Faculty profile

Derek MacFadden

ResearcherPediatricsUniversity of Ottawa

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a University of Ottawa directory, so their courses and email address may be missing. Find their university profile.

Derek MacFadden

Researcher

Pediatrics

Health Sciences

University of Ottawa

Ottawa, Ontario, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
17 publications in the last five years, latest in 2026.
Senior (last) author on 5 recent papers, a sign of leading a research group.
Principal investigator on 5 research grants (5 CIHR), most recently in 2025.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

Publications

223

Citations

h-index

Collaborators

Grants

Publications by year

Counts cover the works listed on the university profile; citation counts come from Dimensions.

Profiles and links

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Signals and details

Research

Antibiotic Resistance Covid-19 Antimicrobial Resistance Biomarker C.Difficile Infection Chimeric Antigen Receptor T-Cell Therapy Feasibility Hematopoietic Stem Cell Transplantation

Latest papers

Targeted metatranscriptomic detection of viruses from floors for simultaneous evaluation of respiratory disease burden and viral variant identification.
mSphere · 2026
Antibiotic and Nonantibiotic Drugs Associated With Clostridioides difficile Infection Risk: a Pharmacopoeia-Wide Case-Cohort Study
Journal of Infectious Diseases · 2026
Duration of antibiotic therapy for bacteremia in immune compromised hosts—a post hoc subgroup analysis of the BALANCE randomized clinical trial
Clinical Microbiology and Infection (CMI) · 2026

All 19 publications

Latest funding

Oral Vancomycin for the Prevention of C. difficile Infection in High-Risk HCT and CAR-T Patients (VAPOR-HCT): A Pilot Randomized Placebo-Controlled Trial
CIHR · 2025 · Nominated PI
$100,000
Bridging Farm Practices and Policy: Co-Producing AMR Research with Ontario's Agricultural Communities
CIHR · 2025 · Co-investigator
$125,000
High-dose cephalexin for cellulitis (HI-DOCC): a randomized controlled trial
CIHR · 2023 · Co-investigator
$382,500

All 8 grants and awards

19 publications.

Targeted metatranscriptomic detection of viruses from floors for simultaneous evaluation of respiratory disease burden and viral variant identification.

Carroll AC, Hinz A, Hicks AMA, Khov E, Van Bakel T, Doukhanine E, Fralick M, Nott C, Kassen R, Thampi N, Hug LA, MacFadden D, Wong A

mSphere2026

DOI: 10.1128/msphere.00086-26 PMID: 42007699

Antibiotic and Nonantibiotic Drugs Associated With Clostridioides difficile Infection Risk: a Pharmacopoeia-Wide Case-Cohort Study

Brown KA, Coburn B, Hernandez A, Langford BJ, Leung V, MacFadden D, Rooney AM, Schwartz KL, Daneman N

Journal of Infectious Diseases20263 citations

DOI: 10.1093/infdis/jiag001

Duration of antibiotic therapy for bacteremia in immune compromised hosts—a post hoc subgroup analysis of the BALANCE randomized clinical trial

Hamani M, Pinto R, Lee TC, MacFadden D, McDonald EG, Sligl W, Fowler RA, Daneman N, consortium TB, Daneman N

Clinical Microbiology and Infection (CMI)20261 citations

DOI: 10.1016/j.cmi.2026.06.003

Secondary Prophylaxis of Recurrent Clostridioides difficile Infections During Systemic Antibiotics with Vancomycin (SPORES-V): study protocol for a randomized controlled trial

Prosty C, Carignan A, Chan AK, Chen Y, Daley P, Daneman N, Kandel C, Longtin Y, Perez-Patrigeon S, Wuerz T

Trials20261 citations

DOI: 10.1186/s13063-026-09883-1

Using routine asymptomatic Clostridioides difficile testing to identify patients at high risk of developing C. difficile infection during hematopoietic cell transplantation.

Janusz N, Mortimer L, Leite T, Carroll A, Kekre N, Kennah M, Yan A, Senechal J, Buchan CA, MacFadden D

Journal of the Association of Medical Microbiology and Infectious Disease Canada = Journal officiel de l'Association pour la microbiologie medicale et l'infectiologie Canada2025Senior author

DOI: 10.3138/jammi-2024-0032 PMID: 41311620

The Burden of Antimicrobial Resistant Bacteremia in Ontario: A Population-Wide Analysis of Attributable Mortality From 110 Pathogen-Antibiotic Combinations

Brown KA, Fridman DJ, Garber GE, Johnstone J, Langford BJ, Leung V, MacFadden D, Patel SN, Schwartz KL, Sander B

Clinical Infectious Diseases20256 citations

DOI: 10.1093/cid/ciaf213

Introduction of a penicillin allergy de-labelling program with direct oral challenge and its effects on utilization of beta-lactam antimicrobials: a multicenter retrospective parallel cohort study.

