Faculty profile

Louis Gendron

ResearcherMédecineUniversité de Sherbrooke

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a Université de Sherbrooke directory, so their courses may be missing. Find their university profile.

Louis Gendron

Researcher

Médecine

Health Sciences

Université de Sherbrooke

Sherbrooke, Quebec, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
19 publications in the last five years, latest in 2026.
Senior (last) author on 3 recent papers, a sign of leading a research group.
Principal investigator on 15 research grants (9 CIHR, 6 NSERC), most recently in 2024.
Supervised 6 trainees who won CIHR awards, most recently in 2022.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

Publications

Citations

h-index

Collaborators

Grants

Publications by year

Counts cover the works listed on the university profile; citation counts come from Dimensions.

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Signals and details

Research

Pharmacology Douleur Animal Behavior Opioid Receptors Opioids Trafficking Signaling Medicinal Chemistry

Latest papers

Trifluoromethylthio and Trifluoromethyl Functionalization of Endomorphin-1 Enhances its Hydrophobicity and Plasma Stability while Preserving its Affinity for the μ-Opioid Receptor.
The Journal of organic chemistry · 2026
Pharmacogenetic association study of cannabis use in chronic pain.
Journal of cannabis research · 2026
Dual-target opioid/neurotensin ligands drive potent and safer analgesia in vivo.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2026

All 63 publications

Latest funding

Neurobiology and molecular mechanisms of the opioid system
NSERC · 2024 · Principal investigator
$40,000
Mechanisms of opioid tolerance: A role for the delta opioid receptor
CIHR · 2024 · Nominated PI
$100,000
23rd Joint meeting of the Great Lakes GPCR Retreat and the Club des récepteurs à sept domaines transmembranaires du Québec
CIHR · 2024 · Co-investigator
$15,000

All 29 grants and awards

63 publications.

Trifluoromethylthio and Trifluoromethyl Functionalization of Endomorphin-1 Enhances its Hydrophobicity and Plasma Stability while Preserving its Affinity for the μ-Opioid Receptor.

Gregorc J, De Neve J, Guitot K, Holleran BJ, Lensen N, Gendron L, Brigaud T, Iskra J, Ballet S, Chaume G

The Journal of organic chemistry2026

DOI: 10.1021/acs.joc.6c00321 PMID: 41983725

Pharmacogenetic association study of cannabis use in chronic pain.

Beauchesne W, Turcotte J, Mercier P, Lavoie F, Tessier L, Gagnon AL, Allard C, Fortin E, Léonard G, Gendron L, Tremblay K

Journal of cannabis research2026

DOI: 10.1186/s42238-026-00408-w PMID: 41691361

Dual-target opioid/neurotensin ligands drive potent and safer analgesia in vivo.

Breault É, Neve J, Ranjbaran A, Tremblay A, Robberechts I, Lussier F, Bélair F, Tremblay V, Holleran BJ, Brochu I, Bisi N, Côté J, Longpré JM, Gendron L, Ballet S, Sarret P

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie2026

DOI: 10.1016/j.biopha.2026.119488 PMID: 42116252

Spotlight on Endocannabinoids in Healthy Individuals Using Volumetric Absorptive Microsampling Combined with LC-MS/MS Analysis.

Haroune L, Saibi S, Bellenger JP, Vincenot M, Léonard G, Gendron L, Sarret P

ACS omega2025

DOI: 10.1021/acsomega.5c05574 PMID: 41280873

Modeling Temporal Summation and Conditioned Pain Modulation in Individuals With and Without Chronic Pain.

Vincenot M, Lévesque S, Gendron L, Camirand Lemyre F, Marchand S, Léonard G

The Clinical journal of pain2025

DOI: 10.1097/ajp.0000000000001320 PMID: 40808589

Contribution of peripheral and central delta opioid receptors in the relief of migraine-like headache in female and male rats.

Dussol M, da Silva Borges G, Beaulieu C, Ghorbel H, Descheemaeker A, Herault K, Voisin D, Luccarini P, Gendron L, Dallel R

British journal of pharmacology2025

DOI: 10.1111/bph.70098 PMID: 40456686

Pain experience of children with Christianson syndrome.

Premachandran S, Ocay DD, Beaulieu C, Balduzzi J, Ye DL, Davidova A, Bokhari R, Ouellet JA, Orlowski J, Gendron L, Sharif-Naeini R, Ferland CE

Pain2025

DOI: 10.1097/j.pain.0000000000003522 PMID: 39945731

Design, Synthesis, and In Vitro Characterization of Proteolytically-Stable Opioid-Neurotensin Hybrid Peptidomimetics.

De Neve J, Breault É, Previti S, Vangeloven E, Loranger B, Chartier M, Brouillette R, Lanoie A, Holleran BJ, Longpré JM, Gendron L, Tourwé D, Sarret P, Ballet S

ACS pharmacology & translational science2024

DOI: 10.1021/acsptsci.4c00236 PMID: 39296263

Data-driven dynamic profiles of tonic heat pain perception in pain-free volunteers are associated with differences in anandamide levels.

Potvin S, Vincenot M, Haroune L, Giguère CÉ, Gendron L, Léonard G, Marchand S

Scientific reports2024

DOI: 10.1038/s41598-024-67401-2 PMID: 39060336

Reliability and minimal detectable change of dynamic temporal summation and conditioned pain modulation using a single experimental paradigm.

