Faculty profile

Olivier Lesur

ResearcherMédecineUniversité de Sherbrooke

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a Université de Sherbrooke directory, so their courses may be missing. Find their university profile.

Olivier Lesur

Researcher

Médecine

Health Sciences

Université de Sherbrooke

Sherbrooke, Quebec, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
7 publications in the last five years, latest in 2025.
Senior (last) author on 2 recent papers, a sign of leading a research group.
Principal investigator on 3 research grants (2 CIHR, 1 NSERC), most recently in 2018.
Supervised 1 trainee who won CIHR awards, most recently in 2018.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

Publications

251

Citations

h-index

Collaborators

Grants

Publications by year

Counts cover the works listed on the university profile; citation counts come from Dimensions.

Profiles and links

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Signals and details

Research

Animal Models Apelin Receptor Apelins Cardiovascular Dysfunction Drug Discovery Elabela G Protein-Coupled Receptors Septic Shock

Latest papers

A Metabolically Stable Apelin-13 Analog Acting as a Potent ITo Potassium Current Blocker with Potential Benefits for Brugada Syndrome.
International journal of molecular sciences · 2025
Process-Specific Blood Biomarkers and Outcomes in COVID-19 Versus Non-COVID-19 ARDS (APEL-COVID Study): A Prospective, Observational Cohort Study.
Journal of clinical medicine · 2024 · first author
Apelin-13 administration allows for norepinephrine sparing in a rat model of cecal ligation and puncture-induced septic shock.
Intensive care medicine experimental · 2024 · senior author

All 56 publications

Latest funding

Évaluation de l'efficacité des probiotiques sur les affections post-COVID-19.
CIHR · 2021 · Co-investigator
$997,273
Do bias signaling of the apelinergic receptor can improve the treatment of acute cardiovascular dysfunction and injury related to septic shock?
CIHR · 2018 · Supervisor
$90,000
Exploiting ELABELA and analogues to Protect from Septic Shock
CIHR · 2018 · Nominated PI
$707,626

All 7 grants and awards

56 publications.

A Metabolically Stable Apelin-13 Analog Acting as a Potent ITo Potassium Current Blocker with Potential Benefits for Brugada Syndrome.

Contreras Vite JA, Tiffinger A, Théroux L, Morin N, Auger-Messier M, Boudreault PL, Sarret P, Lesur O, Dumaine R

International journal of molecular sciences2025

DOI: 10.3390/ijms26062735 PMID: 40141374

Process-Specific Blood Biomarkers and Outcomes in COVID-19 Versus Non-COVID-19 ARDS (APEL-COVID Study): A Prospective, Observational Cohort Study.

Lesur O, Segal ED, Rego K, Mercat A, Asfar P, Chagnon F

Journal of clinical medicine2024First author

DOI: 10.3390/jcm13195919 PMID: 39407979

Apelin-13 administration allows for norepinephrine sparing in a rat model of cecal ligation and puncture-induced septic shock.

Salvail W, Salvail D, Chagnon F, Lesur O

Intensive care medicine experimental2024Senior author

DOI: 10.1186/s40635-024-00650-7 PMID: 39103658

Hemodynamic impacts of apelin-13 in a neonatal lamb model of septic peritonitis.

Simard É, Morin C, Coquerel D, Chagnon F, Nadeau C, Samson N, Praud JP, Lesur O, Fortin-Pellerin É

Pediatric research2023

DOI: 10.1038/s41390-022-02407-y PMID: 36460738

Ventriculo-arterial (un)coupling in septic shock: Impact of current and upcoming hemodynamic drugs.

Demailly Z, Besnier E, Tamion F, Lesur O

Frontiers in cardiovascular medicine2023Senior author

DOI: 10.3389/fcvm.2023.1172703 PMID: 37324631

Relationship Between the Degree of Carotid Stenosis and the Risk of Stroke in Patients Undergoing Cardiac Surgery.

