Faculty profile

Sara Mostafavi

ResearcherUniversity of British Columbia

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a University of British Columbia directory, so their courses may be missing. Find their university profile.

Sara Mostafavi

Researcher

Health Sciences

University of British Columbia

Vancouver, British Columbia, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
11 publications in the last five years, latest in 2025.
Senior (last) author on 2 recent papers, a sign of leading a research group.
Principal investigator on 3 research grants (2 NSERC, 1 CIHR), most recently in 2020.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

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Citations

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Collaborators

Grants

Publications by year

Counts cover the works listed on the university profile; citation counts come from Dimensions.

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Signals and details

Research

Crc

Latest papers

A Germline Heterozygous Dominant Negative IKZF2 Variant Causing Syndromic Primary Immune Regulatory Disorder and ICHAD.
Journal of clinical immunology · 2025
DNA methylation differences between cord and adult white blood cells reflect postnatal immune cell maturation.
Communications biology · 2025
Sex-dependent placental methylation quantitative trait loci provide insight into the prenatal origins of childhood onset traits and conditions.
iScience · 2024

All 61 publications

Latest funding

Local Computing Infrastructure for Large Scale Genomic Analysis
NSERC · 2020 · Principal investigator
$150,000
Metabolic regulation of immune defenses in newborns
CIHR · 2019 · Co-investigator
$1,013,816
Analysis of multiomic Data to Accelerate Personalized health interventions against inhaled Toxicants (ADAPT)
CIHR · 2017 · Co-investigator
$187,400

All 11 grants and awards

61 publications.

A Germline Heterozygous Dominant Negative IKZF2 Variant Causing Syndromic Primary Immune Regulatory Disorder and ICHAD.

Lu HY, Vaseghi-Shanjani M, Lam AJ, Sharma M, Mohajeri A, Silva LBR, Gillies J, Yang GX, Lin S, Fu MP, Salman A, Rahmanian R, Armstrong L, Halparin J, Yang CL, Chilvers M, Henkelman E, Rehmus W, Morrison D, Setiadi A, Mostafavi S, Kobor MS, Kozak FK, Biggs CM, van Karnebeek C, Hildebrand KJ, Anna Lehman on behalf of the Care4Rare Canada Consortium, Levings MK, Turvey SE

Journal of clinical immunology2025

DOI: 10.1007/s10875-025-01882-2 PMID: 40295428

DNA methylation differences between cord and adult white blood cells reflect postnatal immune cell maturation.

Jones MJ, Konwar C, Asiimwe R, Dinh L, Razzaghian HR, de Goede O, MacIsaac JL, Morin AM, Kolsun KP, Gervin K, Lyle R, Ng RT, Koestler DC, Felix JF, Lavoie PM, Robinson WP, Mostafavi S, Kobor MS

Communications biology2025

DOI: 10.1038/s42003-025-07661-4 PMID: 39953282

Sex-dependent placental methylation quantitative trait loci provide insight into the prenatal origins of childhood onset traits and conditions.

Casazza W, Inkster AM, Del Gobbo GF, Yuan V, Delahaye F, Marsit C, Park YP, Robinson WP, Mostafavi S, Dennis JK

iScience2024

DOI: 10.1016/j.isci.2024.109047 PMID: 38357671

Cell subtype-specific effects of genetic variation in the Alzheimer's disease brain.

Fujita M, Gao Z, Zeng L, McCabe C, White CC, Ng B, Green GS, Rozenblatt-Rosen O, Phillips D, Amir-Zilberstein L, Lee H, Pearse RV, Khan A, Vardarajan BN, Kiryluk K, Ye CJ, Klein HU, Wang G, Regev A, Habib N, Schneider JA, Wang Y, Young-Pearse T, Mostafavi S, Bennett DA, Menon V, De Jager PL

Nature genetics2024

DOI: 10.1038/s41588-024-01685-y PMID: 38514782

Dominant negative variants in IKZF2 cause ICHAD syndrome, a new disorder characterised by immunodysregulation, craniofacial anomalies, hearing impairment, athelia and developmental delay.

