Faculty profile
Ryan Zarychanski
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Research
Latest papers
Liberal or Restrictive Transfusion Strategy in Patients with Traumatic Brain Injury
New England Journal of Medicine · 2024
Stress Ulcer Prophylaxis during Invasive Mechanical Ventilation
New England Journal of Medicine · 2024
Simvastatin in Critically Ill Patients with Covid-19.
The New England journal of medicine · 2023
Latest funding
- $1,143,676
Enabling Bayesian Clinical Trials: Improving the use of Bayesian methods in randomised clinical trials of efficacy and effectiveness
CIHR · 2026 · Co-investigator
- $883,029
The Randomized Embedded Multifactorial Adaptive Platform Trial in Community-Acquired Pneumonia (REMAP-CAP): Enshrining a Global Pandemic Research Response to COVID-19 and Beyond
CIHR · 2022 · Co-investigator
- $1,000,000
Canadian Critical Care Trials Group COVID-19 Response: defining critical care capacity in Canada; testing treatments through large-scale adaptive clinical trials; & establishing the evidence base to inform clinical and health system management decisions
CIHR · 2022 · Principal investigator
10 publications.
Liberal or Restrictive Transfusion Strategy in Patients with Traumatic Brain Injury
Clayton L, Patton M-P, Walsh TS, Moore L, Laroche V, Greenbaum J, Kramer A, Rey VG, Khwaja K, Wise M
Stress Ulcer Prophylaxis during Invasive Mechanical Ventilation
Iqbal M, Reeve B, Forrest D, Trop S, Reynolds S, Saunders L, Heels-Ansdell D, Marshall J, English S, Ostermann M
Simvastatin in Critically Ill Patients with Covid-19.
REMAP-CAP Investigators, Hills TE, Lorenzi E, Berry LR, Shyamsundar M, Al-Beidh F, Annane D, Arabi Y, Aryal D, Au C, Beane A, Bhimani Z, Bonten M, Bradbury CA, Brunkhorst FM, Burrell A, Buxton M, Calfee CS, Cecconi M, Cheng AC, Cove ME, Detry MA, Estcourt LJ, Fitzgerald M, Goligher EC, Goossens H, Green C, Haniffa R, Harrison DA, Hashmi M, Higgins AM, Horvat C, Huang DT, Ichihara N, Jayakumar D, Kruger PS, Lamontagne F, Lampro L, Lawler PR, Marshall JC, Mason AJ, McGlothlin A, McGuinness S, McQuilten ZK, McVerry BJ, Mouncey PR, Murthy S, Neal MD, Nichol AD, O'Kane CM, Parke RL, Parker JC, Rabindrarajan E, Reyes LF, Rowan KM, Saito H, Santos M, Saunders CT, Seymour CW, Shankar-Hari M, Sinha P, Thompson BT, Turgeon AF, Turner AM, van de Veerdonk F, Weis S, Young IS, Zarychanski R, Lewis RJ, McArthur CJ, Angus DC, Berry SM, Derde LPG, Webb SA, Gordon AC, McAuley DF
Remdesivir for the treatment of patients in hospital with COVID-19 in Canada: a randomized controlled trial
Ali K, Azher T, Baqi M, Binnie A, Borgia S, Carrier FM, Cavayas YA, Chagnon N, Cheng MP, Conly J
Interleukin-6 Receptor Antagonists in Critically Ill Patients with Covid-19.
REMAP-CAP Investigators, Gordon AC, Mouncey PR, Al-Beidh F, Rowan KM, Nichol AD, Arabi YM, Annane D, Beane A, van Bentum-Puijk W, Berry LR, Bhimani Z, Bonten MJM, Bradbury CA, Brunkhorst FM, Buzgau A, Cheng AC, Detry MA, Duffy EJ, Estcourt LJ, Fitzgerald M, Goossens H, Haniffa R, Higgins AM, Hills TE, Horvat CM, Lamontagne F, Lawler PR, Leavis HL, Linstrum KM, Litton E, Lorenzi E, Marshall JC, Mayr FB, McAuley DF, McGlothlin A, McGuinness SP, McVerry BJ, Montgomery SK, Morpeth SC, Murthy S, Orr K, Parke RL, Parker JC, Patanwala AE, Pettilä V, Rademaker E, Santos MS, Saunders CT, Seymour CW, Shankar-Hari M, Sligl WI, Turgeon AF, Turner AM, van de Veerdonk FL, Zarychanski R, Green C, Lewis RJ, Angus DC, McArthur CJ, Berry S, Webb SA, Derde LPG
Therapeutic Anticoagulation with Heparin in Critically Ill Patients with Covid-19
Effron MB, Berger JS, Gong MN, Kumar A, Kahn SR, McQuilten Z, Farkouh ME, Brooks MM, Lewis RJ, Berry LR
Therapeutic Anticoagulation with Heparin in Noncritically Ill Patients with Covid-19
Chen J-T, Effron MB, Silva DG, Berger JS, Gong MN, Rosenson RS, Kumar A, Kahn SR, Cushman M, McQuilten Z
The Efficacy and Safety of Heparin in Patients With Sepsis
Zarychanski R, Abou-Setta AM, Kanji S, Turgeon AF, Kumar A, Houston DS, Rimmer E, Houston BL, McIntyre L, Fox-Robichaud AE
Failure of Anticoagulant Thromboprophylaxis
Lim W, Meade M, Lauzier F, Zarychanski R, Mehta S, Lamontagne F, Dodek P, McIntyre L, Hall R, Heels-Ansdell D
Helmet legislation and admissions to hospital for cycling related head injuries in Canadian provinces and territories: interrupted time series analysis.
