Faculty profile

Richard Leduc

ResearcherPhysiology and PharmacologyUniversité de Sherbrooke

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a Université de Sherbrooke directory, so their courses may be missing. Find their university profile.

Richard Leduc

Researcher

Physiology and Pharmacology

Health Sciences

Université de Sherbrooke

Sherbrooke, Quebec, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
26 publications in the last five years, latest in 2026.
Senior (last) author on 5 recent papers, a sign of leading a research group.
Principal investigator on 8 research grants (7 CIHR, 1 NSERC), most recently in 2021.
Supervised 3 trainees who won CIHR awards, most recently in 2025.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

103

Publications

Citations

h-index

Collaborators

Grants

Publications by year

Counts cover the works listed on the university profile; citation counts come from Dimensions.

Profiles and links

Search on Google Scholar

Find them onX · LinkedIn · Bluesky · YouTube

Signals and details

Research

Serine Protease Protease Inhibitors Host Protease Cell-Surface Protease Hepcidin Iron Disease Protease Inhibition Splice-Switching Oligonucleotides

Latest papers

TMPRSS2 inhibitors with broad-spectrum efficacy against SARS-CoV-2 (JN.1) and influenza A (H1N1) viruses protect mice from influenza A infection.
Emerging microbes & infections · 2026
Discovery of Highly Selective Noncovalent Macrocyclic Peptide Inhibitors Suppressing Both TMPRSS2 Protease Activity and Viral Receptor Function.
Journal of medicinal chemistry · 2026
Adhesion G protein-coupled receptors.
Pharmacological reviews · 2026

All 103 publications

Latest funding

Rôle et modulation de protéases de l'hôte impliquées dans les infections par les virus respiratoires.
CIHR · 2025 · Supervisor
$120,000
23rd Joint meeting of the Great Lakes GPCR Retreat and the Club des récepteurs à sept domaines transmembranaires du Québec
CIHR · 2024 · Co-investigator
$15,000
Impact of novel ubiquitin-based Galphas regulation on receptor signaling and trafficking
CIHR · 2023 · Co-investigator
$1,009,800

All 20 grants and awards

103 publications.

TMPRSS2 inhibitors with broad-spectrum efficacy against SARS-CoV-2 (JN.1) and influenza A (H1N1) viruses protect mice from influenza A infection.

Presley L, Pérez-Vargas J, Saintigny A, Villanueva I, Ho M, Fone J, Brinsden L, Kaushik N, Olver S, Thompson CAH, Bautista-Sánchez D, Ennis S, Chen M, McCallum M, Brown JT, Ferková S, Hetrick B, Veesler D, Leduc R, Niikura M, Boudreault PL, Warner B, Jean F

Emerging microbes & infections2026

DOI: 10.1080/22221751.2026.2616944 PMID: 41612887

Discovery of Highly Selective Noncovalent Macrocyclic Peptide Inhibitors Suppressing Both TMPRSS2 Protease Activity and Viral Receptor Function.

Tombling BJ, Lemieux G, Joushomme A, Wei Y, Adaligil E, Farrell B, Fleming S, Yu Q, Ma B, Cunningham CN, Krystufek R, Song A, Désilets A, Leduc R, Kirchhofer D

Journal of medicinal chemistry2026

DOI: 10.1021/acs.jmedchem.6c01094 PMID: 42720461

Adhesion G protein-coupled receptors.

Langenhan T, Anderson GR, Araç D, Aust G, Avila-Zozaya M, Bagger SM, Barth P, Berndt S, Blacklow SC, Blanco-Redondo B, Boucard AA, Bridges JP, Brodmerkel LS, Caron KM, Chung YK, Dates AN, de Araujo Farias V, Del Toro D, Duman JG, Engel FB, Favara DM, Formstone CJ, Fu C, Garcia De Las Bayonas A, Georgiadi A, Gloriam DE, Hall RA, Hamann J, Hildebrand PW, Hsiao CC, Huang BX, Javitch JA, Kim HY, Kittel RJ, Kleinau G, Leduc R, Liebscher I, Lin HH, Linnert J, Ludwig MG, Martinelli DC, Mathiasen S, Matúš D, Melkumyan M, Moreno-Salinas AL, Mulder J, Nash MA, Pal K, Pederick DT, Perry-Hauser NA, Piao X, Ping YQ, Placantonakis DG, Pohl F, Prömel S, Rosenkilde MM, Sabbagh L, Sando RC, Scheerer P, Schöneberg T, Seiradake E, Selcho M, Seufert F, Singh AK, Skiniotis G, Spiess K, Sträter N, Strutt D, Südhof TC, Sun J, Tall GG, Thor D, Tilley DG, Tolias KF, Vallon M, Van Meir EG, Vanhollebeke B, Wiggin GR, Wolfrum U, Yan J, Zaidman NA, Zou Y, Scholz N

Pharmacological reviews2026

DOI: 10.1016/j.pharmr.2026.100116 PMID: 41895071

Adhesion GPCR ADGRL1/Latrophilin-1 mobilizes β-arrestins as a prerequisite for endosomal restriction of G protein activation and splice-dependent scaffolds.

