Arezu Jahani-Asl, McGill University

Research

Glioblastoma Stat3 Transcription Egfrviii Osmr Chip-Seq Rna-Seq Cytokines

Latest papers

An oncostatin M receptor and chloride intracellular channel 1 crosstalk drives key oncogenic pathways in glioblastoma.
Signal transduction and targeted therapy · 2026 · senior author
Targeting glioblastoma with a brain-penetrant drug that impairs brain tumor stem cells via NLE1-Notch1 complex.
Stem cell reports · 2024 · senior author
Master regulators of neurogenesis: the dynamic roles of Ephrin receptors across diverse cellular niches.
Translational psychiatry · 2024 · senior author

All 19 publications

Latest funding

Lgals1 regulation of glioblastoma pathogenesis
CIHR · 2020 · Nominated PI
$60,000
OSMR Regulation of Glioblastoma Pathogenesis
CIHR · 2018 · Nominated PI
$753,525
Transcriptional control of neuronal migration
NSERC · 2016 · Principal investigator
$196,000

All 5 grants and awards

19 publications.

01

An oncostatin M receptor and chloride intracellular channel 1 crosstalk drives key oncogenic pathways in glioblastoma.

Mansourabadi AH, Qu D, Cianci F, Snider J, Randhawa K, Raco L, Kotlyar M, Al Ayach M, Rey G, Sanghvi S, Abovsky M, Singh H, Luchman HA, Burger D, Rak J, Soleimani VD, Jurisica I, Stagljar I, Mazzanti M, Jahani-Asl A

Signal transduction and targeted therapy2026Senior author

DOI: 10.1038/s41392-026-02723-3 PMID: 42177207

02

Targeting glioblastoma with a brain-penetrant drug that impairs brain tumor stem cells via NLE1-Notch1 complex.

Burban A, Sharanek A, Hernandez-Corchado A, Najafabadi HS, Soleimani VD, Jahani-Asl A

Stem cell reports2024Senior author

DOI: 10.1016/j.stemcr.2024.09.007 PMID: 39423824

03

Master regulators of neurogenesis: the dynamic roles of Ephrin receptors across diverse cellular niches.

Rasool D, Jahani-Asl A

Translational psychiatry2024Senior author

DOI: 10.1038/s41398-024-03168-4 PMID: 39505843

04

PHF6-mediated transcriptional control of NSC via Ephrin receptors is impaired in the intellectual disability syndrome BFLS.

Rasool D, Burban A, Sharanek A, Madrigal A, Hu J, Yan K, Qu D, Voss AK, Slack RS, Thomas T, Bonni A, Picketts DJ, Soleimani VD, Najafabadi HS, Jahani-Asl A

EMBO reports2024Senior author

DOI: 10.1038/s44319-024-00082-0 PMID: 38429579

05

In situ detection of protein-protein interaction by proximity ligation assay in patient derived brain tumor stem cells.

Sharanek A, Raco L, Soleimani VD, Jahani-Asl A

STAR protocols2022Senior author

DOI: 10.1016/j.xpro.2022.101554 PMID: 35880130

06

Subcellular fractionation of brain tumor stem cells.

Sharanek A, Raco L, Soleimani VD, Jahani-Asl A

Methods in cell biology2022Senior author

DOI: 10.1016/bs.mcb.2022.02.006 PMID: 35811103

07

Isolation of Adult Mouse Neural Stem Cells and Assessment of Self-Renewal by ELDA.

Rasool D, Soleimani VD, Jahani-Asl A

Methods in molecular biology (Clifton, N.J.)2022Senior author

DOI: 10.1007/978-1-0716-2409-8_21 PMID: 35776362

08

Isolation of Mouse Embryonic Neural Stem Cells and Characterization of Neural Stem Markers by Flow Cytometry.

Burban A, Jahani-Asl A

Methods in molecular biology (Clifton, N.J.)2022Senior author

DOI: 10.1007/978-1-0716-2409-8_18 PMID: 35776359

09

Monitoring Mitochondrial Respiration in Mouse Cerebellar Granule Neurons.

Sharanek A, Jahani-Asl A

Methods in molecular biology (Clifton, N.J.)2022Senior author

DOI: 10.1007/978-1-0716-2409-8_1 PMID: 35776342

10

Transcriptional control of brain tumor stem cells by a carbohydrate binding protein.

Sharanek A, Burban A, Hernandez-Corchado A, Madrigal A, Fatakdawala I, Najafabadi HS, Soleimani VD, Jahani-Asl A

Cell reports2021Senior author

DOI: 10.1016/j.celrep.2021.109647 PMID: 34469737

Lgals1 regulation of glioblastoma pathogenesis

Nominated PICIHR2020CIHR - ICR / Cancer Research Society Partnership - Research Grants

Principal investigators: Jahani-Asl, Arezu

Keywords: Chip-Seq; Egfrviii; Glioblastoma; Glioma Stem Cells; Hoxa5; Lgals1; Rna-Seq; Stat3; Transcription; Tumourigenesis

$60,000

OSMR Regulation of Glioblastoma Pathogenesis

Nominated PICIHR2018Project Grant

Principal investigators: Jahani-Asl, Arezu

Keywords: Brain; Egfrviii; Genetics; Glioblastoma; Neuroscience; Osmr; Phosphorylation; Rna-Seq; Stat3; Transcription

$753,525

Transcriptional control of neuronal migration

Principal investigatorNSERC2016Discovery Grants Program - Individual

Principal investigators: JahaniAsl, Arezu

$196,000

OSMR Signalling in Glioblastoma Pathogenesis

Nominated PICIHR2016Operating Grant: Targeting High Fatality Cancers - Innovation Grant

Principal investigators: Jahani-Asl, Arezu

Keywords: Astrocytes; Brain Tumor Stem Cells; Chip-Seq; Cytokines; Egfrviii; Feed Forward; Glioblastoma; Osmr; Stat3; Transcription

$97,500

Glioblastoma Pathogenesis: Molecular Targets and Therapies

Nominated PICIHR2016Project Grant

Principal investigators: Jahani-Asl, Arezu

Keywords: Brain Tumour; Brain Tumour Stem Cells; Cytokines; Egfr/Egfrviii; Glioblastoma; Growth Factors; Osmr; Signalling; Stat3; Transcription

$100,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Cellular and Molecular Medicine
Lady Davis Institute for Medical Research
Rheumatology
Biochemistry
Pediatrics
Cell Biology and Anatomy
Other

Co-authors at McGill University, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

Arezu Jahani-Asl

Cellular and Molecular Medicine

11 shared papers, latest 2026

Samuel Weiss

Cell Biology and Anatomy

1 shared papers, latest 2016

Isabella Irrcher

Faculty

1 shared papers, latest 2015

Igor Stagljar

Biochemistry

1 shared papers, latest 2026

Igor Jurisica

Rheumatology

1 shared papers, latest 2026

Janusz Rak

Pediatrics

1 shared papers, latest 2026

Dylan Burger

Cellular and Molecular Medicine

1 shared papers, latest 2026

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mentionMention their CIHR grant from 2020

Subject: Prospective PhD student: Glioblastoma Dear Professor Jahani-Asl, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "An oncostatin M receptor and chloride intracellular channel 1 crosstalk drives key oncogenic pathways in glioblastoma." (2026), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your CIHR-funded project "Lgals1 regulation of glioblastoma pathogenesis" (2020), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]