Faculty profile
Masahiro Niikura
Back to facultyThis profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a Simon Fraser University directory, so their courses may be missing. Find their university profile.
Research
Latest papers
TMPRSS2 inhibitors with broad-spectrum efficacy against SARS-CoV-2 (JN.1) and influenza A (H1N1) viruses protect mice from influenza A infection.
Emerging microbes & infections · 2026
From N-0385 to N-0920: Unveiling a Host-Directed Protease Inhibitor with Picomolar Antiviral Efficacy against Prevalent SARS-CoV-2 Variants.
Journal of medicinal chemistry · 2025
Effects of Ikaros (IKZF1) gene in the virulence of Marek's disease virus.
Veterinary microbiology · 2025
Latest funding
- $96,000
Marek's disease avian herpesvirus - Learning from differences
NSERC · 2022 · Principal investigator
Evaluating the durability and cross-reactivity of SARS-CoV-2 immunity elicited by COVID-19 vaccines
CIHR · 2021 · Co-investigator
- $516,980
SARS-CoV-2 Rapid Research: Fast track isothermal viral diagnostics
CIHR · 2020 · Principal investigator
35 publications.
TMPRSS2 inhibitors with broad-spectrum efficacy against SARS-CoV-2 (JN.1) and influenza A (H1N1) viruses protect mice from influenza A infection.
Presley L, Pérez-Vargas J, Saintigny A, Villanueva I, Ho M, Fone J, Brinsden L, Kaushik N, Olver S, Thompson CAH, Bautista-Sánchez D, Ennis S, Chen M, McCallum M, Brown JT, Ferková S, Hetrick B, Veesler D, Leduc R, Niikura M, Boudreault PL, Warner B, Jean F
From N-0385 to N-0920: Unveiling a Host-Directed Protease Inhibitor with Picomolar Antiviral Efficacy against Prevalent SARS-CoV-2 Variants.
Lemieux G, Pérez-Vargas J, Désilets A, Hassanzadeh M, Thompson CAH, Gravel-Trudeau A, Joushomme A, Ennis S, Villanueva I, Marouseau É, Fraser BJ, Champagne W, Lepage M, Niikura M, Arrowsmith CH, Jean F, Leduc R, Boudreault PL
Effects of Ikaros (IKZF1) gene in the virulence of Marek's disease virus.
Kim T, Niikura M, Dunn JR, Cheng HH, Hearn CJ
Nanomolar anti-SARS-CoV-2 Omicron activity of the host-directed TMPRSS2 inhibitor N-0385 and synergistic action with direct-acting antivirals.
Pérez-Vargas J, Lemieux G, Thompson CAH, Désilets A, Ennis S, Gao G, Gordon DG, Schulz AL, Niikura M, Nabi IR, Krajden M, Boudreault PL, Leduc R, Jean F
Corrigendum to "Discovery of lead natural products for developing pan-SARS-CoV-2 therapeutics" "Antiviral Research 209 (2023)/105484".
Perez-Vargas J, Shapira T, Olmstead AD, Villanueva I, Thompson CAH, Ennis S, Gao G, De Guzman J, Williams DE, Wang M, Chin A, Bautista-Sanchez D, Agafitei O, Levett P, Xie X, Nuzzo G, Freire VF, Quintana-Bulla JI, Bernardi DI, Gubiani JR, Suthiphasilp V, Raksat A, Meesakul P, Polbuppha I, Cheenpracha S, Jaidee W, Kanokmedhakul K, Yenjai C, Chaiyosang B, Teles HL, Manzo E, Fontana A, Leduc R, Boudreault PL, Berlinck RGS, Laphookhieo S, Kanokmedhakul S, Tietjen I, Cherkasov A, Krajden M, Nabi IR, Niikura M, Shi PY, Andersen RJ, Jean F
People With Human Immunodeficiency Virus Receiving Suppressive Antiretroviral Therapy Show Typical Antibody Durability After Dual Coronavirus Disease 2019 Vaccination and Strong Third Dose Responses.
