Andrew Advani, University of Toronto

Research

Diabetes Diabetic Nephropathy Inflammation Acute Kidney Injury Chronic Kidney Disease Sting Glucose Kidney

Latest papers

Splicing factor proline- and glutamine-rich (SFPQ) protein causes transcriptional repression of SNAIL to counteract TGF-β signaling.
Biochimica et biophysica acta. Gene regulatory mechanisms · 2026
Reduced podocyte stiffness is a feature of proteinuric kidney disease.
Kidney international · 2026
Stimulator of Interferon Genes Is a Fine-Tuner, but Not a Prime Mover, of Kidney Inflammation.
The American journal of pathology · 2026 · senior author

All 90 publications

Latest funding

Unraveling the role of ISG15 in diabetic kidney disease
CIHR · 2025 · Nominated PI
$1,059,526
Acarbose as a biological analogy for understanding the potential of viscous fibre in the prevention of diabetes: The PRANDIAL (Psyllium veRsus Acarbose iNtervention for Dysglycemia In At Risk individuaLs) trial
CIHR · 2024 · Co-investigator
$914,176
Taking the Sting out of acute kidney injury in diabetes
CIHR · 2023 · Supervisor
$135,000

All 17 grants and awards

90 publications.

01

Splicing factor proline- and glutamine-rich (SFPQ) protein causes transcriptional repression of SNAIL to counteract TGF-β signaling.

Thakkar NP, Jayakumar H, Ramakrishnan SK, Narayanan G, Chakraborty S, Bhattacharyya R, Katakia YT, Advani SL, Advani A, Majumder S

Biochimica et biophysica acta. Gene regulatory mechanisms2026

DOI: 10.1016/j.bbagrm.2026.195179 PMID: 42617997

02

Reduced podocyte stiffness is a feature of proteinuric kidney disease.

Severino LU, He X, Mandapati A, Zhang T, Batchu SN, Sachan V, Kennedy J, Kek K, Krizova A, Lausecker F, Yip C, Advani A, Lennon R, Chase SE, Krendel M, Yuen DA

Kidney international2026

DOI: 10.1016/j.kint.2026.02.028 PMID: 41881106

03

Stimulator of Interferon Genes Is a Fine-Tuner, but Not a Prime Mover, of Kidney Inflammation.

Syeda MZ, Yeung ESH, Hong LYQ, Advani SL, Liu Y, Geldenhuys L, Siddiqi FS, Yerra VG, Batchu SN, Advani A

The American journal of pathology2026Senior author

DOI: 10.1016/j.ajpath.2025.10.013 PMID: 41571339

04

Biphasic actions of the adenosine A2a receptor antagonist istradefylline in mice with obstructive uropathy.

Yeung ESH, Tran DT, Batchu SN, Advani SL, Liu Y, Kaur H, Yuen DA, Aslam R, Luk CT, Advani A

Scientific reports2025Senior author

DOI: 10.1038/s41598-025-24912-w PMID: 41266603

05

European Association for the Study of Diabetes (EASD) Standard Operating Procedure for the development of guidelines.

Karagiannis T, Advani A, Davies MJ, Del Prato S, Dinneen SF, Kuss O, Lorenzoni V, Mathieu C, Mauricio D, Tankova T, Zaccardi F, Holt RIG, Tsapas A, EASD Guidelines Oversight Committee

Diabetologia2025

DOI: 10.1007/s00125-025-06370-1 PMID: 40447848

06

Finerenone attenuates downregulation of the kidney GLP-1 receptor and glucagon receptor and cardiac GIP receptor in mice with comorbid diabetes.

Tran DT, Yeung ESH, Hong LYQ, Kaur H, Advani SL, Liu Y, Syeda MZ, Batchu SN, Advani A

Diabetology & metabolic syndrome2024Senior author

DOI: 10.1186/s13098-024-01525-3 PMID: 39582036

07

Patient, family and caregiver engagement in diabetes care: a scoping review protocol.

