Faculty profile

Przemyslaw Sapieha

ResearcherOphthalmologyUniversité de Montréal

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a Université de Montréal directory, so their courses may be missing. Find their university profile.

Przemyslaw Sapieha

Researcher

Ophthalmology

Health Sciences

Université de Montréal

Montreal, Quebec, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
12 publications in the last five years, latest in 2026.
Senior (last) author on 8 recent papers, a sign of leading a research group.
Principal investigator on 15 research grants (13 CIHR, 2 NSERC), most recently in 2024.
Supervisor on 1 trainee award (1 CIHR), most recently in 2010.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

Publications

Collaborators

Grants

Publications by year

Counts cover the publications linked to this profile. Citations and the h-index appear when the source records them.

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Signals and details

Research

Angiogenesis Age Related Macular Degeneration Microglia Aging Infection Retina Neuroinlfammation Inflammation

Latest papers

Adipocytes influence choroidal neovascularization via PRDM16.
EMBO molecular medicine · 2026 · senior author
Designed to remember.
Science (New York, N.Y.) · 2026 · senior author
Metabolic reprogramming of the neovascular niche promotes regenerative angiogenesis in proliferative retinopathy.
Nature communications · 2025

All 61 publications

Latest funding

Past history of infection as a trigger of immune reprograming and neuroinflammation in late life
CIHR · 2024 · Nominated PI
$50,000
Past history of infection as a trigger of immune reprograming and neuroinflammation in late life
CIHR · 2024 · Nominated PI
$1,132,200
Past history of infection as a trigger of immune reprograming and neuroinflammation in late life.
CIHR · 2022 · Nominated PI
$100,000

All 22 grants and awards

61 publications.

Adipocytes influence choroidal neovascularization via PRDM16.

Diaz-Marin R, Hata M, Guber V, De Guire V, Wilson AM, Crespo-Garcia S, Sapieha P

EMBO molecular medicine2026Senior author

DOI: 10.1038/s44321-026-00441-5 PMID: 42156503

Designed to remember.

Blot G, Sapieha P

Science (New York, N.Y.)2026Senior author

DOI: 10.1126/science.aeg3891 PMID: 41886590

Metabolic reprogramming of the neovascular niche promotes regenerative angiogenesis in proliferative retinopathy.

Cagnone G, Pundir S, Betus C, Agnihotri T, Ren A, -Kim JS, Harvey NR, Heckel E, Chen MX, Situ A, Gaub P, Kim N, Das A, Leclerc S, Wünnemann F, Berillon L, Andelfinger G, Crespo-Garcia S, Dubrac A, Rezende FA, Clish CB, Maranda B, Rivera JC, Smith LEH, Sapieha P, Joyal JS

Nature communications2025

DOI: 10.1038/s41467-025-60061-4 PMID: 40562775

Hypoxia-inducible factors link poor glycemic controlto diabetic retinopathy.

Ichiyama Y, Sapieha P

Science translational medicine2025Senior author

DOI: 10.1126/scitranslmed.adu7718 PMID: 40305571

Corticosteroids reduce pathological angiogenesis yet compromise reparative vascular remodeling in a model of retinopathy.

Hata M, Hata M, Dejda A, Pilon F, Diaz-Marin R, Fournier F, Joyal JS, Cagnone G, Ochi Y, Crespo-Garcia S, Wilson AM, Sapieha P

Proceedings of the National Academy of Sciences of the United States of America2024Senior author

DOI: 10.1073/pnas.2411640121 PMID: 39693344

Multifocal Electroretinography Changes after UBX1325 (Foselutoclax) Treatment in Neovascular Age-Related Macular Degeneration.

Macha N, Yu M, Sapieha P, Klier S, Ghosh A, White L, Maturi RK

Journal of clinical medicine2024

DOI: 10.3390/jcm13185540 PMID: 39337030

Therapeutic targeting of cellular senescence in diabetic macular edema: preclinical and phase 1 trial results.

Crespo-Garcia S, Fournier F, Diaz-Marin R, Klier S, Ragusa D, Masaki L, Cagnone G, Blot G, Hafiane I, Dejda A, Rizk R, Juneau R, Buscarlet M, Chorfi S, Patel P, Beltran PJ, Joyal JS, Rezende FA, Hata M, Nguyen A, Sullivan L, Damiano J, Wilson AM, Mallette FA, David NE, Ghosh A, Tsuruda PR, Dananberg J, Sapieha P

Nature medicine2024Senior author

DOI: 10.1038/s41591-024-02802-4 PMID: 38321220

HIF1α-dependent hypoxia response in myeloid cells requires IRE1α.

Mawambo G, Oubaha M, Ichiyama Y, Blot G, Crespo-Garcia S, Dejda A, Binet F, Diaz-Marin R, Sawchyn C, Sergeev M, Juneau R, Kaufman RJ, Affar EB, Mallette FA, Wilson AM, Sapieha P

Journal of neuroinflammation2023Senior author

DOI: 10.1186/s12974-023-02793-y PMID: 37344842

Early-life peripheral infections reprogram retinal microglia and aggravate neovascular age-related macular degeneration in later life.

Hata M, Hata M, Andriessen EM, Juneau R, Pilon F, Crespo-Garcia S, Diaz-Marin R, Guber V, Binet F, Fournier F, Buscarlet M, Grou C, Calderon V, Heckel E, Melichar HJ, Joyal JS, Wilson AM, Sapieha P

The Journal of clinical investigation2023Senior author

DOI: 10.1172/jci159757 PMID: 36787231

Past history of obesity triggers persistent epigenetic changes in innate immunity and exacerbates neuroinflammation.

