Pascal Chartrand, Université de Montréal

Research

Cancer Telomeres Budding Yeast Live Cell Imaging Telomerase Yeast Bone Marow Failure Syndrome Dnajc21

Latest papers

TERRA transcripts localize at long telomeres to regulate telomerase access to chromosome ends.
Science advances · 2024
Phosphorylation controls the oligomeric state of She2 and mRNA localization in yeast.
RNA (New York, N.Y.) · 2023 · senior author
TERRA, a Multifaceted Regulator of Telomerase Activity at Telomeres.
Journal of molecular biology · 2020 · senior author

All 11 publications

Latest funding

Exploring the mechanisms of telomere biology disorders
CIHR · 2024 · Nominated PI
$100,000
Defining the repertoires and functional impacts of RNA binding proteins that undergo sequestration by toxic repeat RNA
CIHR · 2021 · Principal investigator
$818,550
Mechanisms regulating mRNA localization and localized translation
NSERC · 2019 · Principal investigator
$252,000

All 14 grants and awards

11 publications.

01

TERRA transcripts localize at long telomeres to regulate telomerase access to chromosome ends.

Bettin N, Querido E, Gialdini I, Grupelli GP, Goretti E, Cantarelli M, Andolfato M, Soror E, Sontacchi A, Jurikova K, Chartrand P, Cusanelli E

Science advances2024

DOI: 10.1126/sciadv.adk4387 PMID: 38865460

02

Phosphorylation controls the oligomeric state of She2 and mRNA localization in yeast.

Farajzadeh N, Shahbabian K, Bouaziz Y, Querido E, Chartrand P

RNA (New York, N.Y.)2023Senior author

DOI: 10.1261/rna.079555.122 PMID: 36921931

03

TERRA, a Multifaceted Regulator of Telomerase Activity at Telomeres.

Lalonde M, Chartrand P

Journal of molecular biology2020Senior author

DOI: 10.1016/j.jmb.2020.02.004 PMID: 32084415

04

Single-Molecule Imaging of Telomerase RNA Reveals a Recruitment-Retention Model for Telomere Elongation.

Laprade H, Querido E, Smith MJ, Guérit D, Crimmins H, Conomos D, Pourret E, Chartrand P, Sfeir A

Molecular cell2020

DOI: 10.1016/j.molcel.2020.05.005 PMID: 32497497

05

Induction and relocalization of telomeric repeat-containing RNAs during diauxic shift in budding yeast.

Perez-Romero CA, Lalonde M, Chartrand P, Cusanelli E

Current genetics2018

DOI: 10.1007/s00294-018-0829-5 PMID: 29569051

06

Telomerase RNA Imaging in Budding Yeast and Human Cells by Fluorescent In Situ Hybridization.

Guérit D, Lalonde M, Chartrand P

Methods in molecular biology (Clifton, N.J.)2018Senior author

DOI: 10.1007/978-1-4939-7306-4_27 PMID: 29043638

07

RNA fluorescence in situ hybridization for high-content screening.

Querido E, Dekakra-Bellili L, Chartrand P

Methods (San Diego, Calif.)2017Senior author

DOI: 10.1016/j.ymeth.2017.07.005 PMID: 28694064

08

Cell cycle-dependent spatial segregation of telomerase from sites of DNA damage.

Ouenzar F, Lalonde M, Laprade H, Morin G, Gallardo F, Tremblay-Belzile S, Chartrand P

The Journal of cell biology2017Senior author

DOI: 10.1083/jcb.201610071 PMID: 28637749

09

Live-cell imaging of budding yeast telomerase RNA and TERRA.

Laprade H, Lalonde M, Guérit D, Chartrand P

Methods (San Diego, Calif.)2017Senior author

DOI: 10.1016/j.ymeth.2016.07.014 PMID: 27474163

10

Co-transcriptional recruitment of Puf6 by She2 couples translational repression to mRNA localization.

