Faculty profile

Maja Tarailo-Graovac

ResearcherBiochemistry and Molecular BiologyUniversity of Calgary

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a University of Calgary directory, so their courses may be missing. Find their university profile.

Maja Tarailo-Graovac

Researcher

Biochemistry and Molecular Biology

Health Sciences

University of Calgary

Calgary, Alberta, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
22 publications in the last five years, latest in 2026.
Senior (last) author on 15 recent papers, a sign of leading a research group.
Principal investigator on 6 research grants (4 CIHR, 2 NSERC), most recently in 2025.
Supervisor on 3 trainee awards (3 CIHR), most recently in 2022.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

Publications

Collaborators

Grants

Publications by year

Counts cover the publications linked to this profile. Citations and the h-index appear when the source records them.

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Signals and details

Research

Bioinformatics Caenorhabditis Elegans Genetic Modifiers Phenotypic Variability Genome Sequencing Rare Disease Centriole Biogenesis Genetic Screen

Latest papers

A course-undergraduate research experience (CURE) to explore the effect of structural variants on gene expression in C. elegans balancers.
PloS one · 2026 · senior author
Human germline biallelic loss-of-function OSMR variants cause severe allergic disease.
Journal of human immunity · 2026
Functional studies of human variants in C. elegans link iron metabolism to DPD deficiency and 5-FU sensitivity.
Genetics · 2026 · senior author

All 44 publications

Latest funding

MicroModifier: Delineating genetic modifier networks for primary microcephaly
CIHR · 2025 · Nominated PI
$1,096,246
The hidden genetics of focal epilepsy: Brain-specific pathogenic somatic variants
CIHR · 2024 · Principal investigator
$1,185,750
Solving the genomics of unsolved rare life-threatening COVID-19 using genome sequencing
CIHR · 2022 · Supervisor
$59,060

All 9 grants and awards

44 publications.

A course-undergraduate research experience (CURE) to explore the effect of structural variants on gene expression in C. elegans balancers.

Maroilley T, Barbosa VRA, Mascarenhas R, Ferris S, Diao C, AlAwadhi F, Aldakheel S, Ali A, Alkanderi D, Alshatti M, Alsuwaileh S, Bui R, Chai B, Dsouza L, Nezhad PE, Garcia-Volk E, Haq Z, Hossain S, Johnson G, Kotikalapudi N, Lalani I, Lenz C, Louie T, Moore S, Patel S, Prasai S, Qureshi R, Rahmani F, Shakir B, Ahamed SS, Tran HA, Waziha R, Wood CM, Zbinden S, Anderson D, Tarailo-Graovac M

PloS one2026Senior author

DOI: 10.1371/journal.pone.0342806 PMID: 42579690

Human germline biallelic loss-of-function OSMR variants cause severe allergic disease.

Samra S, Sharma M, Körholz J, Liu Y, James A, Michalski C, Yousefi P, Del Bel KL, Lu HY, Sharma AA, Tarailo-Graovac M, Dalmann J, Buder L, Modi B, Wiedemuth R, Golding L, Drögemöller B, Blanchard-Rohner G, Senger C, Rehmus W, Prendiville JS, Mangino M, Ross CJ, van Karnebeek CDM, Wasserman WW, D Rosenzweig S, Niemela J, Lavoie PM, Prathibha PM, Wegehaupt O, Biggs CM, Boehnke M, Kinnunen L, Koistinen HA, McKinnon ML, Breuer JM, Schönenkorb J, Brock R, Thull S, Netzer C, Velmans C, Altuwaijri N, Hamadah IR, Altassan R, Alfares A, Maddirevula S, Patil SJ, Bayer DK, Lyons JJ, Turvey SE

Journal of human immunity2026

DOI: 10.70962/jhi.20260067 PMID: 42221229

Functional studies of human variants in C. elegans link iron metabolism to DPD deficiency and 5-FU sensitivity.

Li X, Menendez Perdomo IM, van Kuilenburg ABP, Tarailo-Graovac M

Genetics2026Senior author

DOI: 10.1093/genetics/iyaf228 PMID: 41131702

Functional analysis of FH variants of uncertain significance using Caenorhabditis elegans model.

Ferris S, Menendez Perdomo IM, Tarailo-Graovac M

Genetics in medicine open2025Senior author

DOI: 10.1016/j.gimo.2025.103469 PMID: 41438304

The cost and cost trajectory of genome sequencing and bioinformatics analysis for Indigenous children with suspected rare diseases.

