Faculty profile
Cornelis Van Breemen
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Latest papers
Nanojunctions: Specificity of Ca2+ signaling requires nano-scale architecture of intracellular membrane contact sites.
Cell calcium · 2024
Two-Dimensional Interfacial Exchange Diffusion Has the Potential to Augment Spatiotemporal Precision of Ca2+ Signaling.
International journal of molecular sciences · 2022 · first author
Aortic Dimensions, Biophysical Properties, and Plasma Biomarkers in Children and Adults with Marfan or Loeys-Dietz Syndrome.
CJC open · 2021
Latest funding
- $669,376
The role of endothelial function in the pathogenesis and management of Marfan syndrome-associated aortic disease
CIHR · 2018 · Principal investigator
- $759,525
Cellular Mechanisms underlying vascular dysfunction & aortic aneurysm in Marfan syndrome
CIHR · 2010 · Nominated PI
46 publications.
Nanojunctions: Specificity of Ca2+ signaling requires nano-scale architecture of intracellular membrane contact sites.
Fameli N, van Breemen C, Groschner K
Two-Dimensional Interfacial Exchange Diffusion Has the Potential to Augment Spatiotemporal Precision of Ca2+ Signaling.
van Breemen C, Fameli N, Groschner K
Aortic Dimensions, Biophysical Properties, and Plasma Biomarkers in Children and Adults with Marfan or Loeys-Dietz Syndrome.
Cui JZ, Harris KC, Raedschelders K, Hollander Z, Potts JE, De Souza A, Kiess M, McManus BM, Bernatchez P, Raffin LA, Paine H, van Breemen C, Sandor GGS, Esfandiarei M
Characterization of doxycycline-mediated inhibition of Marfan syndrome-associated aortic dilation by multiphoton microscopy.
Tehrani AY, Cui JZ, Bucky Jones T, Hotova E, Castro M, Bernatchez P, van Breemen C, Esfandiarei M
In vivo characterization of doxycycline-mediated protection of aortic function and structure in a mouse model of Marfan syndrome-associated aortic aneurysm.
Cui JZ, Lee L, Sheng X, Chu F, Gibson CP, Aydinian T, Walker DC, Sandor GGS, Bernatchez P, Tibbits GF, van Breemen C, Esfandiarei M
Neurofibromin haploinsufficiency results in altered spermatogenesis in a mouse model of neurofibromatosis type 1.
Chohan H, Esfandiarei M, Arman D, Van Raamsdonk CD, van Breemen C, Friedman JM, Jett KA
Na +/Ca2+ exchangers and Orai channels jointly refill endoplasmic reticulum (ER) Ca2+ via ER nanojunctions in vascular endothelial cells.
Di Giuro CML, Shrestha N, Malli R, Groschner K, van Breemen C, Fameli N
Mild aerobic exercise blocks elastin fiber fragmentation and aortic dilatation in a mouse model of Marfan syndrome associated aortic aneurysm.
Gibson C, Nielsen C, Alex R, Cooper K, Farney M, Gaufin D, Cui JZ, van Breemen C, Broderick TL, Vallejo-Elias J, Esfandiarei M
Tissue Specificity: The Role of Organellar Membrane Nanojunctions in Smooth Muscle Ca2+ Signaling.
Fameli N, Evans AM, van Breemen C
Urinary Retention, Incontinence, and Dysregulation of Muscarinic Receptors in Male Mice Lacking Mras.
Ehrhardt A, Wang B, Yung AC, Wang Y, Kozlowski P, van Breemen C, Schrader JW
The role of endothelial function in the pathogenesis and management of Marfan syndrome-associated aortic disease
Principal investigators: Bernatchez, Pascal N; Esfandiarei, Mitra; Harris, Kevin; Potts, James E; Sandor, George G; Van Breemen, Cornelis C
Keywords: Aorta; Endothelial Function; Endothelium; Losartan; Marfan
Cellular Mechanisms underlying vascular dysfunction & aortic aneurysm in Marfan syndrome
Principal investigators: Van Breemen, Cornelis C
Keywords: Aortic Aneurysm; Cell & Molecular Biology; Disease Biomarker; Histopathology/Pathophysiology; Human Aortic Explants; In Vivo Pharmacology; Signalling Pathway; Whole Organ &Cell Culture
From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.
Frequent collaborators
- Anesthesiology, Pharmacology and Therapeutics
- Pathology and Laboratory Medicine
- Pediatrics
- Electrical and Computer Engineering
- Biochemistry and Molecular Biology
Co-authors at University of British Columbia, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.
Mitra Esfandiarei
Anesthesiology, Pharmacology and Therapeutics
11 shared papers, latest 2021
Honglin Luo
Pathology and Laboratory Medicine
4 shared papers, latest 2007
Pascal Bernatchez
Anesthesiology, Pharmacology and Therapeutics
4 shared papers, latest 2021
Piotr Kozlowski
Electrical and Computer Engineering
1 shared papers, latest 2015
Shoukat Dedhar
Biochemistry and Molecular Biology
1 shared papers, latest 2010
Ismail Laher
Pediatrics
1 shared papers, latest 2007
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