Vincenot M, Beaulieu LD, Gendron L, Marchand S, Léonard G

PloS one2024

DOI: 10.1371/journal.pone.0307556 PMID: 39052569

Neurobiology and molecular mechanisms of the opioid system

Principal investigatorNSERC2024Discovery Grants Program - Individual

Principal investigators: Gendron, Louis

Keywords: veterinary research; opioid receptors; phylogeny; exotic birds; prey birds; pain and analgesia; receptor pharmacology; cell signaling; horses; ocular pain

$40,000

Mechanisms of opioid tolerance: A role for the delta opioid receptor

Nominated PICIHR2024Project Grant - PA: IMHA: Myalgic Encephalomyelitis

Principal investigators: Gendron, Louis

Keywords: Analgesic Tolerance; Animal Behavior; Cellular And Molecular Biology; Electron Microscopy; Electrophysiology; Morphine; Opioid Receptors; Opioids; Pharmacology; Receptor Interactions

$100,000

23rd Joint meeting of the Great Lakes GPCR Retreat and the Club des récepteurs à sept domaines transmembranaires du Québec

Co-investigatorCIHR2024Planning and Dissemination Grant - Institute Community Support

Principal investigators: Lavoie, Christine

Keywords: Animal Model; Drug Design; G Protein-Coupled Receptors; Heterotrimeric G-Protein; Pharmacology; Protein Trafficking; Signaling; Structure Biology; Therapeutic

$15,000

The mitochondrial delta opioid receptor: role, targeting and molecular mechanisms

Principal investigatorCIHR2023Project Grant

Principal investigators: Parent, Jean-Luc; Gendron, Louis

Keywords: G Protein-Coupled Receptor; Gpcr; Mitochondria; Opioid; Signaling; Stress; Trafficking

$952,426

Le récepteur opioïde delta comme cible dans le traitement de la migraine.

SupervisorCIHR2022Canada Graduate Scholarships - Michael Smith Foreign Study Supplements

Principal investigators: Beaulieu, Claudie

Keywords: Delta; Migraine; Opioide

$4,000

Dissiper la fumée : Cannabis et Santé Colloque scientifique conjoint du Réseau québécois de recherche sur les médicaments, du Réseau santé respiratoire et du Réseau québécois de recherche sur la douleur

Principal investigatorCIHR2019Planning and Dissemination Grant - Institute Community Support

Principal investigators: Marsault, Eric; Bissonnette, Elyse; Gendron, Louis

Keywords: Cannabis; Douleur; Découverte Du Médicament; Neurosciences Et Toxicomanie; Populations Vulnérables; Potentiel Thérapeutique; Santé Des Populations; Santé Publique; Santé Respiratoire; Usage Du Médicament

$20,000

20th Joint meeting of the Great Lakes GPCR Retreat and the Club des récepteurs à sept domaines transmembranaires du Québec

Nominated PICIHR2019Planning and Dissemination Grant - Institute Community Support

Principal investigators: Gendron, Louis

Keywords: Bias Signaling; Endocytosis; Functional Selectivity; G Protein-Coupled Receptors; Pharmacology; Protein Trafficking; Signaling; Structure Biology

$20,000

Targeting the delta opioid receptor to alleviate pain.

SupervisorCIHR2019Undergraduate: Summer Studentship Award - Institute Community Support

Principal investigators: Quirion, Béatrice

Keywords: Animal Studies; Dorsal Root Ganglia; Immunohistochemistry; In Situ Hybridization; Opioid Receptors; Opioids; Pain

$5,000

Confocal calcium imaging and electrophysiology in live brain cells for neuroscience research at Université de Sherbrooke

Co-investigatorNSERC2019Research Tools and Instruments

Principal investigators: Ryczko, Dimitri

$149,916

PAINtalks

Principal investigatorCIHR2019Planning and Dissemination Grant - Institute Community Support

Principal investigators: Cyr, Marie-Pierre; Gendron, Louis

Keywords: Communication Scientifique; Dissémination; Douleur; Patients

$20,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

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Louis Gendron

Research

Latest papers

Latest funding

Trifluoromethylthio and Trifluoromethyl Functionalization of Endomorphin-1 Enhances its Hydrophobicity and Plasma Stability while Preserving its Affinity for the &#x3bc;-Opioid Receptor.

Pharmacogenetic association study of cannabis use in chronic pain.

Dual-target opioid/neurotensin ligands drive potent and safer analgesia in vivo.

Spotlight on Endocannabinoids in Healthy Individuals Using Volumetric Absorptive Microsampling Combined with LC-MS/MS Analysis.

Modeling Temporal Summation and Conditioned Pain Modulation in Individuals With and Without Chronic Pain.

Contribution of peripheral and central delta opioid receptors in the relief of migraine-like headache in female and male rats.

Pain experience of children with Christianson syndrome.

Design, Synthesis, and In Vitro Characterization of Proteolytically-Stable Opioid-Neurotensin Hybrid Peptidomimetics.

Data-driven dynamic profiles of tonic heat pain perception in pain-free volunteers are associated with differences in anandamide levels.

Reliability and minimal detectable change of dynamic temporal summation and conditioned pain modulation using a single experimental paradigm.

Neurobiology and molecular mechanisms of the opioid system

Confocal calcium imaging and electrophysiology in live brain cells for neuroscience research at Université de Sherbrooke

Frequent collaborators

Philippe Sarret

Jean-Luc Parent

Alain Frigon

Graciela Pineyro

Jean-Bernard Denault

Louis Gendron

Reza Sharif-Naeini

Richard Leduc

Abdelaziz Amrani

Michel Bouvier

Marie-Ève Tremblay

Subburaj Ilangumaran

John Orlowski

Rebecca Brouillette

Christine Lavoie

Jean-Paul Praud

Robert Day

Martin Lepage

Melissa Roy

Trifluoromethylthio and Trifluoromethyl Functionalization of Endomorphin-1 Enhances its Hydrophobicity and Plasma Stability while Preserving its Affinity for the μ-Opioid Receptor.