Jean-Philippe Brosseau, Université de Sherbrooke

Research

Neurofibromatosis Gene Therapy Schwann Cells Tumor Mouse Model Brain And Nervous System Childhood And Young Adult Oncogenes And Tumour Suppressors Benign Tumor

Latest papers

Splicing isoforms associated with TGFβ-induced myofibroblast activation.
BMC molecular and cell biology · 2026 · senior author
Proof-of-principle of NF1 gene therapy in plexiform neurofibroma xenograft mouse models.
Communications biology · 2026 · senior author
Development, validation, and preliminary phenotypic characterization of a Col6a3 knockout mouse model targeting exon 3.
Animal models and experimental medicine · 2025 · senior author

All 20 publications

Latest funding

Validation of NF Gene Therapy in cutaneous neurofibroma pre-clinical mouse models
CIHR · 2025 · Nominated PI
$150,000
Development of NF1 Gene Therapy
CIHR · 2022 · Nominated PI
$60,000
Tumor-Associated Fibroblasts Impairing Malignant Progression
CIHR · 2022 · Nominated PI
$100,000

All 5 grants and awards

20 publications.

01

Splicing isoforms associated with TGFβ-induced myofibroblast activation.

Alli-Oke O, Bergeron D, Kessai F, Thibault P, Durand M, Brosseau JP

BMC molecular and cell biology2026Senior author

DOI: 10.1186/s12860-026-00579-7 PMID: 41787265

02

Proof-of-principle of NF1 gene therapy in plexiform neurofibroma xenograft mouse models.

Hewa Bostanthirige D, Plante C, Caron M, Gascon S, Lévesque M, Poirier C, Deschenes M, Sabo Vatasescu JP, Chabot B, Geha S, Laurent B, Brosseau JP

Communications biology2026Senior author

DOI: 10.1038/s42003-026-09695-8 PMID: 41680443

03

Development, validation, and preliminary phenotypic characterization of a Col6a3 knockout mouse model targeting exon 3.

ElChoueiry M, Sidhu H, Lévesque M, Lévesque D, Jacques JF, Sarrhini O, Beaudoin JF, Caron M, Gaudette B, Lecomte R, Roucou X, Boisvert FM, Brosseau JP

Animal models and experimental medicine2025Senior author

DOI: 10.1002/ame2.70063 PMID: 40792431

04

Best evidence linking the extracellular factor TGF-β to cancer-associated alternative splicing programs.

Alli-Oke O, Brosseau JP

BBA advances2025Senior author

DOI: 10.1016/j.bbadva.2024.100132 PMID: 40585016

05

Assessing tissue mechanical properties: Development of a custom-made tensile device and application on rodents sciatic nerves.

Petit E, Bavykina V, Thibault M, Bilodeau A, Choinière W, Brosseau JP, Laurent B, Lauzon MA

Journal of the mechanical behavior of biomedical materials2024

DOI: 10.1016/j.jmbbm.2024.106709 PMID: 39216337

06

Revisiting the NPcis mouse model: A new tool to model plexiform neurofibroma.

Plante C, Mohamad T, Hewa Bostanthirige D, Renaud M, Sidhu H, ElChoueiry M, Vatasescu JS, Poirier M, Geha S, Brosseau JP

PloS one2024Senior author

DOI: 10.1371/journal.pone.0301040 PMID: 38900740

07

ITPRIPL1 binds CD3ε to impede T cell activation and enable tumor immune evasion.

Deng S, Zhang Y, Wang H, Liang W, Xie L, Li N, Fang Y, Wang Y, Liu J, Chi H, Sun Y, Ye R, Shan L, Shi J, Shen Z, Wang Y, Wang S, Brosseau JP, Wang F, Liu G, Quan Y, Xu J

Cell2024

DOI: 10.1016/j.cell.2024.03.019 PMID: 38614099

08

Toward Understanding the Mechanisms of Malignant Peripheral Nerve Sheath Tumor Development.

Mohamad T, Plante C, Brosseau JP

International journal of molecular sciences2021Senior author

DOI: 10.3390/ijms22168620 PMID: 34445326

09

A peptidic inhibitor for PD-1 palmitoylation targets its expression and functions.

Yao H, Li C, He F, Song T, Brosseau JP, Wang H, Lu H, Fang C, Shi H, Lan J, Fang JY, Xu J

RSC chemical biology2021

DOI: 10.1039/d0cb00157k PMID: 34458782

10

Human cutaneous neurofibroma matrisome revealed by single-cell RNA sequencing.

Brosseau JP, Sathe AA, Wang Y, Nguyen T, Glass DA, Xing C, Le LQ

Acta neuropathologica communications2021First author

DOI: 10.1186/s40478-020-01103-4 PMID: 33413690