Faculty profile

Wei Zhang

ResearcherDepartment of Molecular & Cellular BiologyUniversity of Guelph

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a University of Guelph directory, so their courses may be missing. Find their university profile.

Wei Zhang

Researcher

Department of Molecular & Cellular Biology

College of Biological Science

University of Guelph

Guelph, Ontario, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
15 publications in the last five years, latest in 2026.
Senior (last) author on 6 recent papers, a sign of leading a research group.
Principal investigator on 3 research grants (2 NSERC, 1 CIHR), most recently in 2019.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

Publications

Collaborators

Grants

Publications by year

Counts cover the publications linked to this profile. Citations and the h-index appear when the source records them.

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Signals and details

Research

Phage display Protein engineering DNA double-strand break DNA repair E3 ubiquitin ligase Phosphorylation Protein-protein interaction proteomics

Latest papers

Identification of E3 ligase substrates and PROTAC-induced ubiquitylation sites using proximity-based identification of ubiquitin sites (PrIUS).
Communications biology · 2026
Locking CBL TKBD in its native conformation presents a novel therapeutic opportunity in mutant CBL-dependent leukemia.
Molecular therapy : the journal of the American Society of Gene Therapy · 2025
Structural insights into the biochemical mechanism of the E2/E3 hybrid enzyme UBE2O.
Structure (London, England : 1993) · 2025 · senior author

All 24 publications

Latest funding

Delineating molecular mechanisms of DNA repair through protein engineering
NSERC · 2019 · Principal investigator
$246,000
Delineating molecular mechanisms of DNA repair through protein engineering
NSERC · 2019 · Principal investigator
$12,500
Development of allosteric inhibitors for HECT E3 ligases
CIHR · 2018 · Nominated PI
$745,875

All 3 grants and awards

24 publications.

Identification of E3 ligase substrates and PROTAC-induced ubiquitylation sites using proximity-based identification of ubiquitin sites (PrIUS).

Tessier TM, Maitland MER, Kutera M, Dybas JM, St-Germain J, Arrowsmith CH, Barsyte-Lovejoy D, Zhang W, Raught B, Weitzman MD

Communications biology2026

DOI: 10.1038/s42003-026-09964-6 PMID: 41957433

Locking CBL TKBD in its native conformation presents a novel therapeutic opportunity in mutant CBL-dependent leukemia.

Ahmed SF, Anand J, Zhang W, Buetow L, Rishi L, Mitchell L, Bohlen J, Lilla S, Sibbet GJ, Nixon C, Patel A, Majorek KA, Zanivan S, Bustamante JC, Sidhu SS, Blyth K, Huang DT

Molecular therapy : the journal of the American Society of Gene Therapy2025

DOI: 10.1016/j.ymthe.2025.04.042 PMID: 40329529

Structural insights into the biochemical mechanism of the E2/E3 hybrid enzyme UBE2O.

Huang H, Zhu W, Huang B, Fu Z, Xiong Y, Cao D, Ye Y, Chang Q, Li W, Li L, Zhou H, Niu X, Zhang W

Structure (London, England : 1993)2025Senior author

DOI: 10.1016/j.str.2024.12.002 PMID: 39740670

Analysis of the impact of pluronic acid on the thermal stability and infectivity of AAV6.2FF.

Thomas SP, Spinelli MM, Rghei AD, Lopes JA, Zielinska N, McLeod BM, Pei Y, Zhang W, Thebaud B, Karimi K, Wootton SK

BMC biotechnology2024

DOI: 10.1186/s12896-024-00853-6 PMID: 38664752

Generation and Characterization of Engineered Ubiquitin Variants to Modulate the Ubiquitin Signaling Cascade.

Liang CT, Roscow O, Zhang W

Cold Spring Harbor protocols2024Senior author

DOI: 10.1101/pdb.over107784 PMID: 36997275

Structural and functional validation of a highly specific Smurf2 inhibitor.

Tessier TM, Chowdhury A, Stekel Z, Fux J, Sartori MA, Teyra J, Jarvik N, Chung J, Kurinov I, Sicheri F, Sidhu SS, Singer AU, Zhang W

Protein science : a publication of the Protein Society2024Senior author

DOI: 10.1002/pro.4885 PMID: 38147466

A promoterless AAV6.2FF-based lung gene editing platform for the correction of surfactant protein B deficiency.

Thomas SP, Domm JM, van Vloten JP, Xu L, Vadivel A, Yates JGE, Pei Y, Ingrao J, van Lieshout LP, Jackson SR, Minott JA, Achuthan A, Mehrani Y, McAusland TM, Zhang W, Karimi K, Vaughan AE, de Jong J, Kang MH, Thebaud B, Wootton SK

Molecular therapy : the journal of the American Society of Gene Therapy2023

DOI: 10.1016/j.ymthe.2023.10.002 PMID: 37805711

Time-resolved cryo-EM (TR-EM) analysis of substrate polyubiquitination by the RING E3 anaphase-promoting complex/cyclosome (APC/C).

Bodrug T, Welsh KA, Bolhuis DL, Paulаkonis E, Martinez-Chacin RC, Liu B, Pinkin N, Bonacci T, Cui L, Xu P, Roscow O, Amann SJ, Grishkovskaya I, Emanuele MJ, Harrison JS, Steimel JP, Hahn KM, Zhang W, Zhong ED, Haselbach D, Brown NG

Nature structural & molecular biology2023

DOI: 10.1038/s41594-023-01105-5 PMID: 37735619

Development of an OTUD1 ubiquitin variant inhibitor.

Liu Q, Mallette E, Zheng H, Zhang W

The Biochemical journal2023Senior author

DOI: 10.1042/bcj20230119 PMID: 37589489

A Designer Nanoparticle Platform for Controlled Intracellular Delivery of Bioactive Macromolecules: Inhibition of Ubiquitin-Specific Protease 7 in Breast Cancer Cells.

McClary WD, Catala A, Zhang W, Gamboni F, Dzieciatkowska M, Sidhu SS, D'Alessandro A, Catalano CE

ACS chemical biology2022

DOI: 10.1021/acschembio.2c00256 PMID: 35796308

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Wei Zhang

Research

Latest papers

Latest funding

Identification of E3 ligase substrates and PROTAC-induced ubiquitylation sites using proximity-based identification of ubiquitin sites (PrIUS).

Locking CBL TKBD in its native conformation presents a novel therapeutic opportunity in mutant CBL-dependent leukemia.

Structural insights into the biochemical mechanism of the E2/E3 hybrid enzyme UBE2O.

Analysis of the impact of pluronic acid on the thermal stability and infectivity of AAV6.2FF.

Generation and Characterization of Engineered Ubiquitin Variants to Modulate the Ubiquitin Signaling Cascade.

Structural and functional validation of a highly specific Smurf2 inhibitor.

A promoterless AAV6.2FF-based lung gene editing platform for the correction of surfactant protein B deficiency.

Time-resolved cryo-EM (TR-EM) analysis of substrate polyubiquitination by the RING E3 anaphase-promoting complex/cyclosome (APC/C).

Development of an OTUD1 ubiquitin variant inhibitor.

A Designer Nanoparticle Platform for Controlled Intracellular Delivery of Bioactive Macromolecules: Inhibition of Ubiquitin-Specific Protease 7 in Breast Cancer Cells.

Delineating molecular mechanisms of DNA repair through protein engineering

Delineating molecular mechanisms of DNA repair through protein engineering

Development of allosteric inhibitors for HECT E3 ligases

Frequent collaborators

Yi Sheng

Bernard Thébaud

Yufeng Tong

Dalia Barsyte-Lovejoy

Frank Sicheri

Brian Raught