Karl Fernandes, Université de Sherbrooke

Research

Alzheimer'S Disease Hypothalamus Aging Endothelial Cells Fmri Human Preclinical Mouse Models Rnaseq

Latest papers

Electrocorticographic, astrocytic and transcriptomic signatures in the triple transgenic mouse model of Alzheimer's disease submitted to stearoyl-CoA desaturase inhibition.
Neuropharmacology · 2026
Cerebrospinal fluid CEFA composition is enriched in saturated fatty acids and it is altered in Alzheimer's disease.
Journal of lipid research · 2026

All 2 publications

Latest funding

The hypothalamus in aging and Alzheimer's disease
CIHR · 2026 · Nominated PI
$1,315,800
Novel treatment of Alzheimer's disease by early targeting and visualizing soluble amyloid beta oligomers using cyclic azapeptides
CIHR · 2025 · Co-investigator
$1,086,300
Decoding and challenging choroid plexus inflammation in the aging brain
CIHR · 2024 · Co-investigator
$1,071,000

All 9 grants and awards

2 publications.

01

Electrocorticographic, astrocytic and transcriptomic signatures in the triple transgenic mouse model of Alzheimer's disease submitted to stearoyl-CoA desaturase inhibition.

Hector A, Leduc T, da Costa Caiado MJ, Delignat-Lavaud B, Dufort-Gervais J, Daneault C, Des Rosiers C, Bourguignon C, Lina JM, Fernandes K, Brouillette J, Mongrain V

Neuropharmacology2026

DOI: 10.1016/j.neuropharm.2026.110835 PMID: 41539386

02

Cerebrospinal fluid CEFA composition is enriched in saturated fatty acids and it is altered in Alzheimer's disease.

Pavanello C, Ossoli A, Comi C, Turri M, Tremolizzo L, Conti E, D'Incecco P, Barbiroli A, Parini P, Mitro N, Caruso D, Sierri G, Re F, Chinello C, Fumagalli C, Magni F, Fernandes K, Calabresi L

Journal of lipid research2026

DOI: 10.1016/j.jlr.2026.101034 PMID: 41936849

The hypothalamus in aging and Alzheimer's disease

Nominated PICIHR2026Project Grant

Principal investigators: Fernandes, Karl J

Keywords: Aging; Alzheimer'S Disease; Endothelial Cells; Fmri; Human; Hypothalamus; Preclinical Mouse Models; Rnaseq; Single Cell; Tanycytes

$1,315,800

Novel treatment of Alzheimer's disease by early targeting and visualizing soluble amyloid beta oligomers using cyclic azapeptides

Co-investigatorCIHR2025Project Grant

Principal investigators: Guérin, Brigitte; Lubell, William D; Rahimipour, Shai

Keywords: 64cu-Radiolabeled Conjugates; Abeta-Oligomers; Alzheimer'S Disease (Ad); Anti-Aggregation Activity; Azacyclopeptides; Cognitive Behavioral Studies; Early Diagnosis; Non-Fibrillar Aggregates; Pet-Ct-Mr Imaging; Treatment

$1,086,300

Decoding and challenging choroid plexus inflammation in the aging brain

Co-investigatorCIHR2024Project Grant

Principal investigators: Laurent, Benoit

Keywords: Aging; Brain; Choroid Plexus; Inflammation

$1,071,000

The choroid plexus is the effector of omega-3 fatty acids to support the brain during aging.

Co-investigatorCIHR2024Project Grant

Principal investigators: Plourde, Mélanie

Keywords: Adeno-Associated Virus; Aging; Choroid Plexus; Inflammatory Mediators; Lipid Transporters; Lipidomics; Neurogenesis; Omega-3 Fatty Acids

$1,235,475

Effet de la psychose et des antipsychotiques sur le métabolisme énergétique cérébral et mitochondrial

Co-investigatorSSHRC2024New Frontiers in Research Fund - Exploration

Principal investigators: Cunnane, Stephen

$121,537

Mechanisms of experience-dependent hippocampal neurogenesis

Principal investigatorNSERC2022Discovery Grants Program - Individual

Principal investigators: Fernandes, Karl

$102,000

Canada Research Chair - Tier 1

Nominated PICIHR2021Canada Research Chairs - CIHR Funded - Tier 1

Principal investigators: Fernandes, Karl J

Keywords: Crc

$1,400,000

Imaging the contribution of early cerebrovascular inflammation in Alzheimer's disease

Co-investigatorCIHR2021Project Grant

Principal investigators: Lepage, Martin

Keywords: Alzheimer'S Disease; Cerebrovascular Inflammation; Imaging Biomarker; Magnetic Resonance Imaging; Positron Emission Tomography

$1,002,150

Exploiting brain-body crosstalk to correct brain lipid metabolism in Alzheimer's disease

Nominated PICIHR2021Project Grant

Principal investigators: Fernandes, Karl J

Keywords: Alzheimer'S Disease; Diet; Hypothalamus; Immune Cells; Inflammation; Ketones; Lipids; Medium Chain Triglycerides; Metabolism; Microglia

$952,425

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Médecine
Physiology and Pharmacology
Other

Co-authors at Université de Sherbrooke, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

Christine Des Rosiers

Faculty

1 shared papers, latest 2026

Jonathan Brouillette

Physiology and Pharmacology

1 shared papers, latest 2026

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mentionMention their CIHR grant from 2026

Subject: Prospective PhD student: Alzheimer'S Disease Dear Professor Fernandes, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Electrocorticographic, astrocytic and transcriptomic signatures in the triple transgenic mouse model of Alzheimer's disease submitted to stearoyl-CoA desaturase inhibition." (2026), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your CIHR-funded project "The hypothalamus in aging and Alzheimer's disease" (2026), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]