Ruka E, Lesur O, Gingras M, Buruian M, Voisine E, Marzouk M, Dagenais F, Voisine P

The Canadian journal of cardiology2022

DOI: 10.1016/j.cjca.2021.11.007 PMID: 34808321

Size-Reduced Macrocyclic Analogues of [Pyr1]-apelin-13 Showing Negative Gα12 Bias Still Produce Prolonged Cardiac Effects.

Tran K, Sainsily X, Côté J, Coquerel D, Couvineau P, Saibi S, Haroune L, Besserer-Offroy É, Flynn-Robitaille J, Resua Rojas M, Murza A, Longpré JM, Auger-Messier M, Lesur O, Bouvier M, Marsault É, Boudreault PL, Sarret P

Journal of medicinal chemistry2022

DOI: 10.1021/acs.jmedchem.1c01708 PMID: 34982553

Apelin-13 in septic shock: effective in supporting hemodynamics in sheep but compromised by enzymatic breakdown in patients.

Coquerel D, Lamoureux J, Chagnon F, Trân K, Sage M, Fortin-Pellerin E, Delile E, Sainsily X, Fournier J, Dumont AA, Auger-Messier M, Sarret P, Marsault E, Praud JP, Fülöp T, Lesur O

Scientific reports2021Senior author

DOI: 10.1038/s41598-021-02087-4 PMID: 34815457

Elabela Protects Spontaneously Hypertensive Rats From Hypertension and Cardiorenal Dysfunctions Exacerbated by Dietary High-Salt Intake.

Sainsily X, Coquerel D, Giguère H, Dumont L, Tran K, Noll C, Ionescu AL, Côté J, Longpré JM, Carpentier A, Marsault É, Lesur O, Sarret P, Auger-Messier M

Frontiers in pharmacology2021

DOI: 10.3389/fphar.2021.709467 PMID: 34385922

Constraining the Side Chain of C-Terminal Amino Acids in Apelin-13 Greatly Increases Affinity, Modulates Signaling, and Improves the Pharmacokinetic Profile.

Trân K, Van Den Hauwe R, Sainsily X, Couvineau P, Côté J, Simard L, Echevarria M, Murza A, Serre A, Théroux L, Saibi S, Haroune L, Longpré JM, Lesur O, Auger-Messier M, Spino C, Bouvier M, Sarret P, Ballet S, Marsault É

Journal of medicinal chemistry2021

DOI: 10.1021/acs.jmedchem.0c01941 PMID: 33524256

Évaluation de l'efficacité des probiotiques sur les affections post-COVID-19.

Co-investigatorCIHR2021Op Grant: Emerging COVID-19 Research Gaps & Priorities - Post COVID-19 condition

Principal investigators: Pasquier, Jean Charles; Beaulieu, Jean-François; Chaillet, Nils; Laforest-Lapointe, Isabelle; Piche, Alain; Robitaille, Julie

Keywords: Affections Post-Covid; Application Des Connaissances; Essai Randomisé Contrôlé; Microbiote; Nutrition; Probiotiques; Sars-Cov-2; Virus

$997,273

Do bias signaling of the apelinergic receptor can improve the treatment of acute cardiovascular dysfunction and injury related to septic shock?

SupervisorCIHR2018CIHR Fellowship

Principal investigators: Coquerel, David

Keywords: Acute Heart Failure; Apelin Receptor; Bias Signaling; Cardiomyocytes; Sepsis

$90,000

Exploiting ELABELA and analogues to Protect from Septic Shock

Nominated PICIHR2018Project Grant

Principal investigators: Lesur, Olivier J; Marsault, Eric

Keywords: Animal Models; Apelin Receptor; Apelins; Biased Signalling; Cardiovascular Dysfunction; Drug Discovery; Elabela; G Protein-Coupled Receptors; Renal Dysfunction; Septic Shock

$707,626

Exploiting ELABELA and Analogues to Protect from Septic Shock

Nominated PICIHR2017Project Grant

Principal investigators: Lesur, Olivier J; Marsault, Eric

Keywords: Animal Models; Apelin Receptor; Apelins; Biased Signaling; Cardiovascular Dysfunction; Drug Discovery; Elabela; G Protein-Coupled Receptors; Kidney Dysfunction; Septic Shock