Chamoun D, Ramasamy M, Ziegler C, Yu CH, Wijeyesekera P, Advani A, Pritlove C

BMJ open2024

DOI: 10.1136/bmjopen-2024-086772 PMID: 39209491

08

Effect of hyperglycemia and empagliflozin on markers of cardiorenal injury and inflammation in patients with type 1 diabetes.

Kugathasan L, Sridhar VS, Lytvyn Y, Lovblom LE, Perkins BA, Advani A, Cherney DZI

Diabetes research and clinical practice2024

DOI: 10.1016/j.diabres.2024.111764 PMID: 38960044

09

Interferons and interferon-related pathways in heart disease.

Tran DT, Batchu SN, Advani A

Frontiers in cardiovascular medicine2024Senior author

DOI: 10.3389/fcvm.2024.1357343 PMID: 38665231

10

Minireview: Understanding and targeting inflammatory, hemodynamic and injury markers for cardiorenal protection in type 1 diabetes.

Kugathasan L, Sridhar VS, Tommerdahl KL, Xu C, Bjornstad P, Advani A, Cherney DZI

Metabolism: clinical and experimental2024

DOI: 10.1016/j.metabol.2024.155785 PMID: 38215965

Unraveling the role of ISG15 in diabetic kidney disease

Nominated PICIHR2025Project Grant

Principal investigators: Advani, Andrew

Keywords: Chronic Kidney Disease; Diabetes; Diabetic Kidney Disease; Diabetic Nephropathy; Inflammation; Macrophage

$1,059,526

Acarbose as a biological analogy for understanding the potential of viscous fibre in the prevention of diabetes: The PRANDIAL (Psyllium veRsus Acarbose iNtervention for Dysglycemia In At Risk individuaLs) trial

Co-investigatorCIHR2024Project Grant

Principal investigators: Sievenpiper, John L

Keywords: Carbohydrate Metabolism; Diabetes Prevention; Dietary Fibre; Drug Therapy; Nutrition Therapy; Randomized Controlled Trial

$914,176

Taking the Sting out of acute kidney injury in diabetes

SupervisorCIHR2023CIHR Fellowship

Principal investigators: Syeda, Madiha Zahra

Keywords: Acute Kidney Injury; Diabetes; Inflammation; Sting

$135,000

Taking the Sting out of acute kidney injury in diabetes

Nominated PICIHR2022Project Grant

Principal investigators: Advani, Andrew

Keywords: Acute Kidney Injury; Diabetes; Inflammation; Sting

$1,040,400

'Building Back Better Together': A Multi-stakeholder Approach to Address the Healthcare Workforce Crisis and Promote Healthcare Transformation

Co-investigatorCIHR2022Cat Gr:Policy Res. for Health Sys. Transf.- Canadian Healthcare Workforce

Principal investigators: Pritlove, Cheryl; Dhalla, Irfan

Keywords: Engagement; Equity, Diversity And Inclusion; Heathcare Workforce; Mixed Methods; Participatory Research

$150,000

Gender in Focus: A Photo Elicitation Study of Gender, Self-management, and Care with Emerging Adults with Type 1 Diabetes

Co-investigatorCIHR2021Project Grant

Principal investigators: Pritlove, Cheryl

Keywords: Bourdieusian Theory; Emerging Adulthood; Gender; Photo Elicitation; Qualitative Reserach; Self-Management; Type 1 Diabetes

$351,901

Taking the Sting out of acute kidney injury in diabetes

Nominated PICIHR2021Project Grant - PA: Nutrition, Metabolism and Diabetes

Principal investigators: Advani, Andrew

Keywords: Acute Kidney Injury; Diabetes; Inflammation; Sting

$100,000

Reshaping the epigenetic landscape to improve outcomes after acute kidney injury

Nominated PICIHR2019Project Grant

Principal investigators: Advani, Andrew

Keywords: Acute Kidney Injury; Chronic Kidney Disease; Epigenetics; Fibrosis; Histone Modifications; Senescence; Tubule Epithelial Cells

