Faculty profile

François Boudreau

ResearcherImmunologie-Biologie CellulaireUniversité de Sherbrooke

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a Université de Sherbrooke directory, so their courses may be missing. Find their university profile.

François Boudreau

Researcher

Immunologie-Biologie Cellulaire

Health Sciences

Université de Sherbrooke

Sherbrooke, Quebec, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
3 publications in the last five years, latest in 2026.
Senior (last) author on 3 recent papers, a sign of leading a research group.
Principal investigator on 9 research grants (5 CIHR, 4 NSERC), most recently in 2022.
Supervised 1 trainee who won CIHR awards, most recently in 2009.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

Publications

Citations

h-index

Collaborators

Grants

Publications by year

Counts cover the works listed on the university profile; citation counts come from Dimensions.

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Signals and details

Research

Conditional Knockouts Intestinal Bowel Diseases Intestinal Epithelium Proteomics Transcription Factor Inflammatory Bowel Diseases Cell Culture Gene Expression Assays

Latest papers

HNF4A intestinal ablation positively influences the fate of ileal goblet cells during Salmonella typhimurium infection.
American journal of physiology. Gastrointestinal and liver physiology · 2026 · senior author
Hepatocyte nuclear factor 4α multiple isoforms, their functions, and their interactomes.
Proteomics · 2023 · senior author
HNF4α Acts as Upstream Functional Regulator of Intestinal Wnt3 and Paneth Cell Fate.
Cellular and molecular gastroenterology and hepatology · 2023 · senior author

All 12 publications

Latest funding

Immunopathogenic mechanisms of IL-15 in intestinal inflammation
CIHR · 2024 · Co-investigator
$1,055,700
Targeting mesenchymal cells communication pathways on epithelial cells behaviour in gut-related diseases
CIHR · 2024 · Co-investigator
$1,143,675
Investigating a Novel HNF4A-Gasdermin D Epithelial Regulatory Node in Gut Inflammation
CIHR · 2022 · Nominated PI
$1,109,250

All 16 grants and awards

12 publications.

HNF4A intestinal ablation positively influences the fate of ileal goblet cells during Salmonella typhimurium infection.

Gómez DP, Nicolás VR, Marrero GC, De Castro AC, Jones C, Leon Chirino LM, Perreault N, Menendez A, Boudreau F

American journal of physiology. Gastrointestinal and liver physiology2026Senior author

DOI: 10.1152/ajpgi.00224.2025 PMID: 41452599

Hepatocyte nuclear factor 4α multiple isoforms, their functions, and their interactomes.

Herrera-Pulido JA, Boisvert FM, Boudreau F

Proteomics2023Senior author

DOI: 10.1002/pmic.202200372 PMID: 37232233

HNF4α Acts as Upstream Functional Regulator of Intestinal Wnt3 and Paneth Cell Fate.

Jones C, Avino M, Giroux V, Boudreau F

Cellular and molecular gastroenterology and hepatology2023Senior author

DOI: 10.1016/j.jcmgh.2022.11.010 PMID: 36464209

Organoids and Their Use in Modeling Gut Epithelial Cell Lineage Differentiation and Barrier Properties During Intestinal Diseases.

Gómez DP, Boudreau F

Frontiers in cell and developmental biology2021Senior author

DOI: 10.3389/fcell.2021.732137 PMID: 34485312

JAK-STAT Pathway Inhibition Partially Restores Intestinal Homeostasis in Hdac1- and Hdac2-Intestinal Epithelial Cell-Deficient Mice.

Gonneaud A, Turgeon N, Boisvert FM, Boudreau F, Asselin C

Cells2021

DOI: 10.3390/cells10020224 PMID: 33498747

A Novel Organoid Model of Damage and Repair Identifies HNF4α as a Critical Regulator of Intestinal Epithelial Regeneration.

Montenegro-Miranda PS, van der Meer JHM, Jones C, Meisner S, Vermeulen JLM, Koster J, Wildenberg ME, Heijmans J, Boudreau F, Ribeiro A, van den Brink GR, Muncan V

Cellular and molecular gastroenterology and hepatology2020

DOI: 10.1016/j.jcmgh.2020.02.007 PMID: 32145468

Loss of PTEN Signaling in Foxl1+ Mesenchymal Telocytes Initiates Spontaneous Colonic Neoplasia in Mice.

Langlois MJ, Servant R, Reyes Nicolás V, Jones C, Roy SAB, Paquet M, Carrier JC, Rivard N, Boudreau F, Perreault N

Cellular and molecular gastroenterology and hepatology2019

DOI: 10.1016/j.jcmgh.2019.05.007 PMID: 31146066

The G protein-coupled P2Y₆ receptor promotes colorectal cancer tumorigenesis by inhibiting apoptosis.