Lapointe HR, Mwimanzi F, Cheung PK, Sang Y, Yaseen F, Umviligihozo G, Kalikawe R, Speckmaier S, Moran-Garcia N, Datwani S, Duncan MC, Agafitei O, Ennis S, Young L, Ali H, Ganase B, Omondi FH, Dong W, Toy J, Sereda P, Burns L, Costiniuk CT, Cooper C, Anis AH, Leung V, Holmes DT, DeMarco ML, Simons J, Hedgcock M, Prystajecky N, Lowe CF, Pantophlet R, Romney MG, Barrios R, Guillemi S, Brumme CJ, Montaner JSG, Hull M, Harris M, Niikura M, Brockman MA, Brumme ZL
SARS-CoV-2 live virus neutralization after four COVID-19 vaccine doses in people with HIV receiving suppressive antiretroviral therapy.
Cheung PK, Lapointe HR, Sang Y, Ennis S, Mwimanzi F, Speckmaier S, Barad E, Dong W, Liang R, Simons J, Lowe CF, Romney MG, Brumme CJ, Niikura M, Brockman MA, Brumme ZL, and the COVID-19 vaccine immunity study team
Impact of Age and Severe Acute Respiratory Syndrome Coronavirus 2 Breakthrough Infection on Humoral Immune Responses After Three Doses of Coronavirus Disease 2019 mRNA Vaccine.
Mwimanzi F, Lapointe HR, Cheung PK, Sang Y, Yaseen F, Kalikawe R, Datwani S, Burns L, Young L, Leung V, Ennis S, Brumme CJ, Montaner JSG, Dong W, Prystajecky N, Lowe CF, DeMarco ML, Holmes DT, Simons J, Niikura M, Romney MG, Brumme ZL, Brockman MA
Discovery of lead natural products for developing pan-SARS-CoV-2 therapeutics.
Pérez-Vargas J, Shapira T, Olmstead AD, Villanueva I, Thompson CAH, Ennis S, Gao G, De Guzman J, Williams DE, Wang M, Chin A, Bautista-Sánchez D, Agafitei O, Levett P, Xie X, Nuzzo G, Freire VF, Quintana-Bulla JI, Bernardi DI, Gubiani JR, Suthiphasilp V, Raksat A, Meesakul P, Polbuppha I, Cheenpracha S, Jaidee W, Kanokmedhakul K, Yenjai C, Chaiyosang B, Teles HL, Manzo E, Fontana A, Leduc R, Boudreault PL, Berlinck RGS, Laphookhieo S, Kanokmedhakul S, Tietjen I, Cherkasov A, Krajden M, Nabi IR, Niikura M, Shi PY, Andersen RJ, Jean F
A novel class of broad-spectrum active-site-directed 3C-like protease inhibitors with nanomolar antiviral activity against highly immune-evasive SARS-CoV-2 Omicron subvariants.
Pérez-Vargas J, Worrall LJ, Olmstead AD, Ton AT, Lee J, Villanueva I, Thompson CAH, Dudek S, Ennis S, Smith JR, Shapira T, De Guzman J, Gang S, Ban F, Vuckovic M, Bielecki M, Kovacic S, Kenward C, Hong CY, Gordon DG, Levett PN, Krajden M, Leduc R, Boudreault PL, Niikura M, Paetzel M, Young RN, Cherkasov A, Strynadka NCJ, Jean F
Marek's disease avian herpesvirus - Learning from differences
Principal investigators: Niikura, Masahiro
Evaluating the durability and cross-reactivity of SARS-CoV-2 immunity elicited by COVID-19 vaccines
Principal investigators: Brockman, Mark A; Breden, Felix J
Keywords: B Cell Receptor (Bcr) Diversity; Covid-19 Vaccines; Elderly Adults; Neutralizing Antibodies; Single-Cell Rna Sequencing; Viral Variants / Voc
SARS-CoV-2 Rapid Research: Fast track isothermal viral diagnostics
Principal investigators: Unrau, Peter J; Niikura, Masahiro
Keywords: Covid-19; Flurogenic Rna Mango Aptamers; High Throughput Sequencing; Isothermal Amplification; Medical Testing Device; Nasba; Patient Clinical Samples; Rt-Pcr; Sars-Cov-2; Viral Infection
Enhancement of immunogenicity by increased retention of antigenic proteins to injection sites and multimerization
Principal investigators: Niikura, Masahiro
Barriers to engaging young people in HIV vaccine trials in a priority setting.
