Faculty profile

Michel Bouvier

ResearcherBiochimie et médecine moléculaireUniversité de Montréal

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a Université de Montréal directory, so their courses may be missing. Find their university profile.

Michel Bouvier

Researcher

Biochimie et médecine moléculaire

Health Sciences

Université de Montréal

Montreal, Quebec, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
19 publications in the last five years, latest in 2026.
Senior (last) author on 3 recent papers, a sign of leading a research group.
Principal investigator on 14 research grants (11 CIHR, 3 NSERC), most recently in 2023.
Supervised 5 trainees who won CIHR awards, most recently in 2023.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

Publications

Citations

h-index

Collaborators

Grants

Publications by year

Counts cover the works listed on the university profile; citation counts come from Dimensions.

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Signals and details

Research

G Protein-Coupled Receptors Protein Trafficking Bioluminescence Resonance Energy Transfer Drug Discovery Functional Selectivity Endocytosis Cell Signalling Resonance Energy Transfer (Bret-Fret)

Latest papers

TBXA2R activates ERMs to drive motility, invasion, and metastatic colonization of TNBC cells.
Life science alliance · 2026
From Lead to Clinical Candidate: Discovery of BMS-986331 as a Potent and Selective N-Formyl Peptide Receptor 2 Agonist.
Journal of medicinal chemistry · 2026
Intracrine FFA4 signaling controls lipolysis at lipid droplets.
Nature chemical biology · 2026

All 88 publications

Latest funding

Distilled-DEL: A novel DNA-encoded drug discovery platform enabling biological evaluation of cellular targets on live cells.
CIHR · 2024 · Co-investigator
$100,000
Molecular mechanisms and structural determinants of pharmacological chaperone action; therapeutic potential for the treatment of early onset severe obesity
CIHR · 2023 · Nominated PI
$879,750
Cross-disciplinary Acuity Training Program in Intelligent and Responsible Drug Discovery
NSERC · 2023 · Co-investigator
$463,000

All 26 grants and awards

88 publications.

TBXA2R activates ERMs to drive motility, invasion, and metastatic colonization of TNBC cells.

Leguay K, Naffati O, Kiyan CL, He YY, Hogue M, Tesnière C, Gombos M, Kuasne H, Gaboury L, Le Gouill C, Meloche S, Bouvier M, Carréno S

Life science alliance2026

DOI: 10.26508/lsa.202503601 PMID: 41844278

From Lead to Clinical Candidate: Discovery of BMS-986331 as a Potent and Selective N-Formyl Peptide Receptor 2 Agonist.

Shirude PS, Cheney D, Chattopadhyay AK, Seshadri B, Baligar V, Rachamreddy C, Madduri S, Anjanappa P, Viet A, Valente MN, Rossi K, Abousleiman M, Hsu MY, Everlof G, Gali V, Sun Y, Allocco J, Zhang R, St-Onge S, Lupisella J, Chen XQ, Sarodaya S, Ravindran MS, Tagore DM, Nagar J, Dudhgaonkar S, Putlur S, Héroux M, Bouvier M, Wexler RR, Dierks E, Garcia RA, Kick EK, Wurtz NR

Journal of medicinal chemistry2026

DOI: 10.1021/acs.jmedchem.5c02712 PMID: 41701653

Intracrine FFA4 signaling controls lipolysis at lipid droplets.

O'Brien SL, Tripp E, Barki N, Blondel-Tepaz E, Smith G, Boufersaoui A, Roberts J, Pike JA, Correia J, Miljus T, Bouvier M, Tennant DA, Hudson BD, Gerhart-Hines Z, Milligan G, Schwartz TW, Calebiro D

Nature chemical biology2026

DOI: 10.1038/s41589-025-01982-5 PMID: 40764678

MRAP2 modifies the signaling and oligomerization state of the melanocortin-4 receptor.

Sohail I, Laurin SA, Kleinau G, Chunilal V, Morton A, Brenlla A, Kagiali ZCU, Blouin MJ, Tello JA, Beck-Sickinger AG, Lohse MJ, Scheerer P, Bouvier M, McCormick P, Annibale P, Biebermann H

Nature communications2025

DOI: 10.1038/s41467-025-63988-w PMID: 40998819

Decoding ADGRE5: How Proteolytic Cleavage and Mechanical Forces Unleash Cellular Signals.