Dennis J, Ramsay T, Turgeon AF, Zarychanski R
Enabling Bayesian Clinical Trials: Improving the use of Bayesian methods in randomised clinical trials of efficacy and effectiveness
Principal investigators: Heath, Anna
Keywords: Bayesian Methods; Randomised Clinical Trials; Statistical Analysis Plan; Statistical Translation
The Randomized Embedded Multifactorial Adaptive Platform Trial in Community-Acquired Pneumonia (REMAP-CAP): Enshrining a Global Pandemic Research Response to COVID-19 and Beyond
Principal investigators: Marshall, John C; Dalziel, Sandra; Kho, Michelle E; Lamontagne, Francois; Leligdowicz, Aleksandra; Murthy, Srinivas; Park, Jay; Smith, Kathleen F
Keywords: Acute Organ Dysfunction; Covid-19; Critical Illness; Global Health; Hemodynamic Management; Platform Trial; Research Collaboration; Ventilatory Support
Canadian Critical Care Trials Group COVID-19 Response: defining critical care capacity in Canada; testing treatments through large-scale adaptive clinical trials; & establishing the evidence base to inform clinical and health system management decisions
Principal investigators: Fowler, Robert A; Adhikari, Neill K; Archambault, Patrick; Bagshaw, Sean M; Binnie, Alexandra; Chasse, Michael; Cook, Deborah J; Daneman, Nick; Fiest, Kirsten M; Fox-Robichaud, Alison E; Goligher, Ewan C; Herridge, Margaret S; Kho, Michelle E; Lamontagne, Francois; Lawler, Patrick R; Lee, Todd C; Marshall, John C; McDonald, Emily G; McNally, James D; Meade, Maureen O; Mehta, Sangeeta; Menon, Kusum; Murthy, Srinivas; O'Hearn, Katharine J; Piquette, Dominique; Rochwerg, Bram N; Russell, James A; Tsang, Jennifer L; Turgeon, Alexis F; Wollny, Krista; Yada, Nicole; Zarychanski, Ryan
Keywords: Clinical Trials; Covid-19; Network
Driving Pressure-Limited Ventilation in Hypoxemic Respiratory Failure: the DRIVE RCT
Principal investigators: Goligher, Ewan C; Fan, Eddy; Ferguson, Niall D; Sahetya, Sarina
Keywords: Adaptive Platform Clinical Trial; Hypoxemic Respiratory Failure; Lung-Protective Ventilation
Canadian ADAptive Platform Trial of COVID-19 Therapeutics in Community Settings (Can-ADAPT COVID)
Principal investigators: Pinto, Andrew D; Keynan, Yoav; Greiver, Michelle; Jüni, Peter; Lee, Todd C; McDonald, Emily G; Murthy, Srinivas; Selby, Peter L
Keywords: Adaptive Platform Trial; Covid-19; Nirmatrelvir; Out-Patient; Sars-Cov-2; Therapeutics
The Randomized Embedded Multifactorial Adaptive Platform Trial in Community-Acquired Pneumonia (REMAP-CAP): Enshrining a Global Pandemic Research Response to COVID-19 and Beyond
Principal investigators: Marshall, John C; Dalziel, Sandra; Kho, Michelle E; Lamontagne, Francois; Leligdowicz, Aleksandra; Murthy, Srinivas; Park, Jay; Smith, Kathleen F
Keywords: Acute Organ Dysfunction; Covid-19; Critical Illness; Global Health; Hemodynamic Management; Platform Trial; Research Collaboration; Ventilatory Support
The Canadian Severe Acute Respiratory Infection, Prospective, Perpetual Observational Study: Informing Clinical Care and the Public Health Response
Principal investigators: Fowler, Robert A; Murthy, Srinivas
Keywords: Bacteria; Infection; Outbreak; Pandemic; Respiratory; Virus
Canadian ADAptive Platform Trial of COVID-19 Therapeutics in Community Settings (Can-ADAPT COVID)
Principal investigators: Pinto, Andrew D; Keynan, Yoav; Greiver, Michelle; Jüni, Peter; Lee, Todd C; McDonald, Emily G; Murthy, Srinivas; Selby, Peter L
Keywords: Adaptive Platform Trial; Covid-19; Nirmatrelvir; Out-Patient; Sars-Cov-2; Therapeutics
Driving Pressure-Limited Ventilation in Hypoxemic Respiratory Failure: the DRIVE RCT
Principal investigators: Goligher, Ewan C; Fan, Eddy; Ferguson, Niall D; Heath, Anna; Sahetya, Sarina
Keywords: Adaptive Platform Clinical Trial; Hypoxemic Respiratory Failure; Lung-Protective Ventilation
Lung and Diaphragm Protection in Acute Hypoxemic Respiratory Failure: the LANDMARK II Pilot and Feasibility Randomized Clinical Trial
Principal investigators: Goligher, Ewan C; Fan, Eddy
Keywords: Adaptive Platform Clinical Trial; Diaphragm-Protective Ventilation; Hypoxemic Respiratory Failure; Lung-Protective Ventilation
From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.
