Shoukat Dedhar

Drug tolerance and persistence to EGFR inhibitor treatment are mediated by an ILK-SFK-YAP signaling axis in lung adenocarcinoma.

Shi R, Farnsworth DA, Febres-Aldana CA, Chow JLM, Sheena R, Atwal T, Gomez Marti JL, Li S, Thomas KN, Lee CM, Awrey SJ, McDonald PC, Somwar R, Dedhar S, Ladanyi M, Bennewith KL, Lockwood WW

"Several birds with one stone": exploring the potential of AI methods for multi-target drug design.

Mukaidaisi M, Ahmed M, Grantham K, Al-Jumaily A, Dedhar S, Organ M, Tchagang A, Hou J, Ahmed SE, Dividino R, Li Y

Neutrophil extracellular trap gene expression signatures identify prognostic and targetable signaling axes for inhibiting pancreatic tumour metastasis.

McDonald PC, Topham JT, Awrey S, Tavakoli H, Carroll R, Brown WS, Gerbec ZJ, Kalloger SE, Karasinska JM, Tang P, Goodwin R, Jones SJM, Laskin J, Marra MA, Morin GB, Renouf DJ, Schaeffer DF, Dedhar S

Identification of intratumoral bacteria that enhance breast tumor metastasis.

Gerbec ZJ, Serapio-Palacios A, Metcalfe-Roach A, Krekhno Z, Bar-Yoseph H, Woodward SE, Pena-Díaz J, Nemirovsky O, Awrey S, Moreno SH, Beatty S, Kong E, Radisavljevic N, Cirstea M, Chafe S, McDonald PC, Aparicio S, Finlay BB, Dedhar S

Dual inhibition of carbonic anhydrase IX and glutathione peroxidase 4 as a novel strategy for ferroptosis-induced tumor cell death.

Renzi G, McDonald PC, Awrey S, Tavakoli H, Bokhari Z, Lyle M, Zhang Z, Ferraroni M, Dedhar S, Supuran CT, Angeli A

Combination treatment with histone deacetylase and carbonic anhydrase 9 inhibitors shows therapeutic potential in experimental diffuse intrinsic pontine glioma.

Fujita N, Bondoc A, Simoes S, Ishida J, Taccone MS, Luck A, Srikanthan D, Siddaway R, Levine A, Sabha N, Krumholtz S, Kondo A, Arai H, Smith C, McDonald P, Hawkins C, Dedhar S, Rutka J

PrPC controls epithelial-to-mesenchymal transition in EGFR-mutated NSCLC: implications for TKI resistance and patient follow-up.

Lailler C, Didelot A, Garinet S, Berthou H, Sroussi M, de Reyniès A, Dedhar S, Martin-Lannerée S, Fabre E, Le Pimpec-Barthes F, Perrier A, Poindessous V, Mansuet-Lupo A, Djouadi F, Launay JM, Laurent-Puig P, Blons H, Mouillet-Richard S

Persister cell plasticity in tumour drug resistance.

McDonald PC, Dedhar S

Pancreatic cancer tumor organoids exhibit subtype-specific differences in metabolic profiles.

Ali HA, Karasinska JM, Topham JT, Johal D, Kalloger S, Metcalfe A, Warren CS, Miyagi A, Tao LV, Kevorkova M, Chafe SC, McDonald PC, Dedhar S, Parker SJ, Renouf DJ, Schaeffer DF

A Carbonic Anhydrase IX/SLC1A5 Axis Regulates Glutamine Metabolism Dependent Ferroptosis in Hypoxic Tumor Cells