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Sonya MacParland

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ProfessorDepartment of Laboratory Medicine & PathobiologyUniversity of Toronto

Sonya MacParland

Professor

Department of Laboratory Medicine & Pathobiology

Temerty Faculty of Medicine

University of Toronto

Toronto, Ontario, Canada

Canada Research Chair in Liver Immunobiology

Scholar ORCID

Supervision signals

Professors usually supervise graduate students in their department's programs.
22 publications in the last five years, latest in 2026.
Senior (last) author on 3 recent papers, a sign of leading a research group.
Principal investigator on 11 research grants (9 CIHR, 2 NSERC), most recently in 2025.
Supervisor on 4 trainee awards (4 CIHR), most recently in 2025.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

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Citations

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Grants

Publications by year

Counts cover the publications linked to this profile. Citations and the h-index appear when the source records them.

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Signals and details

Research

Read how they describe their research on their University of Toronto profile.

Liver Disease Transplantation Liver Immunology Single Cell Rna Sequencing Immunology Hepatitis C Virus Human Models Mouse Models

Latest papers

Spatial biology of liver transplantation: Mapping injury, immunity, and repair in the allograft.
Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society · 2026
Immune mechanisms and pathophysiology of T cell-mediated pediatric acute liver failure (TC-PALF).
Hepatology communications · 2026
Ninjurin-1 mediates hepatic ischemia-reperfusion injury.
Science advances · 2026

All 27 publications

Latest funding

Targeting PSC using Human Pre-clinical Models and Spatial Transcriptomics
CIHR · 2025 · Nominated PI
$450,000
LXR Activated TREM2+ Myeloid Cells Promote Liver Tumor Persistence
CIHR · 2025 · Supervisor
$120,000
Unravelling the Cellular and Immunologic Landscape of the Gut in Children with Primary Sclerosing Cholangitis at Single-Cell Resolution
CIHR · 2024 · Principal investigator
$822,376

All 26 grants and awards

27 publications.

Spatial biology of liver transplantation: Mapping injury, immunity, and repair in the allograft.

Lee JTC, Jennings H, Nakib D, Verstegen MMA, Liu J, Mas VR, MacParland S, Emamaullee J, Al-Adra D

Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society2026

DOI: 10.1097/lvt.0000000000000991 PMID: 42758896

Immune mechanisms and pathophysiology of T cell-mediated pediatric acute liver failure (TC-PALF).

Lee JTC, Sutton H, Pai P, Barbetta A, Zhou S, Kohli R, MacParland S, Emamaullee J

Hepatology communications2026

DOI: 10.1097/hc9.0000000000001033 PMID: 42623522

Ninjurin-1 mediates hepatic ischemia-reperfusion injury.

Mossemann J, Martins BX, Zhao Y, Aguilar F, Taskina D, Hur CJ, Nakib D, Volchuk A, Ye G, Ali DM, Mirzaesmaeili A, Siddiqui I, Goodarzi G, Bilan PJ, Stowe IB, Kayagaki N, MacParland S, Freeman SA, Goldenberg NM, Steinberg BE, Sayed BA

Science advances2026

DOI: 10.1126/sciadv.aeg9496 PMID: 42647649

Co-creating discovery in basic science: Challenges and opportunities in patient-partnered research for rare liver disease.

Nakib D, Vyas M, Gomel R, MacParland S

Canadian liver journal2026Senior author

DOI: 10.3138/canlivj-2025-0051 PMID: 42404993

Decoding the PSC fibrotic niche: Hepatocyte stress and metallothioneins.

Nakib D, MacParland S

Hepatology (Baltimore, Md.)2026Senior author

DOI: 10.1097/hep.0000000000001478 PMID: 40960955

Paradoxical oncogenic effects of hepatic Brca1 through modulating Bhmt.

Ghebreselassie M, Park YJ, Nakib D, Dodington D, Patel P, Won S, Hakem A, Hakem R, MacParland S, Woo M

Scientific reports2026

DOI: 10.1038/s41598-026-39581-6 PMID: 41781465

Author Correction: Towards a reference cell atlas of liver diversity over the human lifespan.

