Faculty profile

Benoit Chabot

ResearcherMicrobiologie et d'infectiologieUniversité de Sherbrooke

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a Université de Sherbrooke directory, so their courses may be missing. Find their university profile.

Benoit Chabot

Researcher

Microbiologie et d'infectiologie

Health Sciences

Université de Sherbrooke

Sherbrooke, Quebec, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
13 publications in the last five years, latest in 2026.
Senior (last) author on 4 recent papers, a sign of leading a research group.
Principal investigator on 5 research grants (4 CIHR, 1 NSERC), most recently in 2019.
Supervisor on 1 trainee award (1 CIHR), most recently in 2015.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

Publications

Citations

Collaborators

Grants

Publications by year

Counts cover the publications linked to this profile. Citations and the h-index appear when the source records them.

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Signals and details

Research

Alternative Splicing Apoptosis Cancer Cell Cycle Rna Binding Proteins Anti-Cancer Drugs Dna Damage Organoids

Latest papers

RNA-based discovery and correction of splicing defects caused by POLR3A missense mutations.
Molecular therapy. Nucleic acids · 2026 · senior author
Proof-of-principle of NF1 gene therapy in plexiform neurofibroma xenograft mouse models.
Communications biology · 2026
Regulatory interplay between SR proteins governs CLK1 kinase splice variants production.
RNA (New York, N.Y.) · 2024 · senior author

All 67 publications

Latest funding

Targeting TMPRSS6 to treat hepcidin-deficiency disorders.
CIHR · 2020 · Co-investigator
$960,075
Total liquid ventilation for bronchopulmonary dysplasia prevention in a model of extreme preterm lamb
CIHR · 2019 · Co-investigator
$105,000
The RNA splicing response to DNA damage
CIHR · 2019 · Nominated PI
$807,076

All 16 grants and awards

67 publications.

RNA-based discovery and correction of splicing defects caused by POLR3A missense mutations.

Shkreta L, Delannoy A, Toutant J, McSwiggen J, Chabot B

Molecular therapy. Nucleic acids2026Senior author

DOI: 10.1016/j.omtn.2026.102850 PMID: 41732205

Proof-of-principle of NF1 gene therapy in plexiform neurofibroma xenograft mouse models.

Hewa Bostanthirige D, Plante C, Caron M, Gascon S, Lévesque M, Poirier C, Deschenes M, Sabo Vatasescu JP, Chabot B, Geha S, Laurent B, Brosseau JP

Communications biology2026

DOI: 10.1038/s42003-026-09695-8 PMID: 41680443

Regulatory interplay between SR proteins governs CLK1 kinase splice variants production.

Shkreta L, Delannoy A, Toutant J, Chabot B

RNA (New York, N.Y.)2024Senior author

DOI: 10.1261/rna.080107.124 PMID: 39251328

A defective splicing machinery promotes senescence through MDM4 alternative splicing.

Deschênes M, Durand M, Olivier MA, Pellerin-Viger A, Rodier F, Chabot B

Aging cell2024Senior author

DOI: 10.1111/acel.14301 PMID: 39118304

The dual-specificity kinase DYRK1A interacts with the Hepatitis B virus genome and regulates the production of viral RNA.

Pastor F, Charles E, Di Vona C, Chapelle M, Rivoire M, Passot G, Chabot B, de la Luna S, Lucifora J, Durantel D, Salvetti A

PloS one2024

DOI: 10.1371/journal.pone.0311655 PMID: 39405283

The anticancer potential of the CLK kinases inhibitors 1C8 and GPS167 revealed by their impact on the epithelial-mesenchymal transition and the antiviral immune response.

