Faculty profile

Pierre-Luc Boudreault

ResearcherPharmacologie - PhysiologieUniversité de Sherbrooke

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a Université de Sherbrooke directory, so their courses may be missing. Find their university profile.

Pierre-Luc Boudreault

Researcher

Pharmacologie - Physiologie

Health Sciences

Université de Sherbrooke

Sherbrooke, Quebec, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
50 publications in the last five years, latest in 2026.
Senior (last) author on 15 recent papers, a sign of leading a research group.
Principal investigator on 4 research grants (3 NSERC, 1 CIHR), most recently in 2024.
Supervised 1 trainee who won CIHR awards, most recently in 2025.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

Publications

Citations

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Collaborators

Grants

Publications by year

Counts cover the works listed on the university profile; citation counts come from Dimensions.

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Signals and details

Research

Antibiotic Drug Development Antimicrobial Resistance (Amr)Atp Synthase Bacterial Infections Braod-Spectrum Antibiotic Computer-Assisted Drug Design Gram-Negative And Gram-Positive Bacteria Medicinal Chemistry

Latest papers

TMPRSS2 inhibitors with broad-spectrum efficacy against SARS-CoV-2 (JN.1) and influenza A (H1N1) viruses protect mice from influenza A infection.
Emerging microbes & infections · 2026
Development of Radioligand Therapy-Responsive Syngeneic Prostate Models through Murine Prostate-Specific Membrane Antigen Point Mutation.
ACS pharmacology & translational science · 2026
Structure-Guided Design of Proteomimetics Targeting the SARS-CoV-2 S-RBD/hACE2 Interface.
Journal of medicinal chemistry · 2026 · senior author

All 61 publications

Latest funding

Biomechanical Optimization of 3D Muscle Stem Cell Culture in Elastic Substrates
NSERC · 2025 · Co-investigator
$150,000
Rôle et modulation de protéases de l'hôte impliquées dans les infections par les virus respiratoires.
CIHR · 2025 · Supervisor
$120,000
Validation of Artificial Intelligence and Machine Learning Approaches for the Design, Optimization, and Synthesis of Molecular Tools Targeting Transmembrane Serine Proteases Type 2
NSERC · 2024 · Principal investigator
$135,000

All 9 grants and awards

61 publications.

TMPRSS2 inhibitors with broad-spectrum efficacy against SARS-CoV-2 (JN.1) and influenza A (H1N1) viruses protect mice from influenza A infection.

Presley L, Pérez-Vargas J, Saintigny A, Villanueva I, Ho M, Fone J, Brinsden L, Kaushik N, Olver S, Thompson CAH, Bautista-Sánchez D, Ennis S, Chen M, McCallum M, Brown JT, Ferková S, Hetrick B, Veesler D, Leduc R, Niikura M, Boudreault PL, Warner B, Jean F

Emerging microbes & infections2026

DOI: 10.1080/22221751.2026.2616944 PMID: 41612887

Development of Radioligand Therapy-Responsive Syngeneic Prostate Models through Murine Prostate-Specific Membrane Antigen Point Mutation.

Richard M, Louis B, Taddio MF, Jeanjean P, Diaz Garcia-Prada C, Swaidan A, Carlucci G, Boudreault PL, Besserer-Offroy E, Mona CE

ACS pharmacology & translational science2026

DOI: 10.1021/acsptsci.5c00704 PMID: 42453352

Structure-Guided Design of Proteomimetics Targeting the SARS-CoV-2 S-RBD/hACE2 Interface.

Ferková S, Fayolle A, Boisvert O, Froehlich U, Nepveu-Traversy MÉ, Lavigne P, Grandbois M, Sarret P, Boudreault PL

Journal of medicinal chemistry2026Senior author

DOI: 10.1021/acs.jmedchem.5c03450 PMID: 42289940

Profiling crystal engineered ligands for targeting treatment resistant androgen receptors.

Colah A, Ezekiel C, Ferková S, Boudreault PL, MacGillivray L, Ricke W

bioRxiv : the preprint server for biology2026

DOI: 10.64898/2026.05.01.721995 PMID: 42146362

Biosensor-guided discovery of peptide inhibitors targeting the ribosomal protein uS5-PDCD2 chaperone interaction.

Mir Hassani Z, Goulet F, Nguyen DT, Landry-Voyer AM, Kwiatek L, Gaudet S, Boudreault PL, Azad T, Bachand F

The Journal of biological chemistry2026

DOI: 10.1016/j.jbc.2026.111415 PMID: 41933732

A neurotensin receptor type 1-derived pepducin acts as a biased allosteric modulator to regulate target receptor function.