Ehman M, Sharma K, Weymann D, Maroilley T, Mohajeri A, Lehman A, Tarailo-Graovac M, Jones SJM, Marra MA, Wasserman WW, Caron NR, Arbour L, Regier DA

Genetics in medicine : official journal of the American College of Medical Genetics2025

DOI: 10.1016/j.gim.2025.101568 PMID: 40856105

ASXL1 deficiency causes epigenetic dysfunction, combined immunodeficiency, and EBV-associated lymphoma.

Fu MP, Sharma M, Yousefi P, Merrill SM, Tan R, Samra S, Setiadi A, Golding L, Modi BP, Del Bel KL, Deyell RJ, Rozmus J, Rehmus W, Hildebrand KJ, James E, Blanchard-Rohner G, Lin S, Shopsowitz KE, Terry J, Lee AF, Drögemöller BI, Matthews A, Tarailo-Graovac M, Sauvé L, Mitchell H, Prendiville JS, MacIsaac JL, Dever K, Lin DTS, Meijer M, Ross CJD, Dobson SRM, Vercauteren SM, Wasserman WW, van Karnebeek CDM, McKinnon ML, Kobor MS, Turvey SE, Biggs CM

The Journal of experimental medicine2025

DOI: 10.1084/jem.20240945 PMID: 40742536

Biallelic variants in BBOX1 cause L-Carnitine deficiency and elevated γ-butyrobetaine.

Li X, Yeganeh M, Sinclair G, Mwenifumbo J, Jacob KJ, Arbour L, Lehman A, Rakic B, Vaz FM, Horvath G, Tarailo-Graovac M, Stockler-Ipsiroglu S

NPJ genomic medicine2025

DOI: 10.1038/s41525-025-00523-2 PMID: 41022783

Detecting somatic variants in purified brain DNA obtained from surgically implanted depth electrodes in epilepsy.

Mascarenhas R, Merrikh D, Khanbabaei M, Kaur N, Ghaderi N, Maroilley T, Liu Y, Soule T, Appendino JP, Jacobs J, Wiebe S, Calgary Comprehensive Epilepsy Program Collaborators, Hader W, Pfeffer G, Tarailo-Graovac M, Klein KM

Epilepsia2025Senior author

DOI: 10.1111/epi.18251 PMID: 39751777

Detection of Complex Genomic Rearrangements Using Short-Read Whole Genome Sequencing in C. elegans.

Maroilley T, Tarailo-Graovac M

Methods in molecular biology (Clifton, N.J.)2025Senior author

DOI: 10.1007/978-1-0716-4750-9_7 PMID: 40884641

The critical role of the iron-sulfur cluster and CTC components in DOG-1/BRIP1 function in Caenorhabditis elegans.

Li X, Perdomo IMM, Rodrigues Alves Barbosa V, Diao C, Tarailo-Graovac M

Nucleic acids research2024Senior author

DOI: 10.1093/nar/gkae617 PMID: 39011897

MicroModifier: Delineating genetic modifier networks for primary microcephaly

Nominated PICIHR2025Project Grant

Principal investigators: Tarailo-Graovac, Maja

Keywords: Bioinformatics; Caenorhabditis Elegans; Centriole Biogenesis; Genetic Modifiers; Genetic Screen; Genome Sequencing; Microcephaly; Phenotypic Variability; Rare Disease; Suppressor

$1,096,246

The hidden genetics of focal epilepsy: Brain-specific pathogenic somatic variants

Principal investigatorCIHR2024Project Grant

Principal investigators: Klein, Karl M; Pfeffer, Gerald; Tarailo-Graovac, Maja

Keywords: Depth Electrode; Epilepsy; Epilepsy Surgery; Focal Epilepsy; Genetics; Mosaic; Nonlesional Epilepsy; Seeg; Somatic Mutation; Somatic Variant

$1,185,750

Solving the genomics of unsolved rare life-threatening COVID-19 using genome sequencing

SupervisorCIHR2022HostSeq Fellowship

Principal investigators: Shu, Li

Keywords: Bioinformatic Analysis; Complex Variants; Covid-19; Genetics; Genome Sequencing; Life-Threatening; Pandemic; Rare Disease

$59,060

Unravelling the complex genetic mechanisms of rare diseases using high-throughput sequencing methods