Shkreta L, Toutant J, Delannoy A, Durantel D, Salvetti A, Ehresmann S, Sauvageau M, Delbrouck JA, Gravel-Trudeau A, Comeau C, Huard C, Coulombe-Huntington J, Tyers M, Grierson D, Boudreault PL, Chabot B

Oncotarget2024Senior author

DOI: 10.18632/oncotarget.28585 PMID: 38753413

Intron Retention of DDX39A Driven by SNRPD2 is a Crucial Splicing Axis for Oncogenic MYC/Spliceosome Program in Hepatocellular Carcinoma.

Chang C, Li L, Su L, Yang F, Zha Q, Sun M, Tao L, Wang M, Song K, Jiang L, Gao H, Liang Y, Xu C, Yong C, Wang M, Huang J, Liu J, Jin W, Lv W, Dong H, Li Q, Bu F, Yan S, Qi H, Zhao S, Zhu Y, Wang Y, Shi J, Qiao Y, Xu J, Chabot B, Chen J

Advanced science (Weinheim, Baden-Wurttemberg, Germany)2024

DOI: 10.1002/advs.202403387 PMID: 39018261

Exploiting the Achilles' Heel of Viral RNA Processing to Develop Novel Antivirals.

Zahedi Amiri A, Ahmed C, Dahal S, Grosso F, Leng H, Stoilov P, Mangos M, Toutant J, Shkreta L, Attisano L, Chabot B, Brown M, Huesca M, Cochrane A

Viruses2024

DOI: 10.3390/v17010054 PMID: 39861843

On a path toward a broad-spectrum anti-viral: inhibition of HIV-1 and coronavirus replication by SR kinase inhibitor harmine.

Dahal S, Clayton K, Cabral T, Cheng R, Jahanshahi S, Ahmed C, Koirala A, Villasmil Ocando A, Malty R, Been T, Hernandez J, Mangos M, Shen D, Babu M, Calarco J, Chabot B, Attisano L, Houry WA, Cochrane A

Journal of virology2023

DOI: 10.1128/jvi.00396-23 PMID: 37706687

The Thiazole-5-Carboxamide GPS491 Inhibits HIV-1, Adenovirus, and Coronavirus Replication by Altering RNA Processing/Accumulation

Dahal S, Cheng R, Cheung PK, Been T, Malty R, Geng M, Manianis S, Shkreta L, Jahanshahi S, Toutant J

Viruses202220 citations

DOI: 10.3390/v14010060

Targeting TMPRSS6 to treat hepcidin-deficiency disorders.

Co-investigatorCIHR2020Project Grant

Principal investigators: Leduc, Richard

Keywords: Cell-Surface Protease; Hepcidin; Iron Disease; Protease Inhibition; Serine Protease; Splice-Switching Oligonucleotides

$960,075

Total liquid ventilation for bronchopulmonary dysplasia prevention in a model of extreme preterm lamb

Co-investigatorCIHR2019Operating Grant: ECI grants in Maternal, Reproductive, Child & Youth Health

Principal investigators: Fortin-Pellerin, Étienne

Keywords: Bronchopulmonary Dysplasia; Chronic Lung Disease; Mechanical Ventilation; Prematurity; Total Liquid Ventilation; Ventilator Induced Lung Injury

$105,000

The RNA splicing response to DNA damage

Nominated PICIHR2019Project Grant

Principal investigators: Chabot, Benoit

Keywords: Alternative Splicing; Anti-Cancer Drugs; Apoptosis; Cancer; Cell Cycle; Dna Damage; Organoids; Rna; Rna Binding Proteins; Small Molecule

$807,076

The 19th Annual Meeting of the RiboClub

Co-investigatorCIHR2018Planning and Dissemination Grant - Institute Community Support

Principal investigators: Scott, Michelle

Keywords: Epigenetics And Rna Modification; High-Throughput Technologies; Molecular Biology Of Rna; Non-Coding Rnas; Post-Transcriptional Gene Regulation; Ribosome And Translation Regulation; Rna Biology In Diseases; Rna Degradation; Rna-Seq; Systems Biology And Rna Networks

$20,000

Replacement for Fast Protein Liquid Chromatography System

Co-investigatorNSERC2018Research Tools and Instruments

Principal investigators: AbouElela, Sherif

$138,000

The Annual Riboclub Symposium

Co-investigatorCIHR2017Planning and Dissemination Grant - Institute Community Support

Principal investigators: Massé, Eric

Keywords: Molecular Biology Of Rna; Non-Coding Rnas; Post-Transcriptional Gene Regulation; Rna Biology In Diseases; Rna-Binding Proteins

$10,000

High-throughput nucleic acid detection platform

Co-investigatorNSERC2016Research Tools and Instruments

Principal investigators: AbouElela, Sherif

$149,885

Colorectal Cancer Cell Growth Inhibition by a Novel Class of Compounds that Alter the Activity of Splicing Regulators

SupervisorCIHR2015Fellowship - Priority Announcement: Gastroenterology

Principal investigators: Sohail, Muhammad

Keywords: Alternative Splicing; Cell Proliferation; Colorectal Cancer; Drug Discovery; Rna Binding Proteins; Tumor Growth

$38,062

Mechanisms of alternative splicing

Nominated PICIHR2014Operating Grant

Principal investigators: Chabot, Benoit

Keywords: Alternative Splicing; Apoptosis; Cancer; Cell Cycle; Rna Binding Proteins; Signalling

$647,988

Development of Specific Inhibitors of HIV pre-mRNA Alternative Splicing: A New Anti-HIV/AIDS Strategy

Co-investigatorCIHR2014Proof of Principle Program - Phase I

Principal investigators: Grierson, David S

Keywords: Alternative Splicing; Drug Discovery; Drug Resistance; Hiv-Aids; Inhibitors; Medicinal Chemistry; Mouse Model; Parallel Synthesis; Sr Proteins; Toxicity

$160,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

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Benoit Chabot

Research

Latest papers

Latest funding

RNA-based discovery and correction of splicing defects caused by POLR3A missense mutations.

Proof-of-principle of NF1 gene therapy in plexiform neurofibroma xenograft mouse models.

Regulatory interplay between SR proteins governs CLK1 kinase splice variants production.

A defective splicing machinery promotes senescence through MDM4 alternative splicing.

The dual-specificity kinase DYRK1A interacts with the Hepatitis B virus genome and regulates the production of viral RNA.

The anticancer potential of the CLK kinases inhibitors 1C8 and GPS167 revealed by their impact on the epithelial-mesenchymal transition and the antiviral immune response.

Intron Retention of DDX39A Driven by SNRPD2 is a Crucial Splicing Axis for Oncogenic MYC/Spliceosome Program in Hepatocellular Carcinoma.

Exploiting the Achilles' Heel of Viral RNA Processing to Develop Novel Antivirals.

On a path toward a broad-spectrum anti-viral: inhibition of HIV-1 and coronavirus replication by SR kinase inhibitor harmine.

The Thiazole-5-Carboxamide GPS491 Inhibits HIV-1, Adenovirus, and Coronavirus Replication by Altering RNA Processing/Accumulation

Replacement for Fast Protein Liquid Chromatography System

High-throughput nucleic acid detection platform

Frequent collaborators

Alan Cochrane

Jean-Philippe Brosseau

Sherif Abou Elela

David Grierson

Brendan Bell

Jean-Pierre Perreault

Mohan Babu

Liliana Attisano

John Calarco

Pierre Lavigne

Benoit Laurent

Pierre-Luc Boudreault

Aymeric Ravel-Chapuis

Michel Bouvier

Martin Pelchat

Lincoln Stein

Samira Mubareka

Rashmi Kothary

Donald Branch

Raymund Wellinger

Mathieu Blanchette

Karen Mossman

Scott Gray-Owen

Serge Goekjian

Jack Greenblatt

Jean-Paul Praud

Fernand-Pierre Gendron