Faculty profile
MARK PAETZEL
Back to facultyThis profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a Simon Fraser University directory, so their courses may be missing. Find their university profile.
Research
Latest papers
Crystal structure of Escherichia coli type I signal peptidase P84A in complex with lipopeptide antibiotic arylomycin A2.
Journal of structural biology · 2025 · senior author
Functional and Structural Characterization of Treatment-Emergent Nirmatrelvir Resistance Mutations at Low Frequencies in the Main Protease (Mpro) Reveals a Unique Evolutionary Route for SARS-CoV-2 to Gain Resistance.
The Journal of infectious diseases · 2025
Kinetic comparison of all eleven viral polyprotein cleavage site processing events by SARS-CoV-2 main protease using a linked protein FRET platform.
The Journal of biological chemistry · 2024
Latest funding
- $90,000
High-resolution structural analysis of mechanistic steps in proteolysis
NSERC · 2023 · Principal investigator
- $100,000
COVID-19 Variant Network - Bespoke transition state analog inhibitors of SARS-CoV-2 3CL and PL proteases
CIHR · 2021 · Co-investigator
- $50,000
COVID-19 Variant Supplement - Bespoke transition state analog inhibitors of SARS-CoV-2 3CL and PL proteases
CIHR · 2021 · Co-investigator
36 publications.
Crystal structure of Escherichia coli type I signal peptidase P84A in complex with lipopeptide antibiotic arylomycin A2.
Luo C, Paetzel M
Functional and Structural Characterization of Treatment-Emergent Nirmatrelvir Resistance Mutations at Low Frequencies in the Main Protease (Mpro) Reveals a Unique Evolutionary Route for SARS-CoV-2 to Gain Resistance.
Deschenes NM, Pérez-Vargas J, Zhong Z, Thomas M, Kenward C, Mosimann WA, Worrall LJ, Waglechner N, Li AX, Maguire F, Aftanas P, Smith JR, Lim J, Young RN, Cherkasov A, Farooqi L, Moinuddin A, Siddiqi L, Malik I, Lefebvre M, Paetzel M, Strynadka NCJ, Jean F, McGeer A, Kozak RA
Kinetic comparison of all eleven viral polyprotein cleavage site processing events by SARS-CoV-2 main protease using a linked protein FRET platform.
Kenward C, Vuckovic M, Paetzel M, Strynadka NCJ
A novel class of broad-spectrum active-site-directed 3C-like protease inhibitors with nanomolar antiviral activity against highly immune-evasive SARS-CoV-2 Omicron subvariants.
Pérez-Vargas J, Worrall LJ, Olmstead AD, Ton AT, Lee J, Villanueva I, Thompson CAH, Dudek S, Ennis S, Smith JR, Shapira T, De Guzman J, Gang S, Ban F, Vuckovic M, Bielecki M, Kovacic S, Kenward C, Hong CY, Gordon DG, Levett PN, Krajden M, Leduc R, Boudreault PL, Niikura M, Paetzel M, Young RN, Cherkasov A, Strynadka NCJ, Jean F
Structural basis of broad-spectrum β-lactam resistance in Staphylococcus aureus.
Alexander JAN, Worrall LJ, Hu J, Vuckovic M, Satishkumar N, Poon R, Sobhanifar S, Rosell FI, Jenkins J, Chiang D, Mosimann WA, Chambers HF, Paetzel M, Chatterjee SS, Strynadka NCJ
X-ray crystallographic characterization of the SARS-CoV-2 main protease polyprotein cleavage sites essential for viral processing and maturation.
Lee J, Kenward C, Worrall LJ, Vuckovic M, Gentile F, Ton AT, Ng M, Cherkasov A, Strynadka NCJ, Paetzel M
Crystallographic structure of wild-type SARS-CoV-2 main protease acyl-enzyme intermediate with physiological C-terminal autoprocessing site.
Lee J, Worrall LJ, Vuckovic M, Rosell FI, Gentile F, Ton AT, Caveney NA, Ban F, Cherkasov A, Paetzel M, Strynadka NCJ
Bacterial Signal Peptidases.
Paetzel M
Expression and Purification of the Individual Bam Components BamB-E.
Aulakh S, Kim KH, Paetzel M
Structural characterization of the C3 domain of cardiac myosin binding protein C and its hypertrophic cardiomyopathy-related R502W mutant.
