Faculty profile

Claudia Dos Santos

ResearcherCritical Care MedicineUniversity of Toronto

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a University of Toronto directory, so their courses and email address may be missing. Find their university profile.

Claudia Dos Santos

Researcher

Critical Care Medicine

Health Sciences

University of Toronto

Toronto, Ontario, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
10 publications in the last five years, latest in 2026.
Principal investigator on 14 research grants (13 CIHR, 1 NSERC), most recently in 2024.
Supervised 3 trainees who won CIHR awards, most recently in 2026.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

Publications

286

Citations

h-index

Collaborators

Grants

Publications by year

Counts cover the works listed on the university profile; citation counts come from Dimensions.

Profiles and links

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Signals and details

Research

Sepsis Inflammation Microrna Animal Models Bioinformatics Biomarker Critical Illness Dna Methylation

Latest papers

Systematic review, meta-analysis, and meta-regression of the association of serial leukocyte counts in critically ill patients and mortality.
Annals of intensive care · 2026
Efficacy of swish and gargle and other collection methods with the use of Abbott ID NOW in COVID-19 detection.
Antimicrobial stewardship & healthcare epidemiology : ASHE · 2025
Prediction of lung overdistension during mechanical ventilation using micro-RNA and gene expression.
Intensive care medicine experimental · 2025

All 24 publications

Latest funding

From Injection to Fibrosis: Disrupting Pathogenic Lung Remodeling
CIHR · 2026 · Supervisor
$140,000
Targeting Fibroadipogenic progenitors (FAPs) in the management of traumatic denervation-induced skeletal muscle injury
CIHR · 2025 · Co-investigator
$100,000
Characterizing Individual Patterns of ICU-acquired Weakness and Rehabilitation Responses: Toward Precision Medicine-Based ICU Rehabilitation
CIHR · 2025 · Co-investigator
$818,550

All 50 grants and awards

24 publications.

Systematic review, meta-analysis, and meta-regression of the association of serial leukocyte counts in critically ill patients and mortality.

Arulkumaran N, Dewar F, Ambler G, Arias Lopez MDP, Dos Santos C, De Waele JJ, Lipman J, Paiva JA, Timsit JF

Annals of intensive care2026

DOI: 10.1016/j.aicoj.2026.100054 PMID: 41890439

Efficacy of swish and gargle and other collection methods with the use of Abbott ID NOW in COVID-19 detection.

Ektesabi AM, German GJ, Luu L, Dos Santos C, Matukas LM

Antimicrobial stewardship & healthcare epidemiology : ASHE2025

DOI: 10.1017/ash.2025.10192 PMID: 41180294

Prediction of lung overdistension during mechanical ventilation using micro-RNA and gene expression.

López-Martínez C, Martín-Vicente P, Amado-Rodríguez L, López-Alonso I, Fernández-Rodríguez M, González-López A, Martínez-Camblor P, Gómez J, Boyle AJ, O'Kane CM, McAuley DF, Tsoporis JN, Dos Santos C, Albaiceta GM

Intensive care medicine experimental2025

DOI: 10.1186/s40635-025-00768-2 PMID: 40481913

Mitochondrial Transplantation: A Novel Therapy for Liver Ischemia/Reperfusion Injury.

Mukkala AN, David BA, Ailenberg M, Liang J, Vaswani CM, Karakas D, Goldfarb R, Barbour W, Gasner A, Wu RS, Petrut R, Jerkic M, Andreazza AC, Dos Santos C, Ni H, Zhang H, Kapus A, Kubes P, Rotstein OD

Annals of surgery2025

DOI: 10.1097/sla.0000000000006655 PMID: 39912224

Using a targeted metabolomics approach to explore differences in ARDS associated with COVID-19 compared to ARDS caused by H1N1 influenza and bacterial pneumonia.

Lee CH, Banoei MM, Ansari M, Cheng MP, Lamontagne F, Griesdale D, Lasry DE, Demir K, Dhingra V, Tran KC, Lee T, Burns K, Sweet D, Marshall J, Slutsky A, Murthy S, Singer J, Patrick DM, Lee TC, Boyd JH, Walley KR, Fowler R, Haljan G, Vinh DC, Mcgeer A, Maslove D, Mann P, Donohoe K, Hernandez G, Rocheleau G, Trahtemberg U, Kumar A, Lou M, Dos Santos C, Baker A, Russell JA, Winston BW, *ARBs CORONA I. Investigators

Critical care (London, England)2024

DOI: 10.1186/s13054-024-04843-0 PMID: 38414082

Metabolomics Analysis of Mesenchymal Stem Cell (MSC) Therapy in a Phase I Clinical Trial of Septic Shock: An Exploratory Study.

