Faculty profile

Tillie-Louise Hackett

ResearcherAnesthesiology, Pharmacology and TherapeuticsUniversity of British Columbia

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a University of British Columbia directory, so their courses may be missing. Find their university profile.

Tillie-Louise Hackett

Researcher

Anesthesiology, Pharmacology and Therapeutics

Health Sciences

University of British Columbia

Vancouver, British Columbia, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
29 publications in the last five years, latest in 2026.
Senior (last) author on 12 recent papers, a sign of leading a research group.
Principal investigator on 6 research grants (6 CIHR), most recently in 2024.
Supervised 6 trainees who won CIHR awards, most recently in 2026.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

Publications

620

Citations

h-index

Collaborators

Grants

Publications by year

Counts cover the works listed on the university profile; citation counts come from Dimensions.

Profiles and links

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Signals and details

Research

Copd Gene Expression Lung Morphology Micro Computed Tomography Fibrosis Fibroblasts Micro-Computed Tomography Epithelium

Latest papers

Reply to Noble et al.: The propensity for mucus plug formation in fatal asthma is increased by airway narrowing.
American journal of respiratory and critical care medicine · 2026 · senior author
Reticular Basement Membrane Remodelling Regulates Bronchial Epithelial Attachment, Barrier Integrity and Inflammatory Signalling in Asthma.
Advances in respiratory medicine · 2026 · senior author
Systematic Comparison of the TGF-β Isoforms in Normal Dermal and Lung Fibroblasts Identifies TGF-β2 and TGF-β3 as Priority Targets in Tissue Fibrosis.
Cells · 2026 · senior author

All 83 publications

Latest funding

Identification of Cell-Free DNA Methylation Biomarkers for Progressive Interstitial Lung Disease in Systemic Sclerosis
CIHR · 2026 · Supervisor
$9,000
Cartilage-associated protein (CRTAP) as an environmentally sensitive target in idiopathic pulmonary fibrosis.
CIHR · 2025 · Supervisor
$120,000
Integration of multi-resolution imaging to improve the diagnosis and treatment of fibrotic interstitial lung diseases
CIHR · 2024 · Nominated PI
$910,350

All 15 grants and awards

83 publications.

Reply to Noble et al.: The propensity for mucus plug formation in fatal asthma is increased by airway narrowing.

Hsieh A, Vasilescu DM, Hackett TL

American journal of respiratory and critical care medicine2026Senior author

DOI: 10.1093/ajrccm/aamag179 PMID: 42085306

Reticular Basement Membrane Remodelling Regulates Bronchial Epithelial Attachment, Barrier Integrity and Inflammatory Signalling in Asthma.

Hsieh A, Barker-Mulleder J, Yang CX, Fouadi M, Hackett TL

Advances in respiratory medicine2026Senior author

DOI: 10.3390/arm94030038 PMID: 42345643

Systematic Comparison of the TGF-β Isoforms in Normal Dermal and Lung Fibroblasts Identifies TGF-β2 and TGF-β3 as Priority Targets in Tissue Fibrosis.

Badyal R, Kohlen B, Keen KJ, Dunne JV, Hackett TL

Cells2026Senior author

DOI: 10.3390/cells15080671 PMID: 42041539

Tissue and Isoform-Specific Effects of Platelet-Derived Growth Factor on Neonatal-Derived Dermal and Fetal-Derived Lung Fibroblast Profibrotic Functions.

Kohlen B, Badyal R, Keen KJ, Dunne JV, Hackett TL

Cells2026Senior author

DOI: 10.3390/cells15070637 PMID: 41972725

Classification of collagen remodeling in asthma using second-harmonic generation imaging, supervised machine learning and texture-based analysis.

Kunchur NN, Poole JJA, Levine J, Hackett TL, Thornhill R, Mostaço-Guidolin LB

Frontiers in bioinformatics2025

DOI: 10.3389/fbinf.2025.1539936 PMID: 40313867

Closing the Gap: Use of Polidocanol to Study Human Airway Epithelial Repair.

Heijink IH, Nwozor KO, Hackett TL

American journal of respiratory cell and molecular biology2025Senior author

DOI: 10.1165/rcmb.2025-0165ed PMID: 40315405

Mucus Plugs Correlate with Small Airway Remodelling in Asthma: A Case-Control Study.

Hsieh A, Vasilescu DM, Barker-Mulleder J, Fouadi M, Ledoux S, Erle DJ, Liegeois MA, Fahy JV, Hackett TL

American journal of respiratory and critical care medicine2025Senior author

DOI: 10.1164/rccm.202501-0310oc PMID: 40845271

Effect of age, COPD severity, and cigarette smoke exposure on bronchial epithelial barrier function.

