Graciela Pineyro, Université de Montréal

Research

Opioids Quantitative Pharmacology Adolescence Cannabis Cortex Microglia Phagocytosis Pruning

Latest papers

A type II cannabis extract and a 1:1 blend of Δ(9)-tetrahydrocannabinol and cannabidiol display distinct antinociceptive profiles and engage different endocannabinoid targets when administered into the subarachnoid space.
Frontiers in pharmacology · 2023 · senior author
Signaling diversity of mu- and delta- opioid receptor ligands: Re-evaluating the benefits of β-arrestin/G protein signaling bias.
Cellular signalling · 2021 · first author
Author Correction: Exploring use of unsupervised clustering to associate signaling profiles of GPCR ligands to clinical response.
Nature communications · 2020 · senior author

All 13 publications

Latest funding

Structural effects of THC on adolescent cortex: microglial mechanisms
CIHR · 2025 · Nominated PI
$1,071,000
The GPCR Retreat 2023
CIHR · 2023 · Co-investigator
$15,000
Cross-disciplinary Acuity Training Program in Intelligent and Responsible Drug Discovery
NSERC · 2023 · Co-investigator
$463,000

All 14 grants and awards

13 publications.

01

A type II cannabis extract and a 1:1 blend of Δ(9)-tetrahydrocannabinol and cannabidiol display distinct antinociceptive profiles and engage different endocannabinoid targets when administered into the subarachnoid space.

Benredjem B, Pineyro G

Frontiers in pharmacology2023Senior author

DOI: 10.3389/fphar.2023.1235255 PMID: 37745077

02

Signaling diversity of mu- and delta- opioid receptor ligands: Re-evaluating the benefits of β-arrestin/G protein signaling bias.

Pineyro G, Nagi K

Cellular signalling2021First author

DOI: 10.1016/j.cellsig.2020.109906 PMID: 33383156

03

Author Correction: Exploring use of unsupervised clustering to associate signaling profiles of GPCR ligands to clinical response.

Benredjem B, Gallion J, Pelletier D, Dallaire P, Charbonneau J, Cawkill D, Nagi K, Gosink M, Lukasheva V, Jenkinson S, Ren Y, Somps C, Murat B, Van Der Westhuizen E, Le Gouill C, Lichtarge O, Schmidt A, Bouvier M, Pineyro G

Nature communications2020Senior author

DOI: 10.1038/s41467-020-15945-y PMID: 32300106

04

Exploring use of unsupervised clustering to associate signaling profiles of GPCR ligands to clinical response.

Benredjem B, Gallion J, Pelletier D, Dallaire P, Charbonneau J, Cawkill D, Nagi K, Gosink M, Lukasheva V, Jenkinson S, Ren Y, Somps C, Murat B, Van Der Westhuizen E, Le Gouill C, Lichtarge O, Schmidt A, Bouvier M, Pineyro G

Nature communications2019Senior author

DOI: 10.1038/s41467-019-11875-6 PMID: 31501422

05

Molecular aspects of delta opioid receptors.

Gendron L, Nagi K, Zeghal M, Giguère PM, Pineyro G

Vitamins and hormones2019Senior author

DOI: 10.1016/bs.vh.2019.06.001 PMID: 31421707

06

Delta opioid receptors recycle to the membrane after sorting to the degradation path.

Charfi I, Abdallah K, Gendron L, Pineyro G

Cellular and molecular life sciences : CMLS2018Senior author

DOI: 10.1007/s00018-017-2732-5 PMID: 29288293

07

Analyzing biased responses of GPCR ligands.

Benredjem B, Dallaire P, Pineyro G

Current opinion in pharmacology2017Senior author

DOI: 10.1016/j.coph.2016.11.008 PMID: 27930943

08

Molecular Pharmacology of δ-Opioid Receptors.

Gendron L, Cahill CM, von Zastrow M, Schiller PW, Pineyro G

Pharmacological reviews2016Senior author

DOI: 10.1124/pr.114.008979 PMID: 27343248

09

Practical guide for calculating and representing biased signaling by GPCR ligands: A stepwise approach.

Nagi K, Pineyro G

Methods (San Diego, Calif.)2016Senior author

DOI: 10.1016/j.ymeth.2015.09.010 PMID: 26364590

10

Design and construction of conformational biosensors to monitor ion channel activation: A prototype FlAsH/BRET-approach to Kir3 channels.

Robertson DN, Sleno R, Nagi K, Pétrin D, Hébert TE, Pineyro G

Methods (San Diego, Calif.)2016Senior author

DOI: 10.1016/j.ymeth.2015.07.011 PMID: 26210401

Structural effects of THC on adolescent cortex: microglial mechanisms

Nominated PICIHR2025Project Grant

Principal investigators: Pineyro, Graciela

Keywords: Adolescence; Cannabis; Cortex; Microglia; Phagocytosis; Pruning; Receptors (Cb2r); Thc

$1,071,000

The GPCR Retreat 2023

Co-investigatorCIHR2023Planning and Dissemination Grant - Institute Community Support

Principal investigators: Albert, Paul R

Keywords: Animal Models; Biochemistry; Cell Biology; Drug Design; G-Protein; Molecular Biology; Protein Structure; Receptor; Signalling; Therapeutics

$15,000

Cross-disciplinary Acuity Training Program in Intelligent and Responsible Drug Discovery

Co-investigatorNSERC2023Collaborative Research and Training Experience

Principal investigators: SARRET, Philippe P

Keywords: advanced device technologies; artificial intelligence; biological targets; biosensors; computing science; drug discovery; imaging; medicinal chemistry

$463,000

Multimode determination of gene transcription and metabolic labeling

Co-investigatorNSERC2020Research Tools and Instruments

Principal investigators: Tremblay, André

$70,161

"Towards ideal opioid analgesics: Improving tolerability with novel, functionally selective MOR agonists".