Principal investigators: Brockman, Mark A; De Bruyn, Guy; Gray, Glenda E; Kaida, Angela K; Ndung'u, Thumbi; Snyder, Jeremy C
Keywords: Acute Hiv Infection; Adolescent Populations (High-Risk); Biomedical Research; Hiv/Aids; Medical/Research Ethics; Socio-Behavioral Analysis
Marek's disease, a lymphoma caused by herpesvirus-replication dynamics, pathogenesis and vaccine effect
Principal investigators: Niikura, Masahiro
From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.
Frequent collaborators
- Curtis Cooper and Mark Hull: 27 shared papers
- Richard Leduc and Pierre-Luc Boudreault: 20 shared papers
- Mark Hull and Rolando Barrios: 15 shared papers
- Mel Krajden and Natalie Prystajecky: 8 shared papers
- Ralph Pantophlet and Masahiro Niikura: 7 shared papers
- Richard Leduc and Masahiro Niikura: 6 shared papers
- Masahiro Niikura and Natalie Prystajecky: 6 shared papers
- Masahiro Niikura and Pierre-Luc Boudreault: 6 shared papers
- Curtis Cooper and Rolando Barrios: 5 shared papers
- Curtis Cooper and Ralph Pantophlet: 4 shared papers
- Curtis Cooper and Masahiro Niikura: 4 shared papers
- Ralph Pantophlet and Mark Hull: 4 shared papers
- Ralph Pantophlet and Rolando Barrios: 4 shared papers
- Ralph Pantophlet and Natalie Prystajecky: 4 shared papers
- Mel Krajden and Richard Leduc: 4 shared papers
- Mel Krajden and Masahiro Niikura: 4 shared papers
- Mel Krajden and Pierre-Luc Boudreault: 4 shared papers
- Mark Hull and Masahiro Niikura: 4 shared papers
- Rolando Barrios and Masahiro Niikura: 4 shared papers
- Artem Cherkasov and Mel Krajden: 3 shared papers
- Artem Cherkasov and Richard Leduc: 3 shared papers
- Artem Cherkasov and Masahiro Niikura: 3 shared papers
- Michel Roberge and Masahiro Niikura: 2 shared papers
- Jeremy Hirota and Masahiro Niikura: 1 shared paper
- David Fedida and Masahiro Niikura: 1 shared paper
- Richard Leduc and Bryce Warner: 1 shared paper
- Richard Liggins and Masahiro Niikura: 1 shared paper
- Masahiro Niikura and Bryce Warner: 1 shared paper
- Pierre-Luc Boudreault and Bryce Warner: 1 shared paper
- Molecular Biology and Biochemistry
- Laboratory Medicine and Pathology
- Medicine
- Urologic Sciences
- Pharmacologie - Physiologie
- Physiology and Pharmacology
- Department of Medicine
- Other
Co-authors at Simon Fraser University, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.
Ralph Pantophlet
Molecular Biology and Biochemistry
7 shared papers, latest 2023
Natalie Prystajecky
Laboratory Medicine and Pathology
6 shared papers, latest 2023
Pierre-Luc Boudreault
Pharmacologie - Physiologie
6 shared papers, latest 2026
Richard Leduc
Physiology and Pharmacology
6 shared papers, latest 2026
Curtis Cooper
Department of Medicine
4 shared papers, latest 2023
Rolando Barrios
Faculty
4 shared papers, latest 2023
Mel Krajden
Laboratory Medicine and Pathology
4 shared papers, latest 2024
Mark Hull
Medicine
4 shared papers, latest 2023
Artem Cherkasov
Urologic Sciences
3 shared papers, latest 2023
Michel Roberge
Biochemistry and Molecular Biology
2 shared papers, latest 2020
Bryce Warner
Vaccine and Infectious Disease Organization
1 shared papers, latest 2026
Richard Liggins
Urologic Sciences
1 shared papers, latest 2015
David Fedida
Anesthesiology, Pharmacology and Therapeutics
1 shared papers, latest 2016
Jeremy Hirota
Medicine
1 shared papers, latest 2021
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