Nwozor KO, Hackett TL, Chen Q, Yang CX, Aguilar Lozano SP, Zheng X, Al-Fouadi M, Kole TM, Faiz A, Mahbub RM, Slebos DJ, Klooster K, Timens W, van den Berge M, Brandsma CA, Heijink IH

American journal of physiology. Lung cellular and molecular physiology2025

DOI: 10.1152/ajplung.00223.2024 PMID: 40247649

Cellular and molecular features of asthma mucus plugs provide clues about their formation and persistence.

Liegeois MA, Hsieh A, Al-Fouadi M, Charbit AR, Yang CX, Hackett TL, Fahy JV

The Journal of clinical investigation2025

DOI: 10.1172/jci186889 PMID: 40091838

Computational fluid dynamics of small airway disease in chronic obstructive pulmonary disease

Mohamady YK, Geudens V, De Fays C, Zapata M, Hagrass O, Aversa L, Vermant M, Jin X, Willems L, Gyselinck I

EBioMedicine202512 citations

DOI: 10.1016/j.ebiom.2025.105670

Identification of Cell-Free DNA Methylation Biomarkers for Progressive Interstitial Lung Disease in Systemic Sclerosis

SupervisorCIHR2026CRTAS - Research Travel Supplements

Principal investigators: Badyal, Raveen K

Keywords: Lung Disease

$9,000

Cartilage-associated protein (CRTAP) as an environmentally sensitive target in idiopathic pulmonary fibrosis.

SupervisorCIHR2025DRA : Canada Graduate Research Scholarship - Doctoral Program (CGRS D)

Principal investigators: Abbasidezfouli, Samin

Keywords: Air Pollution; Cartilage-Associated Protein (Crtap); Dna Methylation; Fibroblasts; Idiopathic Pulmonary Fibrosis (Ipf); Lung Fibrosis; Proteomics; Spatial Imaging

$120,000

Integration of multi-resolution imaging to improve the diagnosis and treatment of fibrotic interstitial lung diseases

Nominated PICIHR2024Project Grant

Principal investigators: Hackett, Tillie-Louise; Ryerson, Christopher J

Keywords: Computed Tomography; Fibrosis; Fibrotic Interstitial Lung Disease; Machine Learning, Texture-Based Algorithms; Micro Computed Tomography; Particulate Matter; Patholobiology; Single-Cell Imaging; Spatial Transcriptomics; Therapeutics

$910,350

The Effect of Transforming Growth Factor-Beta Receptor Inhibition on Skin and Lung Fibrosis in Patients with Systemic Sclerosis

SupervisorCIHR2024Doctoral Research Award: Canada Graduate Scholarships

Principal investigators: Badyal, Raveen K

Keywords: Anti-Fibrotic Therapeutics; Extracellular Matrix; Fibroblasts; Interstitial Lung Disease; Lung Fibrosis; Myofibroblasts; Skin Fibrosis; Systemic Sclerosis; Transforming Growth Factor-Beta Pathway; Transforming Growth Factor-Beta Receptor Inhibition

$120,000

The Role of Small Airways Disease Heterogeneity in Asthma

SupervisorCIHR2022Doctoral Research Award: Canada Graduate Scholarships

Principal investigators: Hsieh, Aileen

Keywords: Airway Remodeling Heterogeneity; Asthma; Cell Biology; Gene Expression; Lung Morphology; Micro-Computed Tomography; Single Cell Imaging; Small Airways Disease

$105,000

The contribution of sex differences to small airways disease in chronic obstructive pulmonary disease

Nominated PICIHR2021Project Grant

Principal investigators: Hackett, Tillie-Louise

Keywords: Copd; Fibroblasts; Fibrosis; Macrophages; Single Cell Imaging; Small Airways Disease; Spatial Transciptomics; Ultra Resolution Ct Imaging

$730,576

Air pollution as a modulator of molecular, structural, and clinical outcomes in patients with fibrotic interstitial lung disease.

SupervisorCIHR2021CIHR Fellowship

Principal investigators: Goobie, Gillian C

Keywords: Air Pollution; Environmental Health; Epigenetics; Gene Expression; Interstitial Lung Disease; Ultra-Resolution Imaging

$135,000

Canada Research Chairs - Tier 1

Nominated PICIHR2020Canada Research Chairs - CIHR Funded - Tier 1

Principal investigators: Hackett, Tillie-Louise

Keywords: Crc

$1,400,000

The Role of Small Airways Disease Heterogeneity in Asthma

Nominated PICIHR2017Project Grant

Principal investigators: Hackett, Tillie-Louise

Keywords: Aiway Remodeling Heterogenity; Asthma; Cell Biology; Gene Expression; Lung Morphology; Micro-Computed Tomography; Optical Coherence Tomography; Small Aiways Disease; Super Resolution Multi-Photon Microscopy

$675,340

Gene by Sex Interactions in COPD

Co-investigatorCIHR2017Catalyst Grant: Sex as a Variable in Biomedical Research

Principal investigators: Obeidat, Ma'en

Keywords: Airway Epithelium; Chronic Obstructive Pulmonary Disease; Gene; Inhalers; Lung Tissue; Molecular Mechanisms; Sex; Smoking; Therapeutics; Transcriptome

$150,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

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Tillie-Louise Hackett

Research

Latest papers

Latest funding

Reply to Noble et al.: The propensity for mucus plug formation in fatal asthma is increased by airway narrowing.