Mir A, Lanoue D, Zanichelli V, van Walraven C, Olynych T, Nott C, MacFadden D

Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology2024Senior author

DOI: 10.1186/s13223-024-00877-9 PMID: 38444037

SARS-CoV-2 burden on the floor was associated with COVID-19 cases and outbreaks in two acute care hospitals: a prospective cohort study.

Fralick M, Moggridge JA, Wiebe M, Castellani L, McGeer A, Feenstra B, Hinz A, Hicks AMA, Hug LA, Wong A, Van Bakel T, Abeygunawardena S, Burhunduli T, Mejbel HS, Kassen R, Thampi N, MacFadden D, Nott C

Infection control and hospital epidemiology2024

DOI: 10.1017/ice.2024.121 PMID: 39301606

A simple electronic medical record-based predictors of illness severity in sepsis (sepsis) score.

Cressman AM, Wen B, Saha S, Jun HY, Waters R, Lail S, Jabeen A, Koppula R, Lapointe-Shaw L, Sheehan KA, Weinerman A, Daneman N, Verma AA, Razak F, MacFadden D

PloS one2024Senior author

DOI: 10.1371/journal.pone.0299473 PMID: 38924010

Follow-up blood cultures do not reduce mortality in hospitalized patients with Gram-negative bloodstream infection: a retrospective population-wide cohort study

Ong SWX, Luo J, Fridman DJ, Lee SM, Johnstone J, Schwartz KL, Diong C, Patel SN, MacFadden D, Langford B

Clinical Microbiology and Infection (CMI)202416 citations

DOI: 10.1016/j.cmi.2024.03.025

Oral Vancomycin for the Prevention of C. difficile Infection in High-Risk HCT and CAR-T Patients (VAPOR-HCT): A Pilot Randomized Placebo-Controlled Trial

Nominated PICIHR2025Project Grant - Priority Announcement - Cancer Survivorship

Principal investigators: MacFadden, Derek R; Atkins, Harold L; Buchan, Catharine A; Cheng, Matthew P; Climans, Troy; Coburn, Bryan A; Daneman, Nick; Gauthier, Karine; Hay, Annette; Kabbani, Dima; Kekre, Natasha; Kennah, Michael; McIntyre, Lauralyn A; Mertz, Dominik; Monteith, Bethany E; Mortimer, Leanne M; Purssell, Andrew; Taljaard, Monica; Tsang, Corey

Keywords: Antimicrobial Resistance; Biomarker; C.Difficile Infection; Chimeric Antigen Receptor T-Cell Therapy; Feasibility; Hematopoietic Stem Cell Transplantation; Microbiome; Pilot; Prophylaxis; Randomized Trial

$100,000

Bridging Farm Practices and Policy: Co-Producing AMR Research with Ontario's Agricultural Communities

Co-investigatorCIHR2025Cat. Grant: Partnering for Impact - Pandemic Preparedness and Health Emergencies

Principal investigators: Sulis, Giorgia; Stager, Jeff

Keywords: Antimicrobial Resistance; Antimicrobial Use; Farming Communities; One Health; Vaccination Practices

$125,000

High-dose cephalexin for cellulitis (HI-DOCC): a randomized controlled trial

Co-investigatorCIHR2023Project Grant

Principal investigators: Yadav, Krishan; Eagles, Debra; Emond, Marcel; Perry, Jeffrey J; Stiell, Ian G; Taljaard, Monica

Keywords: Antibiotics; Cellulitis; Treatment Failure

$382,500

A Cluster Randomized Cross-over Trial of an Antibiotic Decision Support Intervention in Sepsis (IDEAS II)

Nominated PICIHR2022Project Grant - PA: ECR Antimicrobial Resistance Multi-Year Grant

Principal investigators: MacFadden, Derek R; Daneman, Nick

Keywords: Antibiotic Prescribing; Clinical Decision Support; Cluster Randomized Trial; Sepsis

$300,000

COVID-19 in the urban built environment (CUBE): Evaluating the use of environmental swabs for the detection and surveillance of SARS-CoV-2 in school and congregate settings

Principal investigatorCIHR2021Op. Gr.:Emer. COVID Res. Gaps/Priorities-Core Public Health and Control Measures

Principal investigators: Thampi, Nisha; Castellani, Lucas; Fralick, Michael P; Kassen, Rees; MacFadden, Derek R; Nott, Caroline; Wong, Alex

Keywords: Covid-19; Environmental Detection; Environmental Swabbing; Reopening; School; Surveillance

$499,415

Incidence and risk factors of inappropriate antibiotic prescribing and related adverse health outcomes among Ontario long-term care residents and marginalized older community-dwelling adults with COVID-19 (I-CARE)

Nominated PICIHR2021Op. Gr.:Emerg. COVID-19 Res. Gaps & Priorities- Health care systems and services

Principal investigators: MacFadden, Derek R; Daneman, Nick; Maxwell, Colleen J; Mishra, Sharmistha; Schwartz, Kevin L

