Sherif Abou Elela, Université de Sherbrooke

Research

Basic Mechanisms Of Cancer Biology Non-Coding Rna Ribosomal Rna Modification Ribosome Biogenesis Snorna Translation Crc Gene Expression

Latest papers

SnoBIRD: a tool to identify C/D box snoRNAs and refine their annotation across all eukaryotes.
Nucleic acids research · 2025
Cells resist starvation through a nutrient stress splice switch.
Nucleic acids research · 2025 · senior author
Transcription factors induce differential splicing of duplicated ribosomal protein genes during meiosis.
Nucleic acids research · 2025 · senior author

All 40 publications

Latest funding

RNA Canada ARN 2024 Meeting
CIHR · 2024 · Co-investigator
$15,000
Bioengineering viruses to create safer and more effective oncolytic viruses
CIHR · 2023 · Co-investigator
$986,850
24th RiboClub Annual Meeting
CIHR · 2023 · Co-investigator
$10,000

All 31 grants and awards

40 publications.

01

SnoBIRD: a tool to identify C/D box snoRNAs and refine their annotation across all eukaryotes.

Fafard-Couture É, Boulanger C, Faucher-Giguère L, Sinagoga V, Berthoumieux M, Hedjam J, Marcel V, Durand S, Bayfield MA, Bachand F, Abou Elela S, Jacques PÉ, Scott MS

Nucleic acids research2025

DOI: 10.1093/nar/gkaf708 PMID: 40737086

02

Cells resist starvation through a nutrient stress splice switch.

Parenteau J, Tsang J, Downs SR, Zhou D, Scott MS, Pleiss JA, Abou Elela S

Nucleic acids research2025Senior author

DOI: 10.1093/nar/gkaf525 PMID: 40550515

03

Transcription factors induce differential splicing of duplicated ribosomal protein genes during meiosis.

Petibon C, Catala M, Morales D, Panchapakesan SS, Unrau PJ, Abou Elela S

Nucleic acids research2025Senior author

DOI: 10.1093/nar/gkae1321 PMID: 39817510

04

Canada's contributions to RNA research: past, present, and future perspectives.

Lécuyer E, Sauvageau M, Kothe U, Unrau PJ, Damha MJ, Perreault J, Abou Elela S, Bayfield MA, Claycomb JM, Scott MS

Biochemistry and cell biology = Biochimie et biologie cellulaire2024

DOI: 10.1139/bcb-2024-0176 PMID: 39320985

05

Intronic small nucleolar RNAs regulate host gene splicing through base pairing with their adjacent intronic sequences.

Bergeron D, Faucher-Giguère L, Emmerichs AK, Choquet K, Song KS, Deschamps-Francoeur G, Fafard-Couture É, Rivera A, Couture S, Churchman LS, Heyd F, Abou Elela S, Scott MS

Genome biology2023

DOI: 10.1186/s13059-023-03002-y PMID: 37415181

06

snoDB 2.0: an enhanced interactive database, specializing in human snoRNAs.

Bergeron D, Paraqindes H, Fafard-Couture É, Deschamps-Francoeur G, Faucher-Giguère L, Bouchard-Bourelle P, Abou Elela S, Catez F, Marcel V, Scott MS

Nucleic acids research2023

DOI: 10.1093/nar/gkac835 PMID: 36165892

07

Reovirus μ2 Protein Impairs Translation to Reduce U5 snRNP Protein Levels.

Boudreault S, Martineau CA, Faucher-Giguère L, Abou-Elela S, Lemay G, Bisaillon M

International journal of molecular sciences2022

DOI: 10.3390/ijms24010727 PMID: 36614170

08

Altered tRNA processing is linked to a distinct and unusual La protein in Tetrahymena thermophila.

Kerkhofs K, Garg J, Fafard-Couture É, Abou Elela S, Scott MS, Pearlman RE, Bayfield MA

Nature communications2022

DOI: 10.1038/s41467-022-34796-3 PMID: 36443289

09

Duplicated ribosomal protein paralogs promote alternative translation and drug resistance.

Malik Ghulam M, Catala M, Reulet G, Scott MS, Abou Elela S

Nature communications2022Senior author

DOI: 10.1038/s41467-022-32717-y PMID: 35999447

10

SAPFIR: A webserver for the identification of alternative protein features.

Zhou D, Tran Y, Abou Elela S, Scott MS

BMC bioinformatics2022

DOI: 10.1186/s12859-022-04804-w PMID: 35751026

RNA Canada ARN 2024 Meeting

Co-investigatorCIHR2024Planning and Dissemination Grant - Institute Community Support

Principal investigators: Côté, Jocelyn

Keywords: Gene Expression; Ribonucleic Acids; Transcription; Translation

$15,000

Bioengineering viruses to create safer and more effective oncolytic viruses

Co-investigatorCIHR2023Project Grant

Principal investigators: Azad, Taha

Keywords: Cancer Immunotherapy; Cancer, Genome Editing; Crispr/Cas9; Immunotherapy; Next Generation Sequencing; Oncolytic Viruses; Screening; Synthetic Biology; Vaccines

$986,850

24th RiboClub Annual Meeting

Co-investigatorCIHR2023Planning and Dissemination Grant - Institute Community Support

