Dake Qi, University of Manitoba

Research

Adipose Tissue Atypical Antipsychotics Macrophage Migration Inhibitory Factor Metabolic Dysfunction Trace Amine-Associated Receptor

Latest papers

Based on the gut-heart axis: Polygonum capitatum improves atherosclerosis by modulating gut microbiota and TMAO, supporting MCPIP1/p53-associated endothelial protection.
Chinese medicine · 2026
Mast cell-expressed Mrgprb2/MRGPRX2 mediates gout pain and inflammation via a neuroimmune axis.
JCI insight · 2026
Salidroside protects against myocardial infarction via activating MIF-mediated mitochondrial quality control.
Chinese medicine · 2025

All 17 publications

Latest funding

TAAR1 in adipose tissue is a novel therapeutic target to combat atypical antipsychotics (AAPs)-induced metabolic dysfunction via downregulation of MIF
CIHR · 2024 · Nominated PI
$849,150

All 1 grants and awards

17 publications.

01

Based on the gut-heart axis: Polygonum capitatum improves atherosclerosis by modulating gut microbiota and TMAO, supporting MCPIP1/p53-associated endothelial protection.

Wang Y, Tian W, Ye Z, Liao Y, Huang C, Qi D, Wang Y, Chen Y, Zhou Y

Chinese medicine2026

DOI: 10.1186/s13020-026-01355-7 PMID: 41803870

02

Mast cell-expressed Mrgprb2/MRGPRX2 mediates gout pain and inflammation via a neuroimmune axis.

Yang L, Liu C, Xiao J, Song Y, Chen H, Li D, Zou C, Hong T, Liu Y, Qi D, Limjunyawong N, Liu W, Qu L

JCI insight2026

DOI: 10.1172/jci.insight.201781 PMID: 41574611

03

Salidroside protects against myocardial infarction via activating MIF-mediated mitochondrial quality control.

You B, Zhang J, Yang C, Dun Y, Qi D, Long Y, Cheng J, Lin Y, Zhou N, Zeng T, Dong J, Liu S

Chinese medicine2025

DOI: 10.1186/s13020-025-01076-3 PMID: 40016840

04

Targeting white adipose tissue to combat insulin resistance.

Huang Y, Gao P, Young LH, Qi D

Trends in pharmacological sciences2024Senior author

DOI: 10.1016/j.tips.2024.06.008 PMID: 39054181

05

Downregulation of adipose LPL by PAR2 contributes to the development of hypertriglyceridemia.

Huang Y, Chen L, Li L, Qi Y, Tong H, Wu H, Xu J, Leng L, Cheema S, Sun G, Xia Z, McGuire J, Rodrigues B, Young LH, Bucala R, Qi D

JCI insight2024Senior author

DOI: 10.1172/jci.insight.173240 PMID: 38973609

06

High circulating MIF levels indicate the association with atypical antipsychotic-induced adverse metabolic effects.

Chen X, Gao P, Qi Y, Li Z, Huang H, Shi Y, Wang L, Cui D, Qi D

Translational psychiatry2024Senior author

DOI: 10.1038/s41398-024-02934-8 PMID: 38802393

07

Extracellular macrophage migration inhibitory factor (MIF) downregulates adipose hormone-sensitive lipase (HSL) and contributes to obesity.

Chen L, Li L, Cui D, Huang Y, Tong H, Zabihi H, Wang S, Qi Y, Lakowski T, Leng L, Liu S, Wu H, Young LH, Bucala R, Qi D

Molecular metabolism2024Senior author

DOI: 10.1016/j.molmet.2023.101834 PMID: 37935315

08

Intermittent fasting activates macrophage migration inhibitory factor and alleviates high-fat diet-induced nonalcoholic fatty liver disease.

Li D, Dun Y, Qi D, Ripley-Gonzalez JW, Dong J, Zhou N, Qiu L, Zhang J, Zeng T, You B, Liu S

Scientific reports2023

DOI: 10.1038/s41598-023-40373-5 PMID: 37567977

09

A pref-1-controlled non-inflammatory mechanism of insulin resistance.

Huang Y, Cui D, Chen L, Tong H, Wu H, Muller GK, Qi Y, Wang S, Xu J, Gao X, Fifield KE, Wang L, Xia Z, Vanderluit JL, Liu S, Leng L, Sun G, McGuire J, Young LH, Bucala R, Qi D

iScience2023Senior author

DOI: 10.1016/j.isci.2023.106923 PMID: 37283810

10

Tauroursodeoxycholic acid functions as a critical effector mediating insulin sensitization of metformin in obese mice.

Zhang Y, Cheng Y, Liu J, Zuo J, Yan L, Thring RW, Ba X, Qi D, Wu M, Gao Y, Tong H

Redox biology2022

DOI: 10.1016/j.redox.2022.102481 PMID: 36148770

TAAR1 in adipose tissue is a novel therapeutic target to combat atypical antipsychotics (AAPs)-induced metabolic dysfunction via downregulation of MIF

Nominated PICIHR2024Project Grant

Principal investigators: Qi, Dake

Keywords: Adipose Tissue; Atypical Antipsychotics; Macrophage Migration Inhibitory Factor; Metabolic Dysfunction; Trace Amine-Associated Receptor

$849,150

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Genetics
Biomedical Sciences
Pharmacy
Department of Medical Biophysics
Cellular and Molecular Pharmacology
Medicine
Orthopedics
Other

Co-authors at University of Manitoba, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

Guangju Zhai

Biomedical Sciences

4 shared papers, latest 2022

Dake Qi

Biomedical Sciences

3 shared papers, latest 2024

John McGuire

Department of Medical Biophysics

2 shared papers, latest 2024

Brian Rodrigues

Cellular and Molecular Pharmacology

1 shared papers, latest 2024

Ted Lakowski

College of Pharmacy

1 shared papers, latest 2024

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mentionMention their CIHR grant from 2024

Subject: Prospective PhD student: Adipose Tissue Dear Professor Qi, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Based on the gut-heart axis: Polygonum capitatum improves atherosclerosis by modulating gut microbiota and TMAO, supporting MCPIP1/p53-associated endothelial protection." (2026), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your CIHR-funded project "TAAR1 in adipose tissue is a novel therapeutic target to combat atypical antipsychotics (AAPs)-induced metabolic dysfunction via downregulation of MIF" (2024), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]

Dake Qi

Research

Latest papers

Latest funding

Based on the gut-heart axis: Polygonum capitatum improves atherosclerosis by modulating gut microbiota and TMAO, supporting MCPIP1/p53-associated endothelial protection.

Mast cell-expressed Mrgprb2/MRGPRX2 mediates gout pain and inflammation via a neuroimmune axis.

Salidroside protects against myocardial infarction via activating MIF-mediated mitochondrial quality control.

Targeting white adipose tissue to combat insulin resistance.

Downregulation of adipose LPL by PAR2 contributes to the development of hypertriglyceridemia.

High circulating MIF levels indicate the association with atypical antipsychotic-induced adverse metabolic effects.

Extracellular macrophage migration inhibitory factor (MIF) downregulates adipose hormone-sensitive lipase (HSL) and contributes to obesity.

Intermittent fasting activates macrophage migration inhibitory factor and alleviates high-fat diet-induced nonalcoholic fatty liver disease.

A pref-1-controlled non-inflammatory mechanism of insulin resistance.

Tauroursodeoxycholic acid functions as a critical effector mediating insulin sensitization of metformin in obese mice.

TAAR1 in adipose tissue is a novel therapeutic target to combat atypical antipsychotics (AAPs)-induced metabolic dysfunction via downregulation of MIF

Frequent collaborators

Guang Sun

Guangju Zhai

Proton Rahman

Dake Qi

John McGuire

Brian Rodrigues

Johanne Martel-Pelletier

Mohit Kapoor

Ted Lakowski