Marie Kmita, Université de Montréal

Research

Hox Genes Congenital Malformations Transcriptional Regulation Human Syndromes Pioneer Factors Swi/Snf Gene Regulation Evolution

Latest papers

Smarcd1 subunit of SWI/SNF chromatin-remodeling complexes collaborates with E2a to promote murine lymphoid specification.
Developmental cell · 2024
40 years of the homeobox: mechanisms of Hox spatial-temporal collinearity in vertebrates.
Development (Cambridge, England) · 2024 · senior author
Mapping the global interactome of the ARF family reveals spatial organization in cellular signaling pathways.
Journal of cell science · 2024

All 13 publications

Latest funding

Force dependent chromatin conformation and transcription
CIHR · 2025 · Co-investigator
$1,021,276
Hox pioneering activity in development and disease
CIHR · 2025 · Nominated PI
$1,105,425
Hox pioneering activity in development and disease
CIHR · 2024 · Nominated PI
$100,000

All 13 grants and awards

13 publications.

01

Smarcd1 subunit of SWI/SNF chromatin-remodeling complexes collaborates with E2a to promote murine lymphoid specification.

Priam P, Krasteva V, Rousseau P, Polsinelli A, Côté L, Desanlis I, Farah A, Lavallée VP, Kmita M, Lessard JA

Developmental cell2024

DOI: 10.1016/j.devcel.2024.08.007 PMID: 39232562

02

40 years of the homeobox: mechanisms of Hox spatial-temporal collinearity in vertebrates.

Peraldi R, Kmita M

Development (Cambridge, England)2024Senior author

DOI: 10.1242/dev.202508 PMID: 39167089

03

Mapping the global interactome of the ARF family reveals spatial organization in cellular signaling pathways.

Quirion L, Robert A, Boulais J, Huang S, Bernal Astrain G, Strakhova R, Jo CH, Kherdjemil Y, Faubert D, Thibault MP, Kmita M, Baskin JM, Gingras AC, Smith MJ, Côté JF

Journal of cell science2024

DOI: 10.1242/jcs.262140 PMID: 38606629

04

The pioneering function of the hox transcription factors.

Paul R, Peraldi R, Kmita M

Seminars in cell & developmental biology2024Senior author

DOI: 10.1016/j.semcdb.2022.11.013 PMID: 36517345

05

Angiopoietin-like 2 is essential to aortic valve development in mice.

Labbé P, Munoz Goyette V, Thorin-Trescases N, Villeneuve L, Desanlis I, Delwarde C, Shi YF, Martel C, Yu C, Alikashani A, Mamarbachi M, Lesage F, Mathieu S, Tardif JC, Mathieu P, Kmita M, Thorin É

Communications biology2022

DOI: 10.1038/s42003-022-04243-6 PMID: 36414704

06

Biasing the conformation of ELMO2 reveals that myoblast fusion can be exploited to improve muscle regeneration.

Tran V, Nahlé S, Robert A, Desanlis I, Killoran R, Ehresmann S, Thibault MP, Barford D, Ravichandran KS, Sauvageau M, Smith MJ, Kmita M, Côté JF

Nature communications2022

DOI: 10.1038/s41467-022-34806-4 PMID: 36400788

07

Editorial: Mechanisms of hox-driven patterning and morphogenesis.

Kmita M, McGlinn E, Sánchez-Herrero E

Frontiers in cell and developmental biology2022First author

DOI: 10.3389/fcell.2022.992341 PMID: 36120568

08

Downregulation of Grem1 expression in the distal limb mesoderm is a necessary precondition for phalanx development.

Lancman JJ, Hasso SM, Suzuki T, Kherdjemil Y, Kmita M, Ferris A, Dong PDS, Ros MA, Fallon JF

Developmental dynamics : an official publication of the American Association of Anatomists2022

DOI: 10.1002/dvdy.431 PMID: 34719843

09

Transcriptional Trajectories in Mouse Limb Buds Reveal the Transition from Anterior-Posterior to Proximal-Distal Patterning at Early Limb Bud Stage.

Desanlis I, Paul R, Kmita M

Journal of developmental biology2020Senior author

DOI: 10.3390/jdb8040031 PMID: 33297480

10

Polycomb Repressive Complexes in Hox Gene Regulation: Silencing and Beyond: The Functional Dynamics of Polycomb Repressive Complexes in Hox Gene Regulation.