Brouillette RL, Lussier F, Breault É, Meneboo N, Hassanzadeh M, Tremblay V, Chartier M, Midavaine É, Ulrich L, Côté J, Blais V, Mona CE, Longpré JM, Grandbois M, Boudreault PL, Audet M, Besserer-Offroy É, Sarret P

Acta pharmaceutica Sinica. B2026

DOI: 10.1016/j.apsb.2025.12.043 PMID: 42039273

Androgen Receptor Point Mutations: A Mechanism of Therapeutic Resistance and a Framework for Rational Drug Design.

Colah A, Ferková S, Zhang H, Liu G, MacGillivray L, Boudreault PL, Ricke W

Cancers2026

DOI: 10.3390/cancers18061043 PMID: 41899643

Tunable Biased Signaling of the Angiotensin II Type 1 Receptor for Inotropy via C-Terminal Peptide Engineering and Allosteric Site Targeting.

Hadjadj M, Hassanzadeh M, Martel J, Roy MF, Giguère H, Murza A, Holleran BJ, Namkung Y, Froehlich U, Leduc R, Auger-Messier M, Laporte SA, Boudreault PL

Journal of medicinal chemistry2026Senior author

DOI: 10.1021/acs.jmedchem.5c01259 PMID: 41545027

In vitro and in vivo activity profiles of broad-spectrum bacterial ATP synthase inhibitors.

Chamberland S, Larose A, Millette G, Langlois JP, Côté-Gravel J, Brouillette E, Almeida DD, Binette R, Delbrouck JA, Diachenko I, Jamaa AB, Normandin C, Murza A, Malouin F, Boudreault PL

Bioorganic & medicinal chemistry2026Senior author

DOI: 10.1016/j.bmc.2025.118493 PMID: 41330226

Identification of skeletal muscle stem cell adhesion motifs using spot-synthesis-based peptide arrays.

Leblanc E, Schüler SC, Liu Y, Théroux L, Le Moal E, Bonin MA, Boudreault PL, Bentzinger CF

iScience2026

DOI: 10.1016/j.isci.2025.114498 PMID: 41550718

Biomechanical Optimization of 3D Muscle Stem Cell Culture in Elastic Substrates

Co-investigatorNSERC2025Research Tools and Instruments

Principal investigators: Bentzinger, Florian

Keywords: hydrogels; 3d stem cell culture; skeletal muscle tissue; decellularization; extracellular matrix; mechanical testing; elasticity; shear stress; torsion; multiple-well tests

$150,000

Rôle et modulation de protéases de l'hôte impliquées dans les infections par les virus respiratoires.

SupervisorCIHR2025DRA : Canada Graduate Research Scholarship - Doctoral Program (CGRS D)

Principal investigators: Lemieux, Gabriel

Keywords: Antiviraux Dirigés Contre L'Hôte; Antiviraux À Large Spectre D'Action; Influenza; Influenza Aviaire; Métapneumovirus Humain; Pharmacocinétique; Protéases À Sérine Transmembranaire De Type Ii; Sras-Cov-2; Validation De Cibles Thérapeutiques; Virus Respiratoires

$120,000

Validation of Artificial Intelligence and Machine Learning Approaches for the Design, Optimization, and Synthesis of Molecular Tools Targeting Transmembrane Serine Proteases Type 2

Principal investigatorNSERC2024FRQ - NOVA

Principal investigators: Boudreault, Pierre-Luc

Keywords: Advancement of knowledge; Life sciences (including biotechnology)

$135,000

Targeting Apelin Signaling for the Treatment of Muscular Dystrophy

Co-investigatorCIHR2023Project Grant

Principal investigators: Bentzinger, Florian

Keywords: Apelin; Cellular Interactions; Drug Development; Endothelial Cells; Microvasculature; Muscular Dystrophy; Satellite Cells; Skeletal Muscle; Skeletal Muscle Stem Cells; Stem Cell Niche

$841,500

Mimicking the secondary structures of proteins and peptides to modulate Protein-Protein Interactions

Principal investigatorNSERC2022Discovery Grants Program - Individual

Principal investigators: Boudreault, Pierre-Luc

$75,000

ATP Synthase as an emerging target for the pre-clinical development of broad-spectrum antibacterial agents against drug-resistant bacterial infections

Nominated PICIHR2022Project Grant - PA: Antimicrobial Resistance (Bridge Grant)

