Martin Audet, Université de Sherbrooke

Research

Biased Signalling G Protein-Coupled Receptors (Gpcr)Heterotrimeric G Proteins Molecular Modelling Preterm Birth Prostaglandin F2 Alpha Receptor Signalling Effectors Structural Biology

Latest papers

A neurotensin receptor type 1-derived pepducin acts as a biased allosteric modulator to regulate target receptor function.
Acta pharmaceutica Sinica. B · 2026
Optimization of the prostaglandin F2α receptor for structural biology.
PloS one · 2025 · senior author
A systematic analysis of prostaglandin E2 type 3 receptor isoform signaling reveals isoform- and species-dependent L798106 Gαz-biased agonist responses.
European journal of pharmacology · 2022 · senior author

All 4 publications

Latest funding

23rd Joint meeting of the Great Lakes GPCR Retreat and the Club des récepteurs à sept domaines transmembranaires du Québec
CIHR · 2024 · Co-investigator
$15,000
Cross-disciplinary Acuity Training Program in Intelligent and Responsible Drug Discovery
NSERC · 2023 · Co-investigator
$463,000
Imaging protein crystals for identification of submicron nucleation and growth optimization
NSERC · 2022 · Principal investigator
$122,917

All 7 grants and awards

4 publications.

01

A neurotensin receptor type 1-derived pepducin acts as a biased allosteric modulator to regulate target receptor function.

Brouillette RL, Lussier F, Breault É, Meneboo N, Hassanzadeh M, Tremblay V, Chartier M, Midavaine É, Ulrich L, Côté J, Blais V, Mona CE, Longpré JM, Grandbois M, Boudreault PL, Audet M, Besserer-Offroy É, Sarret P

Acta pharmaceutica Sinica. B2026

DOI: 10.1016/j.apsb.2025.12.043 PMID: 42039273

02

Optimization of the prostaglandin F2α receptor for structural biology.

Salze M, Chrétien S, Boora TS, Macovei M, Barbeau E, Blais V, Laporte SA, Audet M

PloS one2025Senior author

DOI: 10.1371/journal.pone.0320114 PMID: 40680049

03

A systematic analysis of prostaglandin E2 type 3 receptor isoform signaling reveals isoform- and species-dependent L798106 Gαz-biased agonist responses.

Normand C, Breton B, Salze M, Barbeau E, Mancini A, Audet M

European journal of pharmacology2022Senior author

DOI: 10.1016/j.ejphar.2022.175043 PMID: 35598847

04

Small-scale approach for precrystallization screening in GPCR X-ray crystallography.

Audet M, Villers K, Velasquez J, Chu M, Hanson C, Stevens RC

Nature protocols2020First author

DOI: 10.1038/s41596-019-0259-y PMID: 31784719

23rd Joint meeting of the Great Lakes GPCR Retreat and the Club des récepteurs à sept domaines transmembranaires du Québec

Co-investigatorCIHR2024Planning and Dissemination Grant - Institute Community Support

Principal investigators: Lavoie, Christine

Keywords: Animal Model; Drug Design; G Protein-Coupled Receptors; Heterotrimeric G-Protein; Pharmacology; Protein Trafficking; Signaling; Structure Biology; Therapeutic

$15,000

Cross-disciplinary Acuity Training Program in Intelligent and Responsible Drug Discovery

Co-investigatorNSERC2023Collaborative Research and Training Experience

Principal investigators: SARRET, Philippe P

Keywords: advanced device technologies; artificial intelligence; biological targets; biosensors; computing science; drug discovery; imaging; medicinal chemistry

$463,000

Imaging protein crystals for identification of submicron nucleation and growth optimization

Principal investigatorNSERC2022Research Tools and Instruments

Principal investigators: Audet, Martin

$122,917

Dissecting the molecular mechanism for prostaglandin F2 alpha receptor biased signaling

Nominated PICIHR2021Project Grant

Principal investigators: Audet, Martin

Keywords: Biased Signalling; G Protein-Coupled Receptors (Gpcr); Heterotrimeric G Proteins; Molecular Modelling; Preterm Birth; Prostaglandin F2 Alpha Receptor; Signalling Effectors; Structural Biology; Virtual Ligand Screening; X-Ray Crystallography

$650,250

A multiscale structural understanding of organic anion transporting polypeptide transporters (OATPs) functions

Principal investigatorNSERC2021Discovery Launch Supplement

Principal investigators: Audet, Martin

$12,500

A multiscale structural understanding of organic anion transporting polypeptide transporters (OATPs) functions

Principal investigatorNSERC2021Discovery Grants Program - Individual

Principal investigators: Audet, Martin

$120,000

Functional and structural understanding of angiotensin II type 1 receptor biased signaling.

Co-investigatorCIHR2020Project Grant

Principal investigators: Laporte, Stéphane A; Leduc, Richard

Keywords: Angiotensin Ii Type 1 Receptor; Cardiac Diseases; Cell Signaling; Functional Selectivity; G Protein-Coupled Receptor (Gpcr); Peptide Chemistry; Protein Structure

$1,189,576

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Physiology and Pharmacology
Obstétrique et gynécologie
Pharmacologie - Physiologie

Co-authors at Université de Sherbrooke, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

Pierre-Luc Boudreault

Pharmacologie - Physiologie

1 shared papers, latest 2026

Philippe Sarret

Obstétrique et gynécologie

1 shared papers, latest 2026

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mentionMention their NSERC grant from 2022

Subject: Prospective PhD student: Biased Signalling Dear Professor Audet, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "A neurotensin receptor type 1-derived pepducin acts as a biased allosteric modulator to regulate target receptor function." (2026), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your NSERC-funded project "Imaging protein crystals for identification of submicron nucleation and growth optimization" (2022), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]

Martin Audet

Research

Latest papers

Latest funding

A neurotensin receptor type 1-derived pepducin acts as a biased allosteric modulator to regulate target receptor function.

Optimization of the prostaglandin F2&#x3b1; receptor for structural biology.

A systematic analysis of prostaglandin E2 type 3 receptor isoform signaling reveals isoform- and species-dependent L798106 G&#x3b1;z-biased agonist responses.

Small-scale approach for precrystallization screening in GPCR X-ray crystallography.

23rd Joint meeting of the Great Lakes GPCR Retreat and the Club des récepteurs à sept domaines transmembranaires du Québec

Cross-disciplinary Acuity Training Program in Intelligent and Responsible Drug Discovery

Imaging protein crystals for identification of submicron nucleation and growth optimization

Dissecting the molecular mechanism for prostaglandin F2 alpha receptor biased signaling

A multiscale structural understanding of organic anion transporting polypeptide transporters (OATPs) functions

A multiscale structural understanding of organic anion transporting polypeptide transporters (OATPs) functions

Functional and structural understanding of angiotensin II type 1 receptor biased signaling.

Frequent collaborators

Pierre-Luc Boudreault

Philippe Sarret

Optimization of the prostaglandin F2α receptor for structural biology.

A systematic analysis of prostaglandin E2 type 3 receptor isoform signaling reveals isoform- and species-dependent L798106 Gαz-biased agonist responses.