Mohajeri A, Vaseghi-Shanjani M, Rosenfeld JA, Yang GX, Lu H, Sharma M, Lin S, Salman A, Waqas M, Sababi Azamian M, Worley KC, Del Bel KL, Kozak FK, Rahmanian R, Biggs CM, Hildebrand KJ, Lalani SR, Nicholas SK, Scott DA, Mostafavi S, van Karnebeek C, Henkelman E, Halparin J, Yang CL, Armstrong L, Undiagnosed Diseases Network, Care4Rare Canada Consortium, Turvey SE, Lehman A

Journal of medical genetics2023

DOI: 10.1136/jmg-2022-109127 PMID: 37316189

AAV5-miHTT-mediated huntingtin lowering improves brain health in a Huntington's disease mouse model.

Thomson SB, Stam A, Brouwers C, Fodale V, Bresciani A, Vermeulen M, Mostafavi S, Petkau TL, Hill A, Yung A, Russell-Schulz B, Kozlowski P, MacKay A, Ma D, Beg MF, Evers MM, Vallès A, Leavitt BR

Brain : a journal of neurology2023

DOI: 10.1093/brain/awac458 PMID: 36508327

In silico discovery of small molecules for efficient stem cell differentiation into definitive endoderm.

Novakovsky G, Sasaki S, Fornes O, Omur ME, Huang H, Bayly CL, Zhang D, Lim N, Cherkasov A, Pavlidis P, Mostafavi S, Lynn FC, Wasserman WW

Stem cell reports2023

DOI: 10.1016/j.stemcr.2023.01.008 PMID: 36801003

Dynamic networks of psychotic symptoms in adults living in precarious housing or homelessness.

Jones AA, Gicas KM, Mostafavi S, Woodward ML, Leonova O, Vila-Rodriguez F, Procyshyn RM, Cheng A, Buchanan T, Lang DJ, MacEwan GW, Panenka WJ, Barr AM, Thornton AE, Honer WG

Psychological medicine2022

DOI: 10.1017/s0033291720004444 PMID: 33455593

Human JAK1 gain of function causes dysregulated myelopoeisis and severe allergic inflammation.

Biggs CM, Cordeiro-Santanach A, Prykhozhij SV, Deveau AP, Lin Y, Del Bel KL, Orben F, Ragotte RJ, Saferali A, Mostafavi S, Dinh L, Dai D, Weinacht KG, Dobbs K, Ott de Bruin L, Sharma M, Tsai K, Priatel JJ, Schreiber RA, Rozmus J, Hosking MC, Shopsowitz KE, McKinnon ML, Vercauteren S, Seear M, Notarangelo LD, Lynn FC, Berman JN, Turvey SE

JCI insight2022

DOI: 10.1172/jci.insight.150849 PMID: 36546480

Mosaic loss of Chromosome Y in aged human microglia.

Vermeulen MC, Pearse R, Young-Pearse T, Mostafavi S

Genome research2022Senior author

DOI: 10.1101/gr.276409.121 PMID: 36041859

Local Computing Infrastructure for Large Scale Genomic Analysis

Principal investigatorNSERC2020Research Tools and Instruments

Principal investigators: Mostafavi, Sara

$150,000

Metabolic regulation of immune defenses in newborns

Co-investigatorCIHR2019Project Grant

Principal investigators: Lavoie, Pascal

Keywords: Energy Metabolism; Innate Immunity; Monocytes; Ontogeny; Premature Infant; Translation

$1,013,816

Analysis of multiomic Data to Accelerate Personalized health interventions against inhaled Toxicants (ADAPT)

Co-investigatorCIHR2017Catalyst Grant: Personalized Health Catalyst Grants

Principal investigators: Carlsten, Christopher

Keywords: Air Pollution; Airways; Biosignatures; Crossover; Environment; Lung; Multiomics

$187,400

Precision Fluid Biomarkers of Traumatic Brain Injury

Co-investigatorCIHR2017Project Grant

Principal investigators: Wellington, Cheryl L

Keywords: Biomarkers; Traumatic Brain Injury; Vulnerable Populations

$100,000

Epigenetic Signatures of Successful Aging

Co-investigatorCIHR2016Project Grant

Principal investigators: Kobor, Michael S; Rehkopf, David H

Keywords: Aging; Blood; Centenarians; Demography; Dna Methylation; Epigenetics; Genetic Variation; Health; Longevity