Hata M, Andriessen EMMA, Hata M, Diaz-Marin R, Fournier F, Crespo-Garcia S, Blot G, Juneau R, Pilon F, Dejda A, Guber V, Heckel E, Daneault C, Calderon V, Des Rosiers C, Melichar HJ, Langmann T, Joyal JS, Wilson AM, Sapieha P

Science (New York, N.Y.)2023Senior author

DOI: 10.1126/science.abj8894 PMID: 36603072

Past history of infection as a trigger of immune reprograming and neuroinflammation in late life

Nominated PICIHR2024PRIZE - Project Grant - PA: Mid Career Investigator Prize in Research in Aging

Principal investigators: Sapieha, Przemyslaw (Mike) S

Keywords: Age Related Macular Degeneration; Aging; Angiogenesis; Infection; Microglia; Neuroinlfammation

$50,000

Past history of infection as a trigger of immune reprograming and neuroinflammation in late life

Nominated PICIHR2024Project Grant

Principal investigators: Sapieha, Przemyslaw (Mike) S

Keywords: Age Related Macular Degeneration; Aging; Angiogenesis; Infection; Microglia; Neuroinlfammation

$1,132,200

Past history of infection as a trigger of immune reprograming and neuroinflammation in late life.

Nominated PICIHR2022Project Grant

Principal investigators: Sapieha, Przemyslaw (Mike) S

Keywords: Age Related Macular Degeneration; Angiogenesis; Infection; Inflammation; Microglia; Retina

$100,000

Impact of early life systemic metabolic deregulation on reprogramming of CNS microglia in retinal vascular disease

Nominated PICIHR2022Project Grant

Principal investigators: Sapieha, Przemyslaw (Mike) S

Keywords: Adipose Tissue; Age Related Macular Degeneration; Angiogenesis; Inflammation; Microglia; Obesity; Retina

$1,147,500

Cholesterol metabolism and regulation of the senescence-associated secretory phenotype in retinopathy

Co-investigatorCIHR2020Project Grant

Principal investigators: Mallette, Frédérick A

Keywords: Angiogenesis; Cellular Senescence; Cholesterol; Inflammation; Metabolism; Mrna Translation; Oxysterol; Retinopathy

$868,276

Canada Research Chairs - Tier 1

Nominated PICIHR2020Canada Research Chairs - CIHR Funded - Tier 1

Principal investigators: Sapieha, Przemyslaw (Mike) S

Keywords: Crc

$1,400,000

Cholesterol metabolism and regulation of the senescence-associated secretory phenotype in retinopathy

Co-investigatorCIHR2019Project Grant - Priority Announcement: Aging

Principal investigators: Mallette, Frédérick A

Keywords: Angiogenesis; Cellular Senescence; Cholesterol; Inflammation; Metabolism; Mrna Translation; Oxysterol; Retinopathy

$100,000

Cellular Reprogramming in Retinal Vascular Development

Principal investigatorNSERC2019Discovery Grants Program - Individual

Principal investigators: Sapieha, Przemyslaw

$42,000

Selective laser-mediated gene therapy for ocular diseases

Co-investigatorNSERC2018Collaborative Health Research Projects

Principal investigators: Meunier, Michel

$374,183

Selective laser-mediated gene therapy for ocular diseases

Principal investigatorCIHR2017Collaborative Health Research Projects (NSERC partnered)

Principal investigators: Meunier, Michel; Côté, Christian-Yves; Brunette, Isabelle; Costantino, Santiago; Sapieha, Przemyslaw (Mike) S

Keywords: 1101 Human Health; 1102 Biomedical Engineering; 1901 Biomedical Technology; 2006 Biomaterials; Age-Related Macular Degeneration; Corneal Endothelial Dystrophies; Femtosecond Laser; Gene Therapy; Gold Nanoparticles; Laser Transfection

$369,433

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

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Przemyslaw Sapieha

Research

Latest papers

Latest funding

Adipocytes influence choroidal neovascularization via PRDM16.

Designed to remember.

Metabolic reprogramming of the neovascular niche promotes regenerative angiogenesis in proliferative retinopathy.

Hypoxia-inducible factors link poor glycemic controlto diabetic retinopathy.

Corticosteroids reduce pathological angiogenesis yet compromise reparative vascular remodeling in a model of retinopathy.

Multifocal Electroretinography Changes after UBX1325 (Foselutoclax) Treatment in Neovascular Age-Related Macular Degeneration.

Therapeutic targeting of cellular senescence in diabetic macular edema: preclinical and phase 1 trial results.

HIF1&#x3b1;-dependent hypoxia response in myeloid cells requires IRE1&#x3b1;.

Early-life peripheral infections reprogram retinal microglia and aggravate neovascular age-related macular degeneration in later life.

Past history of obesity triggers persistent epigenetic changes in innate immunity and exacerbates neuroinflammation.

Cellular Reprogramming in Retinal Vascular Development

Selective laser-mediated gene therapy for ocular diseases

Frequent collaborators

Sylvain Chemtob

Pierre Hardy

Jean-Sébastien Joyal

Pierre Lachapelle

Malika Oubaha

Sophie Tremblay

Nathalie Labrecque

Gregor Andelfinger

Santiago Costantino

Michel Meunier

Jean-Philippe Gratton

Alexandre Dubrac

William Lubell

Adriana Di Polo

Alfredo Ribeiro-Da-Silva

Christine Des Rosiers

Jean-Jacques Lebrun

Vincent Pernet

Gilles Hickson

Catherine Martel

Christos Boutopoulos

Thierry Alquier

Derek Bowie

Morley Hollenberg

Eric Milot

Christian Beausejour

Emile Levy

Nikolaus Heveker

Mathieu Laplante

Steve Bourgault

Guillaume Lettre

HIF1α-dependent hypoxia response in myeloid cells requires IRE1α.