Placet M, Arguin G, Molle CM, Babeu JP, Jones C, Carrier JC, Robaye B, Geha S, Boudreau F, Gendron FP

Biochimica et biophysica acta. Molecular basis of disease2018

DOI: 10.1016/j.bbadis.2018.02.008 PMID: 29454075

Gata4 is critical to maintain gut barrier function and mucosal integrity following epithelial injury.

Lepage D, Bélanger É, Jones C, Tremblay S, Allaire JM, Bruneau J, Asselin C, Perreault N, Menendez A, Gendron FP, Boudreau F

Scientific reports2016Senior author

DOI: 10.1038/srep36776 PMID: 27827449

Bmp signaling in colonic mesenchyme regulates stromal microenvironment and protects from polyposis initiation.

Allaire JM, Roy SA, Ouellet C, Lemieux É, Jones C, Paquet M, Boudreau F, Perreault N

International journal of cancer2016

DOI: 10.1002/ijc.30001 PMID: 26773796

Immunopathogenic mechanisms of IL-15 in intestinal inflammation

Co-investigatorCIHR2024Project Grant

Principal investigators: Menendez, Alfredo; Ramanathan, Sheela

Keywords: Epithelial Cells; Interleukin-15 (Il-15); Intestinal Inflammation; Intestinal Organoids; Myeloid Cells

$1,055,700

Targeting mesenchymal cells communication pathways on epithelial cells behaviour in gut-related diseases

Co-investigatorCIHR2024Project Grant

Principal investigators: Perreault, Nathalie

Keywords: Epithelial Mesenchymal Communication; Extracellular Vesicles; Gastrointestinal Ecm Biodynamics; Gastrointestinal Microenvironment; Gut Organoids; Gut-Related Diseases (Ibd, Cac); Matrix Stiffness; Mechanotransduction; Mimetic Matrices; Subepithelial Mesenchymal Cells

$1,143,675

Investigating a Novel HNF4A-Gasdermin D Epithelial Regulatory Node in Gut Inflammation

Nominated PICIHR2022Project Grant

Principal investigators: Boudreau, François

Keywords: Conditional Knockouts; Experimental Colitis; Gut Organoids; Inflammasomes; Intestinal Bowel Diseases; Intestinal Epithelium; Proteomics; Transcription Factor

$1,109,250

In vivo roles of autophagy in gut homeostasis and impact on IBD

Co-investigatorCIHR2020Project Grant

Principal investigators: Jean, Steve

Keywords: Atg16; Autophagy; Drosophila; Genetics; Inflammatory Bowel Diseases; Proteomics

$895,050

Chronic Inflammation, Immunity and Cancer 2019

Nominated PICIHR2019Planning and Dissemination Grant - Institute Community Support

Principal investigators: Boudreau, François

Keywords: Biological Models; Digestive Cancer; Immunotherapy; Inflammatory Bowel Diseases; Mechanisms Of Inflammation; Microbiome

$15,000

Biomolecular and biomechanical impact of Foxl1+ mesenchymal telocytes on epithelial cell behaviour in gut-related diseases.

Co-investigatorCIHR2019Project Grant

Principal investigators: Perreault, Nathalie

Keywords: Gastrointestinal Ecm Biodynamics; Gastrointestinal Foxl1+ Telocytes; Gastrointestinal Mesenchymal Stem Cell Niche; Gastrointestinal Microenvironment; Gastrointestinal Mucosa; Genetically Modified Mice Models; Gut Organoids; Gut-Related Diseases; Matrix Stiffness; Mechanotransduction

$1,105,426

Defining the molecular mechanisms driving intestinal epithelial cell specification

Principal investigatorNSERC2017Discovery Grants Program - Individual

Principal investigators: Boudreau, François

$450,000

The Nuclear Receptor HNF4A as a Regulator of WNT Ligands: Biological Impact of this Novel Interaction in Gut Diseases

Nominated PICIHR2017Project Grant

Principal investigators: Boudreau, François

Keywords: Colorectal Cancer; Conditional Knockouts; Intestinal Bowel Diseases; Intestinal Epithelium; Intestinal Mesenchyme; Intestinal Organoids; Intestinal Stem Cells; Proteomics; Transcription Factor; Transcriptomics

$1,082,475

Defining the molecular mechanisms driving intestinal epithelial cell specification

Principal investigatorNSERC2016Discovery Grants Program - Individual

Principal investigators: Boudreau, François

$31,000

High-throughput protein immunolocalization analysis through virtual fluorescence imaging.

Co-investigatorNSERC2015Research Tools and Instruments - Category 1 (<$150,000)

Principal investigators: Gendron, FernandPierre

$147,500

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

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François Boudreau

Research

Latest papers

Latest funding

HNF4A intestinal ablation positively influences the fate of ileal goblet cells during Salmonella typhimurium infection.

Hepatocyte nuclear factor 4α multiple isoforms, their functions, and their interactomes.

HNF4α Acts as Upstream Functional Regulator of Intestinal Wnt3 and Paneth Cell Fate.

