Andrew Halayko, University of Manitoba

Research

Crc

Latest papers

TSLPR deficiency attenuates AHR independently of eosinophilia and mucus secretion in a chronic HDM mouse model of allergic asthma.
PloS one · 2025
CD11c+ dendritic cells PlexinD1 deficiency exacerbates airway hyperresponsiveness, IgE and mucus production in a mouse model of allergic asthma.
PloS one · 2024
Predicting New-onset Exertional and Resting Hypoxemia in Fibrotic Interstitial Lung Disease.
Annals of the American Thoracic Society · 2023

All 9 publications

Latest funding

Canada Research Chair - Tier 1
CIHR · 2024 · Nominated PI
$1,400,000
Impact of exposure to hyperglycemia during pregnancy on offspring airway smooth muscle contractility and the activity of RhoA
CIHR · 2023 · Co-investigator
$784,125
Impact of maternal hyperglycemia on offspring airway smooth muscle contractility and the activity of RhoA.
CIHR · 2022 · Co-investigator
$100,000

All 16 grants and awards

9 publications.

01

TSLPR deficiency attenuates AHR independently of eosinophilia and mucus secretion in a chronic HDM mouse model of allergic asthma.

Koussih L, Taefehshokr S, Shan L, Basu S, Halayko A, Lamkhioued B, Gounni AS

PloS one2025

DOI: 10.1371/journal.pone.0335742 PMID: 41259396

02

CD11c+ dendritic cells PlexinD1 deficiency exacerbates airway hyperresponsiveness, IgE and mucus production in a mouse model of allergic asthma.

Shan L, Matloubi M, Okwor I, Kung S, Almiski MS, Basu S, Halayko A, Koussih L, Gounni AS

PloS one2024

DOI: 10.1371/journal.pone.0309868 PMID: 39213301

03

Predicting New-onset Exertional and Resting Hypoxemia in Fibrotic Interstitial Lung Disease.

Saleem F, Ryerson CJ, Sarma N, Johannson K, Marcoux V, Fisher J, Assayag D, Manganas H, Khalil N, Morisset J

Annals of the American Thoracic Society202313 citations

DOI: 10.1513/annalsats.202303-208oc

04

PlexinD1 Deficiency in Lung Interstitial Macrophages Exacerbates House Dust Mite-Induced Allergic Asthma.

Aktar A, Shan L, Koussih L, Almiski MS, Basu S, Halayko A, Okwor I, Uzonna JE, Gounni AS

Journal of immunology (Baltimore, Md. : 1950)2022

DOI: 10.4049/jimmunol.2100089 PMID: 35110420

05

Vitamin D3 Attenuates Viral-Induced Inflammation and Fibrotic Responses in Bronchial Smooth Muscle Cells.

Plesa M, Gaudet M, Mogas A, Jalaleddine N, Halayko A, Al Heialy S, Hamid Q

Frontiers in immunology2021

DOI: 10.3389/fimmu.2021.715848 PMID: 34512638

06

Minimum important difference of the EQ-5D-5L and EQ-VAS in fibrotic interstitial lung disease

Tsai APY, Hur SA, Wong A, Safavi M, Assayag D, Johannson KA, Morisset J, Fell C, Fisher JH, Manganas H

Thorax202154 citationsOpen Access

DOI: 10.1136/thoraxjnl-2020-214944 PMID: W3092640658

07

β-Catenin Directs Nuclear Factor-κB p65 Output via CREB-Binding Protein/p300 in Human Airway Smooth Muscle.

Koopmans T, Eilers R, Menzen M, Halayko A, Gosens R

Frontiers in immunology2017

DOI: 10.3389/fimmu.2017.01086 PMID: 28943877

08

Platinum (IV) coiled coil nanotubes selectively kill human glioblastoma cells.

Thanasupawat T, Bergen H, Hombach-Klonisch S, Krcek J, Ghavami S, Del Bigio MR, Krawitz S, Stelmack G, Halayko A, McDougall M, Meier M, Stetefeld J, Klonisch T

Nanomedicine : nanotechnology, biology, and medicine2015

DOI: 10.1016/j.nano.2015.01.014 PMID: 25680541

09

The importance of valine 114 in ligand binding in beta(2)-adrenergic receptor.

