Jean-Claude Lacaille

Research

Long-Term Synaptic Plasticity Synaptic Physiology Alzheimer'S Disease Mouse Model Cre-Lox System Transgenic Mice Hippocampal Network Hippocampal-Dependent Learning And Memory Inhibitory Interneurons Subtypes Molecular Biology

Latest papers

Genetic Reduction of the Translational Repressors FMRP and 4E-BP2 Preserves Memory in Mouse Models of Alzheimer's Disease.
Aging cell · 2026
Dynamic and Homeostatic Neuron-Astrocyte Interactions at GABAergic Synapses.
Neurochemical research · 2025
Hippocampal Inhibitory Interneuron-Specific DREADDs Treatment Alters mTORC1-4E-BP Signaling and Impairs Memory Formation.
Journal of neurochemistry · 2025

All 47 publications

Latest funding

Interneuronopathies and neurodevelopmental disorders
CIHR · 2020 · Co-investigator
$1,078,650
Anesthesia-induced memory impairment is mediated by a specific loss of inhibitory neurons
CIHR · 2020 · Co-investigator
$956,250
Regulation of hippocampal network and memory by inhibitory interneuron synaptic plasticity
CIHR · 2016 · Nominated PI
$1,128,375

All 18 grants and awards

47 publications.

01

Genetic Reduction of the Translational Repressors FMRP and 4E-BP2 Preserves Memory in Mouse Models of Alzheimer's Disease.

Ribeiro FC, Cozachenco D, Parkhill M, Rodrigue B, Borges C, Lacaille JC, Nader K, De Felice FG, Lourenco MV, Aguilar-Valles A, Sonenberg N, Ferreira ST

Aging cell2026

DOI: 10.1111/acel.70315 PMID: 41334801

02

Dynamic and Homeostatic Neuron-Astrocyte Interactions at GABAergic Synapses.

Clarke D, Lacaille JC, Robitaille R

Neurochemical research2025

DOI: 10.1007/s11064-025-04554-0 PMID: 41021144

03

Hippocampal Inhibitory Interneuron-Specific DREADDs Treatment Alters mTORC1-4E-BP Signaling and Impairs Memory Formation.

Huang Z, Mahmood N, Lacaille JC, Wiebe S, Sonenberg N

Journal of neurochemistry2025

DOI: 10.1111/jnc.70048 PMID: 40123570

04

Dysregulating mTORC1-4E-BP2 signaling in GABAergic interneurons impairs hippocampus-dependent learning and memory.

Huang Z, Wiebe S, Nagpal A, Choi J, Walters C, Mahmood N, Khoutorsky A, Lacaille JC, Sonenberg N

Learning & memory (Cold Spring Harbor, N.Y.)2024

DOI: 10.1101/lm.054018.124 PMID: 39467641

05

The ketamine metabolite (2R,6R)-hydroxynorketamine rescues hippocampal mRNA translation, synaptic plasticity and memory in mouse models of Alzheimer's disease.

Ribeiro FC, Cozachenco D, Argyrousi EK, Staniszewski A, Wiebe S, Calixtro JD, Soares-Neto R, Al-Chami A, Sayegh FE, Bermudez S, Arsenault E, Cossenza M, Lacaille JC, Nader K, Sun H, De Felice FG, Lourenco MV, Arancio O, Aguilar-Valles A, Sonenberg N, Ferreira ST

Alzheimer's & dementia : the journal of the Alzheimer's Association2024

DOI: 10.1002/alz.14034 PMID: 38934107

06

Exploration of new space elicits phosphorylation of GluA1(Ser831) and S6K and expression of Arc in the hippocampus in vivo as in long-term potentiation.

Cagnetta R, Lacaille JC, Sonenberg N

Molecular brain2024

DOI: 10.1186/s13041-024-01100-x PMID: 38858726

07

mTORC1-mediated acquisition of reward-related representations by hippocampal somatostatin interneurons.

Michon FX, Laplante I, Bosson A, Robitaille R, Lacaille JC

Molecular brain2023Senior author

DOI: 10.1186/s13041-023-01042-w PMID: 37400913

08

Reversal of memory and autism-related phenotypes in Tsc2+/- mice via inhibition of Nlgn1.

Chalkiadaki K, Statoulla E, Zafeiri M, Haji N, Lacaille JC, Powell CM, Jafarnejad SM, Khoutorsky A, Gkogkas CG

Frontiers in cell and developmental biology2023

DOI: 10.3389/fcell.2023.1205112 PMID: 37293130

09

Syngap1 Disruption Induced by Recombination between Inverted loxP Sites Is Associated with Hippocampal Interneuron Dysfunction.

Khlaifia A, Jadhav V, Danik M, Badra T, Berryer MH, Dionne-Laporte A, Chattopadhyaya B, Di Cristo G, Lacaille JC, Michaud JL

eNeuro2023

DOI: 10.1523/eneuro.0475-22.2023 PMID: 37072176

10

Cell-type-specific translational control of spatial working memory by the cap-binding protein 4EHP.

