Laura Trinkle-Mulcahy, University of Ottawa

Research

Read how they describe their research on their University of Ottawa profile.

Biological Condensates Cell Signalling Fluorescence Imaging Heterochromatin Nucleus Quantitative Genomics Quantitative Proteomics Stress Response

Latest papers

Protocol for conditional mapping of proximal interactomes of dimeric protein complexes using a BioID-based complementation approach.
STAR protocols · 2026 · senior author
SplitTurboID mapping of dimeric protein phosphatase complex interactomes.
iScience · 2026 · senior author
Loss of VHL-mediated pRb regulation promotes clear cell renal cell carcinoma.
Cell death & disease · 2025

All 46 publications

Latest funding

Contribution of a novel nuclear stress response to the promotion of cell survival
CIHR · 2023 · Nominated PI
$772,650
Temporal resolution of phosphorylation-mediated signalling events in DNA Damage Repair
NSERC · 2020 · Principal investigator
$216,000
Microscopy suite for time-lapse multi-wavelength live cell imaging
NSERC · 2015 · Co-investigator
$150,000

All 8 grants and awards

46 publications.

01

Protocol for conditional mapping of proximal interactomes of dimeric protein complexes using a BioID-based complementation approach.

Rajkumar A, Gaudreau-Lapierre A, Anthony CLF, Trinkle-Mulcahy L

STAR protocols2026Senior author

DOI: 10.1016/j.xpro.2026.104759 PMID: 42555348

02

SplitTurboID mapping of dimeric protein phosphatase complex interactomes.

Rajkumar A, Gaudreau-Lapierre A, Anthony CLF, Nguyen V, Ooi S, Campuzano D, Trinkle-Mulcahy L

iScience2026Senior author

DOI: 10.1016/j.isci.2026.115195 PMID: 41869563

03

Loss of VHL-mediated pRb regulation promotes clear cell renal cell carcinoma.

Akuma M, Kim M, Zhu C, Wiljer E, Gaudreau-Lapierre A, Patterson LD, Egevad L, Tanguay S, Trinkle-Mulcahy L, Stanford WL, Riazalhosseini Y, Russell RC

Cell death & disease2025

DOI: 10.1038/s41419-025-07623-y PMID: 40240354

04

Biochemical Properties of CARM1: Impact on Western Blotting and Proteomic Studies.

Bourassa J, Paris G, Trinkle-Mulcahy L, Côté J

ACS omega2024

DOI: 10.1021/acsomega.4c06360 PMID: 39346878

05

Identification of an FMNL2 Interactome by Quantitative Mass Spectrometry.

Fox S, Gaudreau-LaPierre A, Reshke R, Podinic I, Gibbings DJ, Trinkle-Mulcahy L, Copeland JW

International journal of molecular sciences2024

DOI: 10.3390/ijms25115686 PMID: 38891874

06

TRNT-1 Deficiency Is Associated with Loss of tRNA Integrity and Imbalance of Distinct Proteins.

Fatica T, Naas T, Liwak U, Slaa H, Souaid M, Frangione B, Kattini R, Gaudreau-Lapierre A, Trinkle-Mulcahy L, Chakraborty P, Holcik M

Genes2023

DOI: 10.3390/genes14051043 PMID: 37239403

07

Nuclear High Mobility Group A2 (HMGA2) Interactome Revealed by Biotin Proximity Labeling.

Gaudreau-Lapierre A, Klonisch T, Nicolas H, Thanasupawat T, Trinkle-Mulcahy L, Hombach-Klonisch S

International journal of molecular sciences2023

DOI: 10.3390/ijms24044246 PMID: 36835656

08

SPECC1L binds the myosin phosphatase complex MYPT1/PP1β and can regulate its distribution between microtubules and filamentous actin.

Mehta V, Decan N, Ooi S, Gaudreau-Lapierre A, Copeland JW, Trinkle-Mulcahy L

The Journal of biological chemistry2023Senior author

DOI: 10.1016/j.jbc.2023.102893 PMID: 36634848

09

The ribosomal RNA processing 1B:protein phosphatase 1 holoenzyme reveals non-canonical PP1 interaction motifs.

Srivastava G, Bajaj R, Kumar GS, Gaudreau-Lapierre A, Nicolas H, Chamousset D, Kreitler D, Peti W, Trinkle-Mulcahy L, Page R

Cell reports2022

DOI: 10.1016/j.celrep.2022.111726 PMID: 36450254

10

Cooperative assembly of filopodia by the formin FMNL2 and I-BAR domain protein IRTKS.

Fox S, Tran A, Trinkle-Mulcahy L, Copeland JW

The Journal of biological chemistry2022

DOI: 10.1016/j.jbc.2022.102512 PMID: 36259517

Contribution of a novel nuclear stress response to the promotion of cell survival

Nominated PICIHR2023Project Grant

Principal investigators: Trinkle-Mulcahy, Laura

Keywords: Biological Condensates; Cell Signalling; Fluorescence Imaging; Heterochromatin; Nucleus; Quantitative Genomics; Quantitative Proteomics; Stress Response

$772,650

Temporal resolution of phosphorylation-mediated signalling events in DNA Damage Repair

Principal investigatorNSERC2020Discovery Grants Program - Individual

Principal investigators: Trinkle-Mulcahy, Laura

$216,000

Microscopy suite for time-lapse multi-wavelength live cell imaging

Co-investigatorNSERC2015Research Tools and Instruments - Category 1 (<$150,000)

Principal investigators: Gibbings, Derrick

$150,000

Biochemical, proteomic and microscopic insights into regulation of nucleolar structure and function

Principal investigatorNSERC2015Discovery Grants Program - Individual

Principal investigators: TrinkleMulcahy, Laura

$170,000

Dynamic targeting of protein phosphatase 1 (PP1) activity in vivo

Principal investigatorNSERC2014Discovery Grants Program - Individual

Principal investigators: TrinkleMulcahy, Laura

$35,000

Identification and characterization of Protein Phosphatase 1 interactors by affinity-purification and quantitative mass spectrometry using differential metabolic labeling

SupervisorCIHR2012Master's Award: Canada Graduate Scholarships

Principal investigators: Freele, Emily A

Keywords: Affinity Purification; Cancer Prevention; Cloning; Fluorescence Microscopy; Immunohistochemistry; Key Regulator Of Many Essential Pathways; Mutagenesis; Phosphatase Assay; Quantitative Mass Spectrometry; Western Blot Analysis

$17,500

Role of Targeted Phosphatase Activity in the Regulation of Cell Proliferation

Nominated PICIHR2009CIHR New Investigator

Principal investigators: Trinkle-Mulcahy, Laura

Keywords: Apoptosis; Chromatin; Fluorescence Imaging; Pp1; Quantitative Proteomics; Repoman

$300,000

Dynamic targeting of protein phosphatase 1 (PP1) activity in vivo

Principal investigatorNSERC2009Discovery Grants Program - Individual

Principal investigators: TrinkleMulcahy, Laura

$160,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Cellular and Molecular Medicine
Biochemistry, Microbiology and Immunology
Pediatrics
Medicine/Neurology
Human Anatomy & Cell Science
Pathology and Molecular Medicine
Human Genetics
Other

Co-authors at University of Ottawa, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

Mireille Khacho

Biochemistry, Microbiology and Immunology

2 shared papers, latest 2016

Martin Holcik

Pediatrics

1 shared papers, latest 2023

Connie Marras

Medicine/Neurology

1 shared papers, latest 2018

Jean-Yves Masson

Faculty

1 shared papers, latest 2019

Mary-Ellen Harper

Biochemistry, Microbiology and Immunology

1 shared papers, latest 2014

David Lohnes

Cellular and Molecular Medicine

1 shared papers, latest 2017

Yasser Riazalhosseini

Human Genetics

1 shared papers, latest 2025

Xiaolong Yang

Pathology and Molecular Medicine

1 shared papers, latest 2018

Thomas Klonisch

Human Anatomy & Cell Science

1 shared papers, latest 2023

Pranesh Chakraborty

Pediatrics

1 shared papers, latest 2023

Rachid Mazroui

Faculty

1 shared papers, latest 2019

Jocelyn Côté

Cellular and Molecular Medicine

1 shared papers, latest 2020

Sabine Hombach-Klonisch

Faculty

1 shared papers, latest 2023

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mentionMention their CIHR grant from 2023

Subject: Prospective PhD student: Biological Condensates Dear Professor Trinkle-Mulcahy, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Protocol for conditional mapping of proximal interactomes of dimeric protein complexes using a BioID-based complementation approach." (2026), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your CIHR-funded project "Contribution of a novel nuclear stress response to the promotion of cell survival" (2023), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]

Laura Trinkle-Mulcahy

Research

Latest papers

Latest funding

Protocol for conditional mapping of proximal interactomes of dimeric protein complexes using a BioID-based complementation approach.

SplitTurboID mapping of dimeric protein phosphatase complex interactomes.

Loss of VHL-mediated pRb regulation promotes clear cell renal cell carcinoma.

Biochemical Properties of CARM1: Impact on Western Blotting and Proteomic Studies.

Identification of an FMNL2 Interactome by Quantitative Mass Spectrometry.

TRNT-1 Deficiency Is Associated with Loss of tRNA Integrity and Imbalance of Distinct Proteins.

Nuclear High Mobility Group A2 (HMGA2) Interactome Revealed by Biotin Proximity Labeling.

SPECC1L binds the myosin phosphatase complex MYPT1/PP1&#x3b2; and can regulate its distribution between microtubules and filamentous actin.

The ribosomal RNA processing 1B:protein phosphatase 1 holoenzyme reveals non-canonical PP1 interaction motifs.

Cooperative assembly of filopodia by the formin FMNL2 and I-BAR domain protein IRTKS.

Contribution of a novel nuclear stress response to the promotion of cell survival

Temporal resolution of phosphorylation-mediated signalling events in DNA Damage Repair

Microscopy suite for time-lapse multi-wavelength live cell imaging

Biochemical, proteomic and microscopic insights into regulation of nucleolar structure and function

Dynamic targeting of protein phosphatase 1 (PP1) activity in vivo

Identification and characterization of Protein Phosphatase 1 interactors by affinity-purification and quantitative mass spectrometry using differential metabolic labeling

Role of Targeted Phosphatase Activity in the Regulation of Cell Proliferation

Dynamic targeting of protein phosphatase 1 (PP1) activity in vivo

Frequent collaborators

Mireille Khacho

Martin Holcik

Connie Marras

Jean-Yves Masson

Mary-Ellen Harper

David Lohnes

Yasser Riazalhosseini

Xiaolong Yang

Thomas Klonisch

Pranesh Chakraborty

Rachid Mazroui

Jocelyn Côté

Sabine Hombach-Klonisch

SPECC1L binds the myosin phosphatase complex MYPT1/PP1β and can regulate its distribution between microtubules and filamentous actin.