Faculty profile

Simon Hirota

ResearcherPhysiology and PharmacologyUniversity of Calgary

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a University of Calgary directory, so their courses and email address may be missing. Find their university profile.

Simon Hirota

Researcher

Physiology and Pharmacology

Health Sciences

University of Calgary

Calgary, Alberta, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
2 publications in the last five years, latest in 2025.
Principal investigator on 9 research grants (7 CIHR, 2 NSERC), most recently in 2025.
Supervised 1 trainee who won CIHR awards, most recently in 2016.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

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Publications

Citations

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Collaborators

Grants

Publications by year

Counts cover the works listed on the university profile; citation counts come from Dimensions.

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Signals and details

Research

Inflammation Inflammatory Bowel Diseases Crc Crohn'S Disease Cell Differentiation Cytochrome P450 Drug Metabolism Host-Microbe Interactions

Latest papers

Neuronal ALKAL2 and its ALK receptor contribute to the development of colitis-associated colorectal cancer.
Proceedings of the National Academy of Sciences of the United States of America · 2025
Association of Circulating Fibrocytes With Fibrostenotic Small Bowel Crohn's Disease.
Inflammatory bowel diseases · 2022
Proteomics and Imaging in Crohn's Disease: TAILS of Unlikely Allies.
Trends in pharmacological sciences · 2020

All 7 publications

Latest funding

Fungal Contributions to Milk Lipid Metabolism and Fat Absorption in Early Life
CIHR · 2026 · Co-investigator
$1,128,376
The regulation of intestinal first-pass metabolism by IL-22 - understanding the link between host-microbe/pathogen interactions and alterations in drug metabolism.
CIHR · 2025 · Nominated PI
$1,263,780
Intestinal mesenchymal regulation of mucosal inflammation
CIHR · 2020 · Nominated PI
$642,600

All 13 grants and awards

7 publications.

Neuronal ALKAL2 and its ALK receptor contribute to the development of colitis-associated colorectal cancer.

Delanne-Cuménal M, Defaye M, Delanne-Cuménal A, Ahmed M, Ho V, Abdullah NS, Alhassoun M, Svendsen K, Mager L, Schlessinger J, Hirota S, Altier C

Proceedings of the National Academy of Sciences of the United States of America2025

DOI: 10.1073/pnas.2500632122 PMID: 40493183

Association of Circulating Fibrocytes With Fibrostenotic Small Bowel Crohn's Disease.

Ueno A, Jijon HB, Peng R, Sparksman S, Mainoli B, Filyk A, Li Y, Wilson S, Novak K, Panaccione R, Hirota S, Dufour A, Lu C, Beck PL

Inflammatory bowel diseases2022

DOI: 10.1093/ibd/izab157 PMID: 34428284

Proteomics and Imaging in Crohn's Disease: TAILS of Unlikely Allies.

Mainoli B, Hirota S, Edgington-Mitchell LE, Lu C, Dufour A

Trends in pharmacological sciences2020

DOI: 10.1016/j.tips.2019.11.008 PMID: 31952817

A Trypsin-Sensitive Proteoglycan from the Tapeworm Hymenolepis diminuta Inhibits Murine Neutrophil Chemotaxis in vitro by Suppressing p38 MAP Kinase Activation.

Graves N, Venu VP, Yipp BG, Petri B, Hirota S, Gilleard J, McKay DM, Lopes F

Journal of innate immunity2019

DOI: 10.1159/000492303 PMID: 30205385

A simple, cost-effective method for generating murine colonic 3D enteroids and 2D monolayers for studies of primary epithelial cell function.

Fernando EH, Dicay M, Stahl M, Gordon MH, Vegso A, Baggio C, Alston L, Lopes F, Baker K, Hirota S, McKay DM, Vallance B, MacNaughton WK

American journal of physiology. Gastrointestinal and liver physiology2017

DOI: 10.1152/ajpgi.00152.2017 PMID: 28751424

Inflammatory bowel disease cause-specific mortality: a primer for clinicians.

Kassam Z, Belga S, Roifman I, Hirota S, Jijon H, Kaplan GG, Ghosh S, Beck PL

Inflammatory bowel diseases2014

DOI: 10.1097/mib.0000000000000173 PMID: 25185685

The NLRP3 inflammasome promotes renal inflammation and contributes to CKD.

Vilaysane A, Chun J, Seamone ME, Wang W, Chin R, Hirota S, Li Y, Clark SA, Tschopp J, Trpkov K, Hemmelgarn BR, Beck PL, Muruve DA

Journal of the American Society of Nephrology : JASN2010

DOI: 10.1681/asn.2010020143 PMID: 20688930

Fungal Contributions to Milk Lipid Metabolism and Fat Absorption in Early Life

Co-investigatorCIHR2026Project Grant

Principal investigators: Arrieta Mendez, Marie-Claire

Keywords: Gut Mycobiome And Host Nutrient Absorption; Milk Lipid Digestion; Preterm Infant Growth

$1,128,376

The regulation of intestinal first-pass metabolism by IL-22 - understanding the link between host-microbe/pathogen interactions and alterations in drug metabolism.