Moreno-Salinas AL, Mancini A, Aouad S, Kandasamy H, Morissette S, Maiga A, Bouvier M, Leduc R, Sabbagh L

Cells2025

DOI: 10.3390/cells14161284 PMID: 40862763

Sustained Gαs signaling mediated by vasopressin type 2 receptors is ligand dependent but endocytosis and β-arrestin independent.

Teixeira LB, Blouin MJ, Le Gouill C, Picard LP, Costa-Neto CM, Bouvier M, Parreiras-E-Silva LT

Science signaling2025

DOI: 10.1126/scisignal.adf6206 PMID: 40136046

G protein selectivity profile of GPR56/ADGRG1 and its effect on downstream effectors.

Jallouli R, Moreno-Salinas AL, Laniel A, Holleran B, Avet C, Jacob J, Hoang T, Lavoie C, Carmon KS, Bouvier M, Leduc R

Cellular and molecular life sciences : CMLS2024

DOI: 10.1007/s00018-024-05416-8 PMID: 39231834

Pharmacological fingerprint of antipsychotic drugs at the serotonin 5-HT2A receptor.

Gaitonde SA, Avet C, de la Fuente Revenga M, Blondel-Tepaz E, Shahraki A, Pastor AM, Talagayev V, Robledo P, Kolb P, Selent J, González-Maeso J, Bouvier M

Molecular psychiatry2024Senior author

DOI: 10.1038/s41380-024-02531-7 PMID: 38561467

Comprehensive Analysis of Kisspeptin Signaling: Effects on Cellular Dynamics in Cervical Cancer.

Rodríguez-Sarmiento DY, Rondón-Villarreal P, Scarpelli-Pereira PH, Bouvier M

Biomolecules2024Senior author

DOI: 10.3390/biom14080923 PMID: 39199311

Role of the V2R-βarrestin-Gβγ complex in promoting G protein translocation to endosomes.

Sokrat B, Nguyen AH, Thomsen ARB, Huang LY, Kobayashi H, Kahsai AW, Kim J, Ho BX, Ma S, Little J, Ehrhart C, Pyne I, Hammond E, Bouvier M

Communications biology2024Senior author

DOI: 10.1038/s42003-024-06512-y PMID: 38972875

Distilled-DEL: A novel DNA-encoded drug discovery platform enabling biological evaluation of cellular targets on live cells.

Co-investigatorCIHR2024Project Grant - PA: Pandemic Preparedness and Health Emergencies Research

Principal investigators: Marinier, Anne

Keywords: Biased Signaling; Breast Cancer; Cancer Therapeutics; Cell-Based Screens; Dna-Encoded Chemical Libraries (Decl); Drug Discovery; Early Hits Identification; G-Protein Coupled Receptors (Gpcrs); Stem Cell Epigenetics; Target Identification And Active Site Mapping

$100,000

Molecular mechanisms and structural determinants of pharmacological chaperone action; therapeutic potential for the treatment of early onset severe obesity

Nominated PICIHR2023Project Grant

Principal investigators: Bouvier, Michel

Keywords: Conformational Diseases; Drug Discovery; G Protein-Coupled Receptors; Genetic Diseases; Inherited Diseases; Melanocortin Type 4 Receptor; Obesity; Pharmacological Chaperones; Protein Folding; Protein Trafficking

$879,750

Cross-disciplinary Acuity Training Program in Intelligent and Responsible Drug Discovery

Co-investigatorNSERC2023Collaborative Research and Training Experience

Principal investigators: SARRET, Philippe P

Keywords: advanced device technologies; artificial intelligence; biological targets; biosensors; computing science; drug discovery; imaging; medicinal chemistry

$463,000

HOPE-IOID : Régulation et modulation à différents niveaux du système opioïde par le nouveau piégeur de peptides opioïdes ACKR3

SupervisorCIHR2023CIHR Fellowship

Principal investigators: Chappe, Yann

Keywords: Bret; Douleur; Pharmacologie; Récepteur Couplé Aux Protéines G; Système Opioïde; Voies De Transduction Du Signal

$135,000

Mechanisms and consequences of spatially controlled G protein-coupled receptor signaling

Nominated PICIHR2022Project Grant

Principal investigators: Bouvier, Michel

Keywords: Bioluminescence Resonance Energy Transfer; Cell Signaling; Endocytosis; Functional Selectivity; G Protein-Coupled Receptors; Protein Trafficking

$1,063,350

Exploring the repertoire of GPCRs to identify and characterize new receptors that can promote cancer cell invasion and metastasis.

