Sophie Breton, Université de Montréal

Research

Sex Determination Evolutionary Biology Evolutionary Physiology Mitochondria Mitochondrial DNA Mitogenomics Mitoepigenetics altORFs

Latest papers

Unstable mitochondrial heteroplasmy in Mytilus edulis primary cell cultures.
PeerJ · 2026
MTALTCO1: a 259 amino-acid long mtDNA-encoded alternative protein that challenges conventional understandings of mitochondrial genomics.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2026 · senior author
Metabolic consequences of naturally occurring mitochondrial heteroplasmy in bivalves.
Proceedings. Biological sciences · 2026 · senior author

All 27 publications

Latest funding

Mitochondrial Evolutionary Biology
NSERC · 2022 · Principal investigator
$100,000
Mitochondrial epigenetics and ORFan genes: exploiting the mitochondrial genetic system to fuel phenotypic variation and functional novelties
NSERC · 2019 · Principal investigator
$252,000
Evolutionary Mitochondrial Biology
NSERC · 2018 · Principal investigator
$360,000

All 6 grants and awards

27 publications.

01

Unstable mitochondrial heteroplasmy in Mytilus edulis primary cell cultures.

Hosseini Khorami H, Fong-Zazueta R, Breton S, Angers A

PeerJ2026

DOI: 10.7717/peerj.21530 PMID: 42405250

02

MTALTCO1: a 259 amino-acid long mtDNA-encoded alternative protein that challenges conventional understandings of mitochondrial genomics.

Robitaille F, Campbell A, Ben Hadj A, Cornet S, Nadeau-Lachance L, Niaison T, Choquette T, Nyffeler L, Roucou X, Angers A, Breton S

Philosophical transactions of the Royal Society of London. Series B, Biological sciences2026Senior author

DOI: 10.1098/rstb.2025.0078 PMID: 41923604

03

Metabolic consequences of naturally occurring mitochondrial heteroplasmy in bivalves.

Pouliot-Drouin A, Bettinazzi S, Paque O, Breton S

Proceedings. Biological sciences2026Senior author

DOI: 10.1098/rspb.2025.2965 PMID: 41916594

04

Mitochondrial epigenetics brings new perspectives on doubly uniparental inheritance in bivalves.

Leroux É, Khorami HH, Angers A, Angers B, Breton S

Scientific reports2024Senior author

DOI: 10.1038/s41598-024-83368-6 PMID: 39733193

05

Comparative mitogenomics of Brachiopods reveals conservatism in articulate species and unusualness in inarticulate species.

Breton S

Molecular biology reports2024First author

DOI: 10.1007/s11033-024-09270-6 PMID: 38341808

06

Mitonuclear Sex Determination? Empirical Evidence from Bivalves.

Smith CH, Mejia-Trujillo R, Breton S, Pinto BJ, Kirkpatrick M, Havird JC

Molecular biology and evolution2023

DOI: 10.1093/molbev/msad240 PMID: 37935058

07

Validation of the male-specific ORF of the paternally-transmitted mtDNA in Mytilus edulis as a protein-coding gene.

Debelli A, Kienzle L, Khorami HH, Angers A, Breton S

Gene2023Senior author

DOI: 10.1016/j.gene.2023.147586 PMID: 37356740

08

Mitonuclear sex determination? Empirical evidence from bivalves.

Smith CH, Mejia-Trujillo R, Breton S, Pinto BJ, Kirkpatrick M, Havird JC

bioRxiv : the preprint server for biology2023

DOI: 10.1101/2023.07.05.547839 PMID: 37461691

09

A small protein coded within the mitochondrial canonical gene nd4 regulates mitochondrial bioenergetics.

Kienzle L, Bettinazzi S, Choquette T, Brunet M, Khorami HH, Jacques JF, Moreau M, Roucou X, Landry CR, Angers A, Breton S

BMC biology2023Senior author

DOI: 10.1186/s12915-023-01609-y PMID: 37198654

10

Multi-tissue RNA-Seq Analysis and Long-read-based Genome Assembly Reveal Complex Sex-specific Gene Regulation and Molecular Evolution in the Manila Clam.

Xu R, Martelossi J, Smits M, Iannello M, Peruzza L, Babbucci M, Milan M, Dunham JP, Breton S, Milani L, Nuzhdin SV, Bargelloni L, Passamonti M, Ghiselli F

Genome biology and evolution2022

DOI: 10.1093/gbe/evac171 PMID: 36508337