Organoids and Their Use in Modeling Gut Epithelial Cell Lineage Differentiation and Barrier Properties During Intestinal Diseases.

JAK-STAT Pathway Inhibition Partially Restores Intestinal Homeostasis in Hdac1- and Hdac2-Intestinal Epithelial Cell-Deficient Mice.

A Novel Organoid Model of Damage and Repair Identifies HNF4α as a Critical Regulator of Intestinal Epithelial Regeneration.

Loss of PTEN Signaling in Foxl1+ Mesenchymal Telocytes Initiates Spontaneous Colonic Neoplasia in Mice.

The G protein-coupled P2Y₆ receptor promotes colorectal cancer tumorigenesis by inhibiting apoptosis.

Gata4 is critical to maintain gut barrier function and mucosal integrity following epithelial injury.

Bmp signaling in colonic mesenchyme regulates stromal microenvironment and protects from polyposis initiation.

Immunopathogenic mechanisms of IL-15 in intestinal inflammation

Targeting mesenchymal cells communication pathways on epithelial cells behaviour in gut-related diseases

Investigating a Novel HNF4A-Gasdermin D Epithelial Regulatory Node in Gut Inflammation

In vivo roles of autophagy in gut homeostasis and impact on IBD

Chronic Inflammation, Immunity and Cancer 2019

Biomolecular and biomechanical impact of Foxl1+ mesenchymal telocytes on epithelial cell behaviour in gut-related diseases.

Defining the molecular mechanisms driving intestinal epithelial cell specification

The Nuclear Receptor HNF4A as a Regulator of WNT Ligands: Biological Impact of this Novel Interaction in Gut Diseases

Defining the molecular mechanisms driving intestinal epithelial cell specification

High-throughput protein immunolocalization analysis through virtual fluorescence imaging.

Frequent collaborators

Nathalie Perreault

Nathalie Rivard

Alfredo Menendez

Francois-Michel Boisvert

Fernand-Pierre Gendron

François Boudreau

Research

Latest papers

Latest funding

HNF4A intestinal ablation positively influences the fate of ileal goblet cells during Salmonella typhimurium infection.

Hepatocyte nuclear factor 4&#x3b1; multiple isoforms, their functions, and their interactomes.

HNF4&#x3b1; Acts as Upstream Functional Regulator of Intestinal Wnt3 and Paneth Cell Fate.

Organoids and Their Use in Modeling Gut Epithelial Cell Lineage Differentiation and Barrier Properties During Intestinal Diseases.

JAK-STAT Pathway Inhibition Partially Restores Intestinal Homeostasis in Hdac1- and Hdac2-Intestinal Epithelial Cell-Deficient Mice.

A Novel Organoid Model of Damage and Repair Identifies HNF4&#x3b1; as a Critical Regulator of Intestinal Epithelial Regeneration.

Loss of PTEN Signaling&#xa0;in&#xa0;Foxl1+ Mesenchymal Telocytes Initiates Spontaneous Colonic Neoplasia in Mice.

The G protein-coupled P2Y&#x2086; receptor promotes colorectal cancer tumorigenesis by inhibiting apoptosis.

Gata4 is critical to maintain gut barrier function and mucosal integrity following epithelial injury.

Bmp signaling in colonic mesenchyme regulates stromal microenvironment and protects from polyposis initiation.

Immunopathogenic mechanisms of IL-15 in intestinal inflammation

Targeting mesenchymal cells communication pathways on epithelial cells behaviour in gut-related diseases

Investigating a Novel HNF4A-Gasdermin D Epithelial Regulatory Node in Gut Inflammation

In vivo roles of autophagy in gut homeostasis and impact on IBD

Chronic Inflammation, Immunity and Cancer 2019

Biomolecular and biomechanical impact of Foxl1+ mesenchymal telocytes on epithelial cell behaviour in gut-related diseases.

Defining the molecular mechanisms driving intestinal epithelial cell specification

The Nuclear Receptor HNF4A as a Regulator of WNT Ligands: Biological Impact of this Novel Interaction in Gut Diseases

Defining the molecular mechanisms driving intestinal epithelial cell specification

High-throughput protein immunolocalization analysis through virtual fluorescence imaging.

Frequent collaborators

Nathalie Perreault

Nathalie Rivard

Alfredo Menendez

Francois-Michel Boisvert

Fernand-Pierre Gendron

Hepatocyte nuclear factor 4α multiple isoforms, their functions, and their interactomes.

HNF4α Acts as Upstream Functional Regulator of Intestinal Wnt3 and Paneth Cell Fate.

A Novel Organoid Model of Damage and Repair Identifies HNF4α as a Critical Regulator of Intestinal Epithelial Regeneration.

Loss of PTEN Signaling in Foxl1+ Mesenchymal Telocytes Initiates Spontaneous Colonic Neoplasia in Mice.

The G protein-coupled P2Y₆ receptor promotes colorectal cancer tumorigenesis by inhibiting apoptosis.