Taylor SA, Bader GD, MacParland S, Mullen AC, Andrews T, Cuenca AG, DasGupta R, Gehring AJ, Grün D, Guilliams M, Gulamhusein A, Henderson NC, Hirschfield G, Huppert SS, Itzkovitz S, Jiang ZG, Lauer GM, McGilvray I, Mysore KR, Pirola CJ, Quon G, Rahbari M, Regev A, Ricciuto A, Scott CL, Sharma A, Sookoian S, Tana MM, Teichmann SA, Vallier L, Vlachos IS, Wang B, Zhen M

Nature reviews. Gastroenterology & hepatology2026

DOI: 10.1038/s41575-025-01145-w PMID: 41131357

Towards a reference cell atlas of liver diversity over the human lifespan.

Nature reviews. Gastroenterology & hepatology2026

DOI: 10.1038/s41575-025-01114-3 PMID: 41083606

Claudin-1 is a mediator and therapeutic target in primary sclerosing cholangitis.

Del Zompo F, Crouchet E, Ostyn T, Nehme Z, Messé M, Jühling F, Désert R, Vieira AT, Moehlin J, Nakib D, Andrews T, Perciani C, Chung S, Bader GD, McGilvray I, Caime C, Scaravaglio M, Carbone M, Invernizzi P, Yaqub S, Folseraas T, Karlsen TH, Shankar G, Primeaux M, Dhawan P, Banales JM, Roehlen N, Iacone R, Teixeira G, Heikenwälder M, Mailly L, MacParland S, Roskams T, Govaere O, Schuster C, Baumert TF

Journal of hepatology2025

DOI: 10.1016/j.jhep.2025.08.005 PMID: 40846184

No Evidence of Anti-Influenza Nucleoprotein Antibodies in Retail Milk from Across Canada (April-July 2024).

Wallace HL, Wight J, Rzeszutek GJ, Jafri MS, Baz M, Dowding B, Flamand L, Hobman T, Jean F, Joy JB, Lang AS, MacParland S, McCormick C, Noyce R, Russell RS, Sagan SM, Snyman J, Bogoch II, Rasmussen AL, Rimoin AW, Kindrachuk J, Pan-Canadian Milk Study Network

Viral immunology2025

DOI: 10.1089/vim.2025.0029 PMID: 40474813

Targeting PSC using Human Pre-clinical Models and Spatial Transcriptomics

Nominated PICIHR2025Team Grant: ERDERA Joint Transnational Call

Principal investigators: MacParland, Sonya

Keywords: Human Models; Liver Disease; Mouse Models; Organoids; Patient-Partnered Research; Rare Disease

$450,000

LXR Activated TREM2+ Myeloid Cells Promote Liver Tumor Persistence

SupervisorCIHR2025DRA : Canada Graduate Research Scholarship - Doctoral Program (CGRS D)

Principal investigators: Shiwram, Ariya

Keywords: Cell Death; Efferocytosis; Ferroptosis; Hepatocellular Carcinoma; Lipid; Macrophages; Transcriptomics

$120,000

Unravelling the Cellular and Immunologic Landscape of the Gut in Children with Primary Sclerosing Cholangitis at Single-Cell Resolution

Principal investigatorCIHR2024Project Grant

Principal investigators: Ricciuto, Amanda; Bader, Gary D; MacParland, Sonya

Keywords: Colitis; Inflammatory Bowel Disease (Ibd); Machine Learning; Paediatric; Primary Sclerosing Cholangitis (Psc); Screening; Single-Cell Transcriptomics

$822,376

Pathways to Functional Cure in Chronic Hepatitis B

Co-investigatorCIHR2024TG: Biomedical Res. for HIV/AIDS/STBBI-Next-Gen.Therapeutic Interv.-Large Team

Principal investigators: Coffin, Carla S; Ko, Hin Hin; Cooper, Curtis L; Crawley, Angela M; Gehring, Adam J; Jenne, Craig N; Meier-Stephenson, Vanessa

Keywords: Artificial Intelligence (Ai); Flow Cytometry; Functional Cure (Fc); Hepatitis B Virus (Hbv); Human Immunology; Humanized Mouse Liver Model; Liver Disease; Novel Biomarkers; Single Cell Rna Sequencing (Scrnaseq); Woodchuck Hepatitis Virus (Whv) Model

$3,749,969

Uncovering the role of physiologically relevant biliary signaling in engineering 3D bile duct tubes with human pluripotent stem cell-derived cholangiocytes

