Faculty profile

Philippe Sarret

ResearcherObstétrique et gynécologieUniversité de Sherbrooke

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a Université de Sherbrooke directory, so their courses may be missing. Find their university profile.

Philippe Sarret

Researcher

Obstétrique et gynécologie

Health Sciences

Université de Sherbrooke

Sherbrooke, Quebec, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
27 publications in the last five years, latest in 2026.
Senior (last) author on 11 recent papers, a sign of leading a research group.
Principal investigator on 18 research grants (12 CIHR, 6 NSERC), most recently in 2026.
Supervised 13 trainees who won CIHR awards, most recently in 2025.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

120

Publications

Citations

h-index

Collaborators

Grants

Publications by year

Counts cover the works listed on the university profile; citation counts come from Dimensions.

Profiles and links

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Signals and details

Research

Neuropeptides Pain Blood-Brain Barrier Brain Drug Delivery Neurotensin Récepteurs Couplés Aux Protéines G Biobank Brain

Latest papers

Docking of virtual libraries identifies small-molecule agonists of neurotensin receptors with analgesic activity.
Nature communications · 2026
Improved brain penetration of neurotensin(8-13) via blood-brain barrier shuttle conjugation underlies strong analgesia.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2026 · senior author
Structure-Guided Design of Proteomimetics Targeting the SARS-CoV-2 S-RBD/hACE2 Interface.
Journal of medicinal chemistry · 2026

All 120 publications

Latest funding

Cannabis Exposure from Pregnancy to Early Childhood: A Family-Triad Brain Health Program CAN-B+FAM
CIHR · 2026 · Principal investigator
$2,399,873
Crossing the blood-brain barrier for delivery of analgesic peptides
CIHR · 2025 · Nominated PI
$1,067,176
Brain-Penetrating Apelin Receptor Radioligands for Glioblastoma Therapy
CIHR · 2025 · Nominated PI
$1,032,750

All 42 grants and awards

120 publications.

Docking of virtual libraries identifies small-molecule agonists of neurotensin receptors with analgesic activity.

Panel N, Vo DD, Hübner H, Deluigi M, Pach S, Bélair F, Weikert D, Klenk C, Hilge M, Shiva N, Brochu I, Longpré JM, Bällgren F, Saleh A, Hu H, Kapla J, Kampen S, Cabeza de Vaca I, Kihlberg J, Wettschureck N, Sarret P, Plückthun A, Gmeiner P, Carlsson J

Nature communications2026

DOI: 10.1038/s41467-026-74990-1 PMID: 42486867

Improved brain penetration of neurotensin(8-13) via blood-brain barrier shuttle conjugation underlies strong analgesia.

Lagard C, Côté J, Meneboo N, Barreto S, Desgagné M, Beaulieu S, Larocque A, Besserer-Offroy É, Belleville K, Kirby K, Longpré JM, Demeule M, Sarret P

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie2026Senior author

DOI: 10.1016/j.biopha.2026.119551 PMID: 42176569

Structure-Guided Design of Proteomimetics Targeting the SARS-CoV-2 S-RBD/hACE2 Interface.

Ferková S, Fayolle A, Boisvert O, Froehlich U, Nepveu-Traversy MÉ, Lavigne P, Grandbois M, Sarret P, Boudreault PL

Journal of medicinal chemistry2026

DOI: 10.1021/acs.jmedchem.5c03450 PMID: 42289940

Dual-target opioid/neurotensin ligands drive potent and safer analgesia in vivo.

Breault É, Neve J, Ranjbaran A, Tremblay A, Robberechts I, Lussier F, Bélair F, Tremblay V, Holleran BJ, Brochu I, Bisi N, Côté J, Longpré JM, Gendron L, Ballet S, Sarret P

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie2026Senior author

DOI: 10.1016/j.biopha.2026.119488 PMID: 42116252

A neurotensin receptor type 1-derived pepducin acts as a biased allosteric modulator to regulate target receptor function.