Zhang XL, De S, McIntosh LP, Paetzel M
High-resolution structural analysis of mechanistic steps in proteolysis
Principal investigators: PAETZEL, MARK
Keywords: proteases; peptidases; proteolysis; peptide bond hydrolysis; enzyme mechanism; acyl-enzyme complexes; transition states; substrate specificity / selection; enzyme kinetics; x-ray crystallography
COVID-19 Variant Network - Bespoke transition state analog inhibitors of SARS-CoV-2 3CL and PL proteases
Principal investigators: Strynadka, Natalie C
Keywords: Mechanism Based Inhiibtors; Pharmaceutical Development; Single Particle Cryoem; Structure Based Antimicrobial Discovery; Transition State Analogs; Viral Proteases; Xray Crystallography
COVID-19 Variant Supplement - Bespoke transition state analog inhibitors of SARS-CoV-2 3CL and PL proteases
Principal investigators: Strynadka, Natalie C
Keywords: Mechanism Based Inhiibtors; Pharmaceutical Development; Single Particle Cryoem; Structure Based Antimicrobial Discovery; Transition State Analogs; Viral Proteases; Xray Crystallography
Operations and Maintenance Support: UBC Regional Structural Biology Facility
Principal investigators: McIntosh, Lawrence
UV-visible spectrophotometer for specific biochemical utility
Principal investigators: Sen, Dipankar
X-ray Generator for Macromolecular Crystallography
Principal investigators: Paetzel, Mark
Calorimeter for measuring energetics of ligand-binding by titration
Principal investigators: Young, Edgar
Familial hypertrophic cardiomyopathy: etiology involving troponin mutations
Principal investigators: Tibbits, Glen F
Keywords: Ca Handling; Cardiomyocyte; Crystal Structure Of Troponin Complex; Isothermal Calorimetry (Itc); Molecular Dynamic Simulation; Molecular Dynamic Simulations; Myofilament Calcium Sensitivity; Nmr Structure Of Troponin C; Troponin C
Structural and mechanistic studies of Ser/Lys dyad proteases.
Principal investigators: Paetzel, Mark
A surface plasmon resonance instrument for the study of biomolecular interactions
Principal investigators: Scott, JamieKathleen
From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.
Frequent collaborators
- Richard Leduc and Pierre-Luc Boudreault: 20 shared papers
- Richard Leduc and Masahiro Niikura: 6 shared papers
- Masahiro Niikura and Pierre-Luc Boudreault: 6 shared papers
- Artem Cherkasov and MARK PAETZEL: 4 shared papers
- Mel Krajden and Richard Leduc: 4 shared papers
- Mel Krajden and Masahiro Niikura: 4 shared papers
- Mel Krajden and Pierre-Luc Boudreault: 4 shared papers
- Artem Cherkasov and Mel Krajden: 3 shared papers
- Artem Cherkasov and Richard Leduc: 3 shared papers
- Artem Cherkasov and Allison McGeer: 1 shared paper
- Artem Cherkasov and Finlay Maguire: 1 shared paper
- Mel Krajden and Allison McGeer: 1 shared paper
- Mel Krajden and MARK PAETZEL: 1 shared paper
- Richard Leduc and MARK PAETZEL: 1 shared paper
- Allison McGeer and Finlay Maguire: 1 shared paper
- Allison McGeer and MARK PAETZEL: 1 shared paper
- Finlay Maguire and MARK PAETZEL: 1 shared paper
- Masahiro Niikura and MARK PAETZEL: 1 shared paper
- Pierre-Luc Boudreault and MARK PAETZEL: 1 shared paper
- MOLECULAR BIOLOGY AND BIOCHEMISTRY
- Urologic Sciences
- Department of Laboratory Medicine and Pathobiology
- Faculty of Computer Science
- Health Sciences
- Laboratory Medicine and Pathology
- Pharmacologie
- Other
Co-authors at Simon Fraser University, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.
Artem Cherkasov
Urologic Sciences
4 shared papers, latest 2025
Mel Krajden
Laboratory Medicine and Pathology
1 shared papers, latest 2023
Richard Leduc
Physiology and Pharmacology
1 shared papers, latest 2023
Allison McGeer
Department of Laboratory Medicine and Pathobiology
1 shared papers, latest 2025
Finlay Maguire
Faculty of Computer Science
1 shared papers, latest 2025
Masahiro Niikura
Health Sciences
1 shared papers, latest 2023
Pierre-Luc Boudreault
Pharmacologie
1 shared papers, latest 2023
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