Co-investigatorCIHR2024Project Grant

Principal investigators: Ogawa, Shinichiro; Zhang, Boyang

Keywords: Biliary Disease; Cholangiopathies; Cystic Fibrosis; Cystic Fibrosis Related Liver Disease; Liver Disease

$986,850

Mapping the Determinants of Liver Transplant Outcomes

SupervisorCIHR2024CIHR Fellowship

Principal investigators: Edgar, Rachel D

Keywords: Bioinformatics; Liver Immunology; Liver Transplant; Single Cell Transcriptomics

$210,000

Training Program in Engineering Approaches to Preserve and Rejuvenate Organs (TENPRO)

Co-investigatorNSERC2023Collaborative Research and Training Experience

Principal investigators: Sefton, Michael MV

Keywords: bioengineering; biomedical devices; biotechnology; cell therapy; commercialization; gene editing; manufacturing; regeneration; tissue repair; translation

$450,000

Investigating the role of tissue-resident macrophages in the pathogenesis of primary sclerosing cholangitis through single-cell transcriptomics

SupervisorCIHR2023Canada Graduate Scholarships - Michael Smith Foreign Study Supplements

Principal investigators: Nakib, Diana

Keywords: Liver Biopsy; Macrophages; Nanoparticle; Primary Sclerosing Cholangitis (Psc); Single-Cell Technology

$6,000

The 13th Canadian Symposium on Hepatitis C Virus (CSHCV)

Co-investigatorCIHR2023Planning and Dissemination Grant - Institute Community Support

Principal investigators: Saeed, Sahar Z; Wong, William Wai Lun

Keywords: Biomedical; Clinical Research; Community Involvement; Epidemiology; Hepatitis C Virus; Integrated Knowledge Translation; Liver Disease; Public Health/Policy; Stbbi; Viral Hepatitis

$20,000

Manipulating the cellular microenvironment to bioengineer bile ducts

Co-investigatorCIHR2023Project Grant

Principal investigators: Mcgilvray, Ian D

Keywords: Bile Duct; Bioengineering; Fibrosis; Immunology; Liver; Macrophage Phenotype; Microsurgery; Single Cell Transcriptomics; Single Nucleus Transcriptomics; Transplantation

$1,067,175

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Profile data last refreshed on September 26, 2026 from the university directory, publication records and CIHR, NSERC and SSHRC funding.

Something wrong or missing on this profile? Suggest a correction

Sonya MacParland

Research

Latest papers

Latest funding

Spatial biology of liver transplantation: Mapping injury, immunity, and repair in the allograft.

Immune mechanisms and pathophysiology of T cell-mediated pediatric acute liver failure (TC-PALF).

Ninjurin-1 mediates hepatic ischemia-reperfusion injury.

Co-creating discovery in basic science: Challenges and opportunities in patient-partnered research for rare liver disease.

Decoding the PSC fibrotic niche: Hepatocyte stress and metallothioneins.

Paradoxical oncogenic effects of hepatic Brca1 through modulating Bhmt.

Author Correction: Towards a reference cell atlas of liver diversity over the human lifespan.

Towards a reference cell atlas of liver diversity over the&#xa0;human lifespan.

Claudin-1 is a mediator and therapeutic target in primary sclerosing cholangitis.

No Evidence of Anti-Influenza Nucleoprotein Antibodies in Retail Milk from Across Canada (April-July 2024).

Training Program in Engineering Approaches to Preserve and Rejuvenate Organs (TENPRO)

Frequent collaborators

Amanda Ricciuto

Ian Mcgilvray

Gideon Hirschfield

Mei Zhen

Mingyao Liu

Jason Kindrachuk

Tallulah Andrews

Gavin Wilson

Mamatha Bhat

Kathy McCoy

Jonathan Yeung

Shaf Keshavjee

Rupert Kaul

Jun Liu

Louis Flamand

Paul Kubes

Tereza Martinu

Craig McCormick

Stephen Juvet

Jordan Feld

Tom Hobman

Rebecca Gladdy

Adam Gehring

Justin Deniset

Atul Humar

Wael Elhenawy

Bo Wang

Andrew Mason

Jennifer Gommerman

Minna Woo

Mario Ostrowski

Mark Swain

Hong Han

Marcelo Cypel

Towards a reference cell atlas of liver diversity over the human lifespan.