Reticular Basement Membrane Remodelling Regulates Bronchial Epithelial Attachment, Barrier Integrity and Inflammatory Signalling in Asthma.

Systematic Comparison of the TGF-β Isoforms in Normal Dermal and Lung Fibroblasts Identifies TGF-β2 and TGF-β3 as Priority Targets in Tissue Fibrosis.

Tissue and Isoform-Specific Effects of Platelet-Derived Growth Factor on Neonatal-Derived Dermal and Fetal-Derived Lung Fibroblast Profibrotic Functions.

Classification of collagen remodeling in asthma using second-harmonic generation imaging, supervised machine learning and texture-based analysis.

Closing the Gap: Use of Polidocanol to Study Human Airway Epithelial Repair.

Mucus Plugs Correlate with Small Airway Remodelling in Asthma: A Case-Control Study.

Effect of age, COPD severity, and cigarette smoke exposure on bronchial epithelial barrier function.

Cellular and molecular features of asthma mucus plugs provide clues about their formation and persistence.

Computational fluid dynamics of small airway disease in chronic obstructive pulmonary disease

Identification of Cell-Free DNA Methylation Biomarkers for Progressive Interstitial Lung Disease in Systemic Sclerosis

Cartilage-associated protein (CRTAP) as an environmentally sensitive target in idiopathic pulmonary fibrosis.

Integration of multi-resolution imaging to improve the diagnosis and treatment of fibrotic interstitial lung diseases

The Effect of Transforming Growth Factor-Beta Receptor Inhibition on Skin and Lung Fibrosis in Patients with Systemic Sclerosis

The Role of Small Airways Disease Heterogeneity in Asthma

The contribution of sex differences to small airways disease in chronic obstructive pulmonary disease

Air pollution as a modulator of molecular, structural, and clinical outcomes in patients with fibrotic interstitial lung disease.

Canada Research Chairs - Tier 1

The Role of Small Airways Disease Heterogeneity in Asthma

Gene by Sex Interactions in COPD

Frequent collaborators

John McDonough

Ma'en Obeidat

Jeremy Hirota

Parameswaran Krishna Nair

Raveen Badyal

Andre Phillion

Pascal Bernatchez

Janice Leung

Stephen Lam

Philippe Joubert

Samuel Wadsworth

Bruce McManus

Mark David Inman

Wan Lam

Honglin Luo

Tillie-Louise Hackett

Research

Latest papers

Latest funding

Reply to Noble et&#xa0;al.: The propensity for mucus plug formation in fatal asthma is increased by airway narrowing.

Reticular Basement Membrane Remodelling Regulates Bronchial Epithelial Attachment, Barrier Integrity and Inflammatory Signalling in Asthma.

Systematic Comparison of the TGF-&#x3b2; Isoforms in Normal Dermal and Lung Fibroblasts Identifies TGF-&#x3b2;2 and TGF-&#x3b2;3 as Priority Targets in Tissue Fibrosis.

Tissue and Isoform-Specific Effects of Platelet-Derived Growth Factor on Neonatal-Derived Dermal and Fetal-Derived Lung Fibroblast Profibrotic Functions.

Classification of collagen remodeling in asthma using second-harmonic generation imaging, supervised machine learning and texture-based analysis.

Closing the Gap: Use of Polidocanol to Study Human Airway Epithelial Repair.

Mucus Plugs Correlate with Small Airway Remodelling in Asthma: A Case-Control Study.

Effect of age, COPD severity, and cigarette smoke exposure on bronchial epithelial barrier function.

Cellular and molecular features of asthma mucus plugs provide clues about their formation and persistence.

Computational fluid dynamics of small airway disease in chronic obstructive pulmonary disease

Frequent collaborators

John McDonough

Ma'en Obeidat

Jeremy Hirota

Parameswaran Krishna Nair

Raveen Badyal

Andre Phillion

Pascal Bernatchez

Janice Leung

Stephen Lam

Philippe Joubert

Samuel Wadsworth

Bruce McManus

Mark David Inman

Wan Lam

Honglin Luo

Reply to Noble et al.: The propensity for mucus plug formation in fatal asthma is increased by airway narrowing.

Systematic Comparison of the TGF-β Isoforms in Normal Dermal and Lung Fibroblasts Identifies TGF-β2 and TGF-β3 as Priority Targets in Tissue Fibrosis.