David Fedida, University of British Columbia

Research

Heart Biophysics Ion Channels Potassium Channels Arrhythmias Cryo-Electron Microscopy Long Qt Interval Syndrome Pharmacology

Latest papers

Graded activation of mutant K41C-KCNE1:KCNQ1 channel complexes by mefenamic acid.
Channels (Austin, Tex.) · 2025 · senior author
Electrophysiological characterization of the state-dependent inhibition of Kv7.1 and IKs by UCL2077.
Molecular pharmacology · 2025 · senior author
A physiologically-relevant intermediate state structure of a voltage-gated potassium channel.
Nature communications · 2025 · senior author

All 99 publications

Latest funding

The structural basis of state-dependent potassium channel inhibition
CIHR · 2026 · Nominated PI
$1,021,276
Mechanisms of potassium channel arrhythmias
CIHR · 2024 · Nominated PI
$1,017,450
Structural and functional characterization of IKs potassium channel activator drugs and gain-of-function mutations
CIHR · 2023 · Supervisor
$105,000

All 17 grants and awards

99 publications.

01

Graded activation of mutant K41C-KCNE1:KCNQ1 channel complexes by mefenamic acid.

Wang Y, Chan M, Pourrier M, Eldstrom J, Fedida D

Channels (Austin, Tex.)2025Senior author

DOI: 10.1080/19336950.2025.2539494 PMID: 40729370

02

Electrophysiological characterization of the state-dependent inhibition of Kv7.1 and IKs by UCL2077.

Sastre D, Kyriakis E, Schauer J, Chan M, Dou Y, Eldstrom J, Fedida D

Molecular pharmacology2025Senior author

DOI: 10.1016/j.molpha.2025.100076 PMID: 41175503

03

A physiologically-relevant intermediate state structure of a voltage-gated potassium channel.

Kyriakis E, Sastre D, Eldstrom J, Roscioni A, Russo S, Ataei F, Dou Y, Chan M, Molinarolo S, Maragliano L, Van Petegem F, Fedida D

Nature communications2025Senior author

DOI: 10.1038/s41467-025-64060-3 PMID: 41044058

04

Antiviral mechanisms and preclinical evaluation of amantadine analogs that continue to inhibit influenza A viruses with M2S31N-based drug resistance.

Tietjen I, Kwan DC, Petrich A, Zell R, Antoniadou IT, Gavriilidou A, Tzitzoglaki C, Rallis M, Fedida D, Sureda FX, Mestdagh C, Naesens L, Chiantia S, Johnson FB, Kolocouris A

Antiviral research2025

DOI: 10.1016/j.antiviral.2025.106104 PMID: 39947434

05

The conductance of KCNQ2 and its pathogenic variants is determined by individual subunit gating.

Hinojo-Perez A, Eldstrom J, Dou Y, Marinho-Alcara A, Edmond MA, de la Cruz A, Perez Rodriguez ME, Diaz-Solares M, Dykxhoorn DM, Fedida D, Barro-Soria R

Science advances2025

DOI: 10.1126/sciadv.adr7012 PMID: 40043113

06

Dual effects of mefenamic acid on the IKs molecular complex.

Chan M, Pourrier M, Eldstrom J, Sahakyan H, Vardanyan V, Fedida D

British journal of pharmacology2025Senior author

DOI: 10.1111/bph.17389 PMID: 39520043

07

Ion permeation through a narrow cavity constriction in KCNQ1 channels: Mechanism and implications for pathogenic variants.

Mkrtchyan L, Sahakyan H, Eldstrom J, Karapetyan T, Abrahamyan A, Nazaryan K, Schwarz JR, Kneussel M, Fedida D, Vardanyan V

Proceedings of the National Academy of Sciences of the United States of America2024

DOI: 10.1073/pnas.2411182121 PMID: 39671184

08

PUFA stabilizes a conductive state of the selectivity filter in IKs channels.

Golluscio A, Eldstrom J, Jowais JJ, Perez ME, Cunningham KP, De La Cruz A, Wu X, Corradi V, Tieleman DP, Fedida D, Larsson HP

eLife2024

DOI: 10.7554/elife.95852 PMID: 39480699

09

Evaluating sequential and allosteric activation models in IKs channels with mutated voltage sensors.

Fedida D, Sastre D, Dou Y, Westhoff M, Eldstrom J

The Journal of general physiology2024First author

DOI: 10.1085/jgp.202313465 PMID: 38294435

10

Voltage Clamp Fluorometry: Illuminating the Dynamics of Ion Channels.