Gentile C, Kmita M

BioEssays : news and reviews in molecular, cellular and developmental biology2020Senior author

DOI: 10.1002/bies.201900249 PMID: 32743818

Force dependent chromatin conformation and transcription

Co-investigatorCIHR2025Project Grant

Principal investigators: Hopyan, Sevan

Keywords: Chromatin; Chromatin Conformation Capture; Conditional Mutation; Embryonic Development; Gene Regulation; Limb Bud; Physical Forces; Polycomb Repressive Complex; Rna-Sequencing; Transcription

$1,021,276

Hox pioneering activity in development and disease

Nominated PICIHR2025Project Grant

Principal investigators: Kmita, Marie T

Keywords: Congenital Malformations; Hox Genes; Human Syndromes; Pioneer Factors; Swi/Snf; Transcriptional Regulation

$1,105,425

Hox pioneering activity in development and disease

Nominated PICIHR2024Operating Grant - PA: Genetics (Bridge Funding: Research Priorities)

Principal investigators: Kmita, Marie T

Keywords: Congenital Malformations; Embryogenesis; Hox Genes; Human Syndromes; Pioneer Factors; Swi/Snf; Transcriptional Regulation

$100,000

Canadian Developmental Biology Conference

Co-investigatorCIHR2022Planning and Dissemination Grant - Institute Community Support

Principal investigators: Hopyan, Sevan; Simard, Martin J

Keywords: 170-220 Participants Expected; Biennial Meeting; Canadian Developmental Biology Conference; Québec City

$15,000

Hox genes in development and evolution of distal limbs

Nominated PICIHR2020Project Grant

Principal investigators: Kmita, Marie T

Keywords: Digit Formation; Evolution; Gene Regulation; Genetic Network; Hox Genes

$745,875

Pioneer activity of the Hox13 transcription factors in developing limbs

Nominated PICIHR2018Project Grant

Principal investigators: Kmita, Marie T

Keywords: Chromatin Remodellers; Enhancers; Evolution; Hox Genes; Limb Development; Transcriptional Regulation

$826,200

Physical regulation of chromatin during development

Co-investigatorCIHR2018Project Grant

Principal investigators: Hopyan, Sevan

Keywords: 5' Hoxa Cluster; Atomic Force Microscopy; Chromatin Conformation Capture; Limb Development; Mouse Embryo; Nuclear Lamina; Nuclear Mechanotransduction; Polycomb; Storm; Transgenic Force Sensors

$810,900

9th Canadian Developmental Biology Conference

Nominated PICIHR2017Planning and Dissemination Grant - Institute Community Support

Principal investigators: Kmita, Marie T

Keywords: Conference; Developmental Biology

$20,000

Role of chromatin 3D organization in gene transcriptional regulation

SupervisorCIHR2013CIHR Fellowship

Principal investigators: Sheth, Rushikesh S

Keywords: Chromatin Organization; Gene Regulation; Hox Genes; Limb Development; Mouse Genetics

$105,000

Characterization of Hox genes' function in limb morphogenesis

Nominated PICIHR2012Operating Grant

Principal investigators: Kmita, Marie T

Keywords: Chromosome Engineering; Congenital Malformations; Gene Regulation; Hox Genes; Mouse Genetics; Organogenesis

$773,192

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Genetics and Development
Department of Molecular Genetics
Medicine
Chemical Engineering
Biochemistry and Molecular Medicine
Biochemistry
Surgery

Co-authors at Université de Montréal, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

Jean-Claude Tardif

Chemical Engineering

1 shared papers, latest 2022

Patrick Mathieu

Surgery

1 shared papers, latest 2022

Maxime Bouchard

Biochemistry

1 shared papers, latest 2019

Martin Sauvageau

Biochemistry and Molecular Medicine

1 shared papers, latest 2022

Anne-Claude Gingras

Department of Molecular Genetics

1 shared papers, latest 2024

Jean-Claude Tardif

Medicine

1 shared papers, latest 2022

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mentionMention their CIHR grant from 2025

Subject: Prospective PhD student: Hox Genes Dear Professor Kmita, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Smarcd1 subunit of SWI/SNF chromatin-remodeling complexes collaborates with E2a to promote murine lymphoid specification." (2024), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your CIHR-funded project "Hox pioneering activity in development and disease" (2025), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]

Marie Kmita

Research

Latest papers

Latest funding

Smarcd1 subunit of SWI/SNF chromatin-remodeling complexes collaborates with E2a to promote murine lymphoid specification.

40&#x2005;years of the homeobox: mechanisms of Hox spatial-temporal collinearity in vertebrates.

Mapping the global interactome of the ARF family reveals spatial organization in cellular signaling pathways.

The pioneering function of the hox transcription factors.

Angiopoietin-like 2 is essential to aortic valve development in mice.

Biasing the conformation of ELMO2 reveals that myoblast fusion can be exploited to improve muscle regeneration.

Editorial: Mechanisms of hox-driven patterning and morphogenesis.

Downregulation of Grem1 expression in the distal limb mesoderm is a necessary precondition for phalanx development.

Transcriptional Trajectories in Mouse Limb Buds Reveal the Transition from Anterior-Posterior to Proximal-Distal Patterning at Early Limb Bud Stage.

Polycomb Repressive Complexes in Hox Gene Regulation: Silencing and Beyond: The Functional Dynamics of Polycomb Repressive Complexes in Hox Gene Regulation.

Frequent collaborators

Jean-Claude Tardif

Patrick Mathieu

Maxime Bouchard

Martin Sauvageau

Anne-Claude Gingras

Jean-Claude Tardif

40 years of the homeobox: mechanisms of Hox spatial-temporal collinearity in vertebrates.