Nominated PICIHR2025Project Grant

Principal investigators: Hirota, Simon A

Keywords: Cell Differentiation; Cytochrome P450; Drug Metabolism; Host-Microbe Interactions; Il-22; Innate Lymphoid Cells; Intestinal Epithelium; Intestinal Organoids; Intestinal Stem Cells

$1,263,780

Intestinal mesenchymal regulation of mucosal inflammation

Nominated PICIHR2020Project Grant

Principal investigators: Hirota, Simon A

Keywords: Fibroblasts; Indole-3-Propionic Acid; Inflammatory Bowel Diseases; Intestinal Mesenchyme; Intestinal Microbiota; Microbial Metabolites; Pregnane X Receptor; Stromal Cells; T Cells

$642,600

Canada Research Chair - Tier 2

Nominated PICIHR2019Canada Research Chairs - CIHR Funded - Tier 2

Principal investigators: Hirota, Simon A

Keywords: Crc

$500,000

Reducing Morbidity and Mortality in Inflammatory Bowel Disease by Targeting Intestinal Fibrosis

Principal investigatorCIHR2018Team: Human Immun.- LOI - Autoimmune diseases-digestive, kidney, pancreas, liver

Principal investigators: Beck, Paul L; Dufour, Antoine; Hirota, Simon A; Jijon, Humberto B; Lu, Cathy; Seow, Cynthia H

Keywords: Cellular Biology; Crohn'S Disease; Inflammation; Inflammatory Bowel Disease; Intestinal Fibrosis; Meta-Transcriptomics; Proteomics; Rna-Sequencing

$20,000

Kananaskis Inflammation Workshop for Trainees

Nominated PICIHR2017Planning and Dissemination Grant - Institute Community Support

Principal investigators: Hirota, Simon A

Keywords: Digestive System; Host-Parastic Interaction; Immunology; Infectious Diseases; Inflammation; Lymphatics; Microbiome; Neuroinflammation; Pathophysiology; Pharmacology

$10,000

Microbiota modulation of xenbiotic receptor signaling and drug metabolism: A microbial take on precision medicine

SupervisorCIHR2016Fellowship - Priority Announcement: Gastroenterology

Principal investigators: Flannigan, Kyle

Keywords: Crohn'S Disease; Drug Metabolism; Host-Microbe Interactions; Inflammatory Bowel Disease; Microbiota; Personalized Medicine; Ulcerative Colitis

Targeting intestinal mesenchymal cell populations in fibrostenotic Crohn's disease - modulation of proliferative, fibrotic and inflammatory processes by NR4A1.

Nominated PICIHR2016Project Grant

Principal investigators: Hirota, Simon A

Keywords: Crohn'S Disease; Fibroblast; Fibrosis; Inflammation; Inflammatory Bowel Diseases; Mesenchyme; Smooth Muscle; Stricture

$910,350

Developing primary cell enteroid-derived intestinal epithelial monolayers to study barrier function

Principal investigatorNSERC2016Engage Grants Program

Principal investigators: Hirota, Simon

$24,310

The regulation of the intestinal epithelium and host-pathogen interactions by the constitutive androstane receptor

Principal investigatorNSERC2016Discovery Grants Program - Individual

Principal investigators: Hirota, Simon

$186,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

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Simon Hirota

Research

Latest papers

Latest funding

Neuronal ALKAL2 and its ALK receptor contribute to the development of colitis-associated colorectal cancer.

Association of Circulating Fibrocytes With Fibrostenotic Small Bowel Crohn's Disease.

Proteomics and Imaging in Crohn's Disease: TAILS of Unlikely Allies.

A Trypsin-Sensitive Proteoglycan from the Tapeworm Hymenolepis diminuta Inhibits Murine Neutrophil Chemotaxis in vitro by Suppressing p38 MAP Kinase Activation.

A simple, cost-effective method for generating murine colonic 3D enteroids and 2D monolayers for studies of primary epithelial cell function.

Inflammatory bowel disease cause-specific mortality: a primer for clinicians.

The NLRP3 inflammasome promotes renal inflammation and contributes to CKD.

Fungal Contributions to Milk Lipid Metabolism and Fat Absorption in Early Life

The regulation of intestinal first-pass metabolism by IL-22 - understanding the link between host-microbe/pathogen interactions and alterations in drug metabolism.

Intestinal mesenchymal regulation of mucosal inflammation

Canada Research Chair - Tier 2

Reducing Morbidity and Mortality in Inflammatory Bowel Disease by Targeting Intestinal Fibrosis

Kananaskis Inflammation Workshop for Trainees

Microbiota modulation of xenbiotic receptor signaling and drug metabolism: A microbial take on precision medicine

Targeting intestinal mesenchymal cell populations in fibrostenotic Crohn's disease - modulation of proliferative, fibrotic and inflammatory processes by NR4A1.

Developing primary cell enteroid-derived intestinal epithelial monolayers to study barrier function

The regulation of the intestinal epithelium and host-pathogen interactions by the constitutive androstane receptor

Frequent collaborators

Antoine Dufour

Cathy Lu

Kristi Baker

Humberto Jijon

Justin Chun

Remo Panaccione

Christophe Altier

Bruce Vallance