Claude Spino, Université de Sherbrooke

Research

Allylic azides and sulfoxides Chiral auxiliary Molecular switch Natural products Polyketides Quassinoids Ring-closing metathesis Synthetic methods

Latest papers

N-Oxides as Control Element for the Direction of a Sigmatropic Rearrangement: Application as a Switch for Fluorescence.
Chemistry (Weinheim an der Bergstrasse, Germany) · 2023 · first author
A Fluorogenic Disaccharide Substrate for α-Mannosidases Enables High-Throughput Screening and Identification of an Inhibitor of the GH92 Virulence Factor from Streptococcus pneumoniae.
ACS chemical biology · 2023
Constraining the Side Chain of C-Terminal Amino Acids in Apelin-13 Greatly Increases Affinity, Modulates Signaling, and Improves the Pharmacokinetic Profile.
Journal of medicinal chemistry · 2021

All 27 publications

Latest funding

Applying our synthesis skills : natural products and molecular machinery
NSERC · 2019 · Principal investigator
$174,000
New Synthetic Methodologies to Access N-Heterocycles
NSERC · 2014 · Principal investigator
$270,000
The (4+1)-cycloaddition of electron-rich carbenes / la cycloaddition-(4+1) de carbènes riches en électrons
NSERC · 2009 · Principal investigator
$375,000

All 21 grants and awards

27 publications.

01

N-Oxides as Control Element for the Direction of a Sigmatropic Rearrangement: Application as a Switch for Fluorescence.

Spino C, Latil M, Lessard R, Fevre-Renault Q, Legault CY

Chemistry (Weinheim an der Bergstrasse, Germany)2023First author

DOI: 10.1002/chem.202301356 PMID: 37402174

02

A Fluorogenic Disaccharide Substrate for α-Mannosidases Enables High-Throughput Screening and Identification of an Inhibitor of the GH92 Virulence Factor from Streptococcus pneumoniae.

Bhosale S, Deen MC, Proceviat C, Hettle A, Winter DK, Brockerman J, Levene M, Bennet AJ, Spino C, Boraston AB, Vocadlo DJ

ACS chemical biology2023

DOI: 10.1021/acschembio.3c00053 PMID: 37531094

03

Constraining the Side Chain of C-Terminal Amino Acids in Apelin-13 Greatly Increases Affinity, Modulates Signaling, and Improves the Pharmacokinetic Profile.

Trân K, Van Den Hauwe R, Sainsily X, Couvineau P, Côté J, Simard L, Echevarria M, Murza A, Serre A, Théroux L, Saibi S, Haroune L, Longpré JM, Lesur O, Auger-Messier M, Spino C, Bouvier M, Sarret P, Ballet S, Marsault É

Journal of medicinal chemistry2021

DOI: 10.1021/acs.jmedchem.0c01941 PMID: 33524256

04

O-Heterocycles from Unsaturated Carbonyls and Dimethoxycarbene.

Croisetière JP, Spino C

The Journal of organic chemistry2018Senior author

DOI: 10.1021/acs.joc.8b00613 PMID: 29682963

05

A Photorearrangement To Construct the ABDE Tetracyclic Core of Palau'amine.

Aubert-Nicol S, Lessard J, Spino C

Organic letters2018Senior author

DOI: 10.1021/acs.orglett.8b00819 PMID: 29667828

06

Dialkoxycarbenes in (4 + 1) Cycloadditions: Application to the Synthesis of Carotol.

Gund M, Déry M, Amzallag V, Spino C

Organic letters2016Senior author

DOI: 10.1021/acs.orglett.6b02023 PMID: 27540758

07

N-Heterocycles from chromium aminocarbenes.

Déry M, Assouvie K, Heinrich N, Rajotte I, Lefebvre LP, Legault MA, Spino C

Organic letters2015Senior author

DOI: 10.1021/acs.orglett.5b00313 PMID: 25702700

08

Converting cycloalkanones into N-heterocycles: formal synthesis of (-)-gephyrotoxin 287C.

Pichette S, Winter DK, Lessard J, Spino C

The Journal of organic chemistry2013Senior author

DOI: 10.1021/jo402217e PMID: 24188015

09

N-Heteropolycyclic compounds from the formal intramolecular (4 + 1)-cycloaddition of chromium aminocarbenes.

Déry M, Lefebvre LP, Aissa K, Spino C

Organic letters2013Senior author

DOI: 10.1021/ol4025887 PMID: 24117372

10

Photochemical and thermal ring-contraction of cyclic hydroxamic acid derivatives.

Pichette S, Aubert-Nicol S, Lessard J, Spino C

The Journal of organic chemistry2012Senior author

DOI: 10.1021/jo3023507 PMID: 23198744