Faculty profile
Ralph Pantophlet
Back to facultyResearch
Read how they describe their research on their Simon Fraser University profile.
Latest papers
A unified platform for nucleoside analog synthesis.
Science (New York, N.Y.) · 2026
Glycosylation of an N-Acetylated Glucosamine Disaccharide Using an Orthogonally Protected 3-Iodo-Kdo Fluoride Donor.
ChemistryOpen · 2025
Lewis-X-Containing Triterpenoid Saponins Inhibit DC-SIGN- and L-SIGN-Mediated Transfer of HIV-1 Infection.
Chemistry (Weinheim an der Bergstrasse, Germany) · 2025
Latest funding
Evaluating the durability and cross-reactivity of SARS-CoV-2 immunity elicited by COVID-19 vaccines
CIHR · 2021 · Co-investigator
- $30,000
Synthetic saponins as inhibitors of virus:DC-SIGN interactions _x000d_
NSERC · 2020 · Co-investigator
- $110,000
A bacterially derived mimetic of mammalian oligomannose for eliciting anti-HIV glycan antibodies
CIHR · 2016 · Nominated PI
25 publications.
A unified platform for nucleoside analog synthesis.
Anketell MJ, Fung E, Liu W, Shinde M, He CQ, Ng KWC, Silverman SM, Campeau LC, Pantophlet R, Britton R
Glycosylation of an N-Acetylated Glucosamine Disaccharide Using an Orthogonally Protected 3-Iodo-Kdo Fluoride Donor.
Goto T, Kerner L, Blaukopf M, Stöger B, Pantophlet R, Kosma P
Lewis-X-Containing Triterpenoid Saponins Inhibit DC-SIGN- and L-SIGN-Mediated Transfer of HIV-1 Infection.
Gamboa Marin OJ, Ng K, Verma N, Flavien Yapi AG, Pantophlet R, Gauthier C
People With Human Immunodeficiency Virus Receiving Suppressive Antiretroviral Therapy Show Typical Antibody Durability After Dual Coronavirus Disease 2019 Vaccination and Strong Third Dose Responses.
Lapointe HR, Mwimanzi F, Cheung PK, Sang Y, Yaseen F, Umviligihozo G, Kalikawe R, Speckmaier S, Moran-Garcia N, Datwani S, Duncan MC, Agafitei O, Ennis S, Young L, Ali H, Ganase B, Omondi FH, Dong W, Toy J, Sereda P, Burns L, Costiniuk CT, Cooper C, Anis AH, Leung V, Holmes DT, DeMarco ML, Simons J, Hedgcock M, Prystajecky N, Lowe CF, Pantophlet R, Romney MG, Barrios R, Guillemi S, Brumme CJ, Montaner JSG, Hull M, Harris M, Niikura M, Brockman MA, Brumme ZL
Large-Scale Virtual Screening for the Discovery of SARS-CoV-2 Papain-like Protease (PLpro) Non-covalent Inhibitors.
Garland O, Ton AT, Moradi S, Smith JR, Kovacic S, Ng K, Pandey M, Ban F, Lee J, Vuckovic M, Worrall LJ, Young RN, Pantophlet R, Strynadka NCJ, Cherkasov A
Older Adults Mount Less Durable Humoral Responses to Two Doses of COVID-19 mRNA Vaccine but Strong Initial Responses to a Third Dose.
Mwimanzi F, Lapointe HR, Cheung PK, Sang Y, Yaseen F, Umviligihozo G, Kalikawe R, Datwani S, Omondi FH, Burns L, Young L, Leung V, Agafitei O, Ennis S, Dong W, Basra S, Lim LY, Ng K, Pantophlet R, Brumme CJ, Montaner JSG, Prystajecky N, Lowe CF, DeMarco ML, Holmes DT, Simons J, Niikura M, Romney MG, Brumme ZL, Brockman MA
Synthetic Neoglycoconjugates of Hepta- and Nonamannoside Ligands for Eliciting Oligomannose-Specific HIV-1-Neutralizing Antibodies.