Principal investigators: Boudreault, Pierre-Luc; Malouin, François

Keywords: Antibiotic Drug Development; Antimicrobial Resistance (Amr); Atp Synthase; Bacterial Infections; Braod-Spectrum Antibiotic; Computer-Assisted Drug Design; Gram-Negative And Gram-Positive Bacteria; Medicinal Chemistry; Pharmacology

$100,000

Role of the apelinergic system in peripheral arterial disease in diabetes

Co-investigatorCIHR2022Project Grant

Principal investigators: Geraldes, Pedro M

Keywords: Apelin; Apj; Diabetes; Elabela; Endothelial Cell; Peripheral Arterial Disease; Smooth Muscle Cells

$979,200

Mimicking the secondary structures of proteins and peptides to modulate Protein-Protein Interactions

Principal investigatorNSERC2022Discovery Launch Supplement

Principal investigators: Boudreault, Pierre-Luc

$12,500

Journey to the Center of the Cell: Reprogramming intracellular transport to the nucleus enhances HER2+ tumor killing for trastuzumab conjugated to payloads active in the nucleus

Co-investigatorCIHR2021Project Grant

Principal investigators: Leyton, Jeffrey V

Keywords: Antibody-Based Therapeutics; Nls-Based Targeted Therapeutics; Nuclear Localization Signals (Nls)

$581,400

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

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Paper to mentionMention their NSERC grant from 2024

Subject: Prospective PhD student: Antibiotic Drug Development Dear Professor Boudreault, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "TMPRSS2 inhibitors with broad-spectrum efficacy against SARS-CoV-2 (JN.1) and influenza A (H1N1) viruses protect mice from influenza A infection." (2026), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your NSERC-funded project "Validation of Artificial Intelligence and Machine Learning Approaches for the Design, Optimization, and Synthesis of Molecular Tools Targeting Transmembrane Serine Proteases Type 2" (2024), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]

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Pierre-Luc Boudreault

Research

Latest papers

Latest funding

TMPRSS2 inhibitors with broad-spectrum efficacy against SARS-CoV-2 (JN.1) and influenza A (H1N1) viruses protect mice from influenza A infection.

Development of Radioligand Therapy-Responsive Syngeneic Prostate Models through Murine Prostate-Specific Membrane Antigen Point Mutation.

Structure-Guided Design of Proteomimetics Targeting the SARS-CoV-2 S-RBD/hACE2 Interface.

Profiling crystal engineered ligands for targeting treatment resistant androgen receptors.

Biosensor-guided discovery of peptide inhibitors targeting the ribosomal protein uS5-PDCD2 chaperone interaction.

A neurotensin receptor type 1-derived pepducin acts as a biased allosteric modulator to regulate target receptor function.

Androgen Receptor Point Mutations: A Mechanism of Therapeutic Resistance and a Framework for Rational Drug Design.

Tunable Biased Signaling of the Angiotensin II Type 1 Receptor for Inotropy via C-Terminal Peptide Engineering and Allosteric Site Targeting.

In vitro and in vivo activity profiles of broad-spectrum bacterial ATP synthase inhibitors.

Identification of skeletal muscle stem cell adhesion motifs using spot-synthesis-based peptide arrays.

Biomechanical Optimization of 3D Muscle Stem Cell Culture in Elastic Substrates

Rôle et modulation de protéases de l'hôte impliquées dans les infections par les virus respiratoires.

Validation of Artificial Intelligence and Machine Learning Approaches for the Design, Optimization, and Synthesis of Molecular Tools Targeting Transmembrane Serine Proteases Type 2

Targeting Apelin Signaling for the Treatment of Muscular Dystrophy

Mimicking the secondary structures of proteins and peptides to modulate Protein-Protein Interactions

ATP Synthase as an emerging target for the pre-clinical development of broad-spectrum antibacterial agents against drug-resistant bacterial infections

Role of the apelinergic system in peripheral arterial disease in diabetes

Mimicking the secondary structures of proteins and peptides to modulate Protein-Protein Interactions

Journey to the Center of the Cell: Reprogramming intracellular transport to the nucleus enhances HER2+ tumor killing for trastuzumab conjugated to payloads active in the nucleus

Frequent collaborators

Richard Leduc

Philippe Sarret

Eric Marsault

Masahiro Niikura

Mannix Auger-Messier

Mel Krajden

Artem Cherkasov

Christine Lavoie

Pierre Lavigne

Taha Azad

Olivier Lesur

Bryce Warner

Theodore Steiner

Rebecca Brouillette

Jean-Bernard Denault

Martin Audet

Pierre-Luc Boudreault

Richard Leduc

David Chatenet

Pedro Geraldes

Fernand-Pierre Gendron

Benoit Chabot