John Muscedere, University of Ottawa

Research

Exercise Frailty Randomized Trials Surgery Cancer Prehabilitation Complications Disability

Latest papers

Stress Ulcer Prophylaxis during Invasive Mechanical Ventilation
New England Journal of Medicine · 2024
Withholding Pantoprazole for Stress Ulcer Prophylaxis in Critically Ill Patients
Critical Care Medicine · 2017
Duration of Antimicrobial Treatment for Bacteremia in Canadian Critically Ill Patients*
Critical Care Medicine · 2016

All 6 publications

Latest funding

PREPARE for Cancer Surgery Trial: multimodal PReoperative Exercise to decrease PostoperAtive disability, cancer RecurrencE and mortality in older people with frailty
CIHR · 2023 · Principal investigator
$100,000
Establishing an International Core Outcome Set in SAH - What and When to Measure in SAH Research
CIHR · 2019 · Co-investigator
$100,000
Crystalloid FLUID Choices for Resuscitation of Hospitalized Patients: A Pragmatic Comparative Effectiveness Trial (FLUID)
CIHR · 2018 · Co-investigator
$374,851

All 5 grants and awards

6 publications.

01

Stress Ulcer Prophylaxis during Invasive Mechanical Ventilation

Iqbal M, Reeve B, Forrest D, Trop S, Reynolds S, Saunders L, Heels-Ansdell D, Marshall J, English S, Ostermann M

New England Journal of Medicine2024108 citations

DOI: 10.1056/nejmoa2404245

02

Withholding Pantoprazole for Stress Ulcer Prophylaxis in Critically Ill Patients

Alhazzani W, Guyatt G, Alshahrani M, Deane AM, Marshall JC, Hall R, Muscedere J, English SW, Lauzier F, Thabane L

Critical Care Medicine2017106 citations

DOI: 10.1097/ccm.0000000000002461

03

Duration of Antimicrobial Treatment for Bacteremia in Canadian Critically Ill Patients*

Daneman N, Rishu AH, Xiong W, Bagshaw SM, Dodek P, Hall R, Kumar A, Lamontagne F, Lauzier F, Marshall J

Critical Care Medicine201644 citations

DOI: 10.1097/ccm.0000000000001393

04

Failure of Anticoagulant Thromboprophylaxis

Lim W, Meade M, Lauzier F, Zarychanski R, Mehta S, Lamontagne F, Dodek P, McIntyre L, Hall R, Heels-Ansdell D

Critical Care Medicine2015128 citations

DOI: 10.1097/ccm.0000000000000713

05

Knowledge Translation Interventions for Critically Ill Patients

Sinuff T, Muscedere J, Adhikari NKJ, Stelfox HT, Dodek P, Heyland DK, Rubenfeld GD, Cook DJ, Pinto R, Manoharan V

Critical Care Medicine201375 citations

DOI: 10.1097/ccm.0b013e3182982b03

06

Burden of Illness in venous ThromboEmbolism in Critical care: a multicenter observational study

Patel R, Cook DJ, Meade MO, Griffith LE, Mehta G, Rocker GM, Marshall JC, Hodder R, Martin CM, Heyland DK

Journal of Critical Care2005103 citations

DOI: 10.1016/j.jcrc.2005.09.014

PREPARE for Cancer Surgery Trial: multimodal PReoperative Exercise to decrease PostoperAtive disability, cancer RecurrencE and mortality in older people with frailty

Principal investigatorCIHR2023Project Grant - PA: Equity in Cancer Prevention and Control

Principal investigators: McIsaac, Daniel I; Eskander, Antoine; Fergusson, Dean A; Gillis, Chelsia A; Khadaroo, Rachel; Kidd, Gurlavine D; Muscedere, John; Taljaard, Monica

Keywords: Cancer; Exercise; Frailty; Prehabilitation; Randomized Trials; Surgery

$100,000

Establishing an International Core Outcome Set in SAH - What and When to Measure in SAH Research

Co-investigatorCIHR2019Project Grant - Priority Announcement: Patient-Oriented Research

Principal investigators: English, Shane W; Marti, Maria Luisa; Presseau, Justin

Keywords: Aneurysmal Subarachnoid Hemorrhage; Multidisciplinary Stakeholders; Patient And Family Partners; Patient-Centred Outcome Measures