Arakawa M, Yanamala N, Upadhyaya J, Halayko A, Klein-Seetharaman J, Chelikani P

Protein science : a publication of the Protein Society2010

DOI: 10.1002/pro.285 PMID: 19916165

Canada Research Chair - Tier 1

Nominated PICIHR2024Canada Research Chairs - CIHR Funded - Tier 1

Principal investigators: Halayko, Andrew J

Keywords: Crc

$1,400,000

Impact of exposure to hyperglycemia during pregnancy on offspring airway smooth muscle contractility and the activity of RhoA

Co-investigatorCIHR2023Project Grant

Principal investigators: Pascoe, Christopher D

Keywords: Airway Smooth Muscle; Animal Model; Asthma; Developmental Origins; Gestational Diabetes; Rhoa; Stem Cell

$784,125

Impact of maternal hyperglycemia on offspring airway smooth muscle contractility and the activity of RhoA.

Co-investigatorCIHR2022Project Grant

Principal investigators: Pascoe, Christopher D

Keywords: Airway Smooth Muscle; Animal Model; Asthma; Developmental Origins; Gestational Diabetes; Rhoa; Stem Cell

$100,000

The impact of epithelial cell derived semaphorin3E on airway remodeling in allergic asthma

Co-investigatorCIHR2020Project Grant

Principal investigators: Soussi Gounni, Abdelilah

Keywords: Airway Hyprresponsiveness; Asthma; Epithelial Cells; Plexind1; Regulation; Remodeling; Semaphorin3e

$757,350

Understanding the pathology of vaping associated lung damage in young adults

Co-investigatorCIHR2020Catalyst Grant: Health Effects of Vaping

Principal investigators: Pascoe, Christopher D

Keywords: Human; Inflammation; Lung Injury; Pathology; Pneumothorax; Prospective; Rna-Sequencing; Vaping; Young Adult

$100,000

Epigenetic changes linking prenatal exposures to tobacco or cannabis smoke with asthma risk

Co-investigatorCIHR2019Operating Grant: ECI grants in MRC&Y Health - Infection and Immunity

Principal investigators: Jones, Meaghan J

Keywords: Asthma; Cannabis Smoke; Cigarette Smoke; Developmental Origins Of Health And Disease; Dna Methylation; Epigenetics; Lung Function; Prenatal Exposures

$105,000

Molecular adaptation to allergen exposure: sex-related differences in asthma

Co-investigatorCIHR2017Catalyst Grant: Sex as a Variable in Biomedical Research

Principal investigators: Mookherjee, Neeloffer

Keywords: Asthma; Biosignature; Human Controlled Exposure Model; Immune Response; Inflammation; Lung; Murine Model

$148,000

Understanding the role of oxidized lipids in the pathogenesis of asthma: a multi-scale approach

SupervisorCIHR2017CIHR Fellowship

Principal investigators: Pascoe, Christopher D

Keywords: Asthma; Inflammation; Mitochondrial Function; Oxidative Stress; Oxidized Phospholipids; Pollution

$135,000

Canada Research Chair Tier 1

Nominated PICIHR2016Canada Research Chairs - CIHR Funded - Tier 1

Principal investigators: Halayko, Andrew J

Keywords: Crc

$1,400,000

CANADA RESEARCH CHAIRHOLDER - TITULAIRE DE CHAIRE DE RECHERCHE DU CANADA

Nominated PICIHR2010Canada Research Chairs - CIHR Funded - Tier 2

Principal investigators: Halayko, Andrew J

Keywords: Crc

$500,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Medicine
Pediatrics
Oral Biology
Human Anatomy & Cell Science
Other

Co-authors at University of Manitoba, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

Prashen Chelikani

Oral Biology

1 shared papers, latest 2010

Thomas Klonisch

Human Anatomy & Cell Science

1 shared papers, latest 2015

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mentionMention their CIHR grant from 2024

Subject: Prospective PhD student: Crc Dear Professor Halayko, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "TSLPR deficiency attenuates AHR independently of eosinophilia and mucus secretion in a chronic HDM mouse model of allergic asthma." (2025), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your CIHR-funded project "Canada Research Chair - Tier 1" (2024), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]

Andrew Halayko

Research

Latest papers

Latest funding

TSLPR deficiency attenuates AHR independently of eosinophilia and mucus secretion in a chronic HDM mouse model of allergic asthma.