Cattin M, Bruxelle JF, Ng K, Blaukopf M, Pantophlet R, Kosma P
Reduced Magnitude and Durability of Humoral Immune Responses to COVID-19 mRNA Vaccines Among Older Adults.
Brockman MA, Mwimanzi F, Lapointe HR, Sang Y, Agafitei O, Cheung PK, Ennis S, Ng K, Basra S, Lim LY, Yaseen F, Young L, Umviligihozo G, Omondi FH, Kalikawe R, Burns L, Brumme CJ, Leung V, Montaner JSG, Holmes D, DeMarco ML, Simons J, Pantophlet R, Niikura M, Romney MG, Brumme ZL
People with HIV receiving suppressive antiretroviral therapy show typical antibody durability after dual COVID-19 vaccination, and strong third dose responses.
Lapointe HR, Mwimanzi F, Cheung PK, Sang Y, Yaseen F, Umviligihozo G, Kalikawe R, Speckmaier S, Moran-Garcia N, Datwani S, Duncan MC, Agafitei O, Ennis S, Young L, Ali H, Ganase B, Omondi FH, Dong W, Toy J, Sereda P, Burns L, Costiniuk CT, Cooper C, Anis AH, Leung V, Holmes D, DeMarco ML, Simons J, Hedgcock M, Prystajecky N, Lowe CF, Pantophlet R, Romney MG, Barrios R, Guillemi S, Brumme CJ, Montaner JSG, Hull M, Harris M, Niikura M, Brockman MA, Brumme ZL
Humoral immune responses to COVID-19 vaccination in people living with HIV receiving suppressive antiretroviral therapy.
Brumme ZL, Mwimanzi F, Lapointe HR, Cheung PK, Sang Y, Duncan MC, Yaseen F, Agafitei O, Ennis S, Ng K, Basra S, Lim LY, Kalikawe R, Speckmaier S, Moran-Garcia N, Young L, Ali H, Ganase B, Umviligihozo G, Omondi FH, Atkinson K, Sudderuddin H, Toy J, Sereda P, Burns L, Costiniuk CT, Cooper C, Anis AH, Leung V, Holmes D, DeMarco ML, Simons J, Hedgcock M, Romney MG, Barrios R, Guillemi S, Brumme CJ, Pantophlet R, Montaner JSG, Niikura M, Harris M, Hull M, Brockman MA
Evaluating the durability and cross-reactivity of SARS-CoV-2 immunity elicited by COVID-19 vaccines
Principal investigators: Brockman, Mark A; Breden, Felix J
Keywords: B Cell Receptor (Bcr) Diversity; Covid-19 Vaccines; Elderly Adults; Neutralizing Antibodies; Single-Cell Rna Sequencing; Viral Variants / Voc
Synthetic saponins as inhibitors of virus:DC-SIGN interactions _x000d_
Principal investigators: Gauthier, Charles
A bacterially derived mimetic of mammalian oligomannose for eliciting anti-HIV glycan antibodies
Principal investigators: Pantophlet, Ralph A
Keywords: Broadly Neutralizing Antibodies; Hiv; Lipooligosaccharide; Molecular Mimicry; Oligomannose; Synthetic Carbohydrate Vaccine
Probing biased recognition of flu hemagglutinin by precursors of broadly neutralizing antibodies to the HA stem
Principal investigators: Pantophlet, Ralph A
Keywords: B Cell Lineage; Broadly Neutralizing Antibodies; Ha Stem; Human Antibody-Transgenic Animals; Influenza; Maturation Pathways; Naïve Antibody Repertoire
Exploring immunogen requirements for the priming of hetero-subtypic neutralizing antibodies to flu
Principal investigators: Pantophlet, Ralph A
Keywords: Affinity Maturation; Anti-Viral Immunity; B Cell; Deep Sequencing; Germline Antibody Repertoire; Ha2; Human Antibody-Transgenic Animals; Immunization Regimen; Vaccine; Vh1-69
Probing MBL function in oligomannose-specific anti-HIV antibody responses
Principal investigators: Pantophlet, Ralph A
Keywords: Hiv-1; Innate Immunity; Lectin; Neutralizing Antibodies; Oligomannose
ImmunoVancouver 2013
Principal investigators: Choy, Jonathan C; Pantophlet, Ralph A
Keywords: Cancer; Chronic Diseases; Diabetes; Hiv; Immunology; Immunotherapy; Inflammation; Interdisciplinary Collaborations; Vaccines
The Botswana-Canada AIDS Vaccine Discovery Partnership
Principal investigators: Wainberg, Mark A; Musonda, Rosemary M
Keywords: Hiv/Aids; Neutralizing Antibody; Vaccine
Barriers to engaging young people in HIV vaccine trials in a priority setting.