$100,000

Crystalloid FLUID Choices for Resuscitation of Hospitalized Patients: A Pragmatic Comparative Effectiveness Trial (FLUID)

Co-investigatorCIHR2018Project Grant

Principal investigators: McIntyre, Lauralyn A; Fergusson, Dean A; Taljaard, Monica

Keywords: Cluster Cross-Over Randomized Controlled Trial; Comparative Effectiveness Trial; Crystalloid Fluid; Fluid Therapy; Normal Saline; Resuscitation; Ringers Lactate

$374,851

PREPARE Trial: a parallel arm multicenter randomized trial of frailty-focused PReoperative Exercise to decrease PostoperAtive complication Rates and disability scorEs

Principal investigatorCIHR2018Project Grant

Principal investigators: McIsaac, Daniel I; Fergusson, Dean A; Khadaroo, Rachel; Muscedere, John; Taljaard, Monica

Keywords: Complications; Disability; Exercise; Frailty; Geriatrics; Patient Reported Outcomes; Perioperative Care; Randomized Trials; Surgery

$1,136,025

Crystalloid FLUID Choices for Resuscitation of Hospitalized Patients: A Pragmatic Cluster Cross Over Pilot Trial

Co-investigatorCIHR2015Operating Grant

Principal investigators: McIntyre, Lauralyn A; Taljaard, Monica

Keywords: Cluster Cross-Over Randomized Controlled Trial; Crystalloid Fluid; Fluid Therapy; Normal Saline; Pilot Trial; Resuscitation; Ringers Lactate

$99,504

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Critical Care Medicine
Health Research Methods, Evidence, and Impact
Medicine
Clinical Epidemiology
Anesthesiology and Pain Management
Médecine interne
Surgery
Other

Applying for

Paper to mentionMention their CIHR grant from 2023

Subject: Prospective PhD student: Exercise Dear Professor Muscedere, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Stress Ulcer Prophylaxis during Invasive Mechanical Ventilation" (2024), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your CIHR-funded project "PREPARE for Cancer Surgery Trial: multimodal PReoperative Exercise to decrease PostoperAtive disability, cancer RecurrencE and mortality in older people with frailty" (2023), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]

John Muscedere

Research

Latest papers

Latest funding

Stress Ulcer Prophylaxis during Invasive Mechanical Ventilation

Withholding Pantoprazole for Stress Ulcer Prophylaxis in Critically Ill Patients

Duration of Antimicrobial Treatment for Bacteremia in Canadian Critically Ill Patients*

Failure of Anticoagulant Thromboprophylaxis

Knowledge Translation Interventions for Critically Ill Patients

Burden of Illness in venous ThromboEmbolism in Critical care: a multicenter observational study

PREPARE for Cancer Surgery Trial: multimodal PReoperative Exercise to decrease PostoperAtive disability, cancer RecurrencE and mortality in older people with frailty

Establishing an International Core Outcome Set in SAH - What and When to Measure in SAH Research

Crystalloid FLUID Choices for Resuscitation of Hospitalized Patients: A Pragmatic Comparative Effectiveness Trial (FLUID)

PREPARE Trial: a parallel arm multicenter randomized trial of frailty-focused PReoperative Exercise to decrease PostoperAtive complication Rates and disability scorEs

Crystalloid FLUID Choices for Resuscitation of Hospitalized Patients: A Pragmatic Cluster Cross Over Pilot Trial

Frequent collaborators

Deborah Cook

John Muscedere

Gordon Guyatt

Francois Lamontagne

Maureen Meade

Gordon Guyatt

Francois Lamontagne

Peter Dodek

Ryan Zarychanski

Maureen Meade

Sangeeta Mehta

Nick Daneman

Bram Rochwerg

Maureen Meade

Deborah Cook

Francois Lamontagne

John Marshall

Bram Rochwerg

Nick Daneman

Ryan Zarychanski

Lehana Thabane

Bram Rochwerg

Diane Heels-Ansdell

Timothy A Karachi

Lehana Thabane

Lauralyn McIntyre

John Marshall

Nick Daneman

John Marshall

Maureen Meade

Salmaan Kanji

Kirsten Fiest

Maureen Meade

John Muscedere

Menaka Pai

Patrick Archambault

Lauralyn McIntyre

Mark Soth

Dominique Piquette

Paul Hosek