Frequent collaborators
- Medicine
- Critical Care Medicine
- Health Research Methods, Evidence, and Impact
- Internal Medicine
- Anesthesiology & Critical Care Medicine
- Médecine interne
- Pharmacology and Therapeutics
- Other
Co-authors at University of Toronto, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.
Ryan Zarychanski
Internal Medicine
9 shared papers, latest 2024
Ryan Zarychanski
Anesthesiology & Critical Care Medicine
8 shared papers, latest 2024
Francois Lamontagne
Critical Care Medicine
6 shared papers, latest 2024
Francois Lamontagne
Médecine interne
6 shared papers, latest 2024
Srinivas Murthy
Pharmacology and Therapeutics
5 shared papers, latest 2023
Srinivas Murthy
Family Medicine and Emergency Medicine
5 shared papers, latest 2023
Srinivas Murthy
Faculty
5 shared papers, latest 2023
Srinivas Murthy
Critical Care Medicine
5 shared papers, latest 2023
Anand Kumar
General Internal Medicine
3 shared papers, latest 2021
Gloria Vazquez-Grande
Medicine
3 shared papers, latest 2024
Deborah Cook
Medicine
3 shared papers, latest 2024
Francois Lamontagne
Faculty
3 shared papers, latest 2024
John Marshall
Faculty
2 shared papers, latest 2024
John Muscedere
Critical Care Medicine
2 shared papers, latest 2024
Maureen Meade
Faculty
2 shared papers, latest 2024
Marc Carrier
Obstetrics and Gynecology
2 shared papers, latest 2021
Ian Ball
Department of Epidemiology and Biostatistics
2 shared papers, latest 2024
Francois Lamontagne
Community Health Sciences
2 shared papers, latest 2024
Sean van Diepen
Medicine
2 shared papers, latest 2021
Sangeeta Mehta
Faculty
2 shared papers, latest 2024
Maureen Meade
Faculty
2 shared papers, latest 2024
Maureen Meade
Medicine
2 shared papers, latest 2024
John Marshall
Critical Care Medicine
2 shared papers, latest 2024
Gordon Guyatt
Health Research Methods, Evidence, and Impact
2 shared papers, latest 2024
Shane English
Anesthesiology & Critical Care Medicine
2 shared papers, latest 2024
Alexandra Binnie
Critical Care Medicine
2 shared papers, latest 2024
Gordon Guyatt
Surgery
2 shared papers, latest 2024
Alison Fox-Robichaud
Medicine
2 shared papers, latest 2024
Jennifer Tsang
Medicine
2 shared papers, latest 2024
Anand Kumar
Medicine
2 shared papers, latest 2021
Nelson Lee
Epidemiology Division
1 shared papers, latest 2022
Alexis Turgeon
Internal Medicine
1 shared papers, latest 2022
Menaka Pai
Faculty
1 shared papers, latest 2015
Patrick Archambault
Faculty
1 shared papers, latest 2024
Bram Rochwerg
Faculty
1 shared papers, latest 2024
Yoav Keynan
Centre for Urban Health Solutions
1 shared papers, latest 2022
Michael Fralick
Faculty
1 shared papers, latest 2022
Madeleine Durand
Faculty
1 shared papers, latest 2022
Maude St-Onge
Faculty
1 shared papers, latest 2024
Patrick Archambault
Faculty
1 shared papers, latest 2024
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