$1,097,060

Integrating multiple types of genomics data to identify meaningful associations

Principal investigatorNSERC2016Discovery Grants Program - Individual

Principal investigators: Mostafavi, Sara

$215,000

Identifying integrative biomarkers of risk and resilience to childhood psychopathology

Co-investigatorCIHR2016Project Grant

Principal investigators: Goldenberg, Anna

Keywords: Computational Medicine; Data Integration; Disease Trajectory; Dna Methylation; Machine Learning; Mental Disorders

$588,665

Automated analysis of big flow cytometry data.

Co-investigatorCIHR2016Operating Grant: Bioinformatics and Computational Biology

Principal investigators: Brinkman, Ryan

Keywords: Bioinformatics

$131,232

Prenatal Programming of Children's Mental Health: Epigenetic Mechanisms and Resilience Promotion

Co-investigatorCIHR2015Team Grant: DOHaD - Implications for Men, Women, Boys and Girls

Principal investigators: Kobor, Michael S

Keywords: Array Technology; Dna Methylation; Early Life Environments; Environmental Exposures; Epigenetics; Genotyping; Mental Health; Pregnancy; Sex Difference; Social Implications

$1,500,000

Training Program in High-Dimensional Bioinformatics (HDB)

Co-investigatorNSERC2015Collaborative Research and Training Experience

Principal investigators: Pavlidis, Paul

$1,650,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

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Sara Mostafavi

Research

Latest papers

Latest funding

A Germline Heterozygous Dominant Negative IKZF2 Variant Causing Syndromic Primary Immune Regulatory Disorder and ICHAD.

DNA methylation differences between cord and adult white blood cells reflect postnatal immune cell maturation.

Sex-dependent placental methylation quantitative trait loci provide insight into the prenatal origins of childhood onset traits and conditions.

Cell subtype-specific effects of genetic variation in the Alzheimer's disease brain.

Dominant negative variants in IKZF2 cause ICHAD syndrome, a new disorder characterised by immunodysregulation, craniofacial anomalies, hearing impairment, athelia and developmental delay.

AAV5-miHTT-mediated huntingtin lowering improves brain health in a Huntington's disease mouse model.

In silico discovery of small molecules for efficient stem cell differentiation into definitive endoderm.

Dynamic networks of psychotic symptoms in adults living in precarious housing or homelessness.

Human JAK1 gain of function causes dysregulated myelopoeisis and severe allergic inflammation.

Mosaic loss of Chromosome Y in aged human microglia.

Local Computing Infrastructure for Large Scale Genomic Analysis

Metabolic regulation of immune defenses in newborns

Analysis of multiomic Data to Accelerate Personalized health interventions against inhaled Toxicants (ADAPT)

Precision Fluid Biomarkers of Traumatic Brain Injury

Epigenetic Signatures of Successful Aging

Integrating multiple types of genomics data to identify meaningful associations

Identifying integrative biomarkers of risk and resilience to childhood psychopathology

Automated analysis of big flow cytometry data.

Prenatal Programming of Children's Mental Health: Epigenetic Mechanisms and Resilience Promotion

Training Program in High-Dimensional Bioinformatics (HDB)

Frequent collaborators

Maja Tarailo-Graovac

Maryam Vaseghi-Shanjani

Clara van Karnebeek

Rudolf Uher

Philip Awadalla

Fidel Vila-Rodriguez

Stefan Kloiber

Amanda Li

Piotr Kozlowski

Ina Anreiter

Philip Awadalla

Tony Panzarella

Ali Bashashati

Artem Cherkasov

Michael Gold

Christian Steidl

Gregor Reid

Wyeth Wasserman

Brian Cox

Paul Pavlidis

Anna Goldenberg

Philip Awadalla

Harold Siden

Ronan Foley

Michael Kobor

Irwin Ronald Walker