Keywords: Antibiotic Resistance; Clostridium Difficile; Covid-19; Inappropriate Antibiotic Prescribing; Long Term Care; Marginalization; Older Adults

$308,904

COVID-19 in the urban built environment (CUBE): SARS-CoV-2 prevalence in high traffic hospital settings_x000d_ _x000d_ _x000d_

Co-investigatorNSERC2020Alliance Grants

Principal investigators: Kassen, Rees

$50,000

A K-mer Based Approach for Institutional AMR Surveillance, Transmission Monitoring, and Rapid Diagnostics

Nominated PICIHR2019Operating Grant: Joint Programming Initiative on Antimicrobial Resistance

Principal investigators: MacFadden, Derek R; McGeer, Allison J

Keywords: Antibiotic Resistance; Genomics; Infection Control And Surveillance; Rapid Diagnostics

$525,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mentionMention their CIHR grant from 2025

Subject: Prospective PhD student: Antibiotic Resistance Dear Professor MacFadden, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Targeted metatranscriptomic detection of viruses from floors for simultaneous evaluation of respiratory disease burden and viral variant identification." (2026), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your CIHR-funded project "Oral Vancomycin for the Prevention of C. difficile Infection in High-Risk HCT and CAR-T Patients (VAPOR-HCT): A Pilot Randomized Placebo-Controlled Trial" (2025), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]

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Derek MacFadden

Research

Latest papers

Latest funding

Targeted metatranscriptomic detection of viruses from floors for simultaneous evaluation of respiratory disease burden and viral variant identification.

Antibiotic and Nonantibiotic Drugs Associated With Clostridioides difficile Infection Risk: a Pharmacopoeia-Wide Case-Cohort Study

Duration of antibiotic therapy for bacteremia in immune compromised hosts—a post hoc subgroup analysis of the BALANCE randomized clinical trial

Secondary Prophylaxis of Recurrent Clostridioides difficile Infections During Systemic Antibiotics with Vancomycin (SPORES-V): study protocol for a randomized controlled trial

Using routine asymptomatic Clostridioides difficile testing to identify patients at high risk of developing C. difficile infection during hematopoietic cell transplantation.

The Burden of Antimicrobial Resistant Bacteremia in Ontario: A Population-Wide Analysis of Attributable Mortality From 110 Pathogen-Antibiotic Combinations

Introduction of a penicillin allergy de-labelling program with direct oral challenge and its effects on utilization of beta-lactam antimicrobials: a multicenter retrospective parallel cohort study.

SARS-CoV-2 burden on the floor was associated with COVID-19 cases and outbreaks in two acute care hospitals: a prospective cohort study.

A simple electronic medical record-based predictors of illness severity in sepsis (sepsis) score.

Follow-up blood cultures do not reduce mortality in hospitalized patients with Gram-negative bloodstream infection: a retrospective population-wide cohort study

Oral Vancomycin for the Prevention of C. difficile Infection in High-Risk HCT and CAR-T Patients (VAPOR-HCT): A Pilot Randomized Placebo-Controlled Trial

Bridging Farm Practices and Policy: Co-Producing AMR Research with Ontario's Agricultural Communities

High-dose cephalexin for cellulitis (HI-DOCC): a randomized controlled trial

A Cluster Randomized Cross-over Trial of an Antibiotic Decision Support Intervention in Sepsis (IDEAS II)

COVID-19 in the urban built environment (CUBE): Evaluating the use of environmental swabs for the detection and surveillance of SARS-CoV-2 in school and congregate settings

Incidence and risk factors of inappropriate antibiotic prescribing and related adverse health outcomes among Ontario long-term care residents and marginalized older community-dwelling adults with COVID-19 (I-CARE)

COVID-19 in the urban built environment (CUBE): SARS-CoV-2 prevalence in high traffic hospital settings_x000d_ _x000d_ _x000d_

A K-mer Based Approach for Institutional AMR Surveillance, Transmission Monitoring, and Rapid Diagnostics

Frequent collaborators

Derek MacFadden

Nick Daneman

Bradley Langford

Jennie Johnstone

Caroline Nott

Miranda So

Caroline Nott

Michaeline McGuinty

Derek MacFadden

Michael Fralick

Nisha Thampi

Rees Kassen

Bradley Langford

Rees Kassen

Alex Wong

Derek MacFadden

Elizabeth Leung

Bryan Coburn

Alex Wong

Jennifer Tsang

Antonio Giulivi

Juthaporn Cowan

Vicente Corrales-Medina

Kednapa Thavorn

Nicole Ezer

Kednapa Thavorn

Andrea Benedetti

Beate Sander

Salman Qureshi

Fahad Razak

Kednapa Thavorn

Carl van Walraven

Lauren Lapointe-Shaw

Darrell Tan

Colleen Maxwell

Andrea Benedetti

Allison McGeer