Principal investigators: Fabian, Marc R

Keywords: Deregulation In Disease; Gene Expression Regulation; Regulatory Rna; Rna Biology; Rna Complexes; Rna Delivery; Rna In Biotechnology; Rna Interactions; Rna Structure; Transcriptomics

$10,000

Biochemical and Genetic Characterization of Ribosome Biogenesis and Functional Diversity

Principal investigatorNSERC2022Discovery Grants Program - Individual

Principal investigators: Abou Elela, Sherif

$144,000

23rd RiboClub Annual Meeting

Co-investigatorCIHR2022Planning and Dissemination Grant - Institute Community Support

Principal investigators: Scott, Michelle

Keywords: Deregulation In Disease; Gene Expression Regulation; Regulatory Rna; Rna Biology; Rna Complexes; Rna Delivery; Rna In Biotechnology; Rna Interactions; Rna Structure; Transcriptomics

$10,000

Computational and functional characterization of C/D snoRNA regulons of gene expression

Co-investigatorCIHR2022Project Grant

Principal investigators: Scott, Michelle

Keywords: Alternative Splicing; Cancer; Cell Pathways; Gene Expression Regulation; Network Analysis; Ribonucleoprotein Complexes; Rna-Rna Interactions; Rna-Seq; Small Nucleolar Rnas (Snornas); Translation Regulation

$944,776

Targets and function of cancer associated H/ACA snoRNA

Nominated PICIHR2022Project Grant

Principal investigators: Abou Elela, Sherif

Keywords: Basic Mechanisms Of Cancer Biology; Non-Coding Rna; Ribosomal Rna Modification; Ribosome Biogenesis; Snorna; Translation

$887,400

Replacement of automated real-time PCR cluster

Principal investigatorNSERC2021Research Tools and Instruments

Principal investigators: Abou Elela, Sherif

$143,679

Canada Research Chair - Tier 1

Nominated PICIHR2019Canada Research Chairs - CIHR Funded - Tier 1

Principal investigators: Abou Elela, Sherif

Keywords: Crc

$1,400,000

Replacement for Microbial Growth Assay Cluster

Principal investigatorNSERC2019Research Tools and Instruments

Principal investigators: AbouElela, Sherif

$143,350

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Microbiologie et d'infectiologie
Biochimie et génomique fonctionnelle
Immunologie-Biologie Cellulaire
Other

Co-authors at Université de Sherbrooke, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

Benoit Chabot

Microbiologie et d'infectiologie

4 shared papers, latest 2014

Jean-Pierre Perreault

Faculty

2 shared papers, latest 2014

Jean-Philippe Brosseau

Biochimie et génomique fonctionnelle

2 shared papers, latest 2014

Raymund Wellinger

Microbiologie et d'infectiologie

1 shared papers, latest 2008

Isabelle Dionne

Immunologie-Biologie Cellulaire

1 shared papers, latest 2013

Michelle Scott

Biochimie et génomique fonctionnelle

1 shared papers, latest 2019

Simon Boudreault

Faculty

1 shared papers, latest 2022

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mentionMention their NSERC grant from 2022

Subject: Prospective PhD student: Basic Mechanisms Of Cancer Biology Dear Professor Abou Elela, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "SnoBIRD: a tool to identify C/D box snoRNAs and refine their annotation across all eukaryotes." (2025), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your NSERC-funded project "Biochemical and Genetic Characterization of Ribosome Biogenesis and Functional Diversity" (2022), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]

Sherif Abou Elela

Research

Latest papers

Latest funding

SnoBIRD: a tool to identify C/D box snoRNAs and refine their annotation across all eukaryotes.

Cells resist starvation through a nutrient stress splice switch.

Transcription factors induce differential splicing of duplicated ribosomal protein genes during meiosis.

Canada's contributions to RNA research: past, present, and future perspectives.

Intronic small nucleolar RNAs regulate host gene splicing through base pairing with their adjacent intronic sequences.

snoDB 2.0: an enhanced interactive database, specializing in human snoRNAs.

Reovirus &#x3bc;2 Protein Impairs Translation to Reduce U5 snRNP Protein Levels.

Altered tRNA processing is linked to a distinct and unusual La protein in Tetrahymena thermophila.

Duplicated ribosomal protein paralogs promote alternative translation and drug resistance.

SAPFIR: A webserver for the identification of alternative protein features.

RNA Canada ARN 2024 Meeting

Bioengineering viruses to create safer and more effective oncolytic viruses

24th RiboClub Annual Meeting

Biochemical and Genetic Characterization of Ribosome Biogenesis and Functional Diversity

23rd RiboClub Annual Meeting

Computational and functional characterization of C/D snoRNA regulons of gene expression

Targets and function of cancer associated H/ACA snoRNA

Replacement of automated real-time PCR cluster

Canada Research Chair - Tier 1

Replacement for Microbial Growth Assay Cluster

Frequent collaborators

Benoit Chabot

Jean-Pierre Perreault

Jean-Philippe Brosseau

Raymund Wellinger

Isabelle Dionne

Michelle Scott

Simon Boudreault

Reovirus μ2 Protein Impairs Translation to Reduce U5 snRNP Protein Levels.