Principal investigators: Brockman, Mark A; De Bruyn, Guy; Gray, Glenda E; Kaida, Angela K; Ndung'u, Thumbi; Snyder, Jeremy C
Keywords: Acute Hiv Infection; Adolescent Populations (High-Risk); Biomedical Research; Hiv/Aids; Medical/Research Ethics; Socio-Behavioral Analysis
ImmunoVancouver 2012
Principal investigators: Choy, Jonathan C; Pantophlet, Ralph A
Keywords: Cancer; Chronic Diseases; Diabetes; Hiv; Immunology; Inflammation; Interdisciplinary Collaborations
From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.
Frequent collaborators
- Curtis Cooper and Mark Hull: 27 shared papers
- Mark Hull and Rolando Barrios: 15 shared papers
- Masahiro Niikura and Victor Leung: 9 shared papers
- Ralph Pantophlet and Victor Leung: 8 shared papers
- Ralph Pantophlet and Masahiro Niikura: 7 shared papers
- Mark Hull and Victor Leung: 7 shared papers
- Natalie Prystajecky and Victor Leung: 7 shared papers
- Masahiro Niikura and Natalie Prystajecky: 6 shared papers
- Curtis Cooper and Rolando Barrios: 5 shared papers
- Curtis Cooper and Victor Leung: 5 shared papers
- Rolando Barrios and Victor Leung: 5 shared papers
- Curtis Cooper and Ralph Pantophlet: 4 shared papers
- Ralph Pantophlet and Mark Hull: 4 shared papers
- Ralph Pantophlet and Rolando Barrios: 4 shared papers
- Ralph Pantophlet and Natalie Prystajecky: 4 shared papers
- Artem Cherkasov and Masahiro Niikura: 3 shared papers
- Artem Cherkasov and Ralph Pantophlet: 1 shared paper
- Ralph Pantophlet and Charles Gauthier: 1 shared paper
- Ralph Pantophlet and Robert Britton: 1 shared paper
- Department of Medicine
- Department of Electrical and Computer Engineering
- Laboratory Medicine and Pathology
- Department of Urologic Sciences
- Centre Armand-Frappier Santé Biotechnologie
- Department of Chemistry
- Other
Co-authors at Simon Fraser University, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.
Victor Leung
Department of Electrical and Computer Engineering
8 shared papers, latest 2023
Masahiro Niikura
Faculty
7 shared papers, latest 2023
Mark Hull
Department of Medicine
4 shared papers, latest 2023
Rolando Barrios
Faculty
4 shared papers, latest 2023
Natalie Prystajecky
Laboratory Medicine and Pathology
4 shared papers, latest 2023
Curtis Cooper
Department of Medicine
4 shared papers, latest 2023
Charles Gauthier
Centre Armand-Frappier Santé Biotechnologie
1 shared papers, latest 2025
Robert Britton
Department of Chemistry
1 shared papers, latest 2026
Artem Cherkasov
Department of Urologic Sciences
1 shared papers, latest 2023
A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.
Profile data last refreshed on September 27, 2026 from the university directory, publication records and CIHR, NSERC and SSHRC funding.