Co-investigatorCIHR2020Project Grant

Principal investigators: Carreno, Sébastien

Keywords: Cell Invasion; Ezrin; G Protein Coupled-Receptor; Metastasis; Moesin; Radixin; Rho Pathway; Triple Negative Breast Cancer

$918,000

Bioluminescence resonance energy transfer detection system for the monitoring of protein-protein interactions, post-translational modifications and cell signalling.

Principal investigatorNSERC2019Research Tools and Instruments

Principal investigators: Bouvier, Michel

$94,371

Sub-cellular propagation of GPCR signaling; functional imaging in space and time

Principal investigatorNSERC2019Discovery Grants Program - Individual

Principal investigators: Bouvier, Michel

$360,000

G protein functional selectivity in metabolic disorders

Nominated PICIHR2019Joint Canada-Israel Health Research Program

Principal investigators: Bouvier, Michel; Kosloff, Mickey

Keywords: Bioinformatic; Bioluminescence Resonance Energy Transfer; Cell Signalling; Drug Action; G Protein Coupled Receptors; Insulin Secretion; Molecular Modeling; Protein Chemistry; Protein-Protein Interactions; Type Ii Diabetese

Sub-cellular propagation of GPCR signaling; functional imaging in space and time

Principal investigatorNSERC2018Discovery Grants Program - Individual

Principal investigators: Bouvier, Michel

$42,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

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Michel Bouvier

Research

Latest papers

Latest funding

TBXA2R activates ERMs to drive motility, invasion, and metastatic colonization of TNBC cells.

From Lead to Clinical Candidate: Discovery of BMS-986331 as a Potent and Selective N-Formyl Peptide Receptor 2 Agonist.

Intracrine FFA4 signaling controls lipolysis at lipid droplets.

MRAP2 modifies the signaling and oligomerization state of the melanocortin-4 receptor.

Decoding ADGRE5: How Proteolytic Cleavage and Mechanical Forces Unleash Cellular Signals.

Sustained G&#x3b1;s signaling mediated by vasopressin type 2 receptors is ligand dependent but endocytosis and &#x3b2;-arrestin independent.

G protein selectivity profile of GPR56/ADGRG1 and its effect on downstream effectors.

Pharmacological fingerprint of antipsychotic drugs at the serotonin 5-HT2A receptor.

Comprehensive Analysis of Kisspeptin Signaling: Effects on Cellular Dynamics in Cervical Cancer.

Role of the V2R-&#x3b2;arrestin-G&#x3b2;&#x3b3; complex in promoting G protein translocation to endosomes.

Distilled-DEL: A novel DNA-encoded drug discovery platform enabling biological evaluation of cellular targets on live cells.

Molecular mechanisms and structural determinants of pharmacological chaperone action; therapeutic potential for the treatment of early onset severe obesity

Cross-disciplinary Acuity Training Program in Intelligent and Responsible Drug Discovery

HOPE-IOID : Régulation et modulation à différents niveaux du système opioïde par le nouveau piégeur de peptides opioïdes ACKR3

Mechanisms and consequences of spatially controlled G protein-coupled receptor signaling

Exploring the repertoire of GPCRs to identify and characterize new receptors that can promote cancer cell invasion and metastasis.

Bioluminescence resonance energy transfer detection system for the monitoring of protein-protein interactions, post-translational modifications and cell signalling.

Sub-cellular propagation of GPCR signaling; functional imaging in space and time

G protein functional selectivity in metabolic disorders

Sub-cellular propagation of GPCR signaling; functional imaging in space and time

Frequent collaborators

Richard Leduc

Graciela Pineyro

Benjamin Haibe-Kains

Jacek Majewski

Jerry Pelletier

Zamaneh Kassiri

Simon De Denus

Olivier Lesur

Christine Lavoie

Jean-Lucien Rouleau

Richard Leduc

Pierre-Luc Boudreault

Nikolaus Heveker

Jean-Claude Tardif

Jean-Claude Tardif

Philippe Sarret

Mannix Auger-Messier

Vincent Poitout

Benoit Chabot

Audrey Claing

Louis Gendron

Sustained Gαs signaling mediated by vasopressin type 2 receptors is ligand dependent but endocytosis and β-arrestin independent.

Role of the V2R-βarrestin-Gβγ complex in promoting G protein translocation to endosomes.