CD11c+ dendritic cells PlexinD1 deficiency exacerbates airway hyperresponsiveness, IgE and mucus production in a mouse model of allergic asthma.

Predicting New-onset Exertional and Resting Hypoxemia in Fibrotic Interstitial Lung Disease.

PlexinD1 Deficiency in Lung Interstitial Macrophages Exacerbates House Dust Mite-Induced Allergic Asthma.

Vitamin D3 Attenuates Viral-Induced Inflammation and Fibrotic Responses in Bronchial Smooth Muscle Cells.

Minimum important difference of the EQ-5D-5L and EQ-VAS in fibrotic interstitial lung disease

β-Catenin Directs Nuclear Factor-κB p65 Output via CREB-Binding Protein/p300 in Human Airway Smooth Muscle.

Platinum (IV) coiled coil nanotubes selectively kill human glioblastoma cells.

The importance of valine 114 in ligand binding in beta(2)-adrenergic receptor.

Canada Research Chair - Tier 1

Impact of exposure to hyperglycemia during pregnancy on offspring airway smooth muscle contractility and the activity of RhoA

Impact of maternal hyperglycemia on offspring airway smooth muscle contractility and the activity of RhoA.

The impact of epithelial cell derived semaphorin3E on airway remodeling in allergic asthma

Understanding the pathology of vaping associated lung damage in young adults

Epigenetic changes linking prenatal exposures to tobacco or cannabis smoke with asthma risk

Molecular adaptation to allergen exposure: sex-related differences in asthma

Understanding the role of oxidized lipids in the pathogenesis of asthma: a multi-scale approach

Canada Research Chair Tier 1

CANADA RESEARCH CHAIRHOLDER - TITULAIRE DE CHAIRE DE RECHERCHE DU CANADA

Frequent collaborators

Deborah Assayag

Martin Rainer Kolb

Nathan Hambly

Gerard Cox

Teresa To

Prashen Chelikani

Sabine Hombach-Klonisch

Thomas Klonisch

Andrew Halayko

Research

Latest papers

Latest funding

TSLPR deficiency attenuates AHR independently of eosinophilia and mucus secretion in a chronic HDM mouse model of allergic asthma.

CD11c+ dendritic cells PlexinD1 deficiency exacerbates airway hyperresponsiveness, IgE and mucus production in a mouse model of allergic asthma.

Predicting New-onset Exertional and Resting Hypoxemia in Fibrotic Interstitial Lung Disease.

PlexinD1 Deficiency in Lung Interstitial Macrophages Exacerbates House Dust Mite-Induced Allergic Asthma.

Vitamin D3 Attenuates Viral-Induced Inflammation and Fibrotic Responses in Bronchial Smooth Muscle Cells.

Minimum important difference of the EQ-5D-5L and EQ-VAS in fibrotic interstitial lung disease

&#x3b2;-Catenin Directs Nuclear Factor-&#x3ba;B p65 Output via CREB-Binding Protein/p300 in Human Airway Smooth Muscle.

Platinum (IV) coiled coil nanotubes selectively kill human glioblastoma cells.

The importance of valine 114 in ligand binding in beta(2)-adrenergic receptor.

Frequent collaborators

Deborah Assayag

Martin Rainer Kolb

Nathan Hambly

Gerard Cox

Teresa To

Prashen Chelikani

Sabine Hombach-Klonisch

Thomas Klonisch

β-Catenin Directs Nuclear Factor-κB p65 Output via CREB-Binding Protein/p300 in Human Airway Smooth Muscle.