SupervisorCIHR2022CIHR Fellowship

Principal investigators: Shu, Li

Keywords: Bioinformatics Pipeline; Complex Variants; Genetic Mechanisms; Genome Sequencing; High-Throughput Sequencing; Long-Read Sequencing; Rare Diseases; Short-Read Sequencing; Structural Variants; Transcriptome

$90,000

Uncovering complex genetic mechanisms of disease

Nominated PICIHR2022Operating Grant - PA: Genetics (Bridge Funding: Research Priorities)

Principal investigators: Tarailo-Graovac, Maja

Keywords: Bioinformatics; Complex Variants; Genome Sequencing; Genomics; Mechanism Of A Disease; Model Organism; Non-Coding Variants; Rare Disease; Structural Variants; Transcriptomics

$100,000

Improving the diagnosis rate for Canadian Indigenous children with rare diseases by tailoring the analysis of whole genome sequencing

SupervisorCIHR2021Fellowship - PA: First Nations, Inuit and/or Métis Health

Principal investigators: Maroilley, Tatiana

Keywords: Bioinformatics Pipeline; Complex Variants; Genetic Variants; Genome Sequencing; Indigenous; Rare Disease; Silent Genomes; Structural Variants; Variant Detection; Variant Interpretation

$135,000

Deciphering Plasticity of Essentiality

Principal investigatorNSERC2020Discovery Launch Supplement

Principal investigators: Tarailo-Graovac, Maja

$12,500

Deciphering Plasticity of Essentiality

Principal investigatorNSERC2020Discovery Grants Program - Individual

Principal investigators: Tarailo-Graovac, Maja

$150,000

Of Worm and Man: Using C. elegans to uncover genetic modifiers for rare human disorders

Nominated PICIHR2017Project Grant

Principal investigators: Tarailo-Graovac, Maja

Keywords: Bioinformatics; Caenorhabditis Elegans; Genetic Modifiers; Human Rare Disease; Molecular Interactions; Mutagen-Induced Suppressor Screens; Phenotypic Variability; Reverse Genetics; Treatment; Whole Genome Sequencing

$1,032,750

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

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Maja Tarailo-Graovac

Research

Latest papers

Latest funding

A course-undergraduate research experience (CURE) to explore the effect of structural variants on gene expression in C. elegans balancers.

Human germline biallelic loss-of-function OSMR variants cause severe allergic disease.

Functional studies of human variants in C. elegans link iron metabolism to DPD deficiency and 5-FU sensitivity.

Functional analysis of FH variants of uncertain significance using Caenorhabditis elegans model.

The cost and cost trajectory of genome sequencing and bioinformatics analysis for Indigenous children with suspected rare diseases.

ASXL1 deficiency causes epigenetic dysfunction, combined immunodeficiency, and EBV-associated lymphoma.

Biallelic variants in BBOX1 cause L-Carnitine deficiency and elevated &#x3b3;-butyrobetaine.

Detecting somatic variants in purified brain DNA obtained from surgically implanted depth electrodes in epilepsy.

Detection of Complex Genomic Rearrangements Using Short-Read Whole Genome Sequencing in C. elegans.

The critical role of the iron-sulfur cluster and CTC components in DOG-1/BRIP1 function in Caenorhabditis elegans.

MicroModifier: Delineating genetic modifier networks for primary microcephaly

The hidden genetics of focal epilepsy: Brain-specific pathogenic somatic variants

Solving the genomics of unsolved rare life-threatening COVID-19 using genome sequencing

Unravelling the complex genetic mechanisms of rare diseases using high-throughput sequencing methods

Uncovering complex genetic mechanisms of disease

Improving the diagnosis rate for Canadian Indigenous children with rare diseases by tailoring the analysis of whole genome sequencing

Deciphering Plasticity of Essentiality

Deciphering Plasticity of Essentiality

Of Worm and Man: Using C. elegans to uncover genetic modifiers for rare human disorders

Frequent collaborators

Xiao-Yan Wen

Gerald Pfeffer

Laura Arbour

Britt Drogemoller

Wyeth Wasserman

Sara Mostafavi

Marc Ekker

Sylvia Stockler

Quan Long

Tuan Bui

Chad Bousman

Zhengping Jia

Nathalie Lepage

Brett Trost

Paul Gordon

Corey Nislow

David Dyment

Jacek Majewski

Biallelic variants in BBOX1 cause L-Carnitine deficiency and elevated γ-butyrobetaine.