Sastre D, Fedida D

Methods in molecular biology (Clifton, N.J.)2024Senior author

DOI: 10.1007/978-1-0716-3818-7_8 PMID: 38856899

The structural basis of state-dependent potassium channel inhibition

Nominated PICIHR2026Project Grant

Principal investigators: Fedida, David

Keywords: Arrhythmias; Biophysics; Cryo-Electron Microscopy; Heart; Long Qt Interval Syndrome; Pharmacology; Potassium Channels; Short Qt Interval Syndrome; Structural Biochemistry

$1,021,276

Mechanisms of potassium channel arrhythmias

Nominated PICIHR2024Project Grant

Principal investigators: Fedida, David

Keywords: Arrhythmia; Biophysics; Cryo-Em; Electrophysiology; Heart; Long-Qt Syndrome; Mutations; Potassium Channels

$1,017,450

Structural and functional characterization of IKs potassium channel activator drugs and gain-of-function mutations

SupervisorCIHR2023Doctoral Research Award: Canada Graduate Scholarships

Principal investigators: Chan, Magnus

Keywords: Antiarrhythmics; Arrhythmia; Atrial Fibrillation; Cryo-Em; Hi-Pluripotent Stem Cell-Derived Cardiomyocytes; Ion Channels; Long Qt Syndrome; Mutations; Patch Clamp; Short Qt Syndrome

$105,000

Structures of ion channel complexes

Principal investigatorNSERC2022Discovery Grants Program - Individual

Principal investigators: Fedida, David

$144,000

Mechanisms of potassium channel activator action on Kv7.1 ion channel complexes.

Nominated PICIHR2020Project Grant

Principal investigators: Fedida, David

Keywords: Ion Channels

$971,550

Structural elucidation of IKs activators bound to ion channel complexes

SupervisorCIHR2020Master's Award: Canada Graduate Scholarships

Principal investigators: Russo, Sophia C

Keywords: Arrythmias; Cardiology; Cryo-Electron Microscopy; Drug Development; Iks Activators; Kcnq1; Long Qt-Interval Syndrome; Ml277; Slow-Delayed Rectifier Current; Structure Determination

$17,500

Microelectrode array (MEA) technology for functional assessment of novel 3D bioprinted human cardiac tissue models.

Principal investigatorNSERC2019Research Tools and Instruments

Principal investigators: Fedida, David

$150,000

Novel 3D bioprinted human cardiac tissue models for drug safety and efficacy testing

Principal investigatorNSERC2018Collaborative Health Research Projects

Principal investigators: Fedida, David

$381,750

3D bioprinted cardiac tissue models

Principal investigatorNSERC2017Engage Grants Program

Principal investigators: Fedida, David

$23,000

Biophysical properties and regulation of KCNQ1 and KCNE(x) ion channel complexes.

Nominated PICIHR2017Project Grant

Principal investigators: Fedida, David

Keywords: Accessory Subunits; Biophysics; Ion Channel; Patch Clamp Recording; Single Ion Channel Kinetics

$627,300

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Biochemistry and Molecular Biology
Anesthesiology, Pharmacology and Therapeutics
Pediatrics
Medical Genetics
Molecular Biology and Biochemistry
Other

Co-authors at University of British Columbia, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

Filip Van Petegem

Biochemistry and Molecular Biology

2 shared papers, latest 2025

Thibault Mayor

Biochemistry and Molecular Biology

1 shared papers, latest 2016

Laura Arbour

Medical Genetics

1 shared papers, latest 2008

Masahiro Niikura

Molecular Biology and Biochemistry

1 shared papers, latest 2016

Glen Tibbits

Faculty

1 shared papers, latest 2008

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mentionMention their CIHR grant from 2026

Subject: Prospective PhD student: Heart Dear Professor Fedida, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Graded activation of mutant K41C-KCNE1:KCNQ1 channel complexes by mefenamic acid." (2025), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your CIHR-funded project "The structural basis of state-dependent potassium channel inhibition" (2026), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]

David Fedida

Research

Latest papers

Latest funding

Graded activation of mutant K41C-KCNE1:KCNQ1 channel complexes by mefenamic acid.

Electrophysiological characterization of the state-dependent inhibition of Kv7.1 and IKs by UCL2077.

A physiologically-relevant intermediate state structure of a voltage-gated potassium channel.

Antiviral mechanisms and preclinical evaluation of amantadine analogs that continue to inhibit influenza A viruses with M2S31N-based drug resistance.

The conductance of KCNQ2 and its pathogenic variants is determined by individual subunit gating.

Dual effects of mefenamic acid on the IKs molecular complex.

Ion permeation through a narrow cavity constriction in KCNQ1 channels: Mechanism and implications for pathogenic variants.

PUFA stabilizes a conductive state of the selectivity filter in IKs channels.

Evaluating sequential and allosteric activation models in IKs channels with mutated voltage sensors.

Voltage Clamp Fluorometry: Illuminating the Dynamics of Ion Channels.

The structural basis of state-dependent potassium channel inhibition

Mechanisms of potassium channel arrhythmias

Structural and functional characterization of IKs potassium channel activator drugs and gain-of-function mutations

Structures of ion channel complexes

Mechanisms of potassium channel activator action on Kv7.1 ion channel complexes.

Structural elucidation of IKs activators bound to ion channel complexes

Microelectrode array (MEA) technology for functional assessment of novel 3D bioprinted human cardiac tissue models.

Novel 3D bioprinted human cardiac tissue models for drug safety and efficacy testing

3D bioprinted cardiac tissue models

Biophysical properties and regulation of KCNQ1 and KCNE(x) ion channel complexes.

Frequent collaborators

Shubhayan Sanatani

Filip Van Petegem

Thibault Mayor

Laura Arbour

Masahiro Niikura

Glen Tibbits