$929,476

Non-coding RNA in diabetic kidney disease

SupervisorCIHR2017CIHR Fellowship

Principal investigators: Klassen Vakili, Hana

Keywords: Animal Models; Cell Culture; Diabetes; Diabetic Complications; Diabetic Nephropathy; Epigenetic; Glucose; Kidney; Long Non-Coding Rna; Translational Research

$135,000

What is diabetic ketoacidosis (DKA)? - DiaBiteSize

Nominated PICIHR2017Prize - IHDCYH Talks

Principal investigators: Advani, Andrew

Keywords: Diabetes; Diabetic Ketoacidosis; Transition; Type 1 Diabetes; Youth

$750

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Medicine
Critical Care Medicine
Cardiology
Social & Behavioural Health Sciences Division
Medicine/Nephrology
Pathology and Laboratory Medicine
Physiology
Other

Co-authors at University of Toronto, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

Cheryl Pritlove

Social & Behavioural Health Sciences Division

4 shared papers, latest 2024

Daniel Cattran

Medicine/Nephrology

2 shared papers, latest 2018

Eleftherios Diamandis

Pathology and Laboratory Medicine

2 shared papers, latest 2017

Armand Keating

Mechanical Engineering

1 shared papers, latest 2010

Margaret Herridge

Critical Care Medicine

1 shared papers, latest 2016

Gino Somers

Department of Laboratory Medicine and Pathobiology

1 shared papers, latest 2015

Christopher Yip

Institute of Biomedical Engineering

1 shared papers, latest 2026

Claudia Dos Santos

Critical Care Medicine

1 shared papers, latest 2016

Andras Kapus

Department of Surgery

1 shared papers, latest 2016

Ahmad Sidiqi

Surgery

1 shared papers, latest 2016

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mentionMention their CIHR grant from 2025

Subject: Prospective PhD student: Diabetes Dear Professor Advani, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Splicing factor proline- and glutamine-rich (SFPQ) protein causes transcriptional repression of SNAIL to counteract TGF-β signaling." (2026), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your CIHR-funded project "Unraveling the role of ISG15 in diabetic kidney disease" (2025), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]

Andrew Advani

Research

Latest papers

Latest funding

Splicing factor proline- and glutamine-rich (SFPQ) protein causes transcriptional repression of SNAIL to counteract TGF-&#x3b2; signaling.

Reduced podocyte stiffness is a feature of proteinuric kidney disease.

Stimulator of Interferon Genes Is a Fine-Tuner, but Not a Prime Mover, of Kidney Inflammation.

Biphasic actions of the adenosine A2a receptor antagonist istradefylline in mice with obstructive uropathy.

European Association for the Study of Diabetes (EASD) Standard Operating Procedure for the development of guidelines.

Finerenone attenuates downregulation of the kidney GLP-1 receptor and glucagon receptor and cardiac GIP receptor in mice with comorbid diabetes.

Patient, family and caregiver engagement in diabetes care: a scoping review protocol.

Effect of hyperglycemia and empagliflozin on markers of cardiorenal injury and inflammation in patients with type 1 diabetes.

Interferons and interferon-related pathways in heart disease.

Minireview: Understanding and targeting inflammatory, hemodynamic and injury markers for cardiorenal protection in type 1 diabetes.

Frequent collaborators

Howard Leong-Poi

Cheryl Pritlove

Geetha Mukerji

Jeremy Gilbert

Daniel Cattran

Filio Billia

Eleftherios Diamandis

Etienne Sochett

Vathany Kulasingam

Arturo Orellana

Armand Keating

Margaret Herridge

Darren Yuen

Alanna Weisman

Henry Halapy

Joanna Sale

Gino Somers

Jane Batt

Darren Yuen

Christopher Yip

Mansoor Husain

Minna Woo

Claudia Dos Santos

Premysl Bercik

Andras Kapus

Zubin Punthakee

Mohammed Abdul Malik Farooqi

Ahmad Sidiqi

Splicing factor proline- and glutamine-rich (SFPQ) protein causes transcriptional repression of SNAIL to counteract TGF-β signaling.