Banoei MM, McIntyre LA, Stewart DJ, Mei SHJ, Courtman D, Watpool I, Granton J, Marshall J, Dos Santos C, Walley KR, Schlosser K, Fergusson DA, Winston BW, On Behalf Of Canadian Critical Care Trials Group Ccctg, On Behalf Of Canadian Critical Care Translational Biology Group Ccctbg

Metabolites2023

DOI: 10.3390/metabo13111142 PMID: 37999238

Distinct host-response signatures in circulatory shock: a narrative review.

Soussi S, Dos Santos C, Jentzer JC, Mebazaa A, Gayat E, Pöss J, Schaubroeck H, Billia F, Marshall JC, Lawler PR

Intensive care medicine experimental2023

DOI: 10.1186/s40635-023-00531-5 PMID: 37592121

Cell-Free Dot Blot: an Ultra-Low-Cost and Practical Immunoassay Platform for Detection of Anti-SARS-CoV-2 Antibodies in Human and Animal Sera.

Norouzi M, Truong T, Jaenes K, Warner BM, Vendramelli R, Tierney K, Kobasa D, Tailor N, Plant P, Dos Santos C, Babiuk S, Ambagala A, Pardee K

Microbiology spectrum2023

DOI: 10.1128/spectrum.02457-22 PMID: 36719206

Diversity in the Expressed Genomic Host Response to Myocardial Infarction.

Toma A, Dos Santos C, Burzyńska B, Góra M, Kiliszek M, Stickle N, Kirsten H, Kosyakovsky LB, Wang B, van Diepen S, Epelman S, Szekely Y, Marshall JC, Billia F, Lawler PR

Circulation research2022

DOI: 10.1161/circresaha.121.318391 PMID: 35534922

COVID-19 bimodal clinical and pathological phenotypes.

Batah SS, Benatti MN, Siyuan L, Telini WM, Barboza JO, Menezes MB, Nadai TR, Sá KSG, Vaswani CM, Gupta S, Zamboni DS, Wada DT, Calado RT, Oliveira RDR, Louzada-Junior P, Auxiliadora-Martins M, Veras FP, Cunha LD, Cunha TM, Luppino-Assad R, Balancin ML, Morais SS, Martins RB, Arruda E, Chahud F, Santos MK, Cetlin AA, Cunha FQ, Dos Santos C, Capelozzi VL, Fukuoka J, Achcar RD, Fabro AT

Clinical and translational medicine2022

DOI: 10.1002/ctm2.648 PMID: 35075808

From Injection to Fibrosis: Disrupting Pathogenic Lung Remodeling

SupervisorCIHR2026Fellowship: Canada Impact+ Research Training Awards - Postdoctoral

Principal investigators: Batah, Sabrina

Keywords: Covid19; Inflammation; Lnp-Delivery; Microrna; Pulmonary Fibrosis; S/Ards; Therapy; [Pst-Viral

$140,000

Targeting Fibroadipogenic progenitors (FAPs) in the management of traumatic denervation-induced skeletal muscle injury

Co-investigatorCIHR2025Pro. Gr. - PA: Inst. of Musculoskeletal Health and Arthritis: IMHA Mandate Areas

Principal investigators: Batt, Jane Andrea E

Keywords: Denervation; Fibroadipogenic Progenitors; Flow Cytometry/Facs; Glial Cell Derived Neurotrophic Factor (Gdnf); Immunohistochemistry; Primary Cell Culture; Prostaglandin E2 (Pge2); Rat Models; Rna-Seq; Skeletal Muscle

$100,000

Characterizing Individual Patterns of ICU-acquired Weakness and Rehabilitation Responses: Toward Precision Medicine-Based ICU Rehabilitation

Co-investigatorCIHR2025Project Grant

Principal investigators: Goligher, Ewan C

Keywords: Diaphragm; Expiratory Muscles; Inspiratory Muscles; Long-Term Outcomes; Mechanical Ventilation; Rehabilitation; Respiratory Muscle

$818,550

Predict Severity for Sepsis

Nominated PICIHR2024Project Grant

Principal investigators: Dos Santos, Claudia C; Veres, Teodor

Keywords: Biomarker; Device; Inflammation; Rna; Sepsis; Translational Study

$543,150

Development of preclinical data for a phase one clinical trial of a micro-RNA-based formulation to treat early sepsis

Principal investigatorCIHR2024Project Grant

Principal investigators: Walker, Gilbert C; de Rezende, Joao B; Dos Santos, Claudia C

Keywords: Bacterial Induced Sepsis; Cardiomyopathy; Commercialization; Lipid Nanoparticle Formulation; Microrna; Preclinical Data

$508,725

Targeting Fibroadipogenic progenitors (FAPs) in the management of traumatic denervation-induced skeletal muscle injury

Co-investigatorCIHR2024Pro. Gr. - PA: Inst. of Musculoskeletal Health and Arthritis: IMHA Mandate Areas

Principal investigators: Batt, Jane Andrea E

$100,000

Leveraging microRNA-based Modified Lipid Nanoparticles for Targeted Lung Surfactant Rescue in Viral Lung Injury

SupervisorCIHR2024CIHR Fellowship - PA: PPHE Research - Priority Areas

Principal investigators: Vaswani, Chirag M

Keywords: Acute Respiratory Distress Syndrome; Critical Illness; Influenza; Lipid Nanoparticles; Microrna Therapy; Nanomedicine; Sars-Cov-2; Surfactant

$210,000

Improving Access to Diagnostics: The Development of Deployable, Low-Burden Hand-Held Testing for Infectious Disease and Health Biomarkers.

Co-investigatorCIHR2024Project Grant

Principal investigators: Pardee, Keith I

Keywords: Arbovirus Infection; Global Health; Isothermal Amplification; Lyme Disease; Microfluidics; Mirna Detection; Molecular Diagnostics; Nucleic Acid Quantification; Point-Of-Need Bioanalytics; Snp Detection

$952,424

Engineered Lipid Nanoparticle miRNA-therapy Options for ARDS

Nominated PICIHR2023Project Grant

Principal investigators: Dos Santos, Claudia C; Walker, Gilbert C

Keywords: Acute Respiratory Distress Syndrome; Extracellular Vesicles; Influenza; Ko Mice; Lipid Nanoparticles; Microrna; Polymicrobial Sepsis; Preclinical Models

$367,200

Canada Research Chair - Tier 1

Nominated PICIHR2023Canada Research Chairs - CIHR Funded - Tier 1

Principal investigators: Dos Santos, Claudia C

Keywords: Crc

$1,400,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

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Claudia Dos Santos

Research

Latest papers

Latest funding

Systematic review, meta-analysis, and meta-regression of the association of serial leukocyte counts in critically ill patients and mortality.

Efficacy of swish and gargle and other collection methods with the use of Abbott ID NOW in COVID-19 detection.

Prediction of lung overdistension during mechanical ventilation using micro-RNA and gene expression.

Mitochondrial Transplantation: A Novel Therapy for Liver Ischemia/Reperfusion Injury.

Using a targeted metabolomics approach to explore differences in ARDS associated with COVID-19 compared to ARDS caused by H1N1 influenza and bacterial pneumonia.

Metabolomics Analysis of Mesenchymal Stem Cell (MSC) Therapy in a Phase I Clinical Trial of Septic Shock: An Exploratory Study.

Distinct host-response signatures in circulatory shock: a narrative review.

Cell-Free Dot Blot: an Ultra-Low-Cost and Practical Immunoassay Platform for Detection of Anti-SARS-CoV-2 Antibodies in Human and Animal Sera.

Diversity in the Expressed Genomic Host Response to Myocardial Infarction.

COVID-19 bimodal clinical and pathological phenotypes.

Frequent collaborators

John Marshall

Margaret Herridge

Jane Batt

David Courtman

Haibo Zhang

Filio Billia

Hannah Wunsch

John Granton

Heyu Ni

Darwyn Kobasa

Justin Presseau

Slava Epelman

Keith Pardee

Donald Welsh

Anand Kumar

Kirsten Fiest

Kevin Burns

Srinivas Murthy

Braedon McDonald

BO WANG

Sangeeta Mehta

Joseph Beyene

Alison Fox-Robichaud

Patricia Chia-Ying Liaw

Gloria Vazquez-Grande

Michael Glogauer

Ryan Zarychanski

Dean Fergusson

Robert Fowler

Deborah Cook

Francois Lamontagne