Nominated PICIHR2017Project Grant

Principal investigators: Pineyro, Graciela

Keywords: Analgesia; Chronic Pain; Gpcrs; Opioid Receptors; Opioids; Quantitative Pharmacology; Signaling Bias

$929,475

Opioid receptor signaling complexes

Principal investigatorNSERC2015Discovery Grants Program - Individual

Principal investigators: Pineyro, Graciela

$298,518

Harnessing in vitro signaling diversity of opioid analgesics as a means of predicting in vivo development of tolerance

Nominated PICIHR2014Operating Grant

Principal investigators: Pineyro, Graciela

Keywords: Analgesics; Bret; Cellular Signaling; Gpcr; Molecular Pharmacology; Neuronal Cultures; Opioids; Quantitative Pharmacology; Tolerance

$780,405

Design, synthesis and characterization of novel enkephalin analogs for the delta opioid receptor

Co-investigatorCIHR2014Operating Grant

Principal investigators: Gendron, Louis

Keywords: Biased-Agonists; Blood-Brain-Barrier; Delta Opioid Receptor; Enkephalin; Macrocylces; Medicinal Chemistry; Pain; Peptidomimetics; Pet Tracers; Unwanted-Effects

$727,754

12 th Annual Meeting GPCR Retreat

Nominated PICIHR2011Dissemination Events

Principal investigators: Pineyro, Graciela

Keywords: Cell Division And Migration In Development And Disease; Cellular Signalling: Enzymatic And Channel Effectors Of Gpcr; Crystalographic Studies; Membrane Targeting And Post-Endocytic Sorting Of Gpcrs; Rational Drug Design; Theoretical Models Of Gpcr Activity

$24,533

Multimeric signalling complexes of opioid receptors

Principal investigatorNSERC2010Discovery Grants Program - Accelerator Supplements

Principal investigators: Pineyro, Graciela

$120,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Pharmacology
Médecine
Biochimie et médecine moléculaire
Other

Co-authors at Université de Montréal, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

Louis Gendron

Médecine

4 shared papers, latest 2019

Michel Bouvier

Biochimie et médecine moléculaire

2 shared papers, latest 2020

Louis Gendron

Faculty

2 shared papers, latest 2016

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mentionMention their CIHR grant from 2025

Subject: Prospective PhD student: Opioids Dear Professor Pineyro, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "A type II cannabis extract and a 1:1 blend of Δ(9)-tetrahydrocannabinol and cannabidiol display distinct antinociceptive profiles and engage different endocannabinoid targets when administered into the subarachnoid space." (2023), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your CIHR-funded project "Structural effects of THC on adolescent cortex: microglial mechanisms" (2025), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]

Graciela Pineyro

Research

Latest papers

Latest funding

A type II cannabis extract and a 1:1 blend of &#x394;(9)-tetrahydrocannabinol and cannabidiol display distinct antinociceptive profiles and engage different endocannabinoid targets when administered into the subarachnoid space.

Signaling diversity of mu- and delta- opioid receptor ligands: Re-evaluating the benefits of &#x3b2;-arrestin/G protein signaling bias.

Author Correction: Exploring use of unsupervised clustering to associate signaling profiles of GPCR ligands to clinical response.

Exploring use of unsupervised clustering to associate signaling profiles of GPCR ligands to clinical response.

Molecular aspects of delta opioid receptors.

Delta opioid receptors recycle to the membrane after sorting to the degradation path.

Analyzing biased responses of GPCR ligands.

Molecular Pharmacology of &#x3b4;-Opioid Receptors.

Practical guide for calculating and representing biased signaling by GPCR ligands: A stepwise approach.

Design and construction of conformational biosensors to monitor ion channel activation: A prototype FlAsH/BRET-approach to Kir3 channels.

Structural effects of THC on adolescent cortex: microglial mechanisms

The GPCR Retreat 2023

Cross-disciplinary Acuity Training Program in Intelligent and Responsible Drug Discovery

Multimode determination of gene transcription and metabolic labeling

"Towards ideal opioid analgesics: Improving tolerability with novel, functionally selective MOR agonists".

Opioid receptor signaling complexes

Harnessing in vitro signaling diversity of opioid analgesics as a means of predicting in vivo development of tolerance

Design, synthesis and characterization of novel enkephalin analogs for the delta opioid receptor

12 th Annual Meeting GPCR Retreat

Multimeric signalling complexes of opioid receptors

Frequent collaborators

Louis Gendron

Michel Bouvier

Louis Gendron

A type II cannabis extract and a 1:1 blend of Δ(9)-tetrahydrocannabinol and cannabidiol display distinct antinociceptive profiles and engage different endocannabinoid targets when administered into the subarachnoid space.

Signaling diversity of mu- and delta- opioid receptor ligands: Re-evaluating the benefits of β-arrestin/G protein signaling bias.

Molecular Pharmacology of δ-Opioid Receptors.