation: Towards Chemical Strategies to Prevent Amyloid Formation and to Design Non-Aggregating Peptide Therapeutics.

Protein Amyloid and Synthetic Polymer Self-Assemblies: Similar Challenges for Their Preparation Associated with Shared Properties.

Probing the Effect of α-Helical Stapling Strategies on the Inhibition of Peptide Aggregation and Amyloid Cytotoxicity.

Effect of Copper-Catalyzed Oxidation on the Aggregation of the Islet Amyloid Polypeptide.

Polyphenolic Gallotannins 1,3,6-Tri-O-galloyl-β-d-glucose and Corilagin Attenuate IAPP Amyloid Formation and Cytotoxicity by Primarily Targeting Secondary Nucleation.

Design and applications of self-assembled polypeptide matrices in wound healing.

Probing the relationships between self-assembly and the antimicrobial activity of amyloidogenic peptides: The islet amyloid polypeptide as a case study.

Nanoparticles as Delivery Systems for Antigenic Saccharides: From Conjugation Chemistry to Vaccine Design.

Replace an obsolete Zetasizer for nanoparticle, colloid and protein size & charge measurements

Functional Repulpable, Recyclable and Compostable Protein-Based Barrier Paper

Chemistry of Biological Nanoassemblies

COVID-19 Variant Supplement - SARS-CoV-2 immunization strategies to enhance protective immunity with reduced risk of antibody-dependent enhancement (ADE)

Prevention of SARS-CoV2 (COVID-19) related CoV Spike protein neuroinvasion and -induced respiratory distress by polyphenols_x000d_ _x000d_ _x000d_ _x000d_ _x000d_

Inhibition of TMPRSS2 and 3CL Proteases by natural polyphenols to prevent SARS-CoV-2 infectivity and replication_x000d_ _x000d_

SARS-CoV-2 immunization strategies to enhance protective immunity with reduced risk of antibody-dependent enhancement (ADE)

Manipulating amyloid self-assembly: toward the design of functionalized proteinaceous nanostructures

Development of biophysical assays for fragment-based lead discovery strategies

Chemistry Of Biological Nano-Assemblies

Frequent collaborators

Denis Archambault

Isabelle Marcotte

Benoit Barbeau

Hideto Takahashi

Przemyslaw Sapieha

Przemyslaw Sapieha

Steve Bourgault

Research

Latest papers

Latest funding

Comparative study of synthetic nanofilaments assembled from amphiphilic peptides and &#x3b2;-peptides as antigen delivery nanostructures.

Total Chemical Synthesis and Evaluation of the Antimicrobial Properties of Porcine &#x3b2;-Defensin 5 Against Gram-Positive and Gram-Negative Bacteria.

Molecular Mechanisms of Islet Amyloid Polypeptide Aggregation: Towards Chemical Strategies to Prevent Amyloid Formation and to Design Non-Aggregating Peptide Therapeutics.

Protein Amyloid and Synthetic Polymer Self-Assemblies: Similar Challenges for Their Preparation Associated with Shared Properties.

Probing the Effect of &#x3b1;-Helical Stapling Strategies on the Inhibition of Peptide Aggregation and Amyloid Cytotoxicity.

Effect of Copper-Catalyzed Oxidation on the Aggregation of the Islet Amyloid Polypeptide.

Polyphenolic Gallotannins 1,3,6-Tri-O-galloyl-&#x3b2;-d-glucose and Corilagin Attenuate IAPP Amyloid Formation and Cytotoxicity by Primarily Targeting Secondary Nucleation.

Design and applications of self-assembled polypeptide matrices in wound healing.

Probing the relationships between self-assembly and the antimicrobial activity of amyloidogenic peptides: The islet amyloid polypeptide as a case study.

Nanoparticles as Delivery Systems for Antigenic Saccharides: From Conjugation Chemistry to Vaccine Design.

Replace an obsolete Zetasizer for nanoparticle, colloid and protein size & charge measurements

Functional Repulpable, Recyclable and Compostable Protein-Based Barrier Paper

Chemistry of Biological Nanoassemblies

COVID-19 Variant Supplement - SARS-CoV-2 immunization strategies to enhance protective immunity with reduced risk of antibody-dependent enhancement (ADE)

Prevention of SARS-CoV2 (COVID-19) related CoV Spike protein neuroinvasion and -induced respiratory distress by polyphenols_x000d_ _x000d_ _x000d_ _x000d_ _x000d_

Inhibition of TMPRSS2 and 3CL Proteases by natural polyphenols to prevent SARS-CoV-2 infectivity and replication_x000d_ _x000d_

SARS-CoV-2 immunization strategies to enhance protective immunity with reduced risk of antibody-dependent enhancement (ADE)

Manipulating amyloid self-assembly: toward the design of functionalized proteinaceous nanostructures

Development of biophysical assays for fragment-based lead discovery strategies

Chemistry Of Biological Nano-Assemblies

Frequent collaborators

Denis Archambault

Isabelle Marcotte

Benoit Barbeau

Hideto Takahashi

Przemyslaw Sapieha

Przemyslaw Sapieha

Comparative study of synthetic nanofilaments assembled from amphiphilic peptides and β-peptides as antigen delivery nanostructures.

Total Chemical Synthesis and Evaluation of the Antimicrobial Properties of Porcine β-Defensin 5 Against Gram-Positive and Gram-Negative Bacteria.

Probing the Effect of α-Helical Stapling Strategies on the Inhibition of Peptide Aggregation and Amyloid Cytotoxicity.

Polyphenolic Gallotannins 1,3,6-Tri-O-galloyl-β-d-glucose and Corilagin Attenuate IAPP Amyloid Formation and Cytotoxicity by Primarily Targeting Secondary Nucleation.