Wiebe S, Huang Z, Ladak RJ, Skalecka A, Cagnetta R, Lacaille JC, Aguilar-Valles A, Sonenberg N

Molecular brain2023

DOI: 10.1186/s13041-023-00995-2 PMID: 36650535

Interneuronopathies and neurodevelopmental disorders

Co-investigatorCIHR2020Project Grant

Principal investigators: Rossignol, Elsa

Keywords: Autism; Epilepsy; Gabaergic Interneurons; Neurodevelopmental Disorders; Neuronal Migration

$1,078,650

Anesthesia-induced memory impairment is mediated by a specific loss of inhibitory neurons

Co-investigatorCIHR2020Project Grant

Principal investigators: Schricker, Thomas Peter S

Keywords: Anesthesia; Apoptosis; Behavioral Tests; Insulin; Memory Impairment; Mitochondria; Neuronal Cuircuits; Synaptic Plasticity

$956,250

Regulation of hippocampal network and memory by inhibitory interneuron synaptic plasticity

Nominated PICIHR2016Project Grant

Principal investigators: Lacaille, Jean-Claude

Keywords: Alzheimer'S Disease Mouse Model; Cre-Lox System Transgenic Mice; Hippocampal Network; Hippocampal-Dependent Learning And Memory; Inhibitory Interneurons Subtypes; Long-Term Synaptic Plasticity; Molecular Biology; Multiphoton Calcium Imaging; Patch Clamp Recording In Brain Slices; Synaptic Physiology

$1,128,375

Identifying translational regions underlying synaptic plasticity

Co-investigatorCIHR2016Project Grant

Principal investigators: Sossin, Wayne S

Keywords: Aplysia; Elongation Factor 2; Learning And Memory; Long-Term Depression; Long-Term Potentiation; Ribosome; Rna Binding Proteins; Stalled Polysomes; Synaptic Plasticity; Translational Control

$939,040

Canada Research Chair Tier 1

Nominated PICIHR2015Canada Research Chairs - CIHR Funded - Tier 1

Principal investigators: Lacaille, Jean-Claude

Keywords: Crc

$1,400,000

Study of glial cell function in brain synaptic networks

Co-investigatorNSERC2014Discovery Grants Program - Group

Principal investigators: Robitaille, Richard

$246,000

Novel pharmacogenetic strategies to reverse autism-like phenotypes in mouse models of ASD.

Co-investigatorCIHR2014Operating Grant

Principal investigators: Sonenberg, Nahum

Keywords: Animal Models; Autism; Tissue Specific Knockout Mice; Translational Control

$913,670

Translational control in synaptic homeostasis during the generation of exacerbated brain excitability linked to neurodevelopmental psychiatric disorders

SupervisorCIHR2013CIHR Fellowship

Principal investigators: Aguilar Valles, Argel

Keywords: Autism; Behavior; Genome-Wide Analyses Of Translation; Homeostatic Plasticity; Mepsc; Mrna Translation; Neuronal Cultures; Synaptic Scaling; Synaptic Transmission

$86,250

Mechanisms underlying long-term synaptic plasticity and memory formation

SupervisorCIHR2013Master's Award: Canada Graduate Scholarships

Principal investigators: Hébert-Seropian, Sarah

Keywords: Electrophysiology; Field Potentials; Mrna Granules; Neurobiology Of Memory; Patch Clamping; Regulation Of Translation; Rna Binding Proteins; Synaptic Plasticity

$17,500

Endoscopic cellular imaging of astrocyte-neuron interactions in vivo

Co-investigatorNSERC2013Research Tools and Instruments - Category 1 (<$150,000)

Principal investigators: Robitaille, Richard

$107,905

Biochemistry, Microbiology and Immunology

1 shared papers, latest 2017

Linda Wykes

Medicine

1 shared papers, latest 2023

Gustavo Turecki

Psychiatry

1 shared papers, latest 2018

Nabil Seidah

Laboratory of Biochemical Neuroendocrinology

1 shared papers, latest 2005

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mention

Subject: Prospective PhD student: Long-Term Synaptic Plasticity Dear Professor Lacaille, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Genetic Reduction of the Translational Repressors FMRP and 4E-BP2 Preserves Memory in Mouse Models of Alzheimer's Disease." (2026), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]

Jean-Claude Lacaille

Research

Latest papers

Latest funding

Genetic Reduction of the Translational Repressors FMRP and 4E-BP2 Preserves Memory in Mouse Models of Alzheimer's Disease.

Dynamic and Homeostatic Neuron-Astrocyte Interactions at GABAergic Synapses.

Hippocampal Inhibitory Interneuron-Specific DREADDs Treatment Alters mTORC1-4E-BP Signaling and Impairs Memory Formation.

Dysregulating mTORC1-4E-BP2 signaling in GABAergic interneurons impairs hippocampus-dependent learning and memory.

The ketamine metabolite (2R,6R)-hydroxynorketamine rescues hippocampal mRNA translation, synaptic plasticity and memory in mouse models of Alzheimer's disease.

Exploration of new space elicits phosphorylation of GluA1(Ser831)&#xa0;and S6K and expression of Arc in the hippocampus in vivo as in long-term potentiation.

mTORC1-mediated acquisition of reward-related representations by hippocampal somatostatin interneurons.

Reversal of memory and autism-related phenotypes in Tsc2+/- mice via inhibition of Nlgn1.

Syngap1 Disruption Induced by Recombination between Inverted loxP Sites Is Associated with Hippocampal Interneuron Dysfunction.

Cell-type-specific translational control of spatial working memory by the cap-binding protein 4EHP.

Study of glial cell function in brain synaptic networks

Endoscopic cellular imaging of astrocyte-neuron interactions in vivo

Frequent collaborators

Nahum Sonenberg

Arkady Khoutorsky

Karim Nader

Argel Aguilar Valles

Richard Robitaille

Argel Aguilar Valles

Richard Robitaille

Wayne Sossin

Elsa Rossignol

Jerry Pelletier

Gabriella Gobbi

Luc Desgroseillers

Louis-Eric Trudeau

Kobi Rosenblum

Giamal Luheshi

Roberto Araya

Graziella Di Cristo

Sylvie Belleville

Naguib Mechawar

Tommy Alain

Linda Wykes

Gustavo Turecki

Nabil Seidah

Exploration of new space elicits phosphorylation of GluA1(Ser831) and S6K and expression of Arc in the hippocampus in vivo as in long-term potentiation.