Faculty profile

Igor Stagljar

ResearcherBiochemistryUniversity of Toronto

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a University of Toronto directory, so their courses may be missing. Find their university profile.

Igor Stagljar

Researcher

Biochemistry

Health Sciences

University of Toronto

Toronto, Ontario, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
19 publications in the last five years, latest in 2026.
Senior (last) author on 8 recent papers, a sign of leading a research group.
Principal investigator on 9 research grants (7 CIHR, 2 NSERC), most recently in 2022.
Supervised 2 trainees who won CIHR awards, most recently in 2015.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

Publications

Citations

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Collaborators

Grants

Publications by year

Counts cover the works listed on the university profile; citation counts come from Dimensions.

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Signals and details

Research

Abc-Transporters Cancer Computational Analysis Cystic Fibrosis Genomics Interactome Mamth Protein-Protein Interaction

Latest papers

An oncostatin M receptor and chloride intracellular channel 1 crosstalk drives key oncogenic pathways in glioblastoma.
Signal transduction and targeted therapy · 2026
Global mitochondrial connectivity map reveals the landscape of yeast functional assemblies and conserved protein communities.
Nature communications · 2026
Quantum-computing-enhanced algorithm unveils potential KRAS inhibitors.
Nature biotechnology · 2025

All 93 publications

Latest funding

A reference interactome map of human ATP-binding cassette (ABC) transporters.
CIHR · 2022 · Nominated PI
$612,000
Identification and analysis of new small-molecules active against drug-resistant non-small cell lung cancer
CIHR · 2019 · Nominated PI
$749,700
OSMR Regulation of Glioblastoma Pathogenesis
CIHR · 2018 · Co-investigator
$753,525

All 14 grants and awards

93 publications.

An oncostatin M receptor and chloride intracellular channel 1 crosstalk drives key oncogenic pathways in glioblastoma.

Mansourabadi AH, Qu D, Cianci F, Snider J, Randhawa K, Raco L, Kotlyar M, Al Ayach M, Rey G, Sanghvi S, Abovsky M, Singh H, Luchman HA, Burger D, Rak J, Soleimani VD, Jurisica I, Stagljar I, Mazzanti M, Jahani-Asl A

Signal transduction and targeted therapy2026

DOI: 10.1038/s41392-026-02723-3 PMID: 42177207

Global mitochondrial connectivity map reveals the landscape of yeast functional assemblies and conserved protein communities.

Jessulat M, Phanse S, Aoki H, Broderick K, Zhang Q, Castro IG, Novales NA, Hossain SA, Saccon T, Moutaoufik MT, Joseph TP, Amin S, Hoell L, Minic Z, Bykov Y, Preminger N, Crespo SG, Snider J, Golshani A, Stagljar I, Rodriguez-Medina JR, Clarke CF, Schuldiner M, Babu M

Nature communications2026

DOI: 10.1038/s41467-026-72525-2 PMID: 42086547

Quantum-computing-enhanced algorithm unveils potential KRAS inhibitors.

Ghazi Vakili M, Gorgulla C, Snider J, Nigam A, Bezrukov D, Varoli D, Aliper A, Polykovsky D, Padmanabha Das KM, Cox Iii H, Lyakisheva A, Hosseini Mansob A, Yao Z, Bitar L, Tahoulas D, Čerina D, Radchenko E, Ding X, Liu J, Meng F, Ren F, Cao Y, Stagljar I, Aspuru-Guzik A, Zhavoronkov A

Nature biotechnology2025

DOI: 10.1038/s41587-024-02526-3 PMID: 39843581

Author Correction: Systematic protein-protein interaction mapping for clinically relevant human GPCRs.

Sokolina K, Kittanakom S, Snider J, Kotlyar M, Maurice P, Gandía J, Benleulmi-Chaachoua A, Tadagaki K, Oishi A, Wong V, Malty RH, Deineko V, Aoki H, Amin S, Yao Z, Morató X, Otasek D, Kobayashi H, Menendez J, Auerbach D, Angers S, Pržulj N, Bouvier M, Babu M, Ciruela F, Jockers R, Jurisica I, Stagljar I

Molecular systems biology2025Senior author

DOI: 10.1038/s44320-024-00080-3 PMID: 39762653

A split intein and split luciferase-coupled system for detecting protein-protein interactions.