$100,000

Optimizing technical approaches of endoscopic confocal fluorescence microscopic (ECFM) combined with smart probing for small animal studies of the lung

Principal investigatorNSERC2016Discovery Grants Program - Individual

Principal investigators: Lesur, Olivier

$132,000

The Apelin Receptor as a Target for Heart Failure

Co-investigatorCIHR2016Project Grant

Principal investigators: Marsault, Eric; Auger-Messier, Mannix

Keywords: Animal Models; Apelin; Apj Receptor; Biased Signaling; Drug Discovery; G Protein-Coupled Receptor; Heart Failure; Macrocycles; Molecular Dynamics; Peptidomimetic

$665,550

How do catastrophic events by modulating the immune response lead to frailty?

Co-investigatorCIHR2009Other: Canada-UK Aging Initiative

Principal investigators: Fulop, Tamàs

Keywords: Frailty; Hip Fracture; Immune Response; Immune Risk Profile; Neuroendocrineimmune System; Nutrition

$224,760

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

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Olivier Lesur

Research

Latest papers

Latest funding

A Metabolically Stable Apelin-13 Analog Acting as a Potent ITo Potassium Current Blocker with Potential Benefits for Brugada Syndrome.

Process-Specific Blood Biomarkers and Outcomes in COVID-19 Versus Non-COVID-19 ARDS (APEL-COVID Study): A Prospective, Observational Cohort Study.

Apelin-13 administration allows for norepinephrine sparing in a rat model of cecal ligation and puncture-induced septic shock.

Hemodynamic impacts of apelin-13 in a neonatal lamb model of septic peritonitis.

Ventriculo-arterial (un)coupling in septic shock: Impact of current and upcoming hemodynamic drugs.

Relationship Between the Degree of Carotid Stenosis and the Risk of Stroke in Patients Undergoing Cardiac Surgery.

Size-Reduced Macrocyclic Analogues of [Pyr1]-apelin-13 Showing Negative G&#x3b1;12 Bias Still Produce Prolonged Cardiac Effects.

Apelin-13 in septic shock: effective in supporting hemodynamics in sheep but compromised by enzymatic breakdown in patients.

Elabela Protects Spontaneously Hypertensive Rats From Hypertension and Cardiorenal Dysfunctions Exacerbated by Dietary High-Salt Intake.

Constraining the Side Chain of C-Terminal Amino Acids in Apelin-13 Greatly Increases Affinity, Modulates Signaling, and Improves the Pharmacokinetic Profile.

Évaluation de l'efficacité des probiotiques sur les affections post-COVID-19.

Do bias signaling of the apelinergic receptor can improve the treatment of acute cardiovascular dysfunction and injury related to septic shock?

Exploiting ELABELA and analogues to Protect from Septic Shock

Exploiting ELABELA and Analogues to Protect from Septic Shock

Optimizing technical approaches of endoscopic confocal fluorescence microscopic (ECFM) combined with smart probing for small animal studies of the lung

The Apelin Receptor as a Target for Heart Failure

How do catastrophic events by modulating the immune response lead to frailty?

Frequent collaborators

Philippe Sarret

Mannix Auger-Messier

Eric Marsault

Jean-Paul Praud

Richard Leduc

Norma Ybarra

Martin Lepage

Tamàs Fulop

Jan Seuntjens

Pierre-Luc Boudreault

Deborah Cook

Étienne Fortin-Pellerin

John Muscedere

Ted Warkentin

Gordon Guyatt

Ryan Zarychanski

Robert Fowler

Francois Lamontagne

Pierre Voisine

Mark Crowther

Donald Arnold

Issam El Naqa

Michel Bouvier

Lisa Burry

Size-Reduced Macrocyclic Analogues of [Pyr1]-apelin-13 Showing Negative Gα12 Bias Still Produce Prolonged Cardiac Effects.