Faculty profile

Luc Desgroseillers

ResearcherBiochimie et médecine moléculaireUniversité de Montréal

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a Université de Montréal directory, so their courses may be missing. Find their university profile.

Luc Desgroseillers

Researcher

Biochimie et médecine moléculaire

Health Sciences

Université de Montréal

Montreal, Quebec, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
3 publications in the last five years, latest in 2022.
Senior (last) author on 1 recent paper, a sign of leading a research group.
Principal investigator on 14 research grants (11 NSERC, 3 CIHR), most recently in 2019.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

Publications

Citations

h-index

Collaborators

Grants

Publications by year

Counts cover the works listed on the university profile; citation counts come from Dimensions.

Profiles and links

Search on Google Scholar

Find them onX · LinkedIn · Bluesky · YouTube

Signals and details

Research

Cell Division Molecular Biology Mrna Transport Protein Interaction Rna Metabolism Staufen Translation

Latest papers

Phosphomimicry on STAU1 Serine 20 Impairs STAU1 Posttranscriptional Functions and Induces Apoptosis in Human Transformed Cells.
International journal of molecular sciences · 2022 · senior author
Correction to 'The double-stranded RNA-binding protein, Staufen1, is an IRES-transacting factor regulating HIV-1 cap-independent translation initiation'.
Nucleic acids research · 2022
The double-stranded RNA-binding protein, Staufen1, is an IRES-transacting factor regulating HIV-1 cap-independent translation initiation.
Nucleic acids research · 2022

All 19 publications

Latest funding

Staufen2 and DNA damage
NSERC · 2019 · Principal investigator
$192,000
Role of Staufen1 in the regulation of cell proliferation
CIHR · 2016 · Nominated PI
$100,000
Expression of Staufen2 in response to DNA damages
NSERC · 2014 · Principal investigator
$235,000

All 19 grants and awards

19 publications.

Phosphomimicry on STAU1 Serine 20 Impairs STAU1 Posttranscriptional Functions and Induces Apoptosis in Human Transformed Cells.

Gonzalez Quesada Y, Bonnet-Magnaval F, DesGroseillers L

International journal of molecular sciences2022Senior author

DOI: 10.3390/ijms23137344 PMID: 35806349

Correction to 'The double-stranded RNA-binding protein, Staufen1, is an IRES-transacting factor regulating HIV-1 cap-independent translation initiation'.

Ramos H, Monette A, Niu M, Barrera A, López-Ulloa B, Fuentes Y, Guizar P, Pino K, DesGroseillers L, Mouland AJ, López-Lastra M

Nucleic acids research2022

DOI: 10.1093/nar/gkab1266 PMID: 34908137

The double-stranded RNA-binding protein, Staufen1, is an IRES-transacting factor regulating HIV-1 cap-independent translation initiation.

Ramos H, Monette A, Niu M, Barrera A, López-Ulloa B, Fuentes Y, Guizar P, Pino K, DesGroseillers L, Mouland AJ, López-Lastra M

Nucleic acids research2022

DOI: 10.1093/nar/gkab1188 PMID: 34893869

High Level of Staufen1 Expression Confers Longer Recurrence Free Survival to Non-Small Cell Lung Cancer Patients by Promoting THBS1 mRNA Degradation.

Bonnet-Magnaval F, Diallo LH, Brunchault V, Laugero N, Morfoisse F, David F, Roussel E, Nougue M, Zamora A, Marchaud E, Tatin F, Prats AC, Garmy-Susini B, DesGroseillers L, Lacazette E

International journal of molecular sciences2021

DOI: 10.3390/ijms23010215 PMID: 35008641

STAU2 protein level is controlled by caspases and the CHK1 pathway and regulates cell cycle progression in the non-transformed hTERT-RPE1 cells.

Condé L, Gonzalez Quesada Y, Bonnet-Magnaval F, Beaujois R, DesGroseillers L

BMC molecular and cell biology2021Senior author

DOI: 10.1186/s12860-021-00352-y PMID: 33663378

Staufen1 localizes to the mitotic spindle and controls the localization of RNA populations to the spindle.

Hassine S, Bonnet-Magnaval F, Benoit Bouvrette LP, Doran B, Ghram M, Bouthillette M, Lecuyer E, DesGroseillers L

Journal of cell science2020Senior author

DOI: 10.1242/jcs.247155 PMID: 32576666

Staufen1 is Essential for Cell-Cycle Transitions and Cell Proliferation Via the Control of E2F1 Expression.

Ghram M, Bonnet-Magnaval F, Hotea DI, Doran B, Ly S, DesGroseillers L

Journal of molecular biology2020Senior author

DOI: 10.1016/j.jmb.2020.04.016 PMID: 32335035

Correction to: The M-phase specific hyperphosphorylation of Staufen2 involved the cyclin-dependent kinase CDK1.

Beaujois R, Ottoni E, Zhang X, Gagnon C, Hassine S, Mollet S, Viranaicken W, DesGroseillers L

BMC cell biology2018Senior author

DOI: 10.1186/s12860-018-0171-2 PMID: 30200875

The M-phase specific hyperphosphorylation of Staufen2 involved the cyclin-dependent kinase CDK1.