Shahbabian K, Jeronimo C, Forget A, Robert F, Chartrand P

Nucleic acids research2014Senior author

DOI: 10.1093/nar/gku597 PMID: 25013181

Exploring the mechanisms of telomere biology disorders

Nominated PICIHR2024Operating Grant - PA: Genetics (Bridge Funding: Research Priorities)

Principal investigators: Chartrand, Pascal

Keywords: Bone Marow Failure Syndrome; Budding Yeast; Cancer; Dnajc21; Nucleo-Cytoplasmic Trafficking; Single-Molecule Imaging; Telomerase Biogenesis; Telomere Biology Disorders

$100,000

Defining the repertoires and functional impacts of RNA binding proteins that undergo sequestration by toxic repeat RNA

Principal investigatorCIHR2021Project Grant

Principal investigators: Lecuyer, Eric; Chartrand, Pascal

Keywords: Drosophila Genetics; Functional Dissection; Neuromuscular Disorders; Protein Sequestration; Repeat Expansion Disorders; Rna Binding Proteins; Subcellular Trafficking Defects

$818,550

Mechanisms regulating mRNA localization and localized translation

Principal investigatorNSERC2019Discovery Grants Program - Individual

Principal investigators: Chartrand, Pascal

$252,000

Studying telomeres maintenance by telomerase using live cell imaging

Nominated PICIHR2018Project Grant

Principal investigators: Chartrand, Pascal

Keywords: Budding Yeast; Human Cancer Cells; Live Cell Imaging; Protein-Rna Interactions; Single Molecule Imaging; Telomerase; Telomeres; Telomeric Repeats-Containing Rna

$852,975

4th Canadian Symposium on Telomeres and Genomic Integrity

Nominated PICIHR2017Planning and Dissemination Grant - Institute Community Support

Principal investigators: Chartrand, Pascal

Keywords: Aging; Cancer; Genome Integrity; Telomeres

$10,000

Mechanisms regulating mRNA localization and translational control

Nominated PICIHR2013Operating Grant

Principal investigators: Chartrand, Pascal

Keywords: Cell Cycle Regulation; Cell Differentiation; Chromatin Immunoprecipitation; Fluorescent In Situ Hybridization; Mrna Transport And Localization; Rna-Binding Proteins; Translational Control; Yeast

$660,559

The roles of MBNL proteins in the pathogenesis of myotonic dystrophy

Nominated PICIHR2013Operating Grant - Priority Announcement: Myotonic Dystrophy (Rachel Fund)

Principal investigators: Chartrand, Pascal

Keywords: Mbnl1; Mrna Localization; Myotonic Dystrophy; Pathogenesis; Rna Aggregation

$113,250

Single cell analysis of telomerase activity and regulation

Nominated PICIHR2012Operating Grant

Principal investigators: Chartrand, Pascal

Keywords: Cancer; Live Cell Imaging; Rna Trafficking; Telomerase; Telomeres; Terra; Yeast

$618,423

High performance imaging and image analysis unit

Principal investigatorNSERC2011Research Tools and Instruments - Category 1 (<$150,000)

Principal investigators: Chartrand, Pascal

$50,000

NSERC CREATE Training Program in Cellular dynamics of macromolelecular complexes

Co-investigatorNSERC2010Collaborative Research and Training Experience

Principal investigators: Baron, Christian

$1,600,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Biochemistry and Molecular Medicine
Biochimie et médecine moléculaire
Microbiology

Co-authors at Université de Montréal, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

Gerardo Ferbeyre

Biochimie et médecine moléculaire

1 shared papers, latest 2010

Gerardo Ferbeyre

Microbiology

1 shared papers, latest 2010

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mentionMention their CIHR grant from 2024

Subject: Prospective PhD student: Cancer Dear Professor Chartrand, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "TERRA transcripts localize at long telomeres to regulate telomerase access to chromosome ends." (2024), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your CIHR-funded project "Exploring the mechanisms of telomere biology disorders" (2024), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]