Ribalta-Mena S, Moreno-Salinas AL, Hernández-Aranda J, Calderón-Amador J, Correoso-Braña KG, Vialou V, Olivares-Reyes JA, Leduc R, Boucard AA

Biochimica et biophysica acta. Molecular cell research2026

DOI: 10.1016/j.bbamcr.2026.120132 PMID: 41819453

Tunable Biased Signaling of the Angiotensin II Type 1 Receptor for Inotropy via C-Terminal Peptide Engineering and Allosteric Site Targeting.

Hadjadj M, Hassanzadeh M, Martel J, Roy MF, Giguère H, Murza A, Holleran BJ, Namkung Y, Froehlich U, Leduc R, Auger-Messier M, Laporte SA, Boudreault PL

Journal of medicinal chemistry2026

DOI: 10.1021/acs.jmedchem.5c01259 PMID: 41545027

Structural insights into frog skin-derived cyclic peptides as selective matriptase inhibitors.

Gitlin-Domagalska A, Hassanzadeh M, Helbik-Maciejewska A, Lepage M, Joushomme A, Désilets A, Dębowski D, Boudreault PL, Leduc R, Rolka K

European journal of medicinal chemistry2026

DOI: 10.1016/j.ejmech.2025.118331 PMID: 41202650

Structure-Guided Optimization of Selective Covalent Reversible Peptidomimetic Inhibitors Targeting TMPRSS6.

Guerrab W, Lepage M, Désilets A, Joushomme A, Desgagné M, Froehlich U, Leduc R, Boudreault PL

Journal of medicinal chemistry2025

DOI: 10.1021/acs.jmedchem.5c01998 PMID: 41349957

Development of ketobenzothiazole-based peptidomimetic TMPRSS13 inhibitors with low nanomolar potency.

Joushomme A, Désilets A, Champagne W, Hassanzadeh M, Lemieux G, Gravel-Trudeau A, Lepage M, Lafrenière S, Froehlich U, List K, Boudreault PL, Leduc R

Journal of enzyme inhibition and medicinal chemistry2025Senior author

DOI: 10.1080/14756366.2025.2466841 PMID: 39976239

Optimizing the pharmacokinetics and selectivity of TMPRSS2 inhibitors.

Ferková S, Lepage M, Désilets A, Assouvie K, Lemieux G, Brochu I, Froehlich U, Gravel-Trudeau A, Vastra J, Jean F, Sarret P, Leduc R, Boudreault PL

European journal of medicinal chemistry2025

DOI: 10.1016/j.ejmech.2025.117579 PMID: 40382841

Decoding ADGRE5: How Proteolytic Cleavage and Mechanical Forces Unleash Cellular Signals.

Moreno-Salinas AL, Mancini A, Aouad S, Kandasamy H, Morissette S, Maiga A, Bouvier M, Leduc R, Sabbagh L

Cells2025

DOI: 10.3390/cells14161284 PMID: 40862763

Something wrong or missing on this profile? Suggest a correction

Richard Leduc

Research

Latest papers

Latest funding

TMPRSS2 inhibitors with broad-spectrum efficacy against SARS-CoV-2 (JN.1) and influenza A (H1N1) viruses protect mice from influenza A infection.

Discovery of Highly Selective Noncovalent Macrocyclic Peptide Inhibitors Suppressing Both TMPRSS2 Protease Activity and Viral Receptor Function.

Adhesion G protein-coupled receptors.

Adhesion GPCR ADGRL1/Latrophilin-1 mobilizes &#x3b2;-arrestins as a prerequisite for endosomal restriction of G protein activation and splice-dependent scaffolds.

Tunable Biased Signaling of the Angiotensin II Type 1 Receptor for Inotropy via C-Terminal Peptide Engineering and Allosteric Site Targeting.

Structural insights into frog skin-derived cyclic peptides as selective matriptase inhibitors.

Structure-Guided Optimization of Selective Covalent Reversible Peptidomimetic Inhibitors Targeting TMPRSS6.

Development of ketobenzothiazole-based peptidomimetic TMPRSS13 inhibitors with low nanomolar potency.

Optimizing the pharmacokinetics and selectivity of TMPRSS2 inhibitors.

Decoding ADGRE5: How Proteolytic Cleavage and Mechanical Forces Unleash Cellular Signals.

Frequent collaborators

Pierre Lavigne

Pierre-Luc Boudreault

Philippe Sarret

Mannix Auger-Messier

Masahiro Niikura

Eric Marsault

Christine Lavoie

Olivier Lesur

Michel Bouvier

Mel Krajden

Artem Cherkasov

Gaétan Guillemette

Pierre-Luc Boudreault

Richard Leduc

Bryce Warner

Aled Edwards

Jean-François Thibodeau

Benjamin Haibe-Kains

Robert Gros

Theodore Steiner

Simon De Denus

Jean-Patrice Baillargeon

Jean-Lucien Rouleau

Richard Leduc

Jean-Claude Tardif

Nikolaus Heveker

Louis Gendron

Christophe Altier

Jean-Claude Tardif

Adhesion GPCR ADGRL1/Latrophilin-1 mobilizes β-arrestins as a prerequisite for endosomal restriction of G protein activation and splice-dependent scaffolds.