Beaujois R, Ottoni E, Zhang X, Gagnon C, Hassine S, Mollet S, Viranaicken W, DesGroseillers L

BMC cell biology2017Senior author

DOI: 10.1186/s12860-017-0142-z PMID: 28705199

The downregulation of the RNA-binding protein Staufen2 in response to DNA damage promotes apoptosis.

Zhang X, Trépanier V, Beaujois R, Viranaicken W, Drobetsky E, DesGroseillers L

Nucleic acids research2016Senior author

DOI: 10.1093/nar/gkw057 PMID: 26843428

Staufen2 and DNA damage

Principal investigatorNSERC2019Discovery Grants Program - Individual

Principal investigators: Desgroseillers, Luc

$192,000

Role of Staufen1 in the regulation of cell proliferation

Nominated PICIHR2016Project Grant

Principal investigators: Desgroseillers, Luc

Keywords: Cell Division; Molecular Biology; Mrna Transport; Protein Interaction; Rna Metabolism; Staufen; Translation

$100,000

Expression of Staufen2 in response to DNA damages

Principal investigatorNSERC2014Discovery Grants Program - Individual

Principal investigators: DesGroseillers, Luc

$235,000

A molecular imager for Quantitative biochemistry

Co-investigatorNSERC2011Research Tools and Instruments - Category 1 (<$150,000)

Principal investigators: Legault, Pascale

$140,400

High performance imaging and image analysis unit

Co-investigatorNSERC2011Research Tools and Instruments - Category 1 (<$150,000)

Principal investigators: Chartrand, Pascal

$50,000

Regulation of Staufen1-mediated mRNA decay by phosphorylation and consequence for G1-S progression

Nominated PICIHR2010Operating Grant

Principal investigators: Desgroseillers, Luc

Keywords: Cell Cycle; Molecular Biology; Mrna Transport; Phosphorylation; Rna Decay; Rna Metabolism; Staufen; Translation

$785,270

Investigations of biomolecules by florescence spectroscopy

Co-investigatorNSERC2010Research Tools and Instruments - Category 1 (<$150,000)

Principal investigators: Omichinski, James

$65,502

Staufen1-mediated post-transcriptional regulation of gene expression

Principal investigatorNSERC2009Discovery Grants Program - Individual

Principal investigators: DesGroseillers, Luc

$440,000

Roles of the RNA-binding protein Staufen in the control of cell cycle progression

Nominated PICIHR2009Operating Grant - PA: Institute of Genetics (Bridge Funding)

Principal investigators: Desgroseillers, Luc

Keywords: Molecular Biology; Mrna Transport; Phosphorylation; Rna Metabolism; Staufen; Translation

$100,000

Nucleofector for gene expression

Principal investigatorNSERC2008Research Tools and Instruments - Category 1 (<$150,000)

Principal investigators: DesGroseillers, Luc

$21,500

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Something wrong or missing on this profile? Suggest a correction

Luc Desgroseillers

Research

Latest papers

Latest funding

Phosphomimicry on STAU1 Serine 20 Impairs STAU1 Posttranscriptional Functions and Induces Apoptosis in Human Transformed Cells.

Correction to 'The double-stranded RNA-binding protein, Staufen1, is an IRES-transacting factor regulating HIV-1 cap-independent translation initiation'.

The double-stranded RNA-binding protein, Staufen1, is an IRES-transacting factor regulating HIV-1 cap-independent translation initiation.

High Level of Staufen1 Expression Confers Longer Recurrence Free Survival to Non-Small Cell Lung Cancer Patients by Promoting THBS1 mRNA Degradation.

STAU2 protein level is controlled by caspases and the CHK1 pathway and regulates cell cycle progression in the non-transformed hTERT-RPE1 cells.

Staufen1 localizes to the mitotic spindle and controls the localization of RNA populations to the spindle.

Staufen1 is Essential for Cell-Cycle Transitions and Cell Proliferation Via the Control of E2F1 Expression.

Correction to: The M-phase specific hyperphosphorylation of Staufen2 involved the cyclin-dependent kinase CDK1.

The M-phase specific hyperphosphorylation of Staufen2 involved the cyclin-dependent kinase CDK1.

The downregulation of the RNA-binding protein Staufen2 in response to DNA damage promotes apoptosis.

Staufen2 and DNA damage

Role of Staufen1 in the regulation of cell proliferation

Expression of Staufen2 in response to DNA damages

A molecular imager for Quantitative biochemistry

High performance imaging and image analysis unit

Regulation of Staufen1-mediated mRNA decay by phosphorylation and consequence for G1-S progression

Investigations of biomolecules by florescence spectroscopy

Staufen1-mediated post-transcriptional regulation of gene expression

Roles of the RNA-binding protein Staufen in the control of cell cycle progression

Nucleofector for gene expression

Frequent collaborators

Jean-Claude Lacaille

Danuta Radzioch

Wayne Sossin

Catherine Martel