Brouillette RL, Lussier F, Breault É, Meneboo N, Hassanzadeh M, Tremblay V, Chartier M, Midavaine É, Ulrich L, Côté J, Blais V, Mona CE, Longpré JM, Grandbois M, Boudreault PL, Audet M, Besserer-Offroy É, Sarret P

Acta pharmaceutica Sinica. B2026Senior author

DOI: 10.1016/j.apsb.2025.12.043 PMID: 42039273

Structure-based design of macrocyclic peptides to generate functional antibodies against G protein-coupled receptors.

Nepveu-Traversy ME, Hassanzadeh M, Bruneau-Cossette L, Besserer-Offroy É, Brouillette R, Morissette S, Traboulsi H, Kirby K, Murza A, Longpré JM, Breton B, Gendron FP, Gaudreau S, Boudreault PL, Sarret P

Nature communications2025Senior author

DOI: 10.1038/s41467-025-66030-1 PMID: 41387675

Spotlight on Endocannabinoids in Healthy Individuals Using Volumetric Absorptive Microsampling Combined with LC-MS/MS Analysis.

Haroune L, Saibi S, Bellenger JP, Vincenot M, Léonard G, Gendron L, Sarret P

ACS omega2025Senior author

DOI: 10.1021/acsomega.5c05574 PMID: 41280873

Structure-activity relationships of contulakin-G: Design, synthesis, and characterization of Thr10 analogs for pain modulation.

Lanoie A, Ferková S, Caron-Duval É, Dallagnol JCC, Diarra S, Murza A, Tremblay A, Théroux L, Breault É, Ranjbaran A, Landry L, Côté J, Longpré JM, Boudreault PL, Chatenet D, Sarret P

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie2025Senior author

DOI: 10.1016/j.biopha.2025.118664 PMID: 41130099

Optimizing the pharmacokinetics and selectivity of TMPRSS2 inhibitors.

Ferková S, Lepage M, Désilets A, Assouvie K, Lemieux G, Brochu I, Froehlich U, Gravel-Trudeau A, Vastra J, Jean F, Sarret P, Leduc R, Boudreault PL

European journal of medicinal chemistry2025

DOI: 10.1016/j.ejmech.2025.117579 PMID: 40382841

Opioid Analgesics: Rise and Fall of Ligand Biased Signaling and Future Perspectives in the Quest for the Holy Grail.

Breault É, Brouillette RL, Hébert TE, Sarret P, Besserer-Offroy É

CNS drugs2025

DOI: 10.1007/s40263-025-01172-w PMID: 40169527

Cannabis Exposure from Pregnancy to Early Childhood: A Family-Triad Brain Health Program CAN-B+FAM

Principal investigatorCIHR2026TG: The CDN Cannabis/Brain Health Cons.-Scaling Novel Measurement Methods

Principal investigators: Ouellet, Annie; Auray-Blais, Christiane; Boucoiran, Isabelle; Brodeur, Magaly; Brunet, Marie A; Carpentier, André C; Jacques, Pierre-Étienne; Lane, Julie; Lariviere, Sara; Lemelin, Jean-Pascal; Lodygensky, Gregory A; Nazif-Munoz, Jose I; Pascuzzo, Katherine; Sarret, Philippe; Therriault, Danyka; Whittingstall, Kevin S

Keywords: Biobank; Brain; Cannabis; Family; Genomics; Neurobehavior; Neurodevelopment; Neuroimaging; Pregnancy; Psychosocial Functionning

$2,399,873

Crossing the blood-brain barrier for delivery of analgesic peptides

Nominated PICIHR2025Project Grant

Principal investigators: Sarret, Philippe

Keywords: Blood-Brain Barrier; Brain Drug Delivery; Macrocycles; Neuropeptides; Neurotensin; Pain

$1,067,176

Brain-Penetrating Apelin Receptor Radioligands for Glioblastoma Therapy

Nominated PICIHR2025Project Grant

Principal investigators: Sarret, Philippe

Keywords: Apelin Ligands; Apelin Recptor; Blood-Brain Barrier; Glioblastoma; Pet Imaging; Radiotherapy

$1,032,750

Étude mécanistique de l'hypothermie induite par la neurotensine.

SupervisorCIHR2025DRA : Canada Graduate Research Scholarship - Doctoral Program (CGRS D)

Principal investigators: Lussier, Frédérique

Keywords: Atteintes Ischémiques; Hypothermie Thérapeutique; Neurotensine; Pharmacologie; Rats Sprague Dawley; Récepteurs Couplés Aux Protéines G; Souris Transgéniques; Stéréotaxie; Thermorégulation; Télémétrie

$120,000

Développement de sondes théranostiques ciblant le récepteur APJ de l'apéline pour lutter contre les cancers localement agressifs

SupervisorCIHR2024Doctoral Research Award: Canada Graduate Scholarships

Principal investigators: Breault, Émile

Keywords: Cancer; Imagerie Tep; Médecine Nucléaire; Peptides; Récepteur Apj De L'Apéline; Sondes Théranostiques

$120,000

Evaluation of Apelinergic Analogs for the Treatment of Peripheral Artery Disease and Chronic Wound Healing in Diabetes

SupervisorCIHR2024Doctoral Research Award: Canada Graduate Scholarships

Principal investigators: Lachance, Marie-Sophie

Keywords: Diabetes; Diabetic Ulcer; Macrophages; Neuropathy; Peripherical Artery Disease

$120,000

Développement et caractérisation de nouveaux outils théranostiques dans le cancer de l’ovaire

SupervisorCIHR2023Canada Graduate Scholarships - Michael Smith Foreign Study Supplements

Principal investigators: Breault, Émile

Keywords: Cancers Localement Agressifs; Cible Thérapeutique; Le Récepteur De L’Apéline (Apj); Les Tumeurs; Métastatique

$6,000

Targeting the endocannabinoid system to correct GABA abnormalities in patients with Fragile-X syndrome

Co-investigatorCIHR2020Project Grant

Principal investigators: Lepage, Jean-Francois; Corbin, François

Keywords: Autism Spectrum Disorder; Cannabidiol; Fragile-X Syndrome; Gaba; Magnetic Resonance Spectroscopy; Transcranial Magnetic Stimulation

$531,675

Development of a Cell-Based High-Throughput Functional Screening Assay To Study Host-Virus (COVID-19) Interaction _x000d_ _x000d_

Principal investigatorNSERC2020Alliance Grants

Principal investigators: SARRET, Philippe

$50,000

Canada Research Chair - Tier 1

Nominated PICIHR2019Canada Research Chairs - CIHR Funded - Tier 1

Principal investigators: Sarret, Philippe

Keywords: Crc

$1,400,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

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Philippe Sarret

Research

Latest papers

Latest funding

Docking of virtual libraries identifies small-molecule agonists of neurotensin receptors with analgesic activity.

Improved brain penetration of neurotensin(8-13) via blood-brain barrier shuttle conjugation underlies strong analgesia.

Structure-Guided Design of Proteomimetics Targeting the SARS-CoV-2 S-RBD/hACE2 Interface.

Dual-target opioid/neurotensin ligands drive potent and safer analgesia in vivo.

A neurotensin receptor type 1-derived pepducin acts as a biased allosteric modulator to regulate target receptor function.

Structure-based design of macrocyclic peptides to generate functional antibodies against G protein-coupled receptors.

Spotlight on Endocannabinoids in Healthy Individuals Using Volumetric Absorptive Microsampling Combined with LC-MS/MS Analysis.

Structure-activity relationships of contulakin-G: Design, synthesis, and characterization of Thr10 analogs for pain modulation.

Optimizing the pharmacokinetics and selectivity of TMPRSS2 inhibitors.

Opioid Analgesics: Rise and Fall of Ligand Biased Signaling and Future Perspectives in the Quest for the Holy Grail.

Development of a Cell-Based High-Throughput Functional Screening Assay To Study Host-Virus (COVID-19) Interaction _x000d_ _x000d_

Frequent collaborators

Olivier Lesur

Mannix Auger-Messier

Pierre-Luc Boudreault

Louis Gendron

Richard Leduc

Martin Lepage

Eric Marsault

Rebecca Brouillette

Kevin Whittingstall

Fernand-Pierre Gendron

Dimitri Ryczko

Benoît Paquette

Pierre Lavigne

Alain Vanasse

Reza Sharif-Naeini

Johanne Martel-Pelletier

Pedro Geraldes

Jean-Paul Praud

Turgay Akay

Jean-Bernard Denault