Arezu Jahani-Asl, University of Ottawa

Research

Read how they describe their research on their University of Ottawa profile.

Transcription Ephrin Receptors Gene Mutation Signalling Receptors Stem Cells Hoxa5 Lgals1

Latest papers

Glycobiology-driven therapeutic targeting of glycan-binding proteins: mechanisms, diseases, and clinical translation.
Signal transduction and targeted therapy · 2026 · senior author
An oncostatin M receptor and chloride intracellular channel 1 crosstalk drives key oncogenic pathways in glioblastoma.
Signal transduction and targeted therapy · 2026 · senior author
REST/NRSF Preserves muscle stem cell identity by repressing alternate cell fate.
Nature communications · 2025

All 24 publications

Latest funding

Transcriptional Regulation of Impaired Neurogenesis in Developmental Disorders of Cognition and Intellectual Disability
CIHR · 2024 · Nominated PI
$960,076
Transcriptional Regulation of Impaired Neurogenesis in Developmental Disorders of Cognition and Intellectual Disability
CIHR · 2023 · Nominated PI
$100,000
Transcriptional Regulation of Impaired Neurogenesis in Developmental Disorders of Cognition and Intellectual Disability
CIHR · 2022 · Nominated PI
$100,000

All 6 grants and awards

24 publications.

01

Glycobiology-driven therapeutic targeting of glycan-binding proteins: mechanisms, diseases, and clinical translation.

Popatia AM, Sharanek A, Jahani-Asl A

Signal transduction and targeted therapy2026Senior author

DOI: 10.1038/s41392-026-02768-4 PMID: 42248861

02

An oncostatin M receptor and chloride intracellular channel 1 crosstalk drives key oncogenic pathways in glioblastoma.

Mansourabadi AH, Qu D, Cianci F, Snider J, Randhawa K, Raco L, Kotlyar M, Al Ayach M, Rey G, Sanghvi S, Abovsky M, Singh H, Luchman HA, Burger D, Rak J, Soleimani VD, Jurisica I, Stagljar I, Mazzanti M, Jahani-Asl A

Signal transduction and targeted therapy2026Senior author

DOI: 10.1038/s41392-026-02723-3 PMID: 42177207

03

REST/NRSF Preserves muscle stem cell identity by repressing alternate cell fate.

Sahinyan K, Blackburn DM, Simon MM, Lazure F, Kwan T, Wilson DH, Vahidyeganeh M, Alsadi N, von Maltzahn J, Yamada Y, Jahani-Asl A, Bourque G, Rudnicki MA, Soleimani VD

Nature communications2025

DOI: 10.1038/s41467-025-62758-y PMID: 40796549

04

Targeting glioblastoma with a brain-penetrant drug that impairs brain tumor stem cells via NLE1-Notch1 complex.

Burban A, Sharanek A, Hernandez-Corchado A, Najafabadi HS, Soleimani VD, Jahani-Asl A

Stem cell reports2024Senior author

DOI: 10.1016/j.stemcr.2024.09.007 PMID: 39423824

05

Master regulators of neurogenesis: the dynamic roles of Ephrin receptors across diverse cellular niches.

Rasool D, Jahani-Asl A

Translational psychiatry2024Senior author

DOI: 10.1038/s41398-024-03168-4 PMID: 39505843

06

The E3 ubiquitin ligase Nedd4L preserves skeletal muscle stem cell quiescence by inhibiting their activation.

Blackburn DM, Sahinyan K, Hernández-Corchado A, Lazure F, Richard V, Raco L, Perron G, Zahedi RP, Borchers CH, Lepper C, Kawabe H, Jahani-Asl A, Najafabadi HS, Soleimani VD

iScience2024

DOI: 10.1016/j.isci.2024.110241 PMID: 39015146

07

PHF6-mediated transcriptional control of NSC via Ephrin receptors is impaired in the intellectual disability syndrome BFLS.

Rasool D, Burban A, Sharanek A, Madrigal A, Hu J, Yan K, Qu D, Voss AK, Slack RS, Thomas T, Bonni A, Picketts DJ, Soleimani VD, Najafabadi HS, Jahani-Asl A

EMBO reports2024Senior author

DOI: 10.1038/s44319-024-00082-0 PMID: 38429579

08

Establishing Brain Tumor Stem Cell Culture from Patient Brain Tumors and Imaging Analysis of Patient-Derived Xenografts.

Mahmoudian E, Jahani-Asl A

Methods in molecular biology (Clifton, N.J.)2024Senior author

DOI: 10.1007/7651_2023_482 PMID: 37243860

09

Transcriptional reprogramming of skeletal muscle stem cells by the niche environment.

Lazure F, Farouni R, Sahinyan K, Blackburn DM, Hernández-Corchado A, Perron G, Lu T, Osakwe A, Ragoussis J, Crist C, Perkins TJ, Jahani-Asl A, Najafabadi HS, Soleimani VD

Nature communications2023

DOI: 10.1038/s41467-023-36265-x PMID: 36726011

10

CLIC1 regulation of cancer stem cells in glioblastoma.

Randhawa K, Jahani-Asl A

Current topics in membranes2023Senior author

DOI: 10.1016/bs.ctm.2023.09.004 PMID: 38007271