Faculty profile
Kathy McCoy
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Research
Latest papers
Adenophages are an atypical macrophage population in exocrine glands sustained by ILC2-derived GM-CSF.
Nature immunology · 2026
Kupffer cell reverse migration into the liver sinusoids mitigates neonatal sepsis and meningitis.
Science immunology · 2024
Kupffer cell-like syncytia replenish resident macrophage function in the fibrotic liver.
Science (New York, N.Y.) · 2023
Latest funding
- $994,500
Mechanistic Dissection of Gut Microbiota-Immune Interactions Driving MASLD Progression
CIHR · 2025 · Co-investigator
- $120,000
Defining microbiome-driven immunomodulatory roles of intestinal stromal cells
CIHR · 2024 · Supervisor
- $872,100
The interaction of sex hormones and bacterial metabolites in inflammatory bowel disease-associated chronic visceral pain.
CIHR · 2024 · Co-investigator
4 publications.
Adenophages are an atypical macrophage population in exocrine glands sustained by ILC2-derived GM-CSF.
Westermann F, Tuzlak S, Kreiner V, Ignacio A, Bejarano D, Bijnen M, Cecconi V, van Hove H, Wang H, Andreadou M, Litscher G, Sparano C, Fróis-Martins R, Gallerand A, Roussel E, Oberbichler L, Lindemann R, DeFeo D, Liu Z, Kipar A, LeibundGut-Landmann S, McCoy K, Nixon I, Bain CC, Schneider C, Ivanov S, Tugues S, Greter M, Ginhoux F, Schlitzer A, Emmerson E, Becher B
Kupffer cell reverse migration into the liver sinusoids mitigates neonatal sepsis and meningitis.
Araujo David B, Atif J, Vargas E Silva Castanheira F, Yasmin T, Guillot A, Ait Ahmed Y, Peiseler M, Hommes JW, Salm L, Brundler MA, Surewaard BGJ, Elhenawy W, MacParland S, Ginhoux F, McCoy K, Kubes P
Kupffer cell-like syncytia replenish resident macrophage function in the fibrotic liver.
Peiseler M, Araujo David B, Zindel J, Surewaard BGJ, Lee WY, Heymann F, Nusse Y, Castanheira FVS, Shim R, Guillot A, Bruneau A, Atif J, Perciani C, Ohland C, Ganguli Mukherjee P, Niehrs A, Thuenauer R, Altfeld M, Amrein M, Liu Z, Gordon PMK, McCoy K, Deniset J, MacParland S, Ginhoux F, Tacke F, Kubes P
Knowledge Gaps in the Understanding of Antimicrobial Resistance in Canada.
McCubbin KD, Anholt RM, de Jong E, Ida JA, Nóbrega DB, Kastelic JP, Conly JM, Götte M, McAllister TA, Orsel K, Lewis I, Jackson L, Plastow G, Wieden HJ, McCoy K, Leslie M, Robinson JL, Hardcastle L, Hollis A, Ashbolt NJ, Checkley S, Tyrrell GJ, Buret AG, Rennert-May E, Goddard E, Otto SJG, Barkema HW
Mechanistic Dissection of Gut Microbiota-Immune Interactions Driving MASLD Progression
Principal investigators: Nguyen, Henry H
Keywords: Adaptive Immunity ( T-Cells); Gnotobiotic Mice; Gut Microbiome; Gut-Liver Axis; Liver Fibrosis; Metabolic Dysfunction Associated Steatotic Liver Disease; Microbial Pathobionts; Patient Liver Biopsies; Precision Medicine; Transcriptomics
Defining microbiome-driven immunomodulatory roles of intestinal stromal cells
Principal investigators: Mellett, Madeline
Keywords: Microbiome; Microbiome-Immune Interactions; Mucosal Immunology; Stromal Cell Biology
The interaction of sex hormones and bacterial metabolites in inflammatory bowel disease-associated chronic visceral pain.
Principal investigators: Nasser, Yasmin
Keywords: Aryl Hydrocarbon Receptor; Calcium Imaging; Chronic Pain; Dss Colitis; Metabolome; Microbiome; Sex Chromosomes; Sex Hormones; Trpv1
Determining the role of the microbiome and microbial metabolites in enhancing the efficacy of CD19 directed CAR-T cell therapy of B cell malignancies.
Principal investigators: McCoy, Kathy
Keywords: Acute Lymphoblastic Leukemia; Anti-Tumor Immunity; Chimeric Antigen Receptor (Car)-T Cells; Gnotobiotic Mouse Models; Human Microbiome Associated Mice; Immunotherapy; Inosine; Metabolites; Microbiome
Investigating the role of intestinal microbiota in intestinal macrophage immune memory
Principal investigators: Ignacio Silvestre da Silva, Aline
Keywords: Early-Life; Gastrointestinal Tract; Germ-Free Mice; Immunological Memory; Immunometabolism; Innate Immunity; Intestinal Epithelium; Macrophage; Microbiome; Transient Colonization
Investigating the role of intestinal commensal bacteria in innate memory induction.
Principal investigators: Ignacio Silvestre da Silva, Aline
Keywords: Early-Life; Epigenetic Modifications; Gastrointestinal Tract; Germ-Free Mice; Immunological Memory; Infection; Innate Immunity; Macrophage; Microbiome; Transient Colonization
Determining the impact of inosine-producing microbes in promoting the efficacy and modulating toxicity of immune checkpoint blockade therapy in cancer.
Principal investigators: McCoy, Kathy
Keywords: Anti-Tumor Immunity; Bifidobacteria; Gnotobiotic Mouse Models; Human Microbiome-Associated Mice; Immune Checkpoint Blockade Therapy; Immune-Related Adverse Events; Inosine; Metabolites; Microbiota; Wild Microbiome
The early-life mycobiome as a determinant of allergic airway inflammation
Principal investigators: Arrieta Mendez, Marie-Claire
Keywords: Asthma; Gut Microbiome; Immune Development
Investigating the role of intestinal commensal bacteria in innate memory induction
Principal investigators: Ignacio Silvestre da Silva, Aline
Keywords: Commensal Bacteria; Early-Life; Epigenetic Modifications; Gastrointestinal Tract; Germ-Free Mice; Infection; Innate Immunity; Memory; Microbiome; Transient Colonization
The gut-liver axis in host defense against bacterial infections and sepsis
Principal investigators: McDonald, Braedon A
Keywords: Bacterial Infection; Gnotobiotic Mice; Gut Microbiota; Inflammation; Kupffer Cells; Liver Immune Firewall; Neutrophils; Sepsis
From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.
Frequent collaborators
- Physiology and Pharmacology
- Department of Laboratory Medicine and Pathobiology
- Pathology and Laboratory Medicine
- Medicine
- Rural Economy
- Biological Sciences
- Medical Microbiology and Immunology
- Other
Co-authors at University of Calgary, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.
Paul Kubes
Physiology and Pharmacology
2 shared papers, latest 2024
Sonya MacParland
Department of Laboratory Medicine and Pathobiology
2 shared papers, latest 2024
Myles Leslie
Faculty
1 shared papers, latest 2021
Justin Deniset
Physiology and Pharmacology
1 shared papers, latest 2023
Wael Elhenawy
Medical Microbiology and Immunology
1 shared papers, latest 2024
Elissa Rennert-May
Medicine
1 shared papers, latest 2021
Paul Kubes
Faculty
1 shared papers, latest 2024
Ellen Goddard
Rural Economy
1 shared papers, latest 2021
Aidan Hollis
Pathology and Laboratory Medicine
1 shared papers, latest 2021
Ian Lewis
Biological Sciences
1 shared papers, latest 2021
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