Gerardo Ferbeyre, McGill University

Research

Cancer Metabolism Signaling Ageing Basic Research Cytokines Immune Response Infectious Diseases

Latest papers

Clearance of p16-positive cardiac cells improves age-related cardiac remodeling in mice.
Experimental physiology · 2026
Development and validation of HPLC-UV and HPLC-MS/MS methods for ML-210 quantification.
Talanta · 2026
The role of ATP synthase subunit e (ATP5I) in mediating the metabolic and antiproliferative effects of metformin in cancer cells.
eLife · 2026 · senior author

All 43 publications

Latest funding

The role of oncogenic hydride ion transfer complex (HTC) in metabolic plasticity, cancer progression and therapeutic responses.
CIHR · 2022 · Principal investigator
$879,750
CIACCO-2023 (10th Annual symposium on Cytokines in Inflammation, Ageing, CanCer and Obesity)
CIHR · 2022 · Principal investigator
$10,000
CIACCO-2019 (8th Annual symposium on Cytokines in Inflammation, Ageing, CanCer and Obesity)
CIHR · 2018 · Co-investigator
$10,000

All 3 grants and awards

43 publications.

01

Clearance of p16-positive cardiac cells improves age-related cardiac remodeling in mice.

Mehdizadeh M, Mackasey M, Gharagozloo K, Aguilar M, Naud P, Ochs A, Vuong-Robillard N, Thorin E, Ferbeyre G, Tardif JC, Sirois MG, Tanguay JF, Nattel S

Experimental physiology2026

DOI: 10.1113/ep093551 PMID: 42734482

02

Development and validation of HPLC-UV and HPLC-MS/MS methods for ML-210 quantification.

Murphy M, Mahrouche L, Jutras M, Friciu M, Rodier F, Ferbeyre G, Yu F, Roullin VG, Leclair G

Talanta2026

DOI: 10.1016/j.talanta.2026.130422 PMID: 42594441

03

The role of ATP synthase subunit e (ATP5I) in mediating the metabolic and antiproliferative effects of metformin in cancer cells.

Lefrançois G, Lavallée E, Rowell MC, Bourdeau V, Mohebali F, Bertomeu T, Duman AM, Nikolova M, Tyers M, Gravel SP, Schmitzer AR, Ferbeyre G

eLife2026Senior author

DOI: 10.7554/elife.102680 PMID: 42138716

04

STAT1/3/5 Functions Driving Lipid and Energy Metabolism in Cancer and Immunity.

Rinnerthaler M, Sykora M, Christoforakos A, Aberger F, Ferbeyre G, Moriggl R

International journal of molecular sciences2026

DOI: 10.3390/ijms27062828 PMID: 41898687

05

Precision targeting of the SASP in cancer therapy.

Hassan S, Ferbeyre G

Nature aging2026Senior author

DOI: 10.1038/s43587-025-01052-4 PMID: 41634463

06

A one-two punch against cancer: combining CDK4 inhibitors with lysosomotropic agents.

Ferbeyre G

The EMBO journal2025First author

DOI: 10.1038/s44318-025-00396-2 PMID: 39994486

07

The role of cellular senescence in profibrillatory atrial remodelling associated with cardiac pathology.

Mehdizadeh M, Naud P, Abu-Taha IH, Hiram R, Xiong F, Xiao J, Saljic A, Kamler M, Vuong-Robillard N, Thorin E, Ferbeyre G, Tardif JC, Sirois MG, Tanguay JF, Dobrev D, Nattel S

Cardiovascular research2024

DOI: 10.1093/cvr/cvae003 PMID: 38181429

08

A senescence restriction point acting on chromatin integrates oncogenic signals.

Lopes-Paciencia S, Bourdeau V, Rowell MC, Amirimehr D, Guillon J, Kalegari P, Barua A, Quoc-Huy Trinh V, Azzi F, Turcotte S, Serohijos A, Ferbeyre G

Cell reports2024Senior author

DOI: 10.1016/j.celrep.2024.114044 PMID: 38568812

09

Extracellular Signal-Regulated Kinases: One Pathway, Multiple Fates.

Deschênes-Simard X, Malleshaiah M, Ferbeyre G

Cancers2023Senior author

DOI: 10.3390/cancers16010095 PMID: 38201521

10

SOCS1 Deficiency Promotes Hepatocellular Carcinoma via SOCS3-Dependent CDKN1A Induction and NRF2 Activation.

Khan MGM, Boufaied N, Yeganeh M, Kandhi R, Petkiewicz S, Sharma A, Yoshimura A, Ferbeyre G, Labbé DP, Ramanathan S, Ilangumaran S

Cancers2023

DOI: 10.3390/cancers15030905 PMID: 36765862

The role of oncogenic hydride ion transfer complex (HTC) in metabolic plasticity, cancer progression and therapeutic responses.

Principal investigatorCIHR2022Project Grant

Principal investigators: Topisirovic, Ivan; Ferbeyre, Gerardo

Keywords: Cancer; Metabolism; Signaling

$879,750

CIACCO-2023 (10th Annual symposium on Cytokines in Inflammation, Ageing, CanCer and Obesity)

Principal investigatorCIHR2022Planning and Dissemination Grant - Institute Community Support

Principal investigators: Fritz, Jorg H; Del Rincon, Sonia V; Ferbeyre, Gerardo; Ilangumaran, Subburaj; Lee, Seung-Hwan; Menendez, Alfredo; Rafei, Moutih; Ramanathan, Sheela; Rodrigue-Gervais, Ian Gaël; Saucier, Caroline

Keywords: Ageing; Basic Research; Cancer; Cytokines; Immune Response; Infectious Diseases; Inflammation; Novel Therapies; Obesity; Translational Medicine

$10,000

CIACCO-2019 (8th Annual symposium on Cytokines in Inflammation, Ageing, CanCer and Obesity)

Co-investigatorCIHR2018Planning and Dissemination Grant - Institute Community Support

Principal investigators: Fritz, Jorg H

Keywords: Aging; Basic Research; Cancer; Cytokines; Immune Response; Infectious Diseases; Inflammation; Novel Therapeutics; Obesity; Translational Medicine

$10,000

Biochimie et médecine moléculaire

1 shared papers, latest 2018

Alfredo Menendez

Microbiologie et d'infectiologie

1 shared papers, latest 2016

Adel Schwertani

Medicine/Cardiology

1 shared papers, latest 2016

Marlene Oeffinger

Systems Biology

1 shared papers, latest 2018

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mentionMention their CIHR grant from 2022

Subject: Prospective PhD student: Cancer Dear Professor Ferbeyre, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Clearance of p16-positive cardiac cells improves age-related cardiac remodeling in mice." (2026), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your CIHR-funded project "The role of oncogenic hydride ion transfer complex (HTC) in metabolic plasticity, cancer progression and therapeutic responses." (2022), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]