Yao Z, Kim J, Geng B, Chen J, Wong V, Lyakisheva A, Snider J, Dimlić MR, Raić S, Stagljar I

Molecular systems biology2025Senior author

DOI: 10.1038/s44320-024-00081-2 PMID: 39668253

Oxidative protein damage negatively affects protein-protein interaction: The case of KRAS-cRAF.

Rudan Dimlić M, Raić S, Močibob M, Sanader Maršić Ž, Yao Z, Radman M, Stagljar I

Biochemical and biophysical research communications2024Senior author

DOI: 10.1016/j.bbrc.2024.150792 PMID: 39378785

Cyprocide selectively kills nematodes via cytochrome P450 bioactivation.

Knox J, Burns AR, Cooke B, Cammalleri SR, Kitner M, Ching J, Castelli JMP, Puumala E, Snider J, Koury E, Collins JB, Geissah S, Dowling JJ, Andersen EC, Stagljar I, Cowen LE, Lautens M, Zasada I, Roy PJ

Nature communications2024

DOI: 10.1038/s41467-024-49738-4 PMID: 38956039

MMD collaborates with ACSL4 and MBOAT7 to promote polyunsaturated phosphatidylinositol remodeling and susceptibility to ferroptosis.

Phadnis VV, Snider J, Varadharajan V, Ramachandiran I, Deik AA, Lai ZW, Kunchok T, Eaton EN, Sebastiany C, Lyakisheva A, Vaccaro KD, Allen J, Yao Z, Wong V, Geng B, Weiskopf K, Clish CB, Brown JM, Stagljar I, Weinberg RA, Henry WS

Cell reports2023

DOI: 10.1016/j.celrep.2023.113023 PMID: 37691145

Identification and characterization of protein interactions with the major Niemann-Pick type C disease protein in yeast reveals pathways of therapeutic potential.

Hammond N, Snider J, Stagljar I, Mitchell K, Lagutin K, Jessulat M, Babu M, Teesdale-Spittle PH, Sheridan JP, Sturley SL, Munkacsi AB

Genetics2023

DOI: 10.1093/genetics/iyad129 PMID: 37440478

Omicron Spike Protein is Vulnerable to Reduction.

Yao Z, Geng B, Marcon E, Pu S, Tang H, Merluza J, Bello A, Snider J, Lu P, Wood H, Stagljar I

Journal of molecular biology2023Senior author

DOI: 10.1016/j.jmb.2023.168128 PMID: 37100168

A reference interactome map of human ATP-binding cassette (ABC) transporters.

Nominated PICIHR2022Project Grant

Principal investigators: Stagljar, Igor

Keywords: Abc-Transporters; Cancer; Computational Analysis; Cystic Fibrosis; Genomics; Interactome; Mamth; Protein-Protein Interaction

$612,000

Identification and analysis of new small-molecules active against drug-resistant non-small cell lung cancer

Nominated PICIHR2019Project Grant

Principal investigators: Stagljar, Igor

Keywords: Drug Development; Drug Discovery; Epidermal Growth Factor Receptor (Egfr); Mamth-Ds; Non Small-Cell Lung Cancer (Nsclc); Protein-Protein Interactions

$749,700

OSMR Regulation of Glioblastoma Pathogenesis

Co-investigatorCIHR2018Project Grant

Principal investigators: Jahani-Asl, Arezu

Keywords: Brain; Egfrviii; Genetics; Glioblastoma; Neuroscience; Osmr; Phosphorylation; Rna-Seq; Stat3; Transcription

$753,525

Examining the Functional Association Between ABC Transporters and Sho1p

Principal investigatorNSERC2015Discovery Grants Program - Individual

Principal investigators: Stagljar, Igor

$30,000

Identification of Novel Inhibitors of the Acquired EGFR C797S Mutation in Non-Small Cell Lung Cancer

SupervisorCIHR2015CIHR Fellowship

Principal investigators: Saraon, Punit

Keywords: Cell Signalling; Epidermal Growth Factor Receptor (Egfr); High-Throughput Screening; Mammalian Membrane Two-Hybrid (Mamth) Assay; Non-Small Cell Lung Cancer; Protein-Protein Interactions; Therapeutic Target

$135,000

Multimodal strategy to identify novel diagnostic and therapeutic targets in lung and pancreatic cancer

Co-investigatorCIHR2015Foundation Grant

Principal investigators: Tsao, Ming-Sound

Keywords: Antibody; Bioinformatics; Cell Line; Microarray; Molecular Imaging; Molecular Pathology; Next Generation Sequencing; Patient Primary Tumor; Primary Xenograft; Shrna Screening

$3,738,542

Development of the Mammalian Membrane Two-Hybrid (MaMTH) technology, a novel protein interaction and drug discovery tool

Nominated PICIHR2012Proof of Principle Program - Phase I

Principal investigators: Stagljar, Igor

Keywords: Cancer Research; Drug Assay Platform; High-Throughput Protein Interaction Assay; Mammalian Membrane Two Hybrid; Protein Protein Interaction; Signalling Pathways

$160,000

Characterizing the Sho1p interactome in Saccharomyces cerevisiae using the membrane Yeast Two-Hybrid (MYTH) system

Principal investigatorNSERC2012Discovery Grants Program - Individual

Principal investigators: Stagljar, Igor

$28,000

Probing the Histone Deacetylase 6 receptor interactome

SupervisorCIHR2010Master's Award: Canada Graduate Scholarships

Principal investigators: Butty, Francis D

Keywords: Hdac6; Membrane Yeast Two Hybrid

$17,500

The interactome of the human G-protein coupled receptors.

Nominated PICIHR2010Operating Grant

Principal investigators: Stagljar, Igor

Keywords: Bioinformatics; G-Protein Coupled Receptors; Membrane Yeast Two Hybrid; Proteomics

$618,998

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

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Igor Stagljar

Research

Latest papers

Latest funding

An oncostatin M receptor and chloride intracellular channel 1 crosstalk drives key oncogenic pathways in glioblastoma.

Global mitochondrial connectivity map reveals the landscape of yeast functional assemblies and conserved protein communities.

Quantum-computing-enhanced algorithm unveils potential KRAS inhibitors.

Author Correction: Systematic protein-protein interaction mapping for clinically relevant human GPCRs.

A split intein and split luciferase-coupled system for detecting protein-protein interactions.

Oxidative protein damage negatively affects protein-protein interaction: The case of KRAS-cRAF.

Cyprocide selectively kills nematodes via cytochrome P450 bioactivation.

MMD collaborates with ACSL4 and MBOAT7 to promote polyunsaturated phosphatidylinositol remodeling and susceptibility to ferroptosis.

Identification and characterization of protein interactions with the major Niemann-Pick type C disease protein in yeast reveals pathways of therapeutic potential.

Omicron Spike Protein is Vulnerable to Reduction.

Examining the Functional Association Between ABC Transporters and Sho1p

Characterizing the Sho1p interactome in Saccharomyces cerevisiae using the membrane Yeast Two-Hybrid (MYTH) system

Frequent collaborators

Igor Jurisica

Mohan Babu

Andrew Emili

Ming-Sound Tsao

Charles Boone

Anne-Claude Gingras

Zhaolei Zhang

Morag Park

Jason Moffat

Adrian Sacher

Thomas Kislinger

Stephane Angers

Chi-Chung Hui

Janusz Rak

Peter Liu

Allison McGeer

Filio Billia

David Andrews

Ahmed Aman

Prabhat Jha

Dylan Burger

Corey Nislow

Samira Mubareka

Yu Sun

Robert Hamilton

Andrea Jurisicova

Minna Woo

Mei Zhen

Cheryl Arrowsmith

Jun Liu

Laurence Pelletier

Gordon Keller

Brenda Andrews