Faculty profile

Xavier Roucou

ResearcherBiochemistryUniversité de Sherbrooke

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a Université de Sherbrooke directory, so their courses may be missing. Find their university profile.

Xavier Roucou

Researcher

Biochemistry

Health Sciences

Université de Sherbrooke

Sherbrooke, Quebec, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
26 publications in the last five years, latest in 2026.
Senior (last) author on 6 recent papers, a sign of leading a research group.
Principal investigator on 6 research grants (6 CIHR), most recently in 2022.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

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Grants

Publications by year

Counts cover the works listed on the university profile; citation counts come from Dimensions.

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Signals and details

Research

Crc Alternative Translation Bioinformatics Functional Proteomics Genome Annotations Open Reading Frame Protein Networks Bradykinin

Latest papers

Author Correction: Community benchmarking and evaluation of human unannotated microprotein detection by mass spectrometry based proteomics.
Nature communications · 2026
Expanding the human proteome with microproteins and peptideins.
Nature · 2026
MTALTCO1: a 259 amino-acid long mtDNA-encoded alternative protein that challenges conventional understandings of mitochondrial genomics.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2026

All 63 publications

Latest funding

Canada Research Chair - Tier 1
CIHR · 2022 · Nominated PI
$1,400,000
Challenging the dogmas of monocistronic genes and pseudogenes using proteogenomics and systems biology approaches to better define the human proteome in health and diseases
CIHR · 2020 · Nominated PI
$1,166,625
Ubiquitin-KEKS: Function of a Novel Ubiquitin Isoform Coded by UBBP4, a Gene Initially Annotated as a Pseudogene.
CIHR · 2018 · Co-investigator
$891,226

All 7 grants and awards

63 publications.

Author Correction: Community benchmarking and evaluation of human unannotated microprotein detection by mass spectrometry based proteomics.

Wacholder A, Deutsch EW, Kok LW, van Dinter JT, Lee J, Wright JC, Leblanc S, Jayatissa AH, Jiang K, Arefiev I, Cao K, Bourassa F, Trifiro FA, Bassani-Sternberg M, Baranov PV, Bogaert A, Chothani S, Fierro-Monti I, Fijalkowska D, Gevaert K, Hubner N, Mudge JM, Ruiz-Orera J, Schulz J, Vizcaíno JA, Prensner JR, Brunet MA, Martinez TF, Slavoff SA, Roucou X, Choudhary JS, van Heesch S, Moritz RL, Carvunis AR

Nature communications2026

DOI: 10.1038/s41467-026-73431-3 PMID: 42230598

Expanding the human proteome with microproteins and peptideins.

Deutsch EW, Kok LW, Mudge JM, Valls CF, Jungreis I, Ruiz-Orera J, Sun Z, Kusebauch U, Fierro-Monti I, Abelin JG, Alba MM, Aspden JL, Bandyopadhyay S, Banerjee K, Baranov PV, Bazzini AA, Bourassa F, Bruford EA, Calviello L, Carr SA, Carvunis AR, Chothani S, Clauwaert J, Dean K, Faridi P, Frankish A, Goodale A, Green T, Hubner N, Ingolia NT, Kellis M, Magrane M, Martin MJ, Martinez TF, Menschaert G, Ohler U, Orchard S, Potter A, Rackham OJL, Rees MG, Root DE, Roth JA, Roucou X, Sialana FJ, Slavoff SA, Świrski MI, Tierney JAS, Trifiro FA, Valen E, Vasylieva V, Wacholder A, Wang S, Wang L, Weissman JS, Wu W, Xie Z, Choudhary JS, Bassani-Sternberg M, Vizcaíno JA, Ternette N, Brunet MA, Moritz RL, Prensner JR, van Heesch S

Nature2026

DOI: 10.1038/s41586-026-10459-x PMID: 42092140

MTALTCO1: a 259 amino-acid long mtDNA-encoded alternative protein that challenges conventional understandings of mitochondrial genomics.

Robitaille F, Campbell A, Ben Hadj A, Cornet S, Nadeau-Lachance L, Niaison T, Choquette T, Nyffeler L, Roucou X, Angers A, Breton S

Philosophical transactions of the Royal Society of London. Series B, Biological sciences2026

DOI: 10.1098/rstb.2025.0078 PMID: 41923604

An expanded reference catalog of translated open reading frames for biomedical research.

Chothani S, Ruiz-Orera J, Tierney JAS, Swirski MI, Tjeldnes H, Kok LW, Clauwaert J, Deutsch EW, Alba MM, Aspden JL, Baranov PV, Bazzini AA, Bruford EA, Brunet MA, Cardon T, Carvunis AR, Casola C, Choudhary JS, Dean K, Faridi P, Fierro-Monti I, Fournier I, Frankish A, Gerstein M, Hubner N, Jiang Y, Kellis M, Martinez TF, Menschaert G, Ni P, Orchard S, Roucou X, Rozowsky J, Salzet M, Siragusa M, Slavoff S, Ternette N, Vizcaino JA, Wacholder A, Wu W, Xie Z, Yang YT, Moritz RL, Valen E, Mudge J, van Heesch S, Prensner JR, Rackham OJL

Nucleic acids research2026

DOI: 10.1093/nar/gkag234 PMID: 41873765

Community benchmarking and evaluation of human unannotated microprotein detection by mass spectrometry based proteomics.

Nature communications2026

DOI: 10.1038/s41467-025-68002-x PMID: 41559053

Translon: a single term for translated regions.

Świrski MI, Tierney JAS, Albà MM, Andreev DE, Aspden JL, Atkins JF, Bassani-Sternberg M, Berry MJ, Biffo S, Boris-Lawrie K, Borodovsky M, Brierley I, Brook M, Brunet MA, Bujnicki JM, Caliskan N, Calviello L, Carvunis AR, Cate JHD, Cenik C, Chang KY, Chen Y, Chothani S, Choudhary JS, Clark PL, Clauwaert J, Cooley L, Dassi E, Dean K, Diaz JJ, Dieterich C, Dikstein R, Dinman JD, Dmitriev SE, Dontsova OA, Dunham CM, Eswarappa SM, Farabaugh PJ, Faridi P, Fierro-Monti I, Firth AE, Gatfield D, Gebauer F, Gelfand MS, Gray NK, Green R, Hill CH, Hou YM, Hübner N, Ignatova Z, Ivanov P, Iwasaki S, Johnson R, Jomaa A, Jovanovic M, Jungreis I, Kellis M, Kieft JS, Kochetov AV, Koonin EV, Korostelev AA, Kufel J, Kulakovskiy IV, Kurian L, Lafontaine DLJ, Larsson O, Loughran G, Lukeš J, Mariotti M, Martens-Uzunova ES, Martinez TF, Matsumoto A, McManus J, Medenbach J, Melnikov SV, Menschaert G, Merchante C, Mikl M, Miller WA, Mühlemann O, Namy O, Nedialkova DD, Nosek J, Orchard S, Ozretić P, Pertea M, Pervouchine DD, Romão L, Ron D, Roucou X, Rubtsova MP, Ruiz-Orera J, Saghatelian A, Salzberg SL, Seale LA, Seoighe C, Sergiev PV, Shah P, Shirokikh N, Slavoff SA, Sonenberg N, Stasevich TJ, Szczesny RJ, Tamm T, Tchórzewski M, Topisirovic I, Tremblay ML, Tuller T, Ulitsky I, Valášek LS, Van Damme P, Viero G, Vizcaino JA, Vogel C, Wallace EWJ, Weissman JS, Westhof E, Whiffin N, Wilson DN, Xie Z, Yewdell JW, Yordanova MM, Yu CH, Yurchenko V, Zagrovic B, TRANSLACORE, Valen E, Baranov PV

Nature methods2025

DOI: 10.1038/s41592-025-02810-3 PMID: 40890551

Development, validation, and preliminary phenotypic characterization of a Col6a3 knockout mouse model targeting exon 3.

ElChoueiry M, Sidhu H, Lévesque M, Lévesque D, Jacques JF, Sarrhini O, Beaudoin JF, Caron M, Gaudette B, Lecomte R, Roucou X, Boisvert FM, Brosseau JP

Animal models and experimental medicine2025

DOI: 10.1002/ame2.70063 PMID: 40792431

Discovery of diverse chimeric peptides in a eukaryotic proteome sets the stage for experimental validation of the mosaic translation hypothesis.

Çakır U, Gabed N, Köroğlu YE, Kaya S, Sinharoy S, Benedito VA, Brunet M, Roucou X, Kryvoruchko IS

Computational and structural biotechnology journal2025

DOI: 10.1016/j.csbj.2025.09.019 PMID: 41035503

High-quality peptide evidence for annotating non-canonical open reading frames as human proteins.

Deutsch EW, Kok LW, Mudge JM, Ruiz-Orera J, Fierro-Monti I, Sun Z, Abelin JG, Alba MM, Aspden JL, Bazzini AA, Bruford EA, Brunet MA, Calviello L, Carr SA, Carvunis AR, Chothani S, Clauwaert J, Dean K, Faridi P, Frankish A, Hubner N, Ingolia NT, Magrane M, Martin MJ, Martinez TF, Menschaert G, Ohler U, Orchard S, Rackham O, Roucou X, Slavoff SA, Valen E, Wacholder A, Weissman JS, Wu W, Xie Z, Choudhary J, Bassani-Sternberg M, Vizcaíno JA, Ternette N, Moritz RL, Prensner JR, van Heesch S

bioRxiv : the preprint server for biology2025

DOI: 10.1101/2024.09.09.612016 PMID: 39314370

Noncanonical altPIDD1 protein: unveiling the true major translational output of the PIDD1 gene.

Comtois F, Jacques JF, Métayer L, Ouedraogo WYD, Ouangraoua A, Denault JB, Roucou X

Life science alliance2025Senior author

DOI: 10.26508/lsa.202402910 PMID: 39532532

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Xavier Roucou

Research

Latest papers

Latest funding

Author Correction: Community benchmarking and evaluation of human unannotated microprotein detection by mass spectrometry based proteomics.

Expanding the human proteome with microproteins and peptideins.

MTALTCO1: a 259 amino-acid long mtDNA-encoded alternative protein that challenges conventional understandings of mitochondrial genomics.

An expanded reference catalog of translated open reading frames for biomedical research.

Community benchmarking and evaluation of human unannotated microprotein detection by mass spectrometry based proteomics.

Translon: a single term for translated regions.

Development, validation, and preliminary phenotypic characterization of a Col6a3 knockout mouse model targeting exon 3.

Discovery of diverse chimeric peptides in a eukaryotic proteome sets the stage for experimental validation of the mosaic translation hypothesis.

High-quality peptide evidence for annotating non-canonical open reading frames as human proteins.

Noncanonical altPIDD1 protein: unveiling the true major translational output of the PIDD1 gene.

Canada Research Chair - Tier 1

Challenging the dogmas of monocistronic genes and pseudogenes using proteogenomics and systems biology approaches to better define the human proteome in health and diseases

Ubiquitin-KEKS: Function of a Novel Ubiquitin Isoform Coded by UBBP4, a Gene Initially Annotated as a Pseudogene.

Canada Research Chair Tier 1

Function of alternative proteins in Neurodegenerative Diseases

Regulation of G protein-coupled receptors by their cognate alternative proteins

Relations moléculaires entre la maladie d’Alzheimer et les maladies à prions : une nouvelle voie dans la lutte contre les démences.

Frequent collaborators

Pierre Lavigne

Marie Brunet

Benoit Laurent

Aida Ouangraoua

Julie St-Pierre

Janice Robertson

Jean-Philippe Brosseau

Pierre Thibault

Jean-Bernard Denault

Xavier Roucou

Steve Jean

Ivan Topisirovic

Francois-Michel Boisvert

Nahum Sonenberg